Published in Nature on July 08, 1983
A v-erbB-related protooncogene, c-erbB-2, is distinct from the c-erbB-1/epidermal growth factor-receptor gene and is amplified in a human salivary gland adenocarcinoma. Proc Natl Acad Sci U S A (1985) 3.80
Transgenic mice harboring SV40 T-antigen genes develop characteristic brain tumors. Cell (1984) 3.56
New human transforming genes detected by a tumorigenicity assay. Mol Cell Biol (1984) 3.43
Moesin: a member of the protein 4.1-talin-ezrin family of proteins. Proc Natl Acad Sci U S A (1991) 3.06
Characterization of the activation of latent TGF-beta by co-cultures of endothelial cells and pericytes or smooth muscle cells: a self-regulating system. J Cell Biol (1990) 2.65
Selective inhibition of growth-related gene expression in murine keratinocytes by transforming growth factor beta. Mol Cell Biol (1988) 2.20
A new type of transforming growth factor-beta, TGF-beta 3. EMBO J (1988) 2.12
Regulation of intestinal epithelial cell growth by transforming growth factor type beta. Proc Natl Acad Sci U S A (1989) 2.09
A highly immunogenic tumor transfected with a murine transforming growth factor type beta 1 cDNA escapes immune surveillance. Proc Natl Acad Sci U S A (1990) 2.03
Structure and localization of genes encoding aberrant and normal epidermal growth factor receptor RNAs from A431 human carcinoma cells. Mol Cell Biol (1985) 2.02
ras gene Amplification and malignant transformation. Mol Cell Biol (1985) 2.02
Enhanced expression of the human gene N-myc consequent to amplification of DNA may contribute to malignant progression of neuroblastoma. Proc Natl Acad Sci U S A (1984) 1.99
Regulated transcription of c-Ki-ras and c-myc during compensatory growth of rat liver. Mol Cell Biol (1984) 1.98
Elevated expression of the human ras oncogene family in premalignant and malignant tumours of the colorectum. Br J Cancer (1984) 1.97
A heparin sulfate-regulated human keratinocyte autocrine factor is similar or identical to amphiregulin. Mol Cell Biol (1991) 1.93
Regulation of eicosanoid production and mitogenesis in rat intestinal epithelial cells by transforming growth factor-alpha and phorbol ester. J Clin Invest (1994) 1.89
Augmented expression of normal c-myc is sufficient for cotransformation of rat embryo cells with a mutant ras gene. Mol Cell Biol (1985) 1.84
Isolation of the amplified dihydrofolate reductase domain from methotrexate-resistant Chinese hamster ovary cells. Mol Cell Biol (1987) 1.78
An S1 nuclease-sensitive homopurine/homopyrimidine domain in the c-Ki-ras promoter interacts with a nuclear factor. Proc Natl Acad Sci U S A (1990) 1.64
Mouse mammary tumor virus integration regions int-1 and int-2 map on different mouse chromosomes. Mol Cell Biol (1984) 1.64
Localization of the beta-globin gene by chromosomal in situ hybridization. Am J Hum Genet (1984) 1.64
Aberrant expression of an amplified c-myb oncogene in two cell lines from a colon carcinoma. Proc Natl Acad Sci U S A (1984) 1.59
"Retroposon" insertion into the cellular oncogene c-myc in canine transmissible venereal tumor. Proc Natl Acad Sci U S A (1985) 1.56
UV radiation facilitates methotrexate resistance and amplification of the dihydrofolate reductase gene in cultured 3T6 mouse cells. Mol Cell Biol (1984) 1.55
Saccharomyces cerevisiae synthesizes proteins related to the p21 gene product of ras genes found in mammals. Mol Cell Biol (1984) 1.53
Gene amplification in Tetrahymena thermophila: formation of extrachromosomal palindromic genes coding for rRNA. Mol Cell Biol (1985) 1.50
Expression of p21ras in fresh primary and metastatic human colorectal tumors. Proc Natl Acad Sci U S A (1985) 1.47
Structure and expression of amplified cKi-ras gene sequences in Y1 mouse adrenal tumor cells. EMBO J (1985) 1.46
p19Arf suppresses growth, progression, and metastasis of Hras-driven carcinomas through p53-dependent and -independent pathways. PLoS Biol (2004) 1.44
Senescent cells fail to express cdc2, cycA, and cycB in response to mitogen stimulation. Proc Natl Acad Sci U S A (1991) 1.44
Organization and genesis of dihydrofolate reductase amplicons in the genome of a methotrexate-resistant Chinese hamster ovary cell line. Mol Cell Biol (1988) 1.42
Structural and functional characterization of the promoter region of the mouse c-Ki-ras gene. Mol Cell Biol (1987) 1.42
