Published in Nature on March 11, 1976
Transforming gene product of Rous sarcoma virus phosphorylates tyrosine. Proc Natl Acad Sci U S A (1980) 22.30
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Uninfected vertebrate cells contain a protein that is closely related to the product of the avian sarcoma virus transforming gene (src). Proc Natl Acad Sci U S A (1979) 7.55
Isolation of monoclonal antibodies that recognize the transforming proteins of avian sarcoma viruses. J Virol (1983) 7.22
Identification of a polypeptide encoded by the avian sarcoma virus src gene. Proc Natl Acad Sci U S A (1978) 6.87
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Structure and biological activity of v-raf, a unique oncogene transduced by a retrovirus. Proc Natl Acad Sci U S A (1983) 4.82
Recovery of avian sarcoma virus from tumors induced by transformation-defective mutants. J Exp Med (1977) 4.79
Construction and isolation of a transmissible retrovirus containing the src gene of Harvey murine sarcoma virus and the thymidine kinase gene of herpes simplex virus type 1. J Virol (1981) 4.54
Nucleotide sequences related to the transforming gene of avian sarcoma virus are present in DNA of uninfected vertebrates. Proc Natl Acad Sci U S A (1978) 4.47
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DNA sequences homologous to vertebrate oncogenes are conserved in Drosophila melanogaster. Proc Natl Acad Sci U S A (1981) 4.17
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A normal cell protein similar in structure and function to the avian sarcoma virus transforming gene product. Proc Natl Acad Sci U S A (1979) 4.02
Rous sarcoma virus variants that carry the cellular src gene instead of the viral src gene cannot transform chicken embryo fibroblasts. Proc Natl Acad Sci U S A (1984) 3.70
Friend strain of spleen focus-forming virus: a recombinant between mouse type C ecotropic viral sequences and sequences related to xenotropic virus. J Virol (1977) 3.70
DNA and RNA from uninfected vertebrate cells contain nucleotide sequences related to the putative transforming gene of avian myelocytomatosis virus. J Virol (1979) 3.68
Cellular information in the genome of recovered avian sarcoma virus directs the synthesis of transforming protein. Proc Natl Acad Sci U S A (1979) 3.66
Characterization of Y73, an avian sarcoma virus: a unique transforming gene and its product, a phosphopolyprotein with protein kinase activity. Proc Natl Acad Sci U S A (1980) 3.58
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Transduction of a cellular oncogene: the genesis of Rous sarcoma virus. Proc Natl Acad Sci U S A (1983) 3.41
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Identification of a Rous sarcoma virus transformation-related protein in normal avian and mammalian cells. Proc Natl Acad Sci U S A (1979) 3.31
Temperature-sensitive changes in surface modulating assemblies of fibroblasts transformed by mutants of Rous sarcoma virus. Proc Natl Acad Sci U S A (1976) 3.29
Neural tissues express high levels of the cellular src gene product pp60c-src. Mol Cell Biol (1983) 3.27
Temperature-sensitive transformation by Rous sarcoma virus and temperature-sensitive protein kinase activity. J Virol (1980) 3.25
Blood platelets express high levels of the pp60c-src-specific tyrosine kinase activity. Proc Natl Acad Sci U S A (1986) 3.22
Human adult T-cell leukemia virus: molecular cloning of the provirus DNA and the unique terminal structure. Proc Natl Acad Sci U S A (1982) 3.19
Proposal for naming host cell-derived inserts in retrovirus genomes. J Virol (1981) 3.18
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Tumor reversion: correction of malignant behavior by microenvironmental cues. Int J Cancer (2003) 3.02
Structural relationship between a normal chicken DNA locus and the transforming gene of the avian acute leukemia virus MC29. J Virol (1982) 3.00
Recombinants between endogenous and exogenous avian tumor viruses: role of the C region and other portions of the genome in the control of replication and transformation. J Virol (1980) 2.93
Biochemical and immunological characterization of polyproteins coded for by the McDonough, Gardner-Arnstein, and Snyder-Theilen strains of feline sarcoma virus. J Virol (1980) 2.92
Nucleotide sequences in mouse DNA and RNA specific for Moloney sarcoma virus. Proc Natl Acad Sci U S A (1976) 2.86
Origin and functional properties of the major gene product of the Snyder-Theilen strain of feline sarcoma virus. Proc Natl Acad Sci U S A (1980) 2.83
