Published in J Cell Biol on November 01, 1981
Translocation of proteins across the endoplasmic reticulum III. Signal recognition protein (SRP) causes signal sequence-dependent and site-specific arrest of chain elongation that is released by microsomal membranes. J Cell Biol (1981) 8.36
Translocation of proteins across the endoplasmic reticulum. I. Signal recognition protein (SRP) binds to in-vitro-assembled polysomes synthesizing secretory protein. J Cell Biol (1981) 7.40
Protein translocation across the endoplasmic reticulum. II. Isolation and characterization of the signal recognition particle receptor. J Cell Biol (1982) 5.20
Protein translocation across the endoplasmic reticulum. I. Detection in the microsomal membrane of a receptor for the signal recognition particle. J Cell Biol (1982) 4.10
Elongation arrest is not a prerequisite for secretory protein translocation across the microsomal membrane. J Cell Biol (1985) 3.19
Biosynthesis and biochemical properties of the hepatitis C virus core protein. J Virol (1994) 3.19
Protein secretion in Bacillus species. Microbiol Rev (1993) 2.74
Yeast secretory mutants that block the formation of active cell surface enzymes. J Cell Biol (1984) 2.71
Light-regulated translation of chloroplast proteins. I. Transcripts of psaA-psaB, psbA, and rbcL are associated with polysomes in dark-grown and illuminated barley seedlings. J Cell Biol (1988) 2.64
Yeast mitochondrial outer membrane specifically binds cytoplasmically-synthesized precursors of mitochondrial proteins. EMBO J (1983) 2.55
Formation of a functional ribosome-membrane junction during translocation requires the participation of a GTP-binding protein. J Cell Biol (1986) 2.44
Export of protein in bacteria. Microbiol Rev (1984) 2.35
Protein export in Escherichia coli requires a soluble activity. Proc Natl Acad Sci U S A (1984) 2.34
Structure and evolution of the 7SL RNA component of the signal recognition particle. EMBO J (1984) 2.29
Mechanisms of integration of de novo-synthesized polypeptides into membranes: signal-recognition particle is required for integration into microsomal membranes of calcium ATPase and of lens MP26 but not of cytochrome b5. Proc Natl Acad Sci U S A (1983) 2.04
The affinity of signal recognition particle for presecretory proteins is dependent on nascent chain length. EMBO J (1988) 2.00
Genes required for completion of import of proteins into the endoplasmic reticulum in yeast. J Cell Biol (1984) 2.00
In vivo and in vitro analysis of ptl1, a yeast ts mutant with a membrane-associated defect in protein translocation. EMBO J (1988) 1.91
Actin mRNA localizes in the absence of protein synthesis. J Cell Biol (1990) 1.83
Determinants for protein localization: beta-lactamase signal sequence directs globin across microsomal membranes. Proc Natl Acad Sci U S A (1984) 1.82
Subcellular distribution of signal recognition particle and 7SL-RNA determined with polypeptide-specific antibodies and complementary DNA probe. J Cell Biol (1983) 1.79
Characterization of secretory protein translocation: ribosome-membrane interaction in endoplasmic reticulum. J Cell Biol (1986) 1.70
Identification of five new essential genes involved in the synthesis of a secreted protein in Escherichia coli. J Bacteriol (1985) 1.68
Signal recognition protein is required for the integration of acetylcholine receptor delta subunit, a transmembrane glycoprotein, into the endoplasmic reticulum membrane. J Cell Biol (1982) 1.62
A deletion that includes the signal peptidase cleavage site impairs processing, glycosylation, and secretion of cell surface yeast acid phosphatase. Mol Cell Biol (1984) 1.61
Secretion of beta-lactamase into the periplasm of Escherichia coli: evidence for a distinct release step associated with a conformational change. Proc Natl Acad Sci U S A (1986) 1.58
Primary role for endoplasmic reticulum-bound ribosomes in cellular translation identified by ribosome profiling. J Biol Chem (2011) 1.56
SV40 T antigen and the exocytotic pathway. EMBO J (1985) 1.52
