Published in Proc Natl Acad Sci U S A on February 01, 1982
The calorically restricted low-fat nutrient-dense diet in Biosphere 2 significantly lowers blood glucose, total leukocyte count, cholesterol, and blood pressure in humans. Proc Natl Acad Sci U S A (1992) 1.45
Energy restriction impairs natural killer cell function and increases the severity of influenza infection in young adult male C57BL/6 mice. J Nutr (2008) 1.14
The role of nutrition in enhancing immunity in aging. Aging Dis (2011) 0.99
Long-term voluntary exercise, representing habitual exercise, lowers visceral fat and alters plasma amino acid levels in mice. Environ Health Prev Med (2011) 0.93
Calories versus protein in onset of renal disease in NZB x NZW mice. Proc Natl Acad Sci U S A (1986) 0.93
Lifespan-extending caloric restriction or mTOR inhibition impair adaptive immunity of old mice by distinct mechanisms. Aging Cell (2014) 0.89
Dietary restriction with and without caloric restriction for healthy aging. F1000Res (2016) 0.85
Combination of physical activity, nutrition, or other metabolic factors and vaccine response. Front Biosci (2007) 0.80
Caloric Restriction as a Strategy to Improve Vascular Dysfunction in Metabolic Disorders. Nutrients (2016) 0.79
Effects of adult onset mild calorie restriction on weight of reproductive organs, plasma parameters and gene expression in male mice. Anim Reprod (2012) 0.76
Improving immunity in the elderly: current and future lessons from nonhuman primate models. Age (Dordr) (2011) 0.76
Dietary restriction modulates synaptic structural dynamics in the aging hippocampus. Age (Omaha) (1999) 0.75
Plaque formation in agar by single antibody-producing cells. Science (1963) 17.94
Influence of dietary restriction on immunologic function and renal disease in (NZB x NZW) F1 mice. Proc Natl Acad Sci U S A (1978) 1.52
Dietary restrictions early and late: effects on the nephropathy of the NZB X NZW mouse. Lab Invest (1978) 1.45
Influence of controlled dietary restriction on immunologic function and aging. Fed Proc (1979) 1.39
Tumor incidence patterns and nutrition in the rat. J Nutr (1965) 1.28
Suppression of adenocarcinoma by the immunological consequences of calorie restriction. Nature (1976) 1.15
Length of life and nutrition in the rat. J Nutr (1961) 1.11
Nutritional deficiency, immunologic function, and disease. Am J Pathol (1976) 1.11
Survival and disease patterns in C57BL/6J mice subjected to undernutrition. Exp Gerontol (1980) 1.07
Lasting influence of early caloric restriction on prevalence of neoplasms in the rat. J Natl Cancer Inst (1971) 1.07
Effect of various restricted dietary regimens on the growth, health and longevity of albino rats. J Nutr (1972) 1.04
Nutritional inhibition of genetically determined renal disease and autoimmunity with prolongation of life in kdkd mice. Proc Natl Acad Sci U S A (1978) 1.03
THE EFFECT OF REDUCED DIETARY INTAKE ON ENZYMATIC ACTIVITIES AND LIFE SPAN OF RATS. J Gerontol (1965) 1.01
Immune function and survival in a long-lived mouse strain subjected to undernutrition. Gerontologia (1975) 0.99
Longevity and protein intake. Exp Gerontol (1968) 0.92
Influence of diet and feed restriction on kidney function of aging male rats. J Gerontol (1976) 0.87
Length of life and caloric intake. Am J Clin Nutr (1972) 0.86
Nutrition, immunity, and cancer--a review. Part III: Effect of diet on the diseases of aging. Clin Bull (1979) 0.85
Cellular immunity during pregnancy. I. Proliferative and cytotoxic reactivity of paraaortic lymph nodes. Am J Reprod Immunol (1980) 0.85
The effect of various dietary restricted regimes on some immunological parameters of mice. Growth (1978) 0.80
Oxidative stress, caloric restriction, and aging. Science (1996) 11.07
