Cotransfer of the Ed alpha and Ad beta genes into L cells results in the surface expression of a functional mixed-isotype Ia molecule.

PubWeight™: 1.17‹?› | Rank: Top 10%

🔗 View Article (PMC 323644)

Published in Proc Natl Acad Sci U S A on June 01, 1986

Authors

B Malissen, N Shastri, M Pierres, L Hood

Articles citing this

The SJL/J T cell response to both spontaneous and transplantable syngeneic reticulum cell sarcoma is mediated predominantly by the V beta 17a+ T cell clonotype. J Exp Med (1988) 1.30

A novel family of human leukocyte antigen class II receptors may have its origin in archaic human species. J Biol Chem (2013) 1.29

Presentation of antigen by mixed isotype class II molecules in normal H-2d mice. J Exp Med (1992) 1.02

Mixed isotype class II antigen expression. A novel class II molecule is expressed on a murine B cell lymphoma. J Exp Med (1989) 0.96

Structural requirements for pairing of alpha and beta chains in HLA-DR and HLA-DP molecules. J Exp Med (1990) 0.95

Expression of major histocompatibility complex antigens on mouse brain microvascular endothelial cells in relation to susceptibility to cerebral malaria. Immunology (1997) 0.93

Quantitative analysis of integrated Ed alpha gene expression in C57BL/6 transgenic mice. Immunology (1988) 0.88

Haplotype-specific differences in signaling by transfected class II molecules to a Ly-1+ B-cell clone. Proc Natl Acad Sci U S A (1989) 0.82

Existence of mixed isotype A beta E alpha class II molecules in Ed alpha gene-introduced C57BL/6 transgenic mice. Immunology (1990) 0.80

Unique mixed lymphocyte-stimulating determinants in Ed alpha gene-introduced C57BL/6 transgenic mice. Immunology (1989) 0.80

Antigen-reactive T cell clones restricted by mixed isotype A beta d/E alpha d class II molecules. J Exp Med (1990) 0.79

Role of the major histocompatibility complex class II Ea gene in lupus susceptibility in mice. Proc Natl Acad Sci U S A (1997) 0.79

Major histocompatibility complex determinants select T-cell receptor alpha chain variable region dominance in a peptide-specific response. Proc Natl Acad Sci U S A (1992) 0.76

Role of a Novel Human Leukocyte Antigen-DQA1*01:02;DRB1*15:01 Mixed Isotype Heterodimer in the Pathogenesis of "Humanized" Multiple Sclerosis-like Disease. J Biol Chem (2015) 0.75

Articles cited by this

Properties of monoclonal antibodies to mouse Ig allotypes, H-2, and Ia antigens. Curr Top Microbiol Immunol (1978) 13.40

Antigen-inducible, H-2-restricted, interleukin-2-producing T cell hybridomas. Lack of independent antigen and H-2 recognition. J Exp Med (1981) 12.03

Hybridoma cell lines secreting monoclonal antibodies to mouse H-2 and Ia antigens. J Immunol (1980) 8.56

A molecular map of the immune response region from the major histocompatibility complex of the mouse. Nature (1982) 5.12

Two-gene control of the expression of a murine Ia antigen. J Exp Med (1978) 4.79

Antigen-reactive T cell clones. I. Transcomplementing hybrid I-A-region gene products function effectively in antigen presentation. J Exp Med (1980) 4.47

Monoclonal antibodies to mouse major histocompatibility complex antigens. Transplantation (1982) 4.11

Antigen presentation by Ia+ B cell hybridomas to H-2-restricted T cell hybridomas. Proc Natl Acad Sci U S A (1982) 3.41

The traditional and a new version of the mouse H-2 complex. Nature (1981) 3.12

A rat anti-mouse T4 monoclonal antibody (H129.19) inhibits the proliferation of Ia-reactive T cell clones and delineates two phenotypically distinct (T4+, Lyt-2,3-, and T4-, Lyt-2,3+) subsets among anti-Ia cytolytic T cell clones. J Immunol (1984) 2.96

Antigen presentation by supported planar membranes containing affinity-purified I-Ad. Proc Natl Acad Sci U S A (1984) 2.80

Clonal analysis of B- and T-cell responses to Ia antigens. I. Topology of epitope regions on I-Ak and I-Ek molecules analyzed with 35 monoclonal alloantibodies. Immunogenetics (1981) 2.27