Signal sequence- and translation-independent mRNA localization to the endoplasmic reticulum. RNA (2008) 1.49
Ff coliphages: structural and functional relationships. Microbiol Rev (1986) 1.45
Nascent polypeptide-associated complex protein prevents mistargeting of nascent chains to the endoplasmic reticulum. Proc Natl Acad Sci U S A (1995) 1.45
Yeast carboxypeptidase Y can be translocated and glycosylated without its amino-terminal signal sequence. J Cell Biol (1987) 1.44
Integration of a small integral membrane protein, M2, of influenza virus into the endoplasmic reticulum: analysis of the internal signal-anchor domain of a protein with an ectoplasmic NH2 terminus. J Cell Biol (1988) 1.44
Demonstration of a multistep mechanism for assembly of the SRP x SRP receptor complex: implications for the catalytic role of SRP RNA. J Mol Biol (2008) 1.43
A novel translational control mechanism involving RNA structures within coding sequences. Genome Res (2016) 1.43
A microsomal ATP-binding protein involved in efficient protein transport into the mammalian endoplasmic reticulum. EMBO J (1996) 1.38
Segregation of the polypeptide translocation apparatus to regions of the endoplasmic reticulum containing ribophorins and ribosomes. I. Functional tests on rat liver microsomal subfractions. J Cell Biol (1984) 1.36
Antiribophorin antibodies inhibit the targeting to the ER membrane of ribosomes containing nascent secretory polypeptides. J Cell Biol (1990) 1.32
Localization and quantitation of proteins characteristic of the complexed membrane of Bacillus subtilis. J Bacteriol (1983) 1.30
Assembly of archaeal signal recognition particle from recombinant components. Nucleic Acids Res (2000) 1.27
Glycosylation and surface expression of the influenza virus neuraminidase requires the N-terminal hydrophobic region. Mol Cell Biol (1984) 1.26
RAP1 controls rhoptry targeting of RAP2 in the malaria parasite Plasmodium falciparum. EMBO J (2000) 1.26
Nascent secretory chain binding and translocation are distinct processes: differentiation by chemical alkylation. J Cell Biol (1989) 1.25
Divergent regulation of protein synthesis in the cytosol and endoplasmic reticulum compartments of mammalian cells. Mol Biol Cell (2007) 1.25
Signal recognition particle is required for co-translational insertion of cytochrome P-450 into microsomal membranes. Proc Natl Acad Sci U S A (1984) 1.22
Integration of membrane proteins into the endoplasmic reticulum requires GTP. J Cell Biol (1988) 1.17
The intrinsic ability of ribosomes to bind to endoplasmic reticulum membranes is regulated by signal recognition particle and nascent-polypeptide-associated complex. Proc Natl Acad Sci U S A (1995) 1.17
Different effects of Sec61α, Sec62 and Sec63 depletion on transport of polypeptides into the endoplasmic reticulum of mammalian cells. J Cell Sci (2012) 1.15
Signal recognition particle-dependent targeting of ribosomes to the rough endoplasmic reticulum in the absence and presence of the nascent polypeptide-associated complex. Mol Biol Cell (1998) 1.14
Binding of signal recognition particle gives ribosome/nascent chain complexes a competitive advantage in endoplasmic reticulum membrane interaction. Mol Biol Cell (1998) 1.13
mRNA translation is compartmentalized to the endoplasmic reticulum following physiological inhibition of cap-dependent translation. RNA (2006) 1.12
Unique features of hepatitis C virus capsid formation revealed by de novo cell-free assembly. J Virol (2004) 1.10
Hierarchical regulation of mRNA partitioning between the cytoplasm and the endoplasmic reticulum of mammalian cells. Mol Biol Cell (2011) 1.10
Molecular evolution of SRP cycle components: functional implications. Nucleic Acids Res (1994) 1.09
The 64-kilodalton membrane protein of Bacillus subtilis is also present as a multiprotein complex on membrane-free ribosomes. Proc Natl Acad Sci U S A (1984) 1.08
ER translocation intermediates are adjacent to a nonglycosylated 34-kD integral membrane protein. J Cell Biol (1991) 1.07
