Published in J Pharmacol Exp Ther on November 01, 1978
Common molecular determinants of local anesthetic, antiarrhythmic, and anticonvulsant block of voltage-gated Na+ channels. Proc Natl Acad Sci U S A (1996) 3.03
Mechanisms of use-dependent block of sodium channels in excitable membranes by local anesthetics. Biophys J (1984) 2.33
Interactions of organic calcium channel antagonists with calcium channels in single frog atrial cells. J Gen Physiol (1985) 2.04
Importance of physico-chemical properties in determining the kinetics of the effects of Class I antiarrhythmic drugs on maximum rate of depolarization in guinea-pig ventricle. Br J Pharmacol (1983) 1.28
Subtype-selective targeting of voltage-gated sodium channels. Br J Pharmacol (2009) 1.13
A quantitative description of QX222 blockade of sodium channels in squid axons. Biophys J (1986) 1.12
Kinetics of local anesthetic inhibition of neuronal sodium currents. pH and hydrophobicity dependence. Biophys J (1990) 1.07
Kinetic analysis of phasic inhibition of neuronal sodium currents by lidocaine and bupivacaine. Biophys J (1990) 1.07
Tonic and phasic block of neuronal sodium currents by 5-hydroxyhexano-2',6'-xylide, a neutral lidocaine homologue. J Gen Physiol (1989) 0.94
The external pore loop interacts with S6 and S3-S4 linker in domain 4 to assume an essential role in gating control and anticonvulsant action in the Na(+) channel. J Gen Physiol (2009) 0.83
Characterization of concentration- and use-dependent effects of quinidine from conduction delay and declining conduction velocity in canine Purkinje fibers. J Clin Invest (1989) 0.81
The response of cat spinal motoneurones to the intracellular application of agents with local anaesthetic action. Br J Pharmacol (1984) 0.78
A method for estimation of drug affinity constants to the open conformational state of calcium channels. Biophys J (1992) 0.77
sec-Butylpropylacetamide (SPD), a New Amide Derivative of Valproic Acid for the Treatment of Neuropathic and Inflammatory Pain. Pharmacol Res (2016) 0.76
Mechanism of frequency-dependent inhibition of sodium currents in frog myelinated nerve by the lidocaine derivative GEA. J Pharmacol Exp Ther (1975) 5.07
Anesthesia, pregnancy, and miscarriage: a study of operating room nurses and anesthetists. Anesthesiology (1971) 2.85
Occupational disease in dentistry and chronic exposure to trace anesthetic gases. J Am Dent Assoc (1980) 1.90
Relevant concentrations of inhaled anesthetics for in vitro studies of anesthetic mechanisms. Anesthesiology (2001) 1.87
Hypothesis: inhaled anesthetics produce immobility and amnesia by different mechanisms at different sites. Anesth Analg (1997) 1.80
Chronic exposure to anesthetic gases in the operating room. Anesthesiology (1971) 1.73
A survey of anesthetic health hazards among dentists. J Am Dent Assoc (1975) 1.70
Structure-activity relations for frequency-dependent sodium channel block in nerve by local anesthetics. J Pharmacol Exp Ther (1980) 1.63
Propofol and barbiturate depression of spinal nociceptive neurotransmission. Anesthesiology (1992) 1.50
Occupational hazards for operating room-based physicians. Analysis of data from the United States and the United Kingdom. JAMA (1977) 1.38
Comparative actions of mexiletine on sodium channels in nerve, skeletal and cardiac muscle. Eur J Pharmacol (1981) 1.33
The metabolism and elimination of d-tubocurarine-H3. Anesthesiology (1967) 1.22
The antagonistic effect of an inhalation anesthetic and high pressure on the phase diagram of mixed dipalmitoyl-dimyristoylphosphatidylcholine bilayers. Proc Natl Acad Sci U S A (1975) 1.17
Application of low-temperature autoradiography to studies of the uptake and metabolism of volatile anesthetics in the mouse. 3. Halothane. Anesthesiology (1969) 1.15
Pressure-induced elevation of phase transition temperature in dipalmitoylphosphatidylcholine bilayers. An electron spin resonance measurement of the enthalpy of phase transition. Biochim Biophys Acta (1974) 1.14
Surgery during pregnancy and fetal outcome. Am J Obstet Gynecol (1980) 1.14
Interval-dependent effects of small antiarrhythmic drugs on excitability of guinea-pig myocardium. J Mol Cell Cardiol (1980) 1.12