Organization of the immune response genes. Science (1979) 2.18

Variable synthesis and expression of E alpha and Ae (E beta) Ia polypeptide chains in mice of different H-2 haplotypes. Immunogenetics (1981) 2.13

Gene transfer of H-2 class II genes: antigen presentation by mouse fibroblast and hamster B-cell lines. Cell (1984) 2.12

Gene conversion between murine class II major histocompatibility complex loci. Functional and molecular evidence from the bm 12 mutant. J Exp Med (1984) 1.66

Membrane Ia expression and antigen-presenting accessory cell function of L cells transfected with class II major histocompatibility complex genes. J Exp Med (1984) 1.65

Molecular characterization of the recombination region of six murine major histocompatibility complex (MHC) I-region recombinants. J Mol Cell Immunol (1984) 1.60

T-cell recognition of a chimaeric class II/class I MHC molecule and the role of L3T4. Nature (1985) 1.53

Immune response gene function correlates with the expression of an Ia antigen. I. Preferential association of certain Ae and E alpha chains results in a quantitative deficiency in expression of an Ae:E alpha complex. J Exp Med (1982) 1.53

The expression of I-Ed molecules in F1 hybrid mice detected with antigen-specific, I-Ed-restricted cloned T-cell lines. Immunogenetics (1984) 1.48

Immune response gene function correlates with the expression of an Ia antigen. II. A quantitative deficiency in Ae:E alpha complex expression causes a corresponding defect in antigen-presenting cell function. J Exp Med (1982) 1.47

Genetics and expression of mouse Ia antigens. Annu Rev Immunol (1985) 1.45

Establishment of B cell hybridomas with B cell surface antigens. J Immunol (1982) 1.44

Tracts of high or low sequence divergence in the mouse major histocompatibility complex. EMBO J (1984) 1.42

Serological and biochemical identification of hybrid Ia antigens. J Exp Med (1980) 1.38

Small subunit of I-A subregion antigens determines the allospecificity recognized by a monoclonal antibody. Nature (1980) 1.38

Cross-blocking studies with monoclonal antibodies against I-A molecules of haplotypes b, d and k. Eur J Immunol (1982) 1.35

Antigen-specific, H-2-restricted helper T cell hybridomas. J Exp Med (1982) 1.29

Expression of I-Ak class II genes in mouse L cells after DNA-mediated gene transfer. Nature (1983) 1.25

Functional expression of a transfected murine class II MHC gene. Nature (1984) 1.22

Ia-transfected L-cell fibroblasts present a lysozyme peptide but not the native protein to lysozyme-specific T cells. Proc Natl Acad Sci U S A (1985) 1.21

Interaction between I region loci influences the expression of a cell surface Ia antigen. Proc Natl Acad Sci U S A (1980) 1.20

Multiple functional sites on a single Ia molecule defined using T cell clones and antibodies with chain-determined specificity. J Exp Med (1984) 1.18

Distinct epitopes of Ik gene products identified by monoclonal antibodies. Eur J Immunol (1980) 1.11

A class II gene conversion event defines an antigen-specific Ir gene epitope. J Exp Med (1984) 1.03

The structure-function relationship of I-A molecules: a biochemical analysis of I-A polypeptides from mutant antigen-presenting cells and evidence of preferential association of allelic forms. J Immunol (1985) 1.02

Assignment of antigenic determinants to separated I-A kappa chains. J Immunol (1983) 1.01

Functional expression of a cloned I-A beta k gene in B-lymphoma cells. Science (1984) 0.93

Analysis of thymocyte MHC specificity with thymocyte hybridomas. J Exp Med (1984) 0.90

Dissection of the poly(glu60 ala30 tyr10) (GAT)-specific T-cell repertoire in H-2Ik mice. I. GAT plus self-I-Ak-reactive T-cell clones can recognize alloactivating and/or restriction determinants on nonself-Ia molecules. Immunogenetics (1983) 0.87

Lack of gene complementation prevents expression of I-Ek in recombinant A.TFR5. J Immunol (1980) 0.84

Molecular specificity of a monoclonal anti-Ik alloantibody identifying a highly conserved determinant on mouse I-A, I-E and human DR antigens. Tissue Antigens (1982) 0.84