Does secA mediate coupling between secretion and translation in Escherichia coli? J Bacteriol (1986) 1.06
Diversity and selectivity in mRNA translation on the endoplasmic reticulum. Nat Rev Mol Cell Biol (2015) 1.04
Analyzing mRNA localization to the endoplasmic reticulum via cell fractionation. Methods Mol Biol (2011) 1.04
An RNA-zipcode-independent mechanism that localizes Dia1 mRNA to the perinuclear ER through interactions between Dia1 nascent peptide and Rho-GTP. J Cell Sci (2011) 0.93
Biogenesis of CFTR and other polytopic membrane proteins: new roles for the ribosome-translocon complex. J Membr Biol (2004) 0.93
The rat hepatocyte plasma membrane organic anion binding protein is immunologically related to the mitochondrial F1 adenosine triphosphatase beta-subunit. J Clin Invest (1990) 0.92
Secretory S complex of Bacillus subtilis forms a large, organized structure when released from ribosomes. Proc Natl Acad Sci U S A (1985) 0.92
Signal sequence recognition and targeting of ribosomes to the endoplasmic reticulum by the signal recognition particle do not require GTP. Mol Biol Cell (1994) 0.91
Mechanisms of CFTR Folding at the Endoplasmic Reticulum. Front Pharmacol (2012) 0.90
Intracellular traffic of newly synthesized proteins. Current understanding and future prospects. J Clin Invest (1989) 0.89
Functional analysis of Plasmodium falciparum merozoite antigens: implications for erythrocyte invasion and vaccine development. Philos Trans R Soc Lond B Biol Sci (2002) 0.89
Protein translocation across the rough endoplasmic reticulum. Cold Spring Harb Perspect Biol (2013) 0.87
Transport of the intracisternal A-type particle Gag polyprotein to the endoplasmic reticulum is mediated by the signal recognition particle. J Virol (2003) 0.87
Structures of the scanning and engaged states of the mammalian SRP-ribosome complex. Elife (2015) 0.87
Plasmodium falciparum signal recognition particle components and anti-parasitic effect of ivermectin in blocking nucleo-cytoplasmic shuttling of SRP. Cell Death Dis (2014) 0.86
In vivo evidence for posttranslational translocation and signal cleavage of the killer preprotoxin of Saccharomyces cerevisiae. Mol Cell Biol (1986) 0.86
Synthetic leader peptide modulates secretion of proteins from microinjected Xenopus oocytes. Proc Natl Acad Sci U S A (1983) 0.86
Molecular insights into intracellular RNA localization. Int Rev Cell Mol Biol (2013) 0.84
Translation and membrane insertion of the hemagglutinin-neuraminidase glycoprotein of Newcastle disease virus. Mol Cell Biol (1987) 0.84
Alkaline phosphatase secretion-negative mutant of Bacillus licheniformis 749/C. J Bacteriol (1983) 0.84
Regulation of the ribosome-membrane junction at early stages of presecretory protein translocation in the mammalian endoplasmic reticulum. J Cell Biol (1997) 0.84
The endoplasmic reticulum: structure, function and response to cellular signaling. Cell Mol Life Sci (2015) 0.82
Aberrant membrane insertion of a cytoplasmic tail deletion mutant of the hemagglutinin-neuraminidase glycoprotein of Newcastle disease virus. Mol Cell Biol (1990) 0.82
Transcriptome-wide high-throughput deep m(6)A-seq reveals unique differential m(6)A methylation patterns between three organs in Arabidopsis thaliana. Genome Biol (2015) 0.82
RNA gymnastics in mammalian signal recognition particle assembly. RNA Biol (2014) 0.81
Translational arrest by a prokaryotic signal recognition particle is mediated by RNA interactions. Nat Struct Mol Biol (2015) 0.81
Mechanistic insights into the inhibition of Sec61-dependent co- and post-translational translocation by mycolactone. J Cell Sci (2016) 0.81
Visualization of endoplasmic reticulum localized mRNAs in mammalian cells. J Vis Exp (2012) 0.80
UBQLN4 recognizes mislocalized transmembrane domain proteins and targets these to proteasomal degradation. EMBO Rep (2016) 0.79
Determinant of the extracellular location of the N-terminus of human multidrug-resistance-associated protein. Biochem J (2000) 0.79
Control of cell migration through mRNA localization and local translation. Wiley Interdiscip Rev RNA (2014) 0.79
SecA - a new twist in the tale. J Bacteriol (2016) 0.77
Immediate translation of Formin DIAPH1 mRNA after its exiting the nucleus is required for its perinuclear localization in fibroblasts. PLoS One (2013) 0.76
How and why does Dia1 mRNA localize? Commun Integr Biol (2011) 0.76
Interactions of signal peptides with signal-recognition particle. Biochem J (1990) 0.75
Control of tissue size and development by a regulatory element in the yorkie 3'UTR. Am J Cancer Res (2017) 0.75
An uncleaved signal peptide directs the Malus xiaojinensis iron transporter protein Mx IRT1 into the ER for the PM secretory pathway. Int J Mol Sci (2014) 0.75
Capturing the signal. Elife (2015) 0.75
Compartmentalization of the endoplasmic reticulum in the early C. elegans embryos. J Cell Biol (2016) 0.75
Transfer of proteins across membranes. I. Presence of proteolytically processed and unprocessed nascent immunoglobulin light chains on membrane-bound ribosomes of murine myeloma. J Cell Biol (1975) 36.95
Intracellular protein topogenesis. Proc Natl Acad Sci U S A (1980) 13.40
The outer membrane proteins of Gram-negative bacteria: biosynthesis, assembly, and functions. Annu Rev Biochem (1978) 7.96
The spontaneous insertion of proteins into and across membranes: the helical hairpin hypothesis. Cell (1981) 7.77
Synchronised transmembrane insertion and glycosylation of a nascent membrane protein. Nature (1977) 7.72
Translocation of proteins across the endoplasmic reticulum. I. Signal recognition protein (SRP) binds to in-vitro-assembled polysomes synthesizing secretory protein. J Cell Biol (1981) 7.40
Purification of a membrane-associated protein complex required for protein translocation across the endoplasmic reticulum. Proc Natl Acad Sci U S A (1980) 7.17
Ribosomal-membrane interaction: in vitro binding of ribosomes to microsomal membranes. J Mol Biol (1974) 5.75
Translocation of proteins across membranes: the signal hypothesis and beyond. Symp Soc Exp Biol (1979) 4.54
Membrane structure: some general principles. Science (1973) 4.49
Proteins of rough microsomal membranes related to ribosome binding. I. Identification of ribophorins I and II, membrane proteins characteristics of rough microsomes. J Cell Biol (1978) 4.33
Tryptic dissection and reconstitution of translocation activity for nascent presecretory proteins across microsomal membranes. Proc Natl Acad Sci U S A (1979) 4.22
Nascent prehormones are intermediates in the biosynthesis of authentic bovine pituitary growth hormone and prolactin. Proc Natl Acad Sci U S A (1977) 4.14
Efficient cleavage and segregation of nascent presecretory proteins in a reticulocyte lysate supplemented with microsomal membranes. J Biol Chem (1978) 3.80
Protein transfer across microsomal membranes reassembled from separated membrane components. Nature (1978) 3.39
Trans-membrane translocation of proteins. The direct transfer model. Eur J Biochem (1979) 3.13
Proteins of rough microsomal membranes related to ribosome binding. II. Cross-linking of bound ribosomes to specific membrane proteins exposed at the binding sites. J Cell Biol (1978) 2.33
Post-translational processing of full-length presecretory proteins with canine pancreatic signal peptidase. Ann N Y Acad Sci (1980) 2.23
A gel filtration approach to the study of ribosome-membrane interactions. Biochim Biophys Acta (1979) 1.91
Membrane-dependent cleavage of the human placental lactogen precursor to its native form in ascites cell-free extracts. Eur J Biochem (1977) 1.79
Inhibition of preprotein processing in ascites tumor lysates by incorporation of a leucine analog. Proc Natl Acad Sci U S A (1980) 1.50
Polyribosomal attachment to rat liver and hepatoma endoplasmic reticulum in vitro. A method for its study. Biochem J (1971) 1.43
Structural properties of signal peptides and their membrane insertion. Biochimie (1980) 1.18
Transfer of proteins across membranes. I. Presence of proteolytically processed and unprocessed nascent immunoglobulin light chains on membrane-bound ribosomes of murine myeloma. J Cell Biol (1975) 36.95
Transfer of proteins across membranes. II. Reconstitution of functional rough microsomes from heterologous components. J Cell Biol (1975) 15.47
Functional and genomic analyses reveal an essential coordination between the unfolded protein response and ER-associated degradation. Cell (2000) 13.44
Intracellular protein topogenesis. Proc Natl Acad Sci U S A (1980) 13.40
Human oestrogen receptor cDNA: sequence, expression and homology to v-erb-A. Nature (1986) 11.35
Nuclei from rat liver: isolation method that combines purity with high yield. Science (1966) 10.35
Transcriptional induction of genes encoding endoplasmic reticulum resident proteins requires a transmembrane protein kinase. Cell (1993) 9.84
70K heat shock related proteins stimulate protein translocation into microsomes. Nature (1988) 9.60
Translocation of proteins across the endoplasmic reticulum III. Signal recognition protein (SRP) causes signal sequence-dependent and site-specific arrest of chain elongation that is released by microsomal membranes. J Cell Biol (1981) 8.36
A novel mechanism for regulating activity of a transcription factor that controls the unfolded protein response. Cell (1996) 8.17
Identification and characterization of a nuclear pore complex protein. Cell (1986) 7.93
Ribosome-membrane interaction. Nondestructive disassembly of rat liver rough microsomes into ribosomal and membranous components. J Cell Biol (1973) 7.92
The GTP-binding protein Ran/TC4 is required for protein import into the nucleus. Nature (1993) 7.80
Signal recognition particle contains a 7S RNA essential for protein translocation across the endoplasmic reticulum. Nature (1982) 7.80
The nuclear envelope lamina is reversibly depolymerized during mitosis. Cell (1980) 7.67
A novel ubiquitin-like modification modulates the partitioning of the Ran-GTPase-activating protein RanGAP1 between the cytosol and the nuclear pore complex. J Cell Biol (1996) 7.64
Translocation of proteins across the endoplasmic reticulum. I. Signal recognition protein (SRP) binds to in-vitro-assembled polysomes synthesizing secretory protein. J Cell Biol (1981) 7.40
Purification of a membrane-associated protein complex required for protein translocation across the endoplasmic reticulum. Proc Natl Acad Sci U S A (1980) 7.17
Protein import into nuclei: association and dissociation reactions involving transport substrate, transport factors, and nucleoporins. Cell (1995) 6.97
Preparation of microsomal membranes for cotranslational protein translocation. Methods Enzymol (1983) 6.94
Dissociation of mammalian polyribosomes into subunits by puromycin. Proc Natl Acad Sci U S A (1971) 6.77
Protein translocation across the endoplasmic reticulum. Cell (1984) 6.69
Immunocytochemical localization of the major polypeptides of the nuclear pore complex-lamina fraction. Interphase and mitotic distribution. J Cell Biol (1978) 6.29
The transmembrane kinase Ire1p is a site-specific endonuclease that initiates mRNA splicing in the unfolded protein response. Cell (1997) 6.26
In vitro synthesis and processing of a putative precursor for the small subunit of ribulose-1,5-bisphosphate carboxylase of Chlamydomonas reinhardtii. Proc Natl Acad Sci U S A (1977) 5.89
Controlled proteolysis of nascent polypeptides in rat liver cell fractions. II. Location of the polypeptides in rough microsomes. J Cell Biol (1970) 5.72
Ribosome pausing and stacking during translation of a eukaryotic mRNA. EMBO J (1988) 5.61
Membrane assembly in vitro: synthesis, glycosylation, and asymmetric insertion of a transmembrane protein. Proc Natl Acad Sci U S A (1977) 5.51
Mitochondrial transmission during mating in Saccharomyces cerevisiae is determined by mitochondrial fusion and fission and the intramitochondrial segregation of mitochondrial DNA. Mol Biol Cell (1997) 5.47
Oligomerization and phosphorylation of the Ire1p kinase during intracellular signaling from the endoplasmic reticulum to the nucleus. EMBO J (1996) 5.46
Mechanism of protein translocation across the endoplasmic reticulum membrane. Annu Rev Cell Biol (1986) 5.28
Crystallographic analysis of the recognition of a nuclear localization signal by the nuclear import factor karyopherin alpha. Cell (1998) 5.27
Import of proteins into mitochondria: precursor forms of the extramitochondrially made F1-ATPase subunits in yeast. Proc Natl Acad Sci U S A (1979) 5.21
Protein translocation across the endoplasmic reticulum. II. Isolation and characterization of the signal recognition particle receptor. J Cell Biol (1982) 5.20
Homology in amino-terminal sequence of precursors to pancreatic secretory proteins. Proc Natl Acad Sci U S A (1975) 5.15
Controlled proteolysis of nascent polypeptides in rat liver cell fractions. I. Location of the polypeptides within ribosomes. J Cell Biol (1970) 5.08
Intracellular signaling from the endoplasmic reticulum to the nucleus: the unfolded protein response in yeast and mammals. Curr Opin Cell Biol (2001) 5.08
cDNA sequencing of nuclear lamins A and C reveals primary and secondary structural homology to intermediate filament proteins. Proc Natl Acad Sci U S A (1986) 5.07
Identification of a protein complex that is required for nuclear protein import and mediates docking of import substrate to distinct nucleoporins. Proc Natl Acad Sci U S A (1995) 5.04
Structure of the 80S ribosome from Saccharomyces cerevisiae--tRNA-ribosome and subunit-subunit interactions. Cell (2001) 5.01
tRNA ligase is required for regulated mRNA splicing in the unfolded protein response. Cell (1996) 4.93
The ubiquitin-like protein Smt3p is activated for conjugation to other proteins by an Aos1p/Uba2p heterodimer. EMBO J (1997) 4.80
Studies on free and membrane-bound ribosomes in rat liver. I. Distribution as related to total cellular RNA. J Mol Biol (1967) 4.71
A modified procedure for the isolation of a pore complex-lamina fraction from rat liver nuclei. J Cell Biol (1976) 4.64
In vitro protein translocation across the yeast endoplasmic reticulum: ATP-dependent posttranslational translocation of the prepro-alpha-factor. Cell (1986) 4.59
Cloning of the human estrogen receptor cDNA. Proc Natl Acad Sci U S A (1985) 4.58
The peptide repeat domain of nucleoporin Nup98 functions as a docking site in transport across the nuclear pore complex. Cell (1995) 4.55
Translocation of proteins across membranes: the signal hypothesis and beyond. Symp Soc Exp Biol (1979) 4.54
Cell-free translation of messenger RNA in a wheat germ system. Methods Enzymol (1983) 4.52
Nup358, a cytoplasmically exposed nucleoporin with peptide repeats, Ran-GTP binding sites, zinc fingers, a cyclophilin A homologous domain, and a leucine-rich region. J Biol Chem (1995) 4.50
Purification of a Ran-interacting protein that is required for protein import into the nucleus. Proc Natl Acad Sci U S A (1994) 4.49
The chicken oestrogen receptor sequence: homology with v-erbA and the human oestrogen and glucocorticoid receptors. EMBO J (1986) 4.47
The signal recognition particle. Annu Rev Biochem (2001) 4.47
Isolation of nuclear pore complexes in association with a lamina. Proc Natl Acad Sci U S A (1975) 4.46
A protein-conducting channel in the endoplasmic reticulum. Cell (1991) 4.45
Gene gating: a hypothesis. Proc Natl Acad Sci U S A (1985) 4.45
A signal sequence for the insertion of a transmembrane glycoprotein. Similarities to the signals of secretory proteins in primary structure and function. J Biol Chem (1978) 4.43
Identification and characterization of a yeast nucleolar protein that is similar to a rat liver nucleolar protein. J Cell Biol (1988) 4.42
Regulation of ribosome biogenesis by the rapamycin-sensitive TOR-signaling pathway in Saccharomyces cerevisiae. Mol Biol Cell (1999) 4.34
Model for signal sequence recognition from amino-acid sequence of 54K subunit of signal recognition particle. Nature (1989) 4.25
Tryptic dissection and reconstitution of translocation activity for nascent presecretory proteins across microsomal membranes. Proc Natl Acad Sci U S A (1979) 4.22
