Published in Science on February 24, 1978
Possible estuary-associated syndrome: symptoms, vision, and treatment. Environ Health Perspect (2001) 1.61
Methods to identify and characterize developmental neurotoxicity for human health risk assessment. III: pharmacokinetic and pharmacodynamic considerations. Environ Health Perspect (2001) 1.05
A review of the mechanism of injury and treatment approaches for illness resulting from exposure to water-damaged buildings, mold, and mycotoxins. ScientificWorldJournal (2013) 0.88
Residential and recreational acquisition of possible estuary-associated syndrome: a new approach to successful diagnosis and treatment. Environ Health Perspect (2001) 0.87
Intestinal disease and the urban environment. Environ Health Perspect (1979) 0.75
Effect of colestimide on the concentrations of polychlorinated dibenzo-p-dioxins, polychlorinated dizenzofurans, and polychlorinated biphenyls in blood of Yusho patients. Environ Health (2016) 0.75
Humanized xenobiotic response in mice expressing nuclear receptor SXR. Nature (2000) 3.41
Identification of glucocorticoid-inducible cytochromes P-450 in the intestinal mucosa of rats and man. J Clin Invest (1987) 2.70
Reciprocal activation of xenobiotic response genes by nuclear receptors SXR/PXR and CAR. Genes Dev (2000) 2.15
Phenotypic stability of adult rat hepatocytes in primary monolayer culture. Ann N Y Acad Sci (1980) 1.96
Regulation of gene expression in adult rat hepatocytes cultured on a basement membrane matrix. J Cell Physiol (1988) 1.76
Identification of an inducible form of cytochrome P-450 in human liver. Proc Natl Acad Sci U S A (1985) 1.62
Erythromycin breath test as an assay of glucocorticoid-inducible liver cytochromes P-450. Studies in rats and patients. J Clin Invest (1989) 1.59
Identification of the cytochrome P-450 induced by macrolide antibiotics in rat liver as the glucocorticoid responsive cytochrome P-450p. Biochemistry (1985) 1.57
Complete cDNA sequence of a cytochrome P-450 inducible by glucocorticoids in human liver. Proc Natl Acad Sci U S A (1986) 1.57
Trans-species gene transfer for analysis of glucocorticoid-inducible transcriptional activation of transiently expressed human CYP3A4 and rabbit CYP3A6 in primary cultures of adult rat and rabbit hepatocytes. Mol Pharmacol (1996) 1.55
Treatment of chlordecone (Kepone) toxicity with cholestyramine. Results of a controlled clinical trial. N Engl J Med (1978) 1.47
Comparative toxicology of chlordecone (Kepone) in humans and experimental animals. Annu Rev Pharmacol Toxicol (1982) 1.45
Induction of cytochrome P-450 by glucocorticoids in rat liver. II. Evidence that glucocorticoids regulate induction of cytochrome P-450 by a nonclassical receptor mechanism. J Biol Chem (1984) 1.37
Drug metabolism in adult rat hepatocytes in primary monolayer culture. Gastroenterology (1977) 1.35
Separation, purification, and characterization of a novel form of hepatic cytochrome P-450 from rats treated with pregnenolone-16 alpha-carbonitrile. J Biol Chem (1980) 1.31
Down regulation of insulin receptors in primary cultures of adult rat hepatocytes in monolayer. Endocrinology (1978) 1.27
Characterization of human liver cytochromes P-450 involved in theophylline metabolism. Drug Metab Dispos (1992) 1.24
Effect of cobalt on synthesis of heme and cytochrome P-450 in the liver. Studies of adult rat hepatocytes in primary monolayer culture and in vivo. J Biol Chem (1976) 1.24
Isolation and characterization of cloned cDNAs encoding human liver chlordecone reductase. Biochemistry (1990) 1.21