The murine bm12 gene conversion provides evidence that T cells recognize predominantly Ia conformation. Proc Natl Acad Sci U S A (1985) 0.82

Use of molecular techniques for analysis of Ia structure-function relationships. Fed Proc (1985) 0.77

Biochemistry of MHC class II molecules. Tissue Antigens (1985) 0.77

Articles by these authors

Initial sequencing and analysis of the human genome. Nature (2001) 212.86

A common language for physical mapping of the human genome. Science (1989) 17.36

Integrated genomic and proteomic analyses of a systematically perturbed metabolic network. Science (2001) 17.11

Characterization of the murine T cell surface molecule, designated L3T4, identified by monoclonal antibody GK1.5: similarity of L3T4 to the human Leu-3/T4 molecule. J Immunol (1983) 14.36

A physical map of the human genome. Nature (2001) 12.39

Characterization of the murine antigenic determinant, designated L3T4a, recognized by monoclonal antibody GK1.5: expression of L3T4a by functional T cell clones appears to correlate primarily with class II MHC antigen-reactivity. Immunol Rev (1983) 10.81

An immunoglobulin heavy chain variable region gene is generated from three segments of DNA: VH, D and JH. Cell (1980) 10.35

Two mRNAs can be produced from a single immunoglobulin mu gene by alternative RNA processing pathways. Cell (1980) 9.86

DNA diagnostics--molecular techniques and automation. Science (1988) 8.85

Gene families: the taxonomy of protein paralogs and chimeras. Science (1997) 8.80

A new approach to decoding life: systems biology. Annu Rev Genomics Hum Genet (2001) 7.79

A ligase-mediated gene detection technique. Science (1988) 7.61

Alagille syndrome is caused by mutations in human Jagged1, which encodes a ligand for Notch1. Nat Genet (1997) 6.66

Ablation of "tolerance" and induction of diabetes by virus infection in viral antigen transgenic mice. Cell (1991) 6.49

Two mRNAs with different 3' ends encode membrane-bound and secreted forms of immunoglobulin mu chain. Cell (1980) 6.32

The molecular genetics of the T-cell antigen receptor and T-cell antigen recognition. Annu Rev Immunol (1986) 6.23

A single VH gene segment encodes the immune response to phosphorylcholine: somatic mutation is correlated with the class of the antibody. Cell (1981) 5.87

Genome sequence of Halobacterium species NRC-1. Proc Natl Acad Sci U S A (2000) 5.87

The organization, expression, and evolution of antibody genes and other multigene families. Annu Rev Genet (1975) 5.87

Ligands for the murine NKG2D receptor: expression by tumor cells and activation of NK cells and macrophages. Nat Immunol (2000) 5.45

A pseudogene homologous to mouse transplantation antigens: transplantation antigens are encoded by eight exons that correlate with protein domains. Cell (1981) 5.43

A molecular map of the immune response region from the major histocompatibility complex of the mouse. Nature (1982) 5.12

Three cDNA clones encoding mouse transplantation antigens: homology to immunoglobulin genes. Cell (1981) 4.95

Pairwise end sequencing: a unified approach to genomic mapping and sequencing. Genomics (1995) 4.83

Clusters of genes encoding mouse transplantation antigens. Cell (1982) 4.71

Antibody diversity: somatic hypermutation of rearranged VH genes. Cell (1981) 4.65

A new strategy for genome sequencing. Nature (1996) 4.61

Transgenic mice that express a myelin basic protein-specific T cell receptor develop spontaneous autoimmunity. Cell (1993) 4.59

Restricted use of T cell receptor V genes in murine autoimmune encephalomyelitis raises possibilities for antibody therapy. Cell (1988) 4.47

Genes of the major histocompatibility complex of the mouse. Annu Rev Immunol (1983) 4.44

An immunoglobulin heavy-chain gene is formed by at least two recombinational events. Nature (1980) 3.99

Detection of rare antigen-presenting cells by the lacZ T-cell activation assay suggests an expression cloning strategy for T-cell antigens. Proc Natl Acad Sci U S A (1992) 3.97

Striking sequence similarity over almost 100 kilobases of human and mouse T-cell receptor DNA. Nat Genet (1994) 3.88

IgG antibodies to phosphorylcholine exhibit more diversity than their IgM counterparts. Nature (1981) 3.86