Nascent prehormones are intermediates in the biosynthesis of authentic bovine pituitary growth hormone and prolactin. Proc Natl Acad Sci U S A (1977) 4.14
Protein translocation across the endoplasmic reticulum. I. Detection in the microsomal membrane of a receptor for the signal recognition particle. J Cell Biol (1982) 4.10
Chicken ovalbumin contains an internal signal sequence. Nature (1979) 4.06
The two steps of nuclear import, targeting to the nuclear envelope and translocation through the nuclear pore, require different cytosolic factors. Cell (1992) 4.05
Immunoprecipitation of proteins from cell-free translations. Methods Enzymol (1983) 4.04
Isolation and characterization of a proteinaceous subnuclear fraction composed of nuclear matrix, peripheral lamina, and nuclear pore complexes from embryos of Drosophila melanogaster. J Cell Biol (1982) 4.03
A nuclear pore complex protein that contains zinc finger motifs, binds DNA, and faces the nucleoplasm. Cell (1993) 3.98
Alignment of conduits for the nascent polypeptide chain in the ribosome-Sec61 complex. Science (1997) 3.95
Nuclear pore complex contains a family of glycoproteins that includes p62: glycosylation through a previously unidentified cellular pathway. Proc Natl Acad Sci U S A (1987) 3.95
Efficient cleavage and segregation of nascent presecretory proteins in a reticulocyte lysate supplemented with microsomal membranes. J Biol Chem (1978) 3.80
Ubc9p is the conjugating enzyme for the ubiquitin-like protein Smt3p. J Biol Chem (1997) 3.76
Mammalian karyopherin alpha 1 beta and alpha 2 beta heterodimers: alpha 1 or alpha 2 subunit binds nuclear localization signal and beta subunit interacts with peptide repeat-containing nucleoporins. Proc Natl Acad Sci U S A (1995) 3.73
Kap104p: a karyopherin involved in the nuclear transport of messenger RNA binding proteins. Science (1996) 3.70
A distinct nuclear import pathway used by ribosomal proteins. Cell (1997) 3.66
SUMO-1 modification and its role in targeting the Ran GTPase-activating protein, RanGAP1, to the nuclear pore complex. J Cell Biol (1998) 3.65
Biogenesis of peroxisomes: intracellular site of synthesis of catalase and uricase. Proc Natl Acad Sci U S A (1978) 3.63
Nopp140 shuttles on tracks between nucleolus and cytoplasm. Cell (1992) 3.63
Secretory protein translocation in a yeast cell-free system can occur posttranslationally and requires ATP hydrolysis. J Cell Biol (1986) 3.62
A new family of yeast nuclear pore complex proteins. J Cell Biol (1992) 3.60
An E. coli ribonucleoprotein containing 4.5S RNA resembles mammalian signal recognition particle. Science (1990) 3.55
Photocrosslinking of the signal sequence of nascent preprolactin to the 54-kilodalton polypeptide of the signal recognition particle. Proc Natl Acad Sci U S A (1986) 3.55
Post-translational cleavage of presecretory proteins with an extract of rough microsomes from dog pancreas containing signal peptidase activity. Proc Natl Acad Sci U S A (1977) 3.54
Karyopherins and nuclear import. Curr Opin Struct Biol (2001) 3.53
Previously identified protein of uncertain function is karyopherin alpha and together with karyopherin beta docks import substrate at nuclear pore complexes. Proc Natl Acad Sci U S A (1995) 3.52
Translocation of secretory proteins across the microsomal membrane occurs through an environment accessible to aqueous perturbants. Cell (1985) 3.50
Detection of prokaryotic signal peptidase in an Escherichia coli membrane fraction: endoproteolytic cleavage of nascent f1 pre-coat protein. Proc Natl Acad Sci U S A (1978) 3.48
NH2-terminal amino acid sequences of precursor and mature forms of the ribulose-1,5-bisphosphate carboxylase small subunit from Chlamydomonas reinhardtii. J Cell Biol (1979) 3.47
The unfolded protein response coordinates the production of endoplasmic reticulum protein and endoplasmic reticulum membrane. Mol Biol Cell (1997) 3.45
Block of HAC1 mRNA translation by long-range base pairing is released by cytoplasmic splicing upon induction of the unfolded protein response. Cell (2001) 3.45