Metabolism of the volatile anesthetics. Anesthesiology (1971) 1.11
Effects of pressure and anesthetics on conduction and synaptic transmission. J Pharmacol Exp Ther (1975) 1.10
Pressure reversal of inhalation anesthetic-induced disorder in spin-labeled phospholipid vesicles. Biochim Biophys Acta (1973) 1.08
The effect of two inhalation anesthetics on the order of spin-labeled phospholipid vesicles. Biochim Biophys Acta (1973) 1.07
Application of low-temperature autoradiography to studies of the uptake and metabolism of volatile anesthetics in the mouse. I. Chloroform. Anesthesiology (1969) 1.07
Halothane and the liver: a review of the epidemiologic, immunologic and metabolic aspects of the relationship. Can J Surg (1972) 1.06
Use of whole-body autoradiography for determination of uptake and distribution of labeled muscle relaxants in the rat. Anesthesiology (1968) 1.04
Fast frequency-dependent block of action potential upstroke in rabbit atrium by small local anesthetics. Life Sci (1979) 1.03
Anesthetics: molecular correlates of voltage- and frequency-dependent sodium channel block in nerve. J Pharmacol Exp Ther (1979) 1.01
Design of a multi-point laser scanned optical monitor of cardiac action potential propagation: application to microreentry in guinea pig atrium. Ann Biomed Eng (1987) 0.99
Anesthetic actions within the spinal cord: contributions to the state of general anesthesia. Trends Neurosci (1995) 0.98
Urinary metabolites of halothane in man. Anesthesiology (1975) 0.97
Enflurane directly depresses glutamate AMPA and NMDA currents in mouse spinal cord motor neurons independent of actions on GABAA or glycine receptors. Anesthesiology (2000) 0.97
Sperm studies in anesthesiologists. Anesthesiology (1981) 0.96
Exposure to nitrous oxide and neurologic disease among dental professionals. Anesth Analg (1981) 0.95
Use-dependent block of single sodium channels by lidocaine in guinea pig ventricular myocytes. Biophys J (1989) 0.95
Quantitative structure/activity relations based on use-dependent block and repriming kinetics in myocardium. J Mol Cell Cardiol (1987) 0.94
Clinical relevance of cancer stem cells in bone marrow of early breast cancer patients. Ann Oncol (2013) 0.94
Enflurane actions on spinal cords from mice that lack the beta3 subunit of the GABA(A) receptor. Anesthesiology (2001) 0.93
On the metabolism of ( 14 C)-diethyl ether in the mouse. Biochem Pharmacol (1971) 0.93
Neuromuscular function at hyperbaric pressures: pressure-anesthetic interactions. Am J Physiol (1976) 0.93
Alterations in muscle resting potentials and electrolytes during halothane and cyclopropane anesthesia. Anesthesiology (1972) 0.92
Voltage-sensitive dyes. Discerning contraction and electrical signals in myocardium. Biophys J (1982) 0.92
Extracellular pH selectively modulates recovery from sodium inactivation in frog myelinated nerve. Biophys J (1979) 0.92
Modeling ion channel blockade at guarded binding sites: application to tertiary drugs. Am J Physiol (1986) 0.92
Ethanol directly depresses AMPA and NMDA glutamate currents in spinal cord motor neurons independent of actions on GABAA or glycine receptors. J Pharmacol Exp Ther (1999) 0.92
Extracellular space, electrolyte distribution, and resting potential in K depletion. Am J Physiol (1970) 0.90
General anaesthetic modification of synaptic facilitation and long-term potentiation in hippocampus. Br J Anaesth (1989) 0.90
Metabolism of halothane-2 14C in the mouse. Anesthesiology (1969) 0.90
Pressure reversal of anesthesia: the extent of small-molecule exclusion from spin-labeled phospholipid model membranes. Anesthesiology (1973) 0.90
Long-term potentiation in an isolated peripheral nerve-spinal cord preparation. J Neurophysiol (1995) 0.89
Quantifying antiarrhythmic drug blocking during action potentials in guinea-pig papillary muscle. J Mol Cell Cardiol (1983) 0.88
Electron spin resonance studies with the volatile anesthetics on phospholipid model membranes. Ann N Y Acad Sci (1973) 0.88
Bupivacaine is an effective potassium channel blocker in heart. Biochim Biophys Acta (1988) 0.87
The excretion of gallamine in the dog. Anesthesiology (1969) 0.87