Activation of the transforming potential of p60c-src by a single amino acid change. Proc Natl Acad Sci U S A (1986) 2.70
Cellular sequences related to three new onc genes of avian sarcoma virus (fps, yes, and ros) and their expression in normal and transformed cells. J Virol (1982) 2.69
Why do viruses cause cancer? Highlights of the first century of human tumour virology. Nat Rev Cancer (2010) 2.68
Identification of nucleotide sequences which may encode the oncogenic capacity of avian retrovirus MC29. J Virol (1978) 2.62
Homology exists among the transforming sequences of avian and feline sarcoma viruses. Proc Natl Acad Sci U S A (1980) 2.50
Characterization of reticuloendotheliosis virus strain T DNA and isolation of a novel variant of reticuloendotheliosis virus strain T by molecular cloning. J Virol (1981) 2.49
Cellular sequences are present in the presumptive avian myeloblastosis virus genome. Proc Natl Acad Sci U S A (1980) 2.45
Flat revertants isolated from Kirsten sarcoma virus-transformed cells are resistant to the action of specific oncogenes. Proc Natl Acad Sci U S A (1983) 2.44
In vitro isolation of stable rat sarcoma viruses. Proc Natl Acad Sci U S A (1978) 2.41
Identification of a 30S RNA with properties of a defective type C virus in murine cells. J Virol (1978) 2.34
Genetic variation in the RNA transcripts of endogenous virus genes in uninfected chicken cells. J Virol (1977) 2.28
Molecular cloning of Moloney murine sarcoma virus: arrangement of virus-related sequences within the normal mouse genome. Proc Natl Acad Sci U S A (1979) 2.27
The product of the protooncogene c-src is modified during the cellular response to platelet-derived growth factor. Proc Natl Acad Sci U S A (1985) 2.19
Transcription of c-onc genes c-rasKi and c-fms during mouse development. Mol Cell Biol (1983) 2.14
Cellular homologue (c-src) of the transforming gene of Rous sarcoma virus: isolation, mapping, and transcriptional analysis of c-src and flanking regions. Proc Natl Acad Sci U S A (1981) 2.11
Molecular events in cells transformed by Rous Sarcoma virus. J Cell Biol (1980) 2.10
Expression of c-onc genes: c-fos transcripts accumulate to high levels during development of mouse placenta, yolk sac and amnion. EMBO J (1983) 2.08
Nucleotide sequence relationships between the genomes of an endogenous and an exogenous avian tumor virus. J Virol (1978) 2.01
DNA sequences similar to those around the simian virus 40 origin of replication are present in the monkey genome. Proc Natl Acad Sci U S A (1981) 1.94
A cancer theory kerfuffle can lead to new lines of research. J Natl Cancer Inst (2014) 1.91
Lymphoma development in mice and humans: diversity of initiation is followed by convergent cytogenetic evolution. Proc Natl Acad Sci U S A (1979) 1.90
Sequence comparison in the crossover region of an oncogenic avian retrovirus recombinant and its nononcogenic parent: genetic regions that control growth rate and oncogenic potential. Mol Cell Biol (1982) 1.89
Androgen-induced programs for prostate epithelial growth and invasion arise in embryogenesis and are reactivated in cancer. Oncogene (2008) 1.88
Markedly elevated levels of an endogenous sarc protein in a hemopoietic precursor cell line. Mol Cell Biol (1981) 1.83
Comparison between the viral transforming gene (src) of recovered avian sarcoma virus and its cellular homolog. Mol Cell Biol (1981) 1.78
Chromosomal mapping of the simian sarcoma virus onc gene analogue in human cells. Proc Natl Acad Sci U S A (1982) 1.72
High-frequency transduction of c-erbB in avian leukosis virus-induced erythroblastosis. J Virol (1985) 1.69
Generation of transforming viruses in cultures of chicken fibroblasts infected with an avian leukosis virus. J Virol (1981) 1.68
Rate of divergence of cellular sequences homologous to segments of Moloney sarcoma virus. J Virol (1977) 1.65
Combined inhibition of c-Src and epidermal growth factor receptor abrogates growth and invasion of head and neck squamous cell carcinoma. Clin Cancer Res (2008) 1.63
CDK1 substitutes for mTOR kinase to activate mitotic cap-dependent protein translation. Proc Natl Acad Sci U S A (2015) 1.61
Cellular Moloney murine sarcoma (c-mos) sequences are hypermethylated and transcriptionally silent in normal and transformed rodent cells. Mol Cell Biol (1982) 1.58
Molecular cloning and comparative analyses of the genomes of simian sarcoma virus and its associated helper virus. Proc Natl Acad Sci U S A (1981) 1.57
Some biological properties of two new avian sarcoma viruses. J Virol (1981) 1.57
Chromosomal assignment of a family of human oncogenes. Proc Natl Acad Sci U S A (1983) 1.53