Mitochondrial DNA mutations, oxidative stress, and apoptosis in mammalian aging. Science (2005) 9.57
Gene expression profile of aging and its retardation by caloric restriction. Science (1999) 8.06
Gene-expression profile of the ageing brain in mice. Nat Genet (2000) 5.46
The retardation of aging in mice by dietary restriction: longevity, cancer, immunity and lifetime energy intake. J Nutr (1986) 4.81
Influences of aging and caloric restriction on the transcriptional profile of skeletal muscle from rhesus monkeys. Proc Natl Acad Sci U S A (2001) 3.63
Dietary restriction in mice beginning at 1 year of age: effect on life-span and spontaneous cancer incidence. Science (1982) 3.59
Calorie restriction lowers body temperature in rhesus monkeys, consistent with a postulated anti-aging mechanism in rodents. Proc Natl Acad Sci U S A (1996) 2.23
Decline in CD28+ T cells in centenarians and in long-term T cell cultures: a possible cause for both in vivo and in vitro immunosenescence. Exp Gerontol (1998) 2.18
Dietary restriction of adult male rhesus monkeys: design, methodology, and preliminary findings from the first year of study. J Gerontol (1993) 2.17
Dietary restriction increases insulin sensitivity and lowers blood glucose in rhesus monkeys. Am J Physiol (1994) 2.13
Dietary restriction and aging in rhesus monkeys: the University of Wisconsin study. Exp Gerontol (2000) 2.02
New family of binary arrays for coded aperture imaging. Appl Opt (1989) 1.89
Dietary restriction and aging: the initiation of a primate study. J Gerontol (1990) 1.84
Lifespan and incidence of cancer and other diseases in selected long-lived inbred mice and their F 1 hybrids. J Natl Cancer Inst (1973) 1.79
DNA damage and repair in female C57BL/10 mice of different ages injected with the carcinogen benzo[a]pyrene-trans-7,8-diol. Mutat Res (1989) 1.68
Lifelong voluntary exercise in the mouse prevents age-related alterations in gene expression in the heart. Physiol Genomics (2003) 1.66
Influence of the main histocompatibility complex on ageing in mice. Nature (1978) 1.63
Caloric restriction of rhesus monkeys lowers oxidative damage in skeletal muscle. FASEB J (2000) 1.63
Controlling caloric consumption: protocols for rodents and rhesus monkeys. Neurobiol Aging (1999) 1.61
Increased incidence of lymphoma after injections of mice with cells differing at weak histocompatibility loci. Science (1966) 1.56
Restriction of energy intake, energy expenditure, and aging. Free Radic Biol Med (2000) 1.51
Acute childhood leukaemia in relation to the HL-A human transplantation genes. Nature (1970) 1.51
Energy metabolism after 2 y of energy restriction: the biosphere 2 experiment. Am J Clin Nutr (2000) 1.50
Interleukin-6 and aging: blood levels and mononuclear cell production increase with advancing age and in vitro production is modifiable by dietary restriction. Lymphokine Cytokine Res (1993) 1.49
Short-term consumption of a resveratrol-containing nutraceutical mixture mimics gene expression of long-term caloric restriction in mouse heart. Exp Gerontol (2008) 1.49
Dietary restriction benefits learning and motor performance of aged mice. J Gerontol (1987) 1.48
Calorie restriction inhibits the age-related dysregulation of the cytokines TNF-alpha and IL-6 in C3B10RF1 mice. Mech Ageing Dev (1997) 1.47
Ageing, oxidative stress, and mitochondrial uncoupling. Acta Physiol Scand (2004) 1.42
Influence of controlled dietary restriction on immunologic function and aging. Fed Proc (1979) 1.39
Caloric intake and aging: mechanisms in rodents and a study in nonhuman primates. Toxicol Sci (1999) 1.37
Dietary intervention at middle age: caloric restriction but not dehydroepiandrosterone sulfate increases lifespan and lifetime cancer incidence in mice. Cancer Res (1999) 1.36
