Published in J Biol Chem on October 25, 1980
Insulin-induced receptor loss in cultured human lymphocytes is due to accelerated receptor degradation. Proc Natl Acad Sci U S A (1981) 2.18
Biosynthetic labeling of insulin receptor: studies of subunits in cultured human IM-9 lymphocytes. Proc Natl Acad Sci U S A (1981) 1.72
Direct demonstration of glycosylation of insulin receptor subunits by biosynthetic and external labeling: evidence for heterogeneity. Proc Natl Acad Sci U S A (1981) 1.64
Internalized insulin receptors are recycled to the cell surface in rat hepatocytes. Proc Natl Acad Sci U S A (1982) 1.63
Challenge of hepatocytes by glucagon triggers a rapid modulation of adenylate cyclase activity in isolated membranes. Biochem J (1983) 1.53
The major histocompatibility complex class I heavy chain as a structural subunit of the human cell membrane insulin receptor: implications for the range of biological functions of histocompatibility antigens. Proc Natl Acad Sci U S A (1986) 1.44
Evidence for insulin-induced internalization and degradation of insulin receptors in rat adipocytes. Proc Natl Acad Sci U S A (1982) 1.27
Glucocorticoid-induced insulin resistance: the importance of postbinding events in the regulation of insulin binding, action, and degradation in freshly isolated and primary cultures of rat hepatocytes. J Clin Invest (1982) 1.15
Control of insulin receptor level in 3T3 cells: effect of insulin-induced down-regulation and dexamethasone-induced up-regulation on rate of receptor inactivation. Proc Natl Acad Sci U S A (1982) 1.06
Transferrin receptors of human fibroblasts. Analysis of receptor properties and regulation. Biochem J (1982) 1.03
On the mechanisms involved in the regulation of the cell-surface receptors for human choriogonadotropin and mouse epidermal growth factor in cultured Leydig tumor cells. J Cell Biol (1983) 0.98
Shedding of TNFR1 in regenerative liver can be induced with TNF alpha and PMA. World J Gastroenterol (2002) 0.91
Role of glycosylation and protein synthesis in insulin receptor metabolism by 3T3-L1 mouse adipocytes. Proc Natl Acad Sci U S A (1981) 0.87
Desensitization of the insulin receptor by antireceptor antibodies in vivo is blocked by treatment of mice with beta-adrenergic agonists. J Clin Invest (1988) 0.85
Isolation of a nuclease-resistant decoy RNA that selectively blocks autoantibody binding to insulin receptors on human lymphocytes. J Exp Med (1996) 0.84
Insulin resistance in uremia. Characterization of insulin action, binding, and processing in isolated hepatocytes from chronic uremic rats. J Clin Invest (1983) 0.83
Reduced insulin-like growth factor I receptor and altered insulin receptor isoform mRNAs in normal mucosa predict colorectal adenoma risk. Cancer Epidemiol Biomarkers Prev (2014) 0.81
Quantitative studies of the rate of insulin internalization in isolated rat hepatocytes. Biochem J (1984) 0.81
Insulin receptor of human cerebral gliomas. Structure and function. J Clin Invest (1986) 0.80
Differences in degradation processes for insulin and its receptor in cultured foetal hepatocytes. Biochem J (1983) 0.80
Analysis of the insulin receptor by anti-receptor antibodies and flow cytometry. Proc Natl Acad Sci U S A (1984) 0.80
Quasi-Steady-State Analysis based on Structural Modules and Timed Petri Net Predict System's Dynamics: The Life Cycle of the Insulin Receptor. Metabolites (2015) 0.79
Glucocorticoids increase insulin binding and the amount of insulin-receptor mRNA in human cultured lymphocytes. Biochem J (1988) 0.79
Internalization of insulin receptors and HLA antigens in human hepatoma cells. Biochem J (1987) 0.79
Presence of insulin receptors in cultured glial C6 cells. Regulation by butyrate. Biochem J (1989) 0.77
Phorbol esters inhibit insulin-induced receptor down-regulation in cultured human lymphocytes: association with diminished insulin receptor autophosphorylation. Biochem J (1993) 0.77
Effect of hormones on dissociation of prolactin from the rabbit mammary gland prolactin receptor. Biochem J (1991) 0.76
Differential morphology and homogeneity of tissue-engineered cartilage in hydrodynamic cultivation with transient exposure to insulin-like growth factor-1 and transforming growth factor-β1. Tissue Eng Part A (2013) 0.75
Genetic engineering in vivo using translocatable drug-resistance elements. New methods in bacterial genetics. J Mol Biol (1977) 20.29