Inhibition of Src family kinases with dasatinib blocks migration and invasion of human melanoma cells. Mol Cancer Res (2008) 1.52
Characterization of some isolates of newly recovered avian sarcoma virus. J Virol (1979) 1.51
Characterization of an immune complex kinase in immunoprecipitates of avian sarcoma virus-transformed fibroblasts. J Virol (1979) 1.48
Human cellular src gene: nucleotide sequence and derived amino acid sequence of the region coding for the carboxy-terminal two-thirds of pp60c-src. Mol Cell Biol (1985) 1.46
Three segments from the monkey genome that hybridize to simian virus 40 have common structural elements. Mol Cell Biol (1981) 1.43
Use of alkaline sucrose gradients in a zonal rotor to detect integrated and unintegrated avian sarcoma virus-specific DNA in cells. J Virol (1976) 1.42
Genetic structure and transforming sequence of avian sarcoma virus UR2. J Virol (1982) 1.42
Avian retroviruses that cause carcinoma and leukemia: identification of nucleotide sequences associated with pathogenicity. J Virol (1980) 1.41
DNA sequence encoding the amino-terminal region of the human c-src protein: implications of sequence divergence among src-type kinase oncogenes. Mol Cell Biol (1987) 1.41
Structural studies on oncornavirus-related sequences in chicken genomic DNA: two-step analyses of EcoRI and Bgl I restriction digests and tentative mapping of a ubiquitous endogenous provirus digests and tentative mapping of a ubiquitous endogenous provirus. Proc Natl Acad Sci U S A (1979) 1.39
Monoclonal antibodies to the transformation-specific glycoprotein encoded by the feline retroviral oncogene v-fms. J Virol (1982) 1.39
Platelet-derived growth factor. Structure, function, and roles in normal and transformed cells. J Clin Invest (1984) 1.38
Membranes from T and B lymphocytes have different patterns of tyrosine phosphorylation. Proc Natl Acad Sci U S A (1984) 1.38
Genetic analysis of p60v-src domains involved in the induction of different cell transformation parameters. J Virol (1986) 1.38
Kinome-wide Decoding of Network-Attacking Mutations Rewiring Cancer Signaling. Cell (2015) 1.38
Relationship of polypeptide products of the transforming gene of Rous sarcoma virus and the homologous gene of vertebrates. Proc Natl Acad Sci U S A (1980) 1.38
Specific association of the proto-oncogene product pp60c-src with an intracellular organelle, the PC12 synaptic vesicle. J Cell Biol (1992) 1.37
The transcription factor NF-E2-related factor 2 (Nrf2): a protooncogene? FASEB J (2012) 1.37
A novel oncogene related to c-mil is transduced in chicken neuroretina cells induced to proliferate by infection with an avian lymphomatosis virus. EMBO J (1988) 1.35
The specific induction of myc protooncogene expression in normal human B cells is not a sufficient event for acquisition of competence to proliferate. Proc Natl Acad Sci U S A (1985) 1.34
Regulation of SRC family kinases in human cancers. J Signal Transduct (2011) 1.32
Chromosome 1 contains the endogenous RAV-0 retrovirus sequences in chicken cells. Proc Natl Acad Sci U S A (1979) 1.32
In vitro translation of Harvey murine sarcoma virus RNA. J Virol (1977) 1.32
Cell-type-specific pattern of myc protooncogene expression in developing human embryos. Proc Natl Acad Sci U S A (1985) 1.26
The metabolic advantage of tumor cells. Mol Cancer (2011) 1.24
100 years of Rous sarcoma virus. J Exp Med (2011) 1.24
Isolation of monoclonal antibodies specific for human c-myc proto-oncogene product. Mol Cell Biol (1985) 25.52
Mapping unintegrated avian sarcoma virus DNA: termini of linear DNA bear 300 nucleotides present once or twice in two species of circular DNA. Cell (1978) 13.33
The molecular biology of the hepatitis B viruses. Annu Rev Biochem (1987) 12.32
Evidence that the transforming gene of avian sarcoma virus encodes a protein kinase associated with a phosphoprotein. Cell (1978) 11.17
Correct integration of retroviral DNA in vitro. Cell (1987) 10.73
Characterization of ribosomal frameshifting in HIV-1 gag-pol expression. Nature (1988) 10.69
Cellular oncogenes and retroviruses. Annu Rev Biochem (1983) 10.65
Human proto-oncogene c-jun encodes a DNA binding protein with structural and functional properties of transcription factor AP-1. Science (1987) 10.25
Amplification of N-myc in untreated human neuroblastomas correlates with advanced disease stage. Science (1984) 9.64
Many tumors induced by the mouse mammary tumor virus contain a provirus integrated in the same region of the host genome. Cell (1982) 9.29
