Published in Int J Womens Health on April 22, 2013
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Maternal choline modifies fetal liver copper, gene expression, DNA methylation, and neonatal growth in the tx-j mouse model of Wilson disease. Epigenetics (2013) 0.91
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Evidence for negative selection of gene variants that increase dependence on dietary choline in a Gambian cohort. FASEB J (2015) 0.82
Eggs as a dietary source for gut microbial production of trimethylamine-N-oxide. Am J Clin Nutr (2014) 0.81
Long-term improvements in sensory inhibition with gestational choline supplementation linked to α7 nicotinic receptors through studies in Chrna7 null mutation mice. Brain Res (2014) 0.79
Characterization of timed changes in hepatic copper concentrations, methionine metabolism, gene expression, and global DNA methylation in the Jackson toxic milk mouse model of Wilson disease. Int J Mol Sci (2014) 0.78
Maternal Choline Supplementation: A Potential Prenatal Treatment for Down Syndrome and Alzheimer's Disease. Curr Alzheimer Res (2016) 0.78
Postnatal choline supplementation selectively attenuates hippocampal microRNA alterations associated with developmental alcohol exposure. Alcohol (2017) 0.75
Dietary Intake Among Opioid- and Alcohol-Using Pregnant Women. Subst Use Misuse (2017) 0.75
Developmental changes in polyunsaturated fetal plasma phospholipids and feto-maternal plasma phospholipid ratios and their association with bronchopulmonary dysplasia. Eur J Nutr (2015) 0.75
Maternal choline status during pregnancy, but not that of betaine, is related to antenatal mental well-being: The growing up in Singapore toward healthy outcomes cohort. Depress Anxiety (2017) 0.75
Chronic vitamin E deficiency impairs cognitive function in adult zebrafish via dysregulation of brain lipids and energy metabolism. Free Radic Biol Med (2017) 0.75
Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease. Nature (2011) 13.53
A practical clinical approach to diagnosis of fetal alcohol spectrum disorders: clarification of the 1996 institute of medicine criteria. Pediatrics (2005) 5.88
Concentrations of choline-containing compounds and betaine in common foods. J Nutr (2003) 4.12
Choline: critical role during fetal development and dietary requirements in adults. Annu Rev Nutr (2006) 2.83
Choline, an essential nutrient for humans. FASEB J (1991) 2.68
Periconceptional dietary intake of choline and betaine and neural tube defects in offspring. Am J Epidemiol (2004) 2.49
Epidemiology and natural history of NAFLD and NASH. Clin Liver Dis (2007) 2.41
Dietary choline and betaine and the risk of distal colorectal adenoma in women. J Natl Cancer Inst (2007) 2.07
Common genetic polymorphisms affect the human requirement for the nutrient choline. FASEB J (2006) 1.88
Molecular basis of osmotic regulation. Am J Physiol (1995) 1.87
Sex and menopausal status influence human dietary requirements for the nutrient choline. Am J Clin Nutr (2007) 1.76
Genetic variation of folate-mediated one-carbon transfer pathway predicts susceptibility to choline deficiency in humans. Proc Natl Acad Sci U S A (2005) 1.73
Choline availability during embryonic development alters progenitor cell mitosis in developing mouse hippocampus. J Nutr (2003) 1.73
Pre- and postnatal choline supplementation produces long-term facilitation of spatial memory. Dev Psychobiol (1988) 1.72
Dietary choline and betaine assessed by food-frequency questionnaire in relation to plasma total homocysteine concentration in the Framingham Offspring Study. Am J Clin Nutr (2006) 1.71
Maternal nutrient intakes and risk of orofacial clefts. Epidemiology (2006) 1.70
Brain acetylcholine: control by dietary choline. Science (1976) 1.52
Formation of methylamines from ingested choline and lecithin. J Pharmacol Exp Ther (1983) 1.51
Choline supplementation following third-trimester-equivalent alcohol exposure attenuates behavioral alterations in rats. Behav Neurosci (2007) 1.50
Pregnancy and lactation are associated with diminished concentrations of choline and its metabolites in rat liver. J Nutr (1995) 1.49
Usual choline and betaine dietary intake and incident coronary heart disease: the Atherosclerosis Risk in Communities (ARIC) study. BMC Cardiovasc Disord (2007) 1.47
Elevated serum creatine phosphokinase in choline-deficient humans: mechanistic studies in C2C12 mouse myoblasts. Am J Clin Nutr (2004) 1.46
Phosphatidylethanolamine N-methyltransferase (PEMT) gene expression is induced by estrogen in human and mouse primary hepatocytes. FASEB J (2007) 1.42
Deletion of betaine-homocysteine S-methyltransferase in mice perturbs choline and 1-carbon metabolism, resulting in fatty liver and hepatocellular carcinomas. J Biol Chem (2011) 1.40
Docosahexaenoic acid promotes hippocampal neuronal development and synaptic function. J Neurochem (2009) 1.38
Prenatal dietary choline supplementation decreases the threshold for induction of long-term potentiation in young adult rats. J Neurophysiol (1998) 1.37
Prenatal choline supplementation mitigates the adverse effects of prenatal alcohol exposure on development in rats. Neurotoxicol Teratol (2009) 1.30
Choline and choline esters in human and rat milk and in infant formulas. Am J Clin Nutr (1996) 1.27