A novel cis-acting element in a liver cytochrome P450 3A gene confers synergistic induction by glucocorticoids plus antiglucocorticoids. J Biol Chem (1995) 1.21
Degradation of endogenous hepatic heme by pathways not yielding carbon monoxide. Studies in normal rat liver and in primary hepatocyte culture. J Clin Invest (1980) 1.21
Collagen formation by the hepatocyte in primary monolayer culture and in vivo. Science (1983) 1.21
Macrolide antibiotics inhibit the degradation of the glucocorticoid-responsive cytochrome P-450p in rat hepatocytes in vivo and in primary monolayer culture. J Biol Chem (1986) 1.20
Comparative analysis of cytochrome P4503A induction in primary cultures of rat, rabbit, and human hepatocytes. Drug Metab Dispos (1995) 1.19
Immunochemical evidence for induction of a common form of hepatic cytochrome P-450 in rats treated with pregnenolone-16 alpha-carbonitrile or other steroidal or non-steroidal agents. Mol Pharmacol (1982) 1.16
Selective expression of cytochrome P450 CYP3A mRNAs in embryonic and adult human liver. Pharmacogenetics (1994) 1.14
Regulation of human liver cytochromes P-450 in family 3A in primary and continuous culture of human hepatocytes. Hepatology (1993) 1.11
Bleeding from polypoid colonic arteriovenous malformations. Am J Gastroenterol (1996) 1.10
Regulation of cytochrome P-450p by phenobarbital and phenobarbital-like inducers in adult rat hepatocytes in primary monolayer culture and in vivo. Biochemistry (1986) 1.10
Changes in the concentration of seven forms of cytochrome P-450 in primary cultures of adult rat hepatocytes. Mol Pharmacol (1985) 1.07
Distribution and excretion of chlordecone (Kepone) in the rat. Drug Metab Dispos (1978) 1.06
Regulation of phenobarbital-inducible cytochrome P450 2B1/2 mRNA by lovastatin and oxysterols in primary cultures of adult rat hepatocytes. Toxicol Appl Pharmacol (1993) 1.04
Coinduction of multiple hepatic cytochrome P-450 proteins and their mRNAs in rats treated with imidazole antimycotic agents. Mol Pharmacol (1989) 1.04
Cyp3A regulation: from pharmacology to nuclear receptors. Drug Metab Dispos (2001) 1.03
In vitro effect of fluoroquinolones on theophylline metabolism in human liver microsomes. Antimicrob Agents Chemother (1990) 1.03
Comparison of urinary 6-beta-cortisol and the erythromycin breath test as measures of hepatic P450IIIA (CYP3A) activity. Clin Pharmacol Ther (1992) 1.00
Paradoxical transcriptional activation of rat liver cytochrome P-450 3A1 by dexamethasone and the antiglucocorticoid pregnenolone 16 alpha-carbonitrile: analysis by transient transfection into primary monolayer cultures of adult rat hepatocytes. Proc Natl Acad Sci U S A (1992) 0.99
Stimulation of de novo synthesis of cytochrome P-450 by phenobarbital in primary nonproliferating cultures of adult rat hepatocytes. Proc Natl Acad Sci U S A (1982) 0.98
Five of 12 forms of vaccinia virus-expressed human hepatic cytochrome P450 metabolically activate aflatoxin B1. Proc Natl Acad Sci U S A (1990) 0.98
Regulation of cytochrome P-450b/e and P-450p gene expression by growth hormone in adult rat hepatocytes cultured on a reconstituted basement membrane. J Biol Chem (1990) 0.96
Induction of cytochrome P-450 by pregnenolone-16 alpha-carbonitrile in primary monolayer cultures of adult rat hepatocytes and in a cell-free translation system. J Biol Chem (1981) 0.95
Heterogeneity of CYP3A isoforms metabolizing erythromycin and cortisol. Clin Pharmacol Ther (1992) 0.95
Suitability of primary monolayer cultures of adult rat hepatocytes for studies of cholesterol and bile acid metabolism. J Biol Chem (1985) 0.95
Hepatocellular phenotype in vitro is influenced by biophysical features of the collagenous substratum. Hepatology (1991) 0.95