Minimum alveolar anesthetic concentration of fluorinated alkanols in rats: relevance to theories of narcosis. Anesth Analg (1999) 0.85
Selective effects of ketamine on amino acid-mediated pathways in neonatal rat spinal cord. Br J Anaesth (1995) 0.85
Pressure antagonism to nerve conduction block by anesthetic agents. Anesthesiology (1977) 0.85
Anesthetic effects on resting membrane potential are voltage-dependent and agent-specific. Anesthesiology (1991) 0.85
Distribution of local anesthetic agents in the neuraxis of the dog. Anesthesiology (1968) 0.85
The effect of pressure on the phase diagram of mixed dipalmitoyl-dimyristoylphosphatidylcholine bilayers. Biochim Biophys Acta (1974) 0.85
Nerve membrane lipid fluidity: opposing effects of high pressure and ethanol. Undersea Biomed Res (1979) 0.84
Occupational exposure to mercury in dentistry and pregnancy outcome. J Am Dent Assoc (1985) 0.84
Pressure and temperature modulation of conduction in a bifurcating axon. Undersea Biomed Res (1986) 0.84
Isoflurane and an alpha 2-adrenoceptor agonist suppress nociceptive neurotransmission in neonatal rat spinal cord. Anesthesiology (1991) 0.84
Descending inhibition in neonatal rat spinal cord: actions of pentobarbital and morphine. Brain Res Bull (1996) 0.84
Pressure and temperature: time-dependent modulation of membrane properties in a bifurcating axon. J Neurophysiol (1984) 0.83
Reentrant tachycardia in a thin layer of ventricular subepicardium: effects of d-sotalol and lidocaine. J Cardiovasc Pharmacol (1990) 0.83
Differential sensitivities of TTX-resistant and TTX-sensitive sodium channels to anesthetic concentrations of ethanol in rat sensory neurons. J Neurosci Res (1998) 0.83
Tolerance, opioid-induced allodynia and withdrawal associated allodynia in infant and young rats. Neuroscience (2006) 0.82
Clinical implications of the modulated receptor hypothesis: local anesthetics and the heart. Anesthesiology (1985) 0.82
Epileptogenesis in neocortical slices. Brain Res (1977) 0.82
Glutamate receptor-mediated hyperexcitability after ethanol exposure in isolated neonatal rat spinal cord. J Pharmacol Exp Ther (1998) 0.82
Halothane stereoisomers: lack of stereospecificity in two model systems. Anesthesiology (1973) 0.82
Pressure, temperature, and repetitive impulse generation in crustacean axons. J Appl Physiol Respir Environ Exerc Physiol (1978) 0.82
Patch clamp studies of motor neurons in spinal cord slices: a tool for high-resolution analysis of drug actions. Acta Pharmacol Sin (2000) 0.82
Peptide T improves psoriasis when infused into lesions in nanogram amounts. J Am Acad Dermatol (1991) 0.82
Frequency-dependent conduction block: the role of nerve impulse pattern in local anesthetic potency. Anesthesiology (1978) 0.82
Editorial views: Anesthetics and cancer. Anesthesiology (1976) 0.82
Volatile metabolites and decomposition products of halothane in man. Anesthesiology (1979) 0.81
Significance of bicarbonate for antiarrhythmic drug action. J Mol Cell Cardiol (1981) 0.81
Ethanol as a general anesthetic: actions in spinal cord. Eur J Pharmacol (1997) 0.81
The compression-ordering and solubility-disordering effects of high pressure gases on phospholipid bilayers. Life Sci (1976) 0.80
Synaptic integrative properties at hyperbaric pressure. J Neurophysiol (1988) 0.80
Size-dependent kinetics associated with drug block of sodium current. Biophys J (1984) 0.80
The actions of neuromuscular relaxants at hyperbaric pressures. Anesthesiology (1977) 0.80
N-methyl-D-aspartate receptors are implicated in hyperresponsiveness following naloxone reversal of alfentanil in isolated rat spinal cord. Neurosci Lett (1995) 0.80
The alpha 2-adrenoceptor agonist dexmedetomidine increases the apparent potency of the volatile anesthetic isoflurane in rats in vivo and in hippocampal slice in vitro. Brain Res (1991) 0.80
Barbiturate alteration of respiratory rhythm and drive in isolated brainstem-spinal cord of newborn rat: studies at normal and hyperbaric pressure. Br J Anaesth (1991) 0.80
Substance P and NMDA receptors mediate a slow nociceptive ventral root potential in neonatal rat spinal cord. Brain Res (1991) 0.80
Barbiturates: active form and site of action at node of Ranvier sodium channels. J Pharmacol Exp Ther (1981) 0.79