Prostate-localized and androgen-regulated expression of the membrane-bound serine protease TMPRSS2. Cancer Res (1999) 3.79

Exon/intron organization and complete nucleotide sequence of an HLA gene. Proc Natl Acad Sci U S A (1982) 3.72

Two gut intraepithelial CD8+ lymphocyte populations with different T cell receptors: a role for the gut epithelium in T cell differentiation. J Exp Med (1991) 3.63

Silkmoth chorion proteins: sequence analysis of the products of a multigene family. Proc Natl Acad Sci U S A (1978) 3.60

Structural studies of the scrapie prion protein using mass spectrometry and amino acid sequencing. Biochemistry (1993) 3.54

Introduced T cell receptor variable region gene segments recombine in pre-B cells: evidence that B and T cells use a common recombinase. Cell (1986) 3.51

LacZ inducible, antigen/MHC-specific T cell hybrids. Int Immunol (1994) 3.47

Identification of an MHC class I-restricted autoantigen in type 1 diabetes by screening an organ-specific cDNA library. Nat Med (1999) 3.45

Large-scale and automated DNA sequence determination. Science (1991) 3.45

Cell-type-specific cDNA probes and the murine I region: the localization and orientation of Ad alpha. Proc Natl Acad Sci U S A (1984) 3.43

The human T cell antigen receptor is encoded by variable, diversity, and joining gene segments that rearrange to generate a complete V gene. Cell (1984) 3.41

Death receptor 5, a new member of the TNFR family, and DR4 induce FADD-dependent apoptosis and activate the NF-kappaB pathway. Immunity (1997) 3.33

T cell antigen receptors and the immunoglobulin supergene family. Cell (1985) 3.23

Cell-cell interaction in prostate gene regulation and cytodifferentiation. Proc Natl Acad Sci U S A (1997) 3.22

Immunoglobulin heavy chain gene organization in mice: analysis of a myeloma genomic clone containing variable and alpha constant regions. Proc Natl Acad Sci U S A (1979) 3.19

The structure, rearrangement and expression of D beta gene segments of the murine T-cell antigen receptor. Nature (1984) 3.18

DNA sequence of a gene encoding a BALB/c mouse Ld transplantation antigen. Science (1982) 3.17

The T cell receptor/CD3 complex is composed of at least two autonomous transduction modules. Cell (1992) 3.11

Mechanism of antibody diversity: germ line basis for variability. Science (1970) 3.05

Predominant use of a V alpha gene segment in mouse T-cell receptors for cytochrome c. Nature (1987) 2.99

A rat anti-mouse T4 monoclonal antibody (H129.19) inhibits the proliferation of Ia-reactive T cell clones and delineates two phenotypically distinct (T4+, Lyt-2,3-, and T4-, Lyt-2,3+) subsets among anti-Ia cytolytic T cell clones. J Immunol (1984) 2.96

Understanding the adaptation of Halobacterium species NRC-1 to its extreme environment through computational analysis of its genome sequence. Genome Res (2001) 2.92

Complete genomic sequence and analysis of 117 kb of human DNA containing the gene BRCA1. Genome Res (1996) 2.91

Automated DNA diagnostics using an ELISA-based oligonucleotide ligation assay. Proc Natl Acad Sci U S A (1990) 2.88

Genes of the major histocompatibility complex in mouse and man. Science (1983) 2.88

Rearrangement of genetic information may produce immunoglobulin diversity. Nature (1979) 2.84

Altered T cell development in mice with a targeted mutation of the CD3-epsilon gene. EMBO J (1995) 2.84

Down-regulation of T cell receptors on self-reactive T cells as a novel mechanism for extrathymic tolerance induction. Cell (1991) 2.83

Engagement of T cell receptor triggers its recruitment to low-density detergent-insoluble membrane domains. EMBO J (1998) 2.83

Requirement for association of p56lck with CD4 in antigen-specific signal transduction in T cells. Cell (1991) 2.79

Mechanism of antibody synthesis: size differences between mouse kappa chains. Science (1967) 2.77

Class I MHC presentation of exogenous soluble antigen via macropinocytosis in bone marrow macrophages. Immunity (1995) 2.77

Zinc-dependent structure of a single-finger domain of yeast ADR1. Science (1988) 2.76

DNA sequence determination by hybridization: a strategy for efficient large-scale sequencing. Science (1993) 2.76

