Choline metabolism and risk of breast cancer in a population-based study.

PubWeight™: 1.51‹?› | Rank: Top 4%

🔗 View Article (PMC 2430758)

Published in FASEB J on January 29, 2008

Authors

Xinran Xu1, Marilie D Gammon, Steven H Zeisel, Yin Leng Lee, James G Wetmur, Susan L Teitelbaum, Patrick T Bradshaw, Alfred I Neugut, Regina M Santella, Jia Chen

Author Affiliations

1: Department of Community and Preventive Medicine, Mt. Sinai School of Medicine, One Gustave L. Levy Place, New York, NY 10029, USA.

Articles citing this

Choline: an essential nutrient for public health. Nutr Rev (2009) 1.97

Choline and betaine in health and disease. J Inherit Metab Dis (2010) 1.61

Perinatal Choline Supplementation Reduces Amyloidosis and Increases Choline Acetyltransferase Expression in the Hippocampus of the APPswePS1dE9 Alzheimer's Disease Model Mice. PLoS One (2017) 1.39

DNA methylation in peripheral blood measured by LUMA is associated with breast cancer in a population-based study. FASEB J (2012) 1.21

BRCA1 promoter methylation is associated with increased mortality among women with breast cancer. Breast Cancer Res Treat (2008) 1.16

Dietary intake of selected B vitamins in relation to risk of major cancers in women. Br J Cancer (2008) 1.13

Marine omega-3 phospholipids: metabolism and biological activities. Int J Mol Sci (2012) 1.12

Epigenetic repression of phosphatidylethanolamine N-methyltransferase (PEMT) in BRCA1-mutated breast cancer. Oncotarget (2014) 1.05

One-carbon metabolism and breast cancer: an epidemiological perspective. J Genet Genomics (2009) 1.02

MTHFR C677T genotype influences the isotopic enrichment of one-carbon metabolites in folate-compromised men consuming d9-choline. Am J Clin Nutr (2010) 1.01

Investigating multiple candidate genes and nutrients in the folate metabolism pathway to detect genetic and nutritional risk factors for lung cancer. PLoS One (2013) 0.99

Deletion of murine choline dehydrogenase results in diminished sperm motility. FASEB J (2010) 0.99

High intakes of choline and betaine reduce breast cancer mortality in a population-based study. FASEB J (2009) 0.99

Neuroprotective properties of citicoline: facts, doubts and unresolved issues. CNS Drugs (2014) 0.95

Dietary choline deficiency causes DNA strand breaks and alters epigenetic marks on DNA and histones. Mutat Res (2011) 0.95

Association of vitamin B6, vitamin B12 and methionine with risk of breast cancer: a dose-response meta-analysis. Br J Cancer (2013) 0.92

Choline dehydrogenase interacts with SQSTM1/p62 to recruit LC3 and stimulate mitophagy. Autophagy (2014) 0.92

Gastric cancer in relation to the intake of nutrients involved in one-carbon metabolism among MTHFR 677 TT carriers. Eur J Nutr (2009) 0.91

Choline and betaine intake and risk of breast cancer among post-menopausal women. Br J Cancer (2010) 0.90

Choline and betaine intake and the risk of colorectal cancer in men. Cancer Epidemiol Biomarkers Prev (2010) 0.90

Choline nutrition programs brain development via DNA and histone methylation. Cent Nerv Syst Agents Med Chem (2012) 0.89

Choline dehydrogenase polymorphism rs12676 is a functional variation and is associated with changes in human sperm cell function. PLoS One (2012) 0.87

Associations between dietary intake of choline and betaine and lung cancer risk. PLoS One (2013) 0.86

Are dietary choline and betaine intakes determinants of total homocysteine concentration? Am J Clin Nutr (2010) 0.85

The influence of one-carbon metabolism on gene promoter methylation in a population-based breast cancer study. Epigenetics (2011) 0.84

The Fifty Year Rehabilitation of the Egg. Nutrients (2015) 0.84

Choline and betaine intakes are associated with reduced risk of nasopharyngeal carcinoma in adults: a case-control study. Br J Cancer (2013) 0.84

LINE-1 methylation in leukocyte DNA, interaction with phosphatidylethanolamine N-methyltransferase variants and bladder cancer risk. Br J Cancer (2014) 0.83

Raising gestational choline intake alters gene expression in DMBA-evoked mammary tumors and prolongs survival. FASEB J (2008) 0.80

Neuroprotective actions of perinatal choline nutrition. Clin Chem Lab Med (2013) 0.80

Targeted DNA Methylation Screen in the Mouse Mammary Genome Reveals a Parity-Induced Hypermethylation of Igf1r That Persists Long after Parturition. Cancer Prev Res (Phila) (2015) 0.78

Choline. Adv Nutr (2010) