Published in J Cell Biol on November 01, 1980
Mechanisms for the incorporation of proteins in membranes and organelles. J Cell Biol (1982) 9.67
Translocation of proteins across the endoplasmic reticulum III. Signal recognition protein (SRP) causes signal sequence-dependent and site-specific arrest of chain elongation that is released by microsomal membranes. J Cell Biol (1981) 8.36
Antibodies to the Golgi complex and the rough endoplasmic reticulum. J Cell Biol (1982) 7.02
Protein translocation across the endoplasmic reticulum. II. Isolation and characterization of the signal recognition particle receptor. J Cell Biol (1982) 5.20
Multiple genes are required for proper insertion of secretory proteins into the endoplasmic reticulum in yeast. J Cell Biol (1989) 4.13
Protein translocation across the endoplasmic reticulum. I. Detection in the microsomal membrane of a receptor for the signal recognition particle. J Cell Biol (1982) 4.10
Single stranded DNA SP6 promoter plasmids for engineering mutant RNAs and proteins: synthesis of a 'stretched' preproparathyroid hormone. Nucleic Acids Res (1985) 2.73
Identification and characterization of a membrane component essential for the translocation of nascent proteins across the membrane of the endoplasmic reticulum. J Cell Biol (1980) 2.63
The secondary structure of the 7SL RNA in the signal recognition particle: functional implications. Nucleic Acids Res (1985) 2.33
The organization of the 7SL RNA in the signal recognition particle. Nucleic Acids Res (1983) 2.03
The signal recognition particle receptor is a complex that contains two distinct polypeptide chains. J Cell Biol (1986) 1.95
M13 procoat and a pre-immunoglobulin share processing specificity but use different membrane receptor mechanisms. Proc Natl Acad Sci U S A (1983) 1.90
Characterization of secretory protein translocation: ribosome-membrane interaction in endoplasmic reticulum. J Cell Biol (1986) 1.70
Characterization of molecules involved in protein translocation using a specific antibody. J Cell Biol (1982) 1.58
Signal recognition particle (SRP) does not mediate a translational arrest of nascent secretory proteins in mammalian cell-free systems. EMBO J (1985) 1.43
Import of frog prepropeptide GLa into microsomes requires ATP but does not involve docking protein or ribosomes. EMBO J (1987) 1.41
The signal sequence receptor, unlike the signal recognition particle receptor, is not essential for protein translocation. J Cell Biol (1992) 1.40
Import of honeybee prepromelittin into the endoplasmic reticulum: structural basis for independence of SRP and docking protein. EMBO J (1987) 1.39
A microsomal ATP-binding protein involved in efficient protein transport into the mammalian endoplasmic reticulum. EMBO J (1996) 1.38
Segregation of the polypeptide translocation apparatus to regions of the endoplasmic reticulum containing ribophorins and ribosomes. I. Functional tests on rat liver microsomal subfractions. J Cell Biol (1984) 1.36
Translocation of nascent secretory proteins across membranes can occur late in translation. EMBO J (1986) 1.35
Evidence for a two-step mechanism involved in assembly of functional signal recognition particle receptor. J Cell Biol (1989) 1.33
Antiribophorin antibodies inhibit the targeting to the ER membrane of ribosomes containing nascent secretory polypeptides. J Cell Biol (1990) 1.32
Signal recognition particle (SRP) stabilizes the translocation-competent conformation of pre-secretory proteins. EMBO J (1988) 1.26
SRbeta coordinates signal sequence release from SRP with ribosome binding to the translocon. EMBO J (2001) 1.25
Integration of membrane proteins into the endoplasmic reticulum requires GTP. J Cell Biol (1988) 1.17
Different effects of Sec61α, Sec62 and Sec63 depletion on transport of polypeptides into the endoplasmic reticulum of mammalian cells. J Cell Sci (2012) 1.15
180-kD ribosome receptor is essential for both ribosome binding and protein translocation. J Cell Biol (1993) 1.14
The latency of rat liver microsomal protein disulphide-isomerase. Biochem J (1985) 1.13
ER translocation intermediates are adjacent to a nonglycosylated 34-kD integral membrane protein. J Cell Biol (1991) 1.07
Dog pancreatic microsomal-membrane polypeptides analysed by two-dimensional gel electrophoresis. Biochem J (1984) 0.97
Mitotic phosphorylation of rab4 prevents binding to a specific receptor on endosome membranes. EMBO J (1997) 0.91
Dual recognition of the ribosome and the signal recognition particle by the SRP receptor during protein targeting to the endoplasmic reticulum. J Cell Biol (2003) 0.91
The role of topogenic sequences in the movement of proteins through membranes. Biochem J (1987) 0.86
Secretion in yeast: in vitro analysis of the sec53 mutant. EMBO J (1988) 0.77
Transfer of proteins across membranes. I. Presence of proteolytically processed and unprocessed nascent immunoglobulin light chains on membrane-bound ribosomes of murine myeloma. J Cell Biol (1975) 36.95
Intracellular aspects of the process of protein synthesis. Science (1975) 25.21
Transfer of proteins across membranes. II. Reconstitution of functional rough microsomes from heterologous components. J Cell Biol (1975) 15.47
A possible precursor of immunoglobulin light chains. Nat New Biol (1972) 11.03
Synchronised transmembrane insertion and glycosylation of a nascent membrane protein. Nature (1977) 7.72
Vectorial discharge of peptides released by puromycin from attached ribosomes. Proc Natl Acad Sci U S A (1966) 5.69
Membrane assembly in vitro: synthesis, glycosylation, and asymmetric insertion of a transmembrane protein. Proc Natl Acad Sci U S A (1977) 5.51
Cell-free synthesis and membrane insertion of mouse H-2Dd histocompatibility antigen and beta 2-microglobulin. Cell (1979) 4.72
The mechanism of protein secretion across membranes. Nature (1980) 4.72
Translocation of proteins across membranes: the signal hypothesis and beyond. Symp Soc Exp Biol (1979) 4.54
Tryptic dissection and reconstitution of translocation activity for nascent presecretory proteins across microsomal membranes. Proc Natl Acad Sci U S A (1979) 4.22
Protein transfer across microsomal membranes reassembled from separated membrane components. Nature (1978) 3.39
Assembly of the Semliki Forest virus membrane glycoproteins in the membrane of the endoplasmic reticulum in vitro. J Mol Biol (1978) 3.16
Coupled cell-free synthesis, segregation, and core glycosylation of a secretory protein. Proc Natl Acad Sci U S A (1978) 3.11
mRNA-dependent synthesis of authentic precursor to human placental lactogen: conversion to its mature hormone form in ascites cell-free extracts. Proc Natl Acad Sci U S A (1976) 2.80
Identification and characterization of a membrane component essential for the translocation of nascent proteins across the membrane of the endoplasmic reticulum. J Cell Biol (1980) 2.63
Transfer of proteins across membranes, Biosynthesis in vitro of pretrypsinogen and trypsinogen by cell fractions of canine pancreas. Eur J Biochem (1978) 2.62
Synthesis and glycosylation in vitro of glycoprotein of vesicular stomatitis virus. Proc Natl Acad Sci U S A (1977) 1.95
Membrane biogenesis. In vitro cleavage, core glycosylation, and integration into microsomal membranes of sindbis virus glycoproteins. J Cell Biol (1979) 1.57
Transfer of proteins across membranes. I. Presence of proteolytically processed and unprocessed nascent immunoglobulin light chains on membrane-bound ribosomes of murine myeloma. J Cell Biol (1975) 36.95
Transfer of proteins across membranes. II. Reconstitution of functional rough microsomes from heterologous components. J Cell Biol (1975) 15.47
Secretory protein translocation across membranes-the role of the "docking protein'. Nature (1982) 7.23
Common principles of protein translocation across membranes. Science (1996) 7.00
In vitro synthesis and processing of a putative precursor for the small subunit of ribulose-1,5-bisphosphate carboxylase of Chlamydomonas reinhardtii. Proc Natl Acad Sci U S A (1977) 5.89
Cell-free synthesis and membrane insertion of mouse H-2Dd histocompatibility antigen and beta 2-microglobulin. Cell (1979) 4.72
A novel in vitro transcription-translation system: accurate and efficient synthesis of single proteins from cloned DNA sequences. EMBO J (1984) 4.50
A T5 promoter-based transcription-translation system for the analysis of proteins in vitro and in vivo. Methods Enzymol (1987) 4.21
Homology of 54K protein of signal-recognition particle, docking protein and two E. coli proteins with putative GTP-binding domains. Nature (1989) 4.05
MHC class II-associated invariant chain contains a sorting signal for endosomal compartments. Cell (1990) 3.85
Isolation and characterization of the intracellular MHC class II compartment. Nature (1994) 3.50
Protein transfer across microsomal membranes reassembled from separated membrane components. Nature (1978) 3.39
Membrane insertion and oligomeric assembly of HLA-DR histocompatibility antigens. Cell (1982) 3.36
Secretion in yeast: reconstitution of the translocation and glycosylation of alpha-factor and invertase in a homologous cell-free system. Cell (1986) 3.20
Signal sequences: more than just greasy peptides. Trends Cell Biol (1998) 3.18
Assembly of the Semliki Forest virus membrane glycoproteins in the membrane of the endoplasmic reticulum in vitro. J Mol Biol (1978) 3.16
Mouse histocompatibility genes: structure and organisation of a Kd gene. EMBO J (1983) 3.07
Characterization of a 50-kDa polypeptide in cytoplasmic dynein preparations reveals a complex with p150GLUED and a novel actin. J Biol Chem (1993) 2.91
Centractin is an actin homologue associated with the centrosome. Nature (1992) 2.84
Immunochemical analysis of rough and smooth microsomes from rat liver. Segregation of docking protein in rough membranes. Eur J Biochem (1985) 2.78
Functional interaction of plant ribosomes with animal microsomal membranes. Biochem Biophys Res Commun (1977) 2.77
Identification and characterization of a membrane component essential for the translocation of nascent proteins across the membrane of the endoplasmic reticulum. J Cell Biol (1980) 2.63
Transfer of proteins across membranes, Biosynthesis in vitro of pretrypsinogen and trypsinogen by cell fractions of canine pancreas. Eur J Biochem (1978) 2.62
ACT3: a putative centractin homologue in S. cerevisiae is required for proper orientation of the mitotic spindle. J Cell Biol (1994) 2.60
Secretion in yeast: translocation and glycosylation of prepro-alpha-factor in vitro can occur via an ATP-dependent post-translational mechanism. EMBO J (1986) 2.59
Human ribophorins I and II: the primary structure and membrane topology of two highly conserved rough endoplasmic reticulum-specific glycoproteins. EMBO J (1987) 2.53
The protein-conducting channel in the membrane of the endoplasmic reticulum is open laterally toward the lipid bilayer. Cell (1995) 2.27
E. coli 4.5S RNA is part of a ribonucleoprotein particle that has properties related to signal recognition particle. Cell (1990) 2.22
Translation arrest by oligodeoxynucleotides complementary to mRNA coding sequences yields polypeptides of predetermined length. Nucleic Acids Res (1986) 2.21
An alternative protein targeting pathway in Escherichia coli: studies on the role of FtsY. EMBO J (1994) 2.13
Regulation by the ribosome of the GTPase of the signal-recognition particle during protein targeting. Nature (1996) 2.07
The membrane-spanning segment of invariant chain (I gamma) contains a potentially cleavable signal sequence. Cell (1986) 2.04
The organization of the 7SL RNA in the signal recognition particle. Nucleic Acids Res (1983) 2.03
Signal-sequence recognition by an Escherichia coli ribonucleoprotein complex. Nature (1992) 2.02
The 54-kD protein of signal recognition particle contains a methionine-rich RNA binding domain. J Cell Biol (1990) 1.95
In vivo and in vitro analysis of ptl1, a yeast ts mutant with a membrane-associated defect in protein translocation. EMBO J (1988) 1.91
Structure of C-terminal half of two H-2 antigens from cloned mRNA. Nature (1981) 1.90
cDNA clone coding for part of a mouse H-2d major histocompatibility antigen. Proc Natl Acad Sci U S A (1981) 1.90
The methionine-rich domain of the 54 kDa subunit of signal recognition particle is sufficient for the interaction with signal sequences. EMBO J (1992) 1.85
Site-specific photocross-linking reveals that Sec61p and TRAM contact different regions of a membrane-inserted signal sequence. J Biol Chem (1993) 1.85
Isolation and identification of a cDNA clone corresponding to an HLA-DR antigen beta chain. Proc Natl Acad Sci U S A (1982) 1.75
Membrane biogenesis during B cell differentiation: most endoplasmic reticulum proteins are expressed coordinately. J Cell Biol (1990) 1.74
Transfer of secretory proteins through the membrane of the endoplasmic reticulum. Int Rev Cytol (1986) 1.74
Characterization of secretory protein translocation: ribosome-membrane interaction in endoplasmic reticulum. J Cell Biol (1986) 1.70
The MHC class II-associated invariant chain contains two endosomal targeting signals within its cytoplasmic tail. J Cell Sci (1993) 1.69
A structural and functional analysis of the docking protein. Characterization of active domains by proteolysis and specific antibodies. J Biol Chem (1985) 1.67
A tripartite structure of the signals that determine protein insertion into the endoplasmic reticulum membrane. J Cell Biol (1989) 1.61
Requirements for the membrane insertion of signal-anchor type proteins. J Cell Biol (1991) 1.59
Characterization of molecules involved in protein translocation using a specific antibody. J Cell Biol (1982) 1.58
Signal recognition particle-dependent membrane insertion of mouse invariant chain: a membrane-spanning protein with a cytoplasmically exposed amino terminus. J Cell Biol (1986) 1.54
Structure of the murine Ia-associated invariant (Ii) chain as deduced from a cDNA clone. EMBO J (1984) 1.51
Interferon messenger RNA content of human fibroblasts during induction, shutoff, and superinduction of interferon production. Proc Natl Acad Sci U S A (1977) 1.51
The identification of proteins in the proximity of signal-anchor sequences during their targeting to and insertion into the membrane of the ER. J Cell Biol (1991) 1.51
Secretion in yeast: structural features influencing the post-translational translocation of prepro-alpha-factor in vitro. EMBO J (1987) 1.47
Isolation and characterization of a cDNA clone encoding the 19 kDa protein of signal recognition particle (SRP): expression and binding to 7SL RNA. Nucleic Acids Res (1988) 1.47
Identification of a ribosome receptor in the rough endoplasmic reticulum. Nature (1990) 1.46
Signal recognition particle (SRP) does not mediate a translational arrest of nascent secretory proteins in mammalian cell-free systems. EMBO J (1985) 1.43
Translation efficiency of zein mRNA is reduced by hybrid formation between the 5'- and 3'-untranslated region. EMBO J (1985) 1.39
Pushing the signal hypothesis: what are the limits? Biol Cell (1984) 1.38
Assembly of the 68- and 72-kD proteins of signal recognition particle with 7S RNA. J Cell Biol (1993) 1.37
The signal sequence receptor has a second subunit and is part of a translocation complex in the endoplasmic reticulum as probed by bifunctional reagents. J Cell Biol (1990) 1.35
Sec61p is adjacent to nascent type I and type II signal-anchor proteins during their membrane insertion. J Cell Biol (1993) 1.35
The signal sequence interacts with the methionine-rich domain of the 54-kD protein of signal recognition particle. J Cell Biol (1991) 1.35
Translocation of nascent secretory proteins across membranes can occur late in translation. EMBO J (1986) 1.35
Signal peptide fragments of preprolactin and HIV-1 p-gp160 interact with calmodulin. EMBO J (1997) 1.33
Mammalian and Escherichia coli signal recognition particles. Mol Microbiol (1994) 1.32
Interaction of the p62 subunit of dynactin with Arp1 and the cortical actin cytoskeleton. Curr Biol (2000) 1.28
Signal recognition particle (SRP) stabilizes the translocation-competent conformation of pre-secretory proteins. EMBO J (1988) 1.26
Signal and membrane anchor functions overlap in the type II membrane protein I gamma CAT. J Cell Biol (1988) 1.26
The leucine-based sorting motifs in the cytoplasmic domain of the invariant chain are recognized by the clathrin adaptors AP1 and AP2 and their medium chains. J Biol Chem (1999) 1.26
Preprotein conformation: the year's major theme in translocation studies. Trends Biochem Sci (1988) 1.26
SRbeta coordinates signal sequence release from SRP with ribosome binding to the translocon. EMBO J (2001) 1.25
Control of glycosylation of MHC class II-associated invariant chain by translocon-associated RAMP4. EMBO J (1999) 1.24
Oligomeric complexes involved in translocation of proteins across the membrane of the endoplasmic reticulum. FEBS Lett (1999) 1.23
Overexpression of normal and mutant Arp1alpha (centractin) differentially affects microtubule organization during mitosis and interphase. J Cell Sci (1999) 1.21
Structure and biosynthesis of the signal-sequence receptor. Eur J Biochem (1990) 1.19
Signal recognition particle-dependent insertion of coronavirus E1, an intracellular membrane glycoprotein. J Biol Chem (1985) 1.17
Signal recognition particle arrests elongation of nascent secretory and membrane proteins at multiple sites in a transient manner. J Biol Chem (1987) 1.17
An ATP transporter is required for protein translocation into the yeast endoplasmic reticulum. EMBO J (1993) 1.17
A complex of the signal sequence binding protein and the SRP RNA promotes translocation of nascent proteins. EMBO J (1995) 1.14
Functional characterization of the 180-kD ribosome receptor in vivo. J Cell Biol (1995) 1.14
180-kD ribosome receptor is essential for both ribosome binding and protein translocation. J Cell Biol (1993) 1.14
Disassembly and domain structure of the proteins in the signal-recognition particle. Eur J Biochem (1987) 1.12
Snapshots of membrane-translocating proteins. Trends Cell Biol (1996) 1.12
Structural requirements for membrane assembly of proteins spanning the membrane several times. J Cell Biol (1989) 1.12
Expression of the 180-kD ribosome receptor induces membrane proliferation and increased secretory activity in yeast. J Cell Biol (1999) 1.10
Signal sequence processing in rough microsomes. J Biol Chem (1995) 1.10
Actin-related protein nomenclature and classification. J Cell Biol (1994) 1.09
An extended RNA/RNA duplex structure within the coding region of mRNA does not block translational elongation. Nucleic Acids Res (1988) 1.08
Membrane insertion of alpha- and beta-subunits of Na+,K+-ATPase. J Biol Chem (1985) 1.07
Sac1p mediates the adenosine triphosphate transport into yeast endoplasmic reticulum that is required for protein translocation. J Cell Biol (1995) 1.06
Mechanisms that determine the transmembrane disposition of proteins. Curr Opin Cell Biol (1992) 1.06
The ribosome regulates the GTPase of the beta-subunit of the signal recognition particle receptor. J Cell Biol (1999) 1.03
Formation of SRP-like particle induces a conformational change in E. coli 4.5S RNA. FEBS Lett (1994) 1.03
Identification of an H-2Kd gene using a specific cDNA probe. EMBO J (1982) 1.02
Beta-centractin: characterization and distribution of a new member of the centractin family of actin-related proteins. Mol Biol Cell (1994) 1.01