Resident and pro-inflammatory macrophages in the colon represent alternative context-dependent fates of the same Ly6Chi monocyte precursors. Mucosal Immunol (2012) 2.73

Regulation of TCR alpha and beta gene allelic exclusion during T-cell development. Immunol Today (1992) 2.71

From hematopoiesis to neuropoiesis: evidence of overlapping genetic programs. Proc Natl Acad Sci U S A (2001) 2.66

Dynorphin-(1-13), an extraordinarily potent opioid peptide. Proc Natl Acad Sci U S A (1979) 2.66

The complete 685-kilobase DNA sequence of the human beta T cell receptor locus. Science (1996) 2.62

The chemokine TECK is expressed by thymic and intestinal epithelial cells and attracts double- and single-positive thymocytes expressing the TECK receptor CCR9. Eur J Immunol (2000) 2.58

The choice of T-cell epitopes utilized on a protein antigen depends on multiple factors distant from, as well as at the determinant site. Immunol Rev (1987) 2.56

Mouse Cmu heavy chain immunoglobulin gene segment contains three intervening sequences separating domains. Nature (1980) 2.52

Separate elements control DJ and VDJ rearrangement in a transgenic recombination substrate. EMBO J (1990) 2.52

Identification of the class I genes of the mouse major histocompatibility complex by DNA-mediated gene transfer. Nature (1982) 2.48

Inhibition of murine T cell-mediated cytolysis and T cell proliferation by a rat monoclonal antibody immunoprecipitating two lymphoid cell surface polypeptides of 94 000 and 180 000 molecular weight. Eur J Immunol (1982) 2.47

Comparative hybridization of an array of 21,500 ovarian cDNAs for the discovery of genes overexpressed in ovarian carcinomas. Gene (1999) 2.45

Messenger RNA translation state: the second dimension of high-throughput expression screening. Proc Natl Acad Sci U S A (1999) 2.42

Intracellular calcium dependence of gene expression in single T lymphocytes. Proc Natl Acad Sci U S A (1994) 2.42

Mouse c-myc oncogene is located on chromosome 15 and translocated to chromosome 12 in plasmacytomas. Science (1982) 2.40

Genomic organization of the genes encoding mouse T-cell receptor alpha-chain. Nature (1985) 2.40

Crystal structure of a T cell receptor bound to an allogeneic MHC molecule. Nat Immunol (2000) 2.37

Cloning and characterization of two Toll/Interleukin-1 receptor-like genes TIL3 and TIL4: evidence for a multi-gene receptor family in humans. Blood (1998) 2.33

Direct evidence for chromosomal inversion during T-cell receptor beta-gene rearrangements. Nature (1986) 2.33

Rearrangement and transcription of the beta-chain genes of the T-cell antigen receptor in different types of murine lymphocytes. Nature (1985) 2.29

Expression of a myelin basic protein gene in transgenic shiverer mice: correction of the dysmyelinating phenotype. Cell (1987) 2.29

The joining of V and J gene segments creates antibody diversity. Nature (1980) 2.28

Clonal analysis of B- and T-cell responses to Ia antigens. I. Topology of epitope regions on I-Ak and I-Ek molecules analyzed with 35 monoclonal alloantibodies. Immunogenetics (1981) 2.27

The human homolog of rat Jagged1 expressed by marrow stroma inhibits differentiation of 32D cells through interaction with Notch1. Immunity (1998) 2.23

Modulation of the NF-kappa B pathway by virally encoded death effector domains-containing proteins. Oncogene (1999) 2.21

Mice lacking the CCR9 CC-chemokine receptor show a mild impairment of early T- and B-cell development and a reduction in T-cell receptor gammadelta(+) gut intraepithelial lymphocytes. Blood (2001) 2.20

Diversity and structure of human T-cell receptor beta-chain variable region genes. Proc Natl Acad Sci U S A (1986) 2.19

Measurement of ligand-induced activation in single viable T cells using the lacZ reporter gene. Proc Natl Acad Sci U S A (1991) 2.16

CD8 modulation of T-cell antigen receptor-ligand interactions on living cytotoxic T lymphocytes. Nature (1995) 2.15

Rearranged beta T cell receptor genes in a helper T cell clone specific for lysozyme: no correlation between V beta and MHC restriction. Cell (1985) 2.14