Multiple arrangements of viral DNA and an activated host oncogene in bursal lymphomas. Nature (1982) 9.12
Form and function of retroviral proviruses. Science (1982) 8.80
A nucleoprotein complex mediates the integration of retroviral DNA. Genes Dev (1989) 8.80
Amplified DNA with limited homology to myc cellular oncogene is shared by human neuroblastoma cell lines and a neuroblastoma tumour. Nature (1983) 8.18
Retroviral integration: structure of the initial covalent product and its precursor, and a role for the viral IN protein. Proc Natl Acad Sci U S A (1989) 8.13
Reversible tumorigenesis by MYC in hematopoietic lineages. Mol Cell (1999) 8.03
The molecular genetics of cancer. Science (1987) 7.64
Uninfected vertebrate cells contain a protein that is closely related to the product of the avian sarcoma virus transforming gene (src). Proc Natl Acad Sci U S A (1979) 7.55
Proviruses of avian sarcoma virus are terminally redundant, co-extensive with unintegrated linear DNA and integrated at many sites. Cell (1978) 7.46
Molecular cloning and characterization of avian sarcoma virus circular DNA molecules. J Virol (1980) 7.37
Continuous tissue culture cell lines derived from chemically induced tumors of Japanese quail. Cell (1977) 7.23
Signals for ribosomal frameshifting in the Rous sarcoma virus gag-pol region. Cell (1988) 7.14
Homogeneously staining chromosomal regions contain amplified copies of an abundantly expressed cellular oncogene (c-myc) in malignant neuroendocrine cells from a human colon carcinoma. Proc Natl Acad Sci U S A (1983) 7.01
Analysis of avian leukosis virus DNA and RNA in bursal tumours: viral gene expression is not required for maintenance of the tumor state. Cell (1981) 6.98
Expression of the int-1 gene in transgenic mice is associated with mammary gland hyperplasia and adenocarcinomas in male and female mice. Cell (1988) 6.48
Virus-specific ribonucleic acid in cells producing rous sarcoma virus: detection and characterization. J Virol (1972) 6.38
Fos-associated protein p39 is the product of the jun proto-oncogene. Science (1988) 6.34
Standardized and simplified nomenclature for proteins common to all retroviruses. J Virol (1988) 6.31
Enhancement and inhibition of avian sarcoma viruses by polycations and polyanions. Virology (1969) 6.24
Nucleotide sequence of the retroviral leukemia gene v-myb and its cellular progenitor c-myb: the architecture of a transduced oncogene. Cell (1982) 6.19
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Expression of the Rous sarcoma virus pol gene by ribosomal frameshifting. Science (1985) 5.90
Defectiveness of avian myelocytomatosis virus MC29: isolation of long-term nonproducer cultures and analysis of virus-specific polypeptide synthesis. Virology (1977) 5.90
A mutant murine leukemia virus with a single missense codon in pol is defective in a function affecting integration. Proc Natl Acad Sci U S A (1984) 5.81
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Three new types of viral oncogene of cellular origin specific for haematopoietic cell transformation. Nature (1979) 5.75
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Gel electrophoresis of avian leukosis and sarcoma viral RNA in formamide: comparison with other viral and cellular RNA species. J Virol (1973) 5.70
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Definition of regions in human c-myc that are involved in transformation and nuclear localization. Mol Cell Biol (1987) 5.67
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The size and genetic composition of virus-specific RNAs in the cytoplasm of cells producing avian sarcoma-leukosis viruses. Cell (1977) 5.23
Nucleotide sequence of an avian sarcoma virus oncogene (src) and proposed amino acid sequence for gene product. Nature (1980) 5.22
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The protein encoded by the transforming gene of avian sarcoma virus (pp60src) and a homologous protein in normal cells (pp60proto-src) are associated with the plasma membrane. Proc Natl Acad Sci U S A (1980) 4.99
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Nucleotide sequences at host-proviral junctions for mouse mammary tumour virus. Nature (1981) 4.38
A putative second cell-derived oncogene of the avian leukaemia retrovirus E26. Nature (1984) 4.35
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Integration of deoxyribonucleic acid specific for Rous sarcoma virus after infection of permissive and nonpermissive hosts. Proc Natl Acad Sci U S A (1973) 4.19
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