A gender-specific role for phosphatidylethanolamine N-methyltransferase-derived phosphatidylcholine in the regulation of plasma high density and very low density lipoproteins in mice. J Biol Chem (2003) 1.27
Choline deficiency causes reversible hepatic abnormalities in patients receiving parenteral nutrition: proof of a human choline requirement: a placebo-controlled trial. JPEN J Parenter Enteral Nutr (2001) 1.22
Effects of choline deficiency and methotrexate treatment upon liver folate content and distribution. Cancer Res (1991) 1.20
Metabolomic profiling can predict which humans will develop liver dysfunction when deprived of dietary choline. FASEB J (2010) 1.18
Choline metabolism provides novel insights into nonalcoholic fatty liver disease and its progression. Curr Opin Gastroenterol (2012) 1.17
Prenatal choline supplementation mitigates behavioral alterations associated with prenatal alcohol exposure in rats. Birth Defects Res A Clin Mol Teratol (2010) 1.17
Maternal choline intake modulates maternal and fetal biomarkers of choline metabolism in humans. Am J Clin Nutr (2012) 1.17
Repeatability and measurement error in the assessment of choline and betaine dietary intake: the Atherosclerosis Risk in Communities (ARIC) study. Nutr J (2009) 1.16
Prenatal choline availability modulates hippocampal neurogenesis and neurogenic responses to enriching experiences in adult female rats. Eur J Neurosci (2007) 1.16
Choline deficiency induces apoptosis in SV40-immortalized CWSV-1 rat hepatocytes in culture. FASEB J (1996) 1.11
Choline, phosphatidylcholine and sphingomyelin in human and bovine milk and infant formulas. J Nutr (1986) 1.08
Developmental changes in rat blood choline concentration. Biochem J (1981) 1.07
Regulation of choline deficiency apoptosis by epidermal growth factor in CWSV-1 rat hepatocytes. Cell Physiol Biochem (2005) 1.05
Maternal choline intake alters the epigenetic state of fetal cortisol-regulating genes in humans. FASEB J (2012) 1.04
Studies on accumulation and metabolic fate of (N-Me3h)choline in human term placenta fragments. Biochem Pharmacol (1976) 1.04
Aberrant estrogen regulation of PEMT results in choline deficiency-associated liver dysfunction. J Biol Chem (2010) 1.04
Elevated choline concentration in neonatal plasma. Life Sci (1980) 1.04
Age-related declines in exploratory behavior and markers of hippocampal plasticity are attenuated by prenatal choline supplementation in rats. Brain Res (2008) 1.03
Characterization of choline transport at maternal and fetal interfaces of the perfused guinea-pig placenta. J Physiol (1985) 1.03
MTHFR C677T genotype influences the isotopic enrichment of one-carbon metabolites in folate-compromised men consuming d9-choline. Am J Clin Nutr (2010) 1.01
Deletion of murine choline dehydrogenase results in diminished sperm motility. FASEB J (2010) 0.99
Choline intake and genetic polymorphisms influence choline metabolite concentrations in human breast milk and plasma. Am J Clin Nutr (2010) 0.99
Folate intake, MTHFR genotype, and sex modulate choline metabolism in mice. J Nutr (2011) 0.98
Uptake of choline by rat mammary-gland epithelial cells. Biochem J (1988) 0.97
Choline and lecithin in the treatment of tardive dyskinesia: preliminary results from a pilot study. Am J Psychiatry (1979) 0.97
Opposing regulation of choline deficiency-induced apoptosis by p53 and nuclear factor kappaB. J Biol Chem (2001) 0.95
Apoptosis is induced by choline deficiency in fetal brain and in PC12 cells. Brain Res Dev Brain Res (1997) 0.93
Dietary choline requirements of women: effects of estrogen and genetic variation. Am J Clin Nutr (2010) 0.92
Phosphatidylcholine supplementation in pregnant women consuming moderate-choline diets does not enhance infant cognitive function: a randomized, double-blind, placebo-controlled trial. Am J Clin Nutr (2012) 0.92
Rat and human mammary tissue can synthesize choline moiety via the methylation of phosphatidylethanolamine. Biochem J (1988) 0.92
Docosahexaenoic acid in plasma phosphatidylcholine may be a potential marker for in vivo phosphatidylethanolamine N-methyltransferase activity in humans. Am J Clin Nutr (2011) 0.91
Choline intake exceeding current dietary recommendations preserves markers of cellular methylation in a genetic subgroup of folate-compromised men. J Nutr (2010) 0.90
Genetic variants in phosphatidylethanolamine N-methyltransferase and methylenetetrahydrofolate dehydrogenase influence biomarkers of choline metabolism when folate intake is restricted. J Am Diet Assoc (2009) 0.89
Dietary intake of choline and plasma choline concentrations in pregnant women in Jamaica. West Indian Med J (2005) 0.89
The relation of dietary choline to cognitive performance and white-matter hyperintensity in the Framingham Offspring Cohort. Am J Clin Nutr (2011) 0.86
Genetic signatures in choline and 1-carbon metabolism are associated with the severity of hepatic steatosis. FASEB J (2013) 0.85
An introduction to the nutrition and metabolism of choline. Cent Nerv Syst Agents Med Chem (2012) 0.82
Glycerophosphocholine and phosphocholine are the major choline metabolites in rat milk. J Nutr (1993) 0.79
A novel cause for abnormal liver function tests in pregnancy and the puerperium: non-alcoholic fatty liver disease. BJOG (2011) 0.78