Procedure for identifying nonsense mutations. J Bacteriol (1968) 8.16
Ultrastructural localization of intracellular antigens by the use of protein A-gold complex. J Histochem Cytochem (1978) 7.15
Immunocytochemical localization of galactosyltransferase in HeLa cells: codistribution with thiamine pyrophosphatase in trans-Golgi cisternae. J Cell Biol (1982) 6.67
Insulin-dependent regulation of insulin receptor concentrations: a direct demonstration in cell culture. Proc Natl Acad Sci U S A (1974) 5.73
The syndromes of insulin resistance and acanthosis nigricans. Insulin-receptor disorders in man. N Engl J Med (1976) 5.09
Spontaneous tandem genetic duplications in Salmonella typhimurium arise by unequal recombination between rRNA (rrn) cistrons. Proc Natl Acad Sci U S A (1981) 4.85
Enhancement of structural preservation and immunocytochemical staining in low temperature embedded pancreatic tissue. J Histochem Cytochem (1981) 4.62
Non-coated membrane invaginations are involved in binding and internalization of cholera and tetanus toxins. Nature (1982) 4.22
Cluster of genes controlling proline degradation in Salmonella typhimurium. J Bacteriol (1978) 4.04
PCR-induced (ligase-free) subcloning: a rapid reliable method to subclone polymerase chain reaction (PCR) products. Nucleic Acids Res (1990) 3.93
Monoiodoinsulin: demonstration of its biological activity and binding to fat cells and liver membranes. Biochem Biophys Res Commun (1971) 3.74
Insulin receptors in the liver: specific binding of ( 125 I)insulin to the plasma membrane and its relation to insulin bioactivity. Proc Natl Acad Sci U S A (1971) 3.65
Demonstration of an extensive trans-tubular network continuous with the Golgi apparatus stack that may function in glycosylation. Cell (1985) 3.54
Hybrid DNA artifact from PCR of closely related target sequences. Nucleic Acids Res (1989) 3.54
Insulin interactions with its receptors: experimental evidence for negative cooperativity. Biochem Biophys Res Commun (1973) 3.41
The 17-gene ethanolamine (eut) operon of Salmonella typhimurium encodes five homologues of carboxysome shell proteins. J Bacteriol (1999) 3.17
Insulin receptors are widely distributed in the central nervous system of the rat. Nature (1978) 3.07
Isolation and characterization of human lysosomal membrane glycoproteins, h-lamp-1 and h-lamp-2. Major sialoglycoproteins carrying polylactosaminoglycan. J Biol Chem (1988) 3.05
Quantitative aspects of the insulin-receptor interaction in liver plasma membranes. J Biol Chem (1974) 3.04
Site-site interactions among insulin receptors. Characterization of the negative cooperativity. J Biol Chem (1976) 3.01
Antibodies that impair insulin receptor binding in an unusual diabetic syndrome with severe insulin resistance. Science (1975) 2.97
Regulation of the major proline permease gene of Salmonella typhimurium. J Bacteriol (1978) 2.87
Insulin-receptor interaction in the obese-hyperglycemic mouse. A model of insulin resistance. J Biol Chem (1973) 2.80
Insulin interactions with liver plasma membranes. Independence of binding of the hormone and its degradation. J Biol Chem (1972) 2.78
Influence of left ventricular function on outcome of patients treated with implantable defibrillators. Circulation (1992) 2.77
The sister of P-glycoprotein represents the canalicular bile salt export pump of mammalian liver. J Biol Chem (1998) 2.72
Characteristics of the human lymphocyte insulin receptor. J Biol Chem (1973) 2.61
Myeloid-related protein (MRP) 8 and MRP14, calcium-binding proteins of the S100 family, are secreted by activated monocytes via a novel, tubulin-dependent pathway. J Biol Chem (1997) 2.57
Plasma insulin and growth hormone levels in obesity and diabetes. Ann N Y Acad Sci (1965) 2.56
Nuclear export of the E1B 55-kDa and E4 34-kDa adenoviral oncoproteins mediated by a rev-like signal sequence. EMBO J (1997) 2.44
Neutrophil derived human S100A12 (EN-RAGE) is strongly expressed during chronic active inflammatory bowel disease. Gut (2003) 2.39
Degradation of misfolded endoplasmic reticulum glycoproteins in Saccharomyces cerevisiae is determined by a specific oligosaccharide structure. J Cell Biol (1998) 2.33
Insulin receptors in human circulating cells and fibroblasts. Proc Natl Acad Sci U S A (1972) 2.24