Influences of dietary restriction and age on liver enzyme activities and lipid peroxidation in mice. J Nutr (1987) 1.32
Caloric restriction prevents age-associated accrual of oxidative damage to mouse skeletal muscle mitochondria. Free Radic Biol Med (1998) 1.32
Life span and lymphoma-incidence of mice injected at birth with spleen cells across a weak histocompatibility locus. Am J Pathol (1965) 1.32
High levels of mitochondrial DNA deletions in skeletal muscle of old rhesus monkeys. Mech Ageing Dev (1995) 1.29
The HL-A system sub-loci and their importance in transplantation. Transplant Proc (1969) 1.27
Histocompatibility systems and disease states with particular reference to cancer. Transplant Rev (1971) 1.27
Oxidative stress and aging reduce COX I RNA and cytochrome oxidase activity in Drosophila. Free Radic Biol Med (1998) 1.23
Longterm dietary restriction and immune function in mice: response to sheep red blood cells and to mitogenic agents. Mech Ageing Dev (1974) 1.23
Mitotic activity in mice is suppressed by energy restriction-induced torpor. J Nutr (1992) 1.21
Caloric restriction reduces fiber loss and mitochondrial abnormalities in aged rat muscle. FASEB J (1997) 1.19
Adult-onset energy restriction of rhesus monkeys attenuates oxidative stress-induced cytokine expression by peripheral blood mononuclear cells. J Nutr (1997) 1.19
Energy expenditure of adult male rhesus monkeys during the first 30 mo of dietary restriction. Am J Physiol (1997) 1.19
Using a closed ecological system to study Earth's biosphere: initial results from Biosphere 2. Bioscience (1993) 1.18
Association of age-related mitochondrial abnormalities with skeletal muscle fiber atrophy. Free Radic Biol Med (1998) 1.18
Influences of aging and dietary restriction on serum thymosin alpha 1 levels in mice. J Gerontol (1988) 1.16
Human T lymphocytes possess a limited in vitro life span. Exp Gerontol (1989) 1.15
Decline in mixed lymphocyte reactivity of spleen cells from aged mice of a long-lived strain. J Immunol (1973) 1.15
Effect of antioxidants on androgen-induced AP-1 and NF-kappaB DNA-binding activity in prostate carcinoma cells. J Natl Cancer Inst (1999) 1.14
Influences of age and dietary restriction on gastrocnemius electron transport system activities in mice. Arch Biochem Biophys (1996) 1.14
HL-A antigens in myasthenia gravis. Lancet (1974) 1.14
Calories and aging alter gene expression for gluconeogenic, glycolytic, and nitrogen-metabolizing enzymes. Am J Physiol (1999) 1.12
Age-related decline in thymic-independent immune function in a long-lived mouse strain. J Gerontol (1974) 1.12
Caloric restriction alters the feeding response of key metabolic enzyme genes. Mech Ageing Dev (2001) 1.12
Studies in immunogerontology. J Am Geriatr Soc (1982) 1.12
The immune response of aged mice to influenza: diminished T-cell proliferation, interleukin 2 production and cytotoxicity. Cell Immunol (1983) 1.12
Age-associated alterations of the mitochondrial genome. Free Radic Biol Med (1997) 1.10
The accumulation of non-replicative, non-functional, senescent T cells with age is avoided in calorically restricted mice by an enhancement of T cell apoptosis. Mech Ageing Dev (1997) 1.09
Dietary calorie restriction in mice induces carbamyl phosphate synthetase I gene transcription tissue specifically. J Biol Chem (1996) 1.07
Survival and disease patterns in C57BL/6J mice subjected to undernutrition. Exp Gerontol (1980) 1.07
Dietary restriction and aging: historical phases, mechanisms and current directions. J Nutr (1987) 1.06
Influences of dietary restriction on immunity to influenza in aged mice. J Gerontol (1991) 1.06
The distribution of HL-A histocompatibility factors and genes in patients with systemic lupus erythematosus. Tissue Antigens (1971) 1.05