The cellular response to induction of the p21 c-Ha-ras oncoprotein includes stimulation of jun gene expression. EMBO J (1989) 1.35
Monoclonal antibodies of predefined specificity detect activated ras gene expression in human mammary and colon carcinomas. Proc Natl Acad Sci U S A (1984) 1.32
Expression of p21ras in normal and malignant human tissues: lack of association with proliferation and malignancy. Proc Natl Acad Sci U S A (1987) 1.29
Amplification and overexpression of the met gene in spontaneously transformed NIH3T3 mouse fibroblasts. EMBO J (1986) 1.28
Chromosome assignments of four mouse cellular homologs of sarcoma and leukemia virus oncogenes. Proc Natl Acad Sci U S A (1984) 1.23
Epidermal growth factor stimulation of stromelysin mRNA in rat fibroblasts requires induction of proto-oncogenes c-fos and c-jun and activation of protein kinase C. Mol Cell Biol (1990) 1.22
Inhibition of tumorigenesis by a cytosine-DNA, methyltransferase, antisense oligodeoxynucleotide. Proc Natl Acad Sci U S A (1997) 1.19
Human tumor cell lines with EGF receptor gene amplification in the absence of aberrant sized mRNAs. Nucleic Acids Res (1985) 1.18
Presence of a Kirsten murine sarcoma virus ras oncogene in cells transformed by 3-methylcholanthrene. Mol Cell Biol (1983) 1.18
Amplification and cloning of the Chinese hamster glutamine synthetase gene. EMBO J (1984) 1.16
Carcinogen-mediated methotrexate resistance and dihydrofolate reductase amplification in Chinese hamster cells. Mol Cell Biol (1986) 1.13
Expression of T cell receptor genes in human B cells. J Exp Med (1986) 1.10
Enhanced c-Ki-ras expression associated with Friend virus integration in a bone marrow-derived mouse cell line. Proc Natl Acad Sci U S A (1986) 1.09
Insertional oncogenesis by non-acute retroviruses: implications for gene therapy. Viruses (2011) 1.09
Modulation of hnRNP A1 protein gene expression by epidermal growth factor in Rat-1 cells. Nucleic Acids Res (1988) 1.09
Human cancer and cellular oncogenes. Biochem J (1987) 1.07
Identification of a provirally activated c-Ha-ras oncogene in an avian nephroblastoma via a novel procedure: cDNA cloning of a chimaeric viral-host transcript. EMBO J (1986) 1.06
Amplification and expression of a cellular oncogene (c-myc) in human gastric adenocarcinoma cells. Mol Cell Biol (1985) 1.05
Identification of immediate-early-type cis-response elements in the promoter for the ribonucleotide reductase large subunit from herpes simplex virus type 2. J Virol (1989) 1.04
Neurotensin expression and release in human colon cancers. Ann Surg (1992) 1.01
Oncogene amplification during tumorigenesis of established rat fibroblasts reversibly transformed by activated human ras oncogenes. Mol Cell Biol (1986) 1.01
Genetic mapping of a cellular DNA region involved in induction of thymic lymphomas (Mlvi-1) to mouse chromosome 15. Mol Cell Biol (1985) 1.01
Expression of the amplified domain in human neuroblastoma cells. Mol Cell Biol (1984) 1.00
A novel germ-line JK transcript starting immediately upstream of JK1. Nucleic Acids Res (1989) 0.98
Loss of tumor-suppressive function during chemically induced neoplastic progression of Syrian hamster embryo cells. Proc Natl Acad Sci U S A (1986) 0.98
Mammary tumorigenesis in feral Mus cervicolor popaeus. J Virol (1986) 0.96
Activation of the neu tyrosine kinase induces the fos/jun transcription factor complex, the glucose transporter and ornithine decarboxylase. J Cell Biol (1989) 0.96
Rearrangement at the 5' end of amplified c-myc in human COLO 320 cells is associated with abnormal transcription. Mol Cell Biol (1986) 0.95
Transcriptional activation of cKi-ras proto-oncogene resulting from retroviral promoter insertion. Nucleic Acids Res (1989) 0.95
Activated K-ras and N-ras oncogenes in primary renal mesenchymal tumors induced in F344 rats by methyl(methoxymethyl)nitrosamine. Mol Cell Biol (1986) 0.94
Inhibition of malignant transformation in vitro by inhibitors of poly(ADP-ribose) synthesis. Proc Natl Acad Sci U S A (1984) 0.94
Unstable expression and amplification of a transfected oncogene in confluent and subconfluent cells. Mol Cell Biol (1985) 0.92