Peptide hormone binding to receptors: a review of direct studies in vitro. Metabolism (1973) 2.23
Fluctuations in the affinity and concentration of insulin receptors on circulating monocytes of obese patients: effects of starvation, refeeding, and dieting. J Clin Invest (1976) 2.12
ACTH receptors in the adrenal: specific binding of ACTH-125I and its relation to adenyl cyclase. Proc Natl Acad Sci U S A (1970) 2.09
Methods for assessing immunologic and biologic properties of iodinated peptide hormones. Methods Enzymol (1975) 2.01
Binding of hormone to tissue: the first step in polypeptide hormone action. Proc Natl Acad Sci U S A (1966) 1.96
Molecular scanning of the human peroxisome proliferator activated receptor gamma (hPPAR gamma) gene in diabetic Caucasians: identification of a Pro12Ala PPAR gamma 2 missense mutation. Biochem Biophys Res Commun (1997) 1.96
Myeloid-related proteins 8 and 14 are specifically secreted during interaction of phagocytes and activated endothelium and are useful markers for monitoring disease activity in pauciarticular-onset juvenile rheumatoid arthritis. Arthritis Rheum (2000) 1.95
The MDM2 oncoprotein binds specifically to RNA through its RING finger domain. Mol Med (1996) 1.94
Defect in insulin binding to receptors in obese man. Amelioration with calorie restriction. J Clin Invest (1975) 1.92
Control of blood glucose and diabetic vascular disease. N Engl J Med (1977) 1.92
The vitamin D endocrine system: steroid metabolism, hormone receptors, and biological response (calcium binding proteins). Endocr Rev (1982) 1.92
Identification and mapping of a second proline permease Salmonella typhimurium. J Bacteriol (1980) 1.91
Purification of the putA gene product. A bifunctional membrane-bound protein from Salmonella typhimurium responsible for the two-step oxidation of proline to glutamate. J Biol Chem (1981) 1.91
Faecal S100A12 as a non-invasive marker distinguishing inflammatory bowel disease from irritable bowel syndrome. Gut (2007) 1.90
Cooperativity in ligand binding: a new graphic analysis. Biochem Biophys Res Commun (1975) 1.87
Glucose intolerance in cystic fibrosis. N Engl J Med (1969) 1.85
Functional magnetic resonance imaging during deep brain stimulation: a pilot study in four patients with Parkinson's disease. Mov Disord (2001) 1.83
Efficacy of conventional pituitary irradiation in acromegaly. N Engl J Med (1970) 1.82
Quantitative immunocytochemical localization of pancreatic secretory proteins in subcellular compartments of the rat acinar cell. J Histochem Cytochem (1980) 1.80
Insulin receptor deficiency in genetic and acquired obesity. J Clin Invest (1975) 1.79
Coloidal gold, ferritin and peroxidase as markers for electron microscopic double labeling lectin techniques. J Histochem Cytochem (1978) 1.77
Characterization of antibodies to the insulin receptor: a cause of insulin-resistant diabetes in man. J Clin Invest (1976) 1.74
Regulation of the genes for proline utilization in Salmonella typhimurium: autogenous repression by the putA gene product. J Mol Biol (1981) 1.74
Differential subcompartmentation of terminal glycosylation in the Golgi apparatus of intestinal absorptive and goblet cells. J Biol Chem (1986) 1.72
Two nonallelic insulin genes in Xenopus laevis are expressed differentially during neurulation in prepancreatic embryos. Proc Natl Acad Sci U S A (1991) 1.72
Insulin receptors in human circulating lymphocytes: application to the study of insulin resistance in man. J Clin Endocrinol Metab (1973) 1.71
Impairment of insulin binding to the fat cell plasma membrane in the obese hyperglycemic mouse. FEBS Lett (1972) 1.71
Genetic susceptibility testing in smoking-cessation treatment: one-year outcomes of a randomized trial. Addict Behav (1998) 1.68
"Big insulin": a new component of plasma insulin detected by immunoassay. Proc Natl Acad Sci U S A (1968) 1.67
Insulin receptors in normal and transformed fibroblasts: relationship to growth and transformation. Cell (1976) 1.65
Direct demonstration of glycosylation of insulin receptor subunits by biosynthetic and external labeling: evidence for heterogeneity. Proc Natl Acad Sci U S A (1981) 1.64
Medical problems of civil disorders. Organization of a volunteer group of health professionals to provide medical services in a riot. N Engl J Med (1969) 1.63
MEN1 gene mutation analysis of sporadic adrenocortical lesions. Int J Cancer (1999) 1.63