Influence of dietary restriction and aging on natural killer cell activity in mice. J Immunol (1983) 1.05
Multiple mitochondrial DNA deletions associated with age in skeletal muscle of rhesus monkeys. J Gerontol (1993) 1.04
Association of HLA-B8, DRw3, and anti-acetylcholine receptor antibodies in myasthenia gravis. Tissue Antigens (1978) 1.03
Autoimmunity in relation to aging as measured by agar plaque technique. Proc Soc Exp Biol Med (1966) 1.03
Changes in plasma lipids and lipoproteins in humans during a 2-year period of dietary restriction in Biosphere 2. Arch Intern Med (1998) 1.03
The effect of dietary restriction of varying duration on survival, tumor patterns, immune function, and body temperature in B10C3F1 female mice. J Gerontol (1983) 1.02
Caloric restriction and body weight independently affect longevity in Wistar rats. Int J Obes Relat Metab Disord (2004) 1.02
Cellular phenotypes of age-associated skeletal muscle mitochondrial abnormalities in rhesus monkeys. Mutat Res (2000) 1.02
Age-related changes, including synergy and suppression, in the mixed lymphocyte reaction in long-lived mice. Fed Proc (1975) 1.02
Diminished T-cell response to influenza virus in aged mice. Immunology (1983) 1.01
Multiple age-associated mitochondrial DNA deletions in skeletal muscle of mice. Aging (Milano) (1994) 1.00
Immune function and survival in a long-lived mouse strain subjected to undernutrition. Gerontologia (1975) 0.99
Immunologic theory of aging: current status. Fed Proc (1974) 0.99
Age-associated mitochondrial DNA deletions in mouse skeletal muscle: comparison of different regions of the mitochondrial genome. Dev Genet (1996) 0.97
Concerns about rodent models for aging research. J Gerontol (1991) 0.96
Caloric restriction, aging, and antioxidant enzymes. Mutat Res (1993) 0.95
Soluble beta 2-microglobulin-free class I heavy chains are released from the surface of activated and leukemia cells by a metalloprotease. J Biol Chem (1994) 0.94
Dietary energy tissue-specifically regulates endoplasmic reticulum chaperone gene expression in the liver of mice. J Nutr (1997) 0.94
Localization of 4-hydroxy-2-nonenal-modified proteins in kidney following iron overload. Free Radic Biol Med (1999) 0.94
Dietary restriction from middle age attenuates age-associated lymphoma development and interleukin 6 dysregulation in C57BL/6 mice. Cancer Res (1994) 0.93
The prevalence of dysequilibrium and related disorders in older persons. Ear Nose Throat J (1989) 0.92
In vitro cellular aging in T-lymphocyte cultures: analysis of DNA content and cell size. Exp Cell Res (1993) 0.92
Autoimmunity and aging: the age-related response of mice of a long-lived strain to trinitrophenylated syngeneic mouse red blood cells. J Immunol (1976) 0.92
Influence of age and caloric restriction on macrophage IL-6 and TNF production. Lymphokine Cytokine Res (1991) 0.92
Dietary energy restriction in mice reduces hepatic expression of glucose-regulated protein 78 (BiP) and 94 mRNA. J Nutr (1990) 0.92
Androgen-induced oxidative stress in human LNCaP prostate cancer cells is associated with multiple mitochondrial modifications. Antioxid Redox Signal (1999) 0.91
Age-related increase in mitochondrial proton leak and decrease in ATP turnover reactions in mouse hepatocytes. Am J Physiol (1998) 0.91
Synergy among responding lymphoid cells in the one-way mixed lymphocyte reaction. Interaction between two types of thymus-dependent cells. J Exp Med (1974) 0.91
Caloric restriction in rhesus monkeys reduces low density lipoprotein interaction with arterial proteoglycans. J Gerontol A Biol Sci Med Sci (1998) 0.91
Antisera for tissue-typing: the production of cytotoxic and agglutinating antibodies following intradermal leukocyte injections in man. Blood (1968) 0.90