Amplified DNA in Y1 mouse adrenal tumor cells: isolation of cDNAs complementary to an amplified c-Ki-ras gene and localization of homologous sequences to mouse chromosome 6. Nucleic Acids Res (1984) 0.92
Fast solid support detection of PCR amplified viral DNA sequences using radioiodinated or hapten labelled primers. Nucleic Acids Res (1990) 0.92
The neurotensin gene is a downstream target for Ras activation. J Clin Invest (1995) 0.91
Mouse chromosomal mapping of a murine leukemia virus integration region (Mis-1) first identified in rat thymic leukemia. J Virol (1985) 0.91
Development and analysis of a transformation-defective mutant of Harvey murine sarcoma tk virus and its gene product. J Virol (1985) 0.90
A highly amplified mouse gene is homologous to the human interferon-responsive Sp100 gene encoding an autoantigen associated with nuclear dots. Mol Cell Biol (1996) 0.90
Loss of unstably amplified dihydrofolate reductase genes from mouse cells is greatly accelerated by hydroxyurea. Proc Natl Acad Sci U S A (1983) 0.89
Dissection of the mouse N-ras gene upstream regulatory sequences and identification of the promoter and a negative regulatory element. Mol Cell Biol (1991) 0.87
Expression of a fms-related oncogene in carcinogen-induced neoplastic epithelial cells. Proc Natl Acad Sci U S A (1987) 0.84
Resolving the network of cell signaling pathways using the evolving yeast two-hybrid system. Biotechniques (2008) 0.84
Mutations of K-ras oncogene in human adrenal tumours in Taiwan. Br J Cancer (1998) 0.84
Analysis of gene amplification in human tumor cell lines. Proc Natl Acad Sci U S A (1988) 0.82
Molecular cloning and chromosome assignment of murine N-ras. Nucleic Acids Res (1984) 0.80
In vitro galactosylation of a 110-kDa glycoprotein by an endogenous cell surface galactosyltransferase correlates with the invasiveness of adrenal carcinoma cells. Proc Natl Acad Sci U S A (1989) 0.80
Regulation of endothelial adhesion molecules by ligands binding to the scavenger receptor. Clin Exp Immunol (1993) 0.80
Fibroblast growth factor 2 causes G2/M cell cycle arrest in ras-driven tumor cells through a Src-dependent pathway. PLoS One (2013) 0.79
Ras-mediated suppression of TGFbetaRII expression in intestinal epithelial cells involves Raf-independent signaling. Neoplasia (2001) 0.78
Expression of viral p21ras during acquisition of a transformed phenotype by rat adrenal cortex cells infected with Kirsten murine sarcoma virus. Mol Cell Biol (1986) 0.76
The expression and localization of urokinase-type plasminogen activator and its type 1 inhibitor are regulated by retinoic acid and fibroblast growth factor in human teratocarcinoma cells. Cell Regul (1991) 0.76
Activation of mitogen-activated protein kinase (mitogen-activated protein kinase/extracellular signal-regulated kinase) cascade by aldosterone. Mol Biol Cell (2002) 0.76
Preferentially expressed genes in stomach adenocarcinoma cells. Br J Cancer (1987) 0.76
Establishment of a human glioma cell line bearing a homogeneously staining chromosomal region and releasing alpha- and beta-type transforming growth factors. Acta Neuropathol (1989) 0.76
Analysis of G banded karyotypes in myeloma cells. J Clin Pathol (1986) 0.75
Expression of autophosphorylating protein kinase 500 in normal and neoplastic rat cells. Proc Natl Acad Sci U S A (1985) 0.75
Isolation of monoclonal antibodies specific for human c-myc proto-oncogene product. Mol Cell Biol (1985) 25.52
Classification and diagnostic prediction of cancers using gene expression profiling and artificial neural networks. Nat Med (2001) 16.65
The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation. Cell (1992) 16.53
Gene expression analysis by massively parallel signature sequencing (MPSS) on microbead arrays. Nat Biotechnol (2000) 15.79
Mapping unintegrated avian sarcoma virus DNA: termini of linear DNA bear 300 nucleotides present once or twice in two species of circular DNA. Cell (1978) 13.33
The molecular biology of the hepatitis B viruses. Annu Rev Biochem (1987) 12.32
Evidence that the transforming gene of avian sarcoma virus encodes a protein kinase associated with a phosphoprotein. Cell (1978) 11.17
Correct integration of retroviral DNA in vitro. Cell (1987) 10.73
Characterization of ribosomal frameshifting in HIV-1 gag-pol expression. Nature (1988) 10.69