Reduction in the body content of DDE in the Mongolian gerbil treated with sucrose polyester and caloric restriction. Toxicol Appl Pharmacol (1988) 0.94
Identification of the fetal liver cytochrome CYP3A7 in human endometrium and placenta. J Clin Invest (1993) 0.93
Induction of digitoxigenin monodigitoxoside UDP-glucuronosyltransferase activity by glucocorticoids and other inducers of cytochrome P-450p in primary monolayer cultures of adult rat hepatocytes and in human liver. J Biol Chem (1986) 0.92
Liver structure and function in patients poisoned with chlordecone (Kepone). Gastroenterology (1980) 0.91
Retention of inhaled formaldehyde, propionaldehyde, and acrolein in the dog. Arch Environ Health (1972) 0.90
Studies of the formation and relase of glycerolipids by primary monolayer cultures of adult rat hepatocytes. Biochim Biophys Acta (1977) 0.90
Characterization of a cDNA encoding a new member of the glucocorticoid-responsive cytochromes P450 in human liver. Arch Biochem Biophys (1989) 0.89
Primary aortoduodenal fistula following radiotherapy. Surg Gynecol Obstet (1983) 0.89
Immunochemical evidence for multiple steroid-inducible hepatic cytochromes P-450 in the rat. Biochem J (1987) 0.88
Collagen synthesis by the hepatocyte: studies in primary cultures of parenchymal cells from adult rat liver. Coll Relat Res (1981) 0.87
Cardiac rate and rhythm in mice affected by haloalkane propellants. JAMA (1972) 0.86
Inhibition by cycloheximide of degradation of cytochrome P-450 in primary cultures of adult rat liver parenchymal cells and in vivo. Biochem J (1979) 0.85
Respiratory retention of inhaled toluene and benzene in the dog. J Toxicol Environ Health (1976) 0.85
Bleeding gastric ulcer: a complication from gastrostomy tube replacement. Gastrointest Endosc (2000) 0.85
Corticosterone 6 beta-hydroxylase in A6 epithelia: a steroid-inducible cytochrome P-450. Am J Physiol (1990) 0.84
Differentiated induction of cytochrome P450b/e and P450p mRNAs by dose of phenobarbital in primary cultures of adult rat hepatocytes. Mol Pharmacol (1990) 0.84
Acute, subchronic, and chronic toxicity of chlordecone. Toxicol Appl Pharmacol (1979) 0.84
Identification of a reduced form of chlordecone (Kepone) in human stool. Bull Environ Contam Toxicol (1978) 0.84
Purification and characterization of chlordecone reductase from human liver. J Biol Chem (1986) 0.84
Purification of a human liver cytochrome P-450 immunochemically related to several cytochromes P-450 purified from untreated rats. J Clin Invest (1987) 0.84
Induction of hepatic heme oxygenase activity by bromobenzene. Arch Biochem Biophys (1979) 0.83
Synthesis and degradation of 3-methylcholanthrene-inducible cytochromes P-450 and their mRNAs in primary monolayer cultures of adult rat hepatocytes. Arch Biochem Biophys (1985) 0.83
Localization of collagen prolyl hydroxylase to the hepatocyte. Studies in primary monolayer cultures of parenchymal cells from adult rat liver. Exp Cell Res (1979) 0.83
Expression of multiple forms of cytochrome P450 mRNAs in primary cultures of rat hepatocytes maintained on matrigel. Mol Pharmacol (1993) 0.83
Absence of negative feedback control of bile acid biosynthesis in cultured rat hepatocytes. J Biol Chem (1985) 0.83
Identification of a cytochrome P-450 in human fetal liver related to glucocorticoid-inducible cytochrome P-450HLp in the adult. Biochem Pharmacol (1988) 0.83
Divergent effects of cycloheximide on the induction of class II and class III cytochrome P450 mRNAs in cultures of adult rat hepatocytes. Arch Biochem Biophys (1990) 0.83
Ascorbic acid deficiency and cytochrome P-450 in adult rat hepatocytes in primary monolayer culture. Arch Biochem Biophys (1979) 0.82
Expression of five forms of microsomal cytochrome P-450 in primary cultures of rabbit hepatocytes treated with various classes of inducers. Biochem Pharmacol (1987) 0.82
Role of heme in phenobarbital induction of cytochromes P450 and 5-aminolevulinate synthase in cultured rat hepatocytes maintained on an extracellular matrix. Arch Biochem Biophys (1990) 0.82
Benzo[a]pyrene differentially alters mitochondrial and nuclear DNA synthesis in primary hepatocyte cultures. Res Commun Chem Pathol Pharmacol (1983) 0.82
Preferential binding of chlordecone to the protein and high density lipoprotein fractions of plasma from humans and other species. J Toxicol Environ Health (1982) 0.81
Rapid loss of delta-aminolevulinic acid dehydratase activity in primary cultures of adult rat hepatocytes: a new model of zinc deficiency. Life Sci (1982) 0.81
Dose-dependent sympathomimetic and cardioinhibitory effects of acrolein and formaldehyde in the anesthetized rat. Toxicol Appl Pharmacol (1974) 0.81
Retention of inhaled acetone and ammonia in the dog. Am Ind Hyg Assoc J (1973) 0.81
Tyrosine kinase growth factor receptors but not seven-membrane-spanning receptors or phorbol esters activate mitogen-activated protein kinase in rat hepatocytes. Hepatology (1995) 0.81
Respiratory retention and acute toxicity of furan. Am Ind Hyg Assoc J (1979) 0.80
Purification and characterization of aldo-keto reductases from gerbil liver: immunochemical evidence for related proteins in other mammalian species. Arch Biochem Biophys (1986) 0.80
Toxicological evaluation of mu-agonists. Part I: Assessment of toxicity following 30 days of repeated oral dosing of male and female rats with levo-alpha-acetylmethadol HCl (LAAM). J Appl Toxicol (1995) 0.80
Characterization of a pretranscriptional pathway for induction by phenobarbital of cytochrome P450 3A23 in primary cultures of adult rat hepatocytes. Arch Biochem Biophys (1997) 0.80
The effects of acetaldehyde and acrolein on blood pressure in guanethidine-pretreated hypertensive rats. Toxicol Appl Pharmacol (1983) 0.80
Evaluation of chlordecone in a two-stage model of hepatocarcinogenesis: a significant sex difference in the hepatocellular carcinoma incidence. Carcinogenesis (1989) 0.80
Transient induction of cytochrome P450 1A1 mRNA by culture medium component in primary cultures of adult rat hepatocytes. In Vitro Cell Dev Biol (1993) 0.80
Measurement of the metabolism of cytochrome P-450 in cultured hepatocytes by a quantitative and specific immunochemical method. Biochem J (1982) 0.80
Regulation of rat hepatic cytochrome P450IIE1 in primary monolayer hepatocyte culture. Xenobiotica (1991) 0.79
Identification of a novel dexamethasone responsive enhancer in the human CYP3A5 gene and its activation in human and rat liver cells. Mol Pharmacol (1996) 0.79
Glucocorticoids suppress formation of collagen by the hepatocyte. Studies in primary monolayer cultures of parenchymal cells prepared from adult rat liver. Gastroenterology (1984) 0.79
Sequence of the 5'-flanking region of CYP3A5: comparative analysis with CYP3A4 and CYP3A7. Biochem Biophys Res Commun (1994) 0.79
Identification of the cyanopregnenolone-inducible form of hepatic cytochrome P-450 as a catalyst of aldrin epoxidation. Biochem Pharmacol (1983) 0.78
Pharmacological effects of 1,2,3,5,6,10b-hexahydropyrido[2,3g]indolizine, a bridged-nicotine analog. Life Sci (1986) 0.78
Adrenergic receptors in the nucleus tractus solitarii of the rat. Eur J Pharmacol (1982) 0.78