Medical student attitudes toward the geriatric patient. J Am Geriatr Soc (1968) 1.63
Identification of insulin in rat brain. Proc Natl Acad Sci U S A (1978) 1.63
Binding of 125I-human growth hormone to specific receptors in human cultured lymphocytes. Characterization of the interaction and a sensitive radioreceptor assay. J Biol Chem (1974) 1.63
Regulation of receptor concentration by homologous hormone. Effect of human growth hormone on its receptor in IM-9 lymphocytes. J Biol Chem (1976) 1.62
Characterization of insulin-mediated phosphorylation of the insulin receptor in a cell-free system. J Biol Chem (1983) 1.62
Application of lectin--gold complexes for electron microscopic localization of glycoconjugates on thin sections. J Histochem Cytochem (1983) 1.62
Cytochemical localization of terminal N-acetyl-D-galactosamine residues in cellular compartments of intestinal goblet cells: implications for the topology of O-glycosylation. J Cell Biol (1984) 1.61
Monitoring disease activity by stool analyses: from occult blood to molecular markers of intestinal inflammation and damage. Gut (2009) 1.58
Expression of the pro-inflammatory protein S100A12 (EN-RAGE) in rheumatoid and psoriatic arthritis. Rheumatology (Oxford) (2003) 1.56
Mapping of the residues responsible for the negative cooperativity of the receptor-binding region of insulin. Nature (1978) 1.55
Thymic lymphocytes in obese (ob-ob) mice. A mirror of the insulin receptor defect in liver and fat. J Biol Chem (1974) 1.55
Alteration of terminal glycosylation sequences on N-linked oligosaccharides of Chinese hamster ovary cells by expression of beta-galactoside alpha 2,6-sialyltransferase. J Biol Chem (1989) 1.55
Reporting whole-body vibration intervention studies: recommendations of the International Society of Musculoskeletal and Neuronal Interactions. J Musculoskelet Neuronal Interact (2010) 1.53
The Ca2+-binding proteins S100A8 and S100A9 are encoded by novel injury-regulated genes. J Biol Chem (2001) 1.52
Calcium-dependent complex assembly of the myeloic differentiation proteins MRP-8 and MRP-14. J Biol Chem (1991) 1.51
Insulin-induced dissociation of its receptor into subunits: possible molecular concomitant of negative cooperativity. Biochem Biophys Res Commun (1976) 1.51
Enzymatic properties of the purified putA protein from Salmonella typhimurium. J Biol Chem (1981) 1.50
Regulation of insulin receptors and insulin responsiveness in 3T3-L1 fatty fibroblasts. Endocrinology (1979) 1.49
Receptors for insulin, NSILA-s, and growth hormone: applications to disease states in man. Recent Prog Horm Res (1975) 1.47
Myeloid-related proteins S100A8/S100A9 regulate joint inflammation and cartilage destruction during antigen-induced arthritis. Ann Rheum Dis (2007) 1.47
ACTH-receptor interaction in the adrenal: a model for the initial step in the action of hormones that stimulate adenyl cyclase. Ann N Y Acad Sci (1971) 1.46
Specificity spillover at the hormone receptor--exploring its role in human disease. N Engl J Med (1989) 1.45
Binding of insulin receptors to lectins: evidence for common carbohydrate determinants on several membrane receptors. Biochemistry (1981) 1.45
Electrolyte effects on the activity of mutant enzymes in vivo and in vitro. Biochemistry (1979) 1.44
Human growth hormone radioreceptor assay using cultured human lymphocytes. Nat New Biol (1973) 1.43
Immunoassay of plasma vasopressin in man. Proc Natl Acad Sci U S A (1970) 1.43
The role of antireceptor antibodies in stimulating phosphorylation of the insulin receptor. J Biol Chem (1984) 1.43
"Golden blot"--detection of polyclonal and monoclonal antibodies bound to antigens on nitrocellulose by protein A-gold complexes. Anal Biochem (1984) 1.41
Myeloid marker S100A8/A9 and lymphocyte marker, soluble interleukin 2 receptor: biomarkers of hidradenitis suppurativa disease activity? Br J Dermatol (2013) 1.40
Insulin receptor defect in insulin resistance: studies in the obese-hyperglycimic mouse. Biochem Biophys Res Commun (1972) 1.39
Specialized transducing phages derived from salmonella phage P22. Genetics (1974) 1.38
Extreme insulin resistance in ataxia telangiectasia: defect in affinity of insulin receptors. N Engl J Med (1978) 1.37
Neural stem cells target intracranial glioma to deliver an oncolytic adenovirus in vivo. Gene Ther (2008) 1.36