Cellular oncogenes and retroviruses. Annu Rev Biochem (1983) 10.65
DNA related to the transforming gene(s) of avian sarcoma viruses is present in normal avian DNA. Nature (1976) 9.81
Amplification of N-myc in untreated human neuroblastomas correlates with advanced disease stage. Science (1984) 9.64
Many tumors induced by the mouse mammary tumor virus contain a provirus integrated in the same region of the host genome. Cell (1982) 9.29
Multiple arrangements of viral DNA and an activated host oncogene in bursal lymphomas. Nature (1982) 9.12
Form and function of retroviral proviruses. Science (1982) 8.80
A nucleoprotein complex mediates the integration of retroviral DNA. Genes Dev (1989) 8.80
Amplified DNA with limited homology to myc cellular oncogene is shared by human neuroblastoma cell lines and a neuroblastoma tumour. Nature (1983) 8.18
Retroviral integration: structure of the initial covalent product and its precursor, and a role for the viral IN protein. Proc Natl Acad Sci U S A (1989) 8.13
Reversible tumorigenesis by MYC in hematopoietic lineages. Mol Cell (1999) 8.03
Induction of tumor lymphangiogenesis by VEGF-C promotes breast cancer metastasis. Nat Med (2001) 7.78
The molecular genetics of cancer. Science (1987) 7.64
Uninfected vertebrate cells contain a protein that is closely related to the product of the avian sarcoma virus transforming gene (src). Proc Natl Acad Sci U S A (1979) 7.55
Proviruses of avian sarcoma virus are terminally redundant, co-extensive with unintegrated linear DNA and integrated at many sites. Cell (1978) 7.46
Molecular cloning and characterization of avian sarcoma virus circular DNA molecules. J Virol (1980) 7.37
Signals for ribosomal frameshifting in the Rous sarcoma virus gag-pol region. Cell (1988) 7.14
Expression of the fms-like tyrosine kinase 4 gene becomes restricted to lymphatic endothelium during development. Proc Natl Acad Sci U S A (1995) 7.11
Homogeneously staining chromosomal regions contain amplified copies of an abundantly expressed cellular oncogene (c-myc) in malignant neuroendocrine cells from a human colon carcinoma. Proc Natl Acad Sci U S A (1983) 7.01
Analysis of avian leukosis virus DNA and RNA in bursal tumours: viral gene expression is not required for maintenance of the tumor state. Cell (1981) 6.98
Expression of the int-1 gene in transgenic mice is associated with mammary gland hyperplasia and adenocarcinomas in male and female mice. Cell (1988) 6.48
Virus-specific ribonucleic acid in cells producing rous sarcoma virus: detection and characterization. J Virol (1972) 6.38
Hyperplasia of lymphatic vessels in VEGF-C transgenic mice. Science (1997) 6.37
Standardized and simplified nomenclature for proteins common to all retroviruses. J Virol (1988) 6.31
Nucleotide sequence of the retroviral leukemia gene v-myb and its cellular progenitor c-myb: the architecture of a transduced oncogene. Cell (1982) 6.19
Structure and variability of human chromosome ends. Mol Cell Biol (1990) 6.18
Expression of the Rous sarcoma virus pol gene by ribosomal frameshifting. Science (1985) 5.90
A mutant murine leukemia virus with a single missense codon in pol is defective in a function affecting integration. Proc Natl Acad Sci U S A (1984) 5.81
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Transcripts from the cellular homologs of retroviral oncogenes: distribution among chicken tissues. Mol Cell Biol (1982) 5.70
Polymerase gene products of hepatitis B viruses are required for genomic RNA packaging as wel as for reverse transcription. Nature (1990) 5.68
Induction and apoptotic regression of lung adenocarcinomas by regulation of a K-Ras transgene in the presence and absence of tumor suppressor genes. Genes Dev (2001) 5.67
Definition of regions in human c-myc that are involved in transformation and nuclear localization. Mol Cell Biol (1987) 5.67
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A novel vascular endothelial growth factor, VEGF-C, is a ligand for the Flt4 (VEGFR-3) and KDR (VEGFR-2) receptor tyrosine kinases. EMBO J (1996) 5.33
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Nucleotide sequence of an avian sarcoma virus oncogene (src) and proposed amino acid sequence for gene product. Nature (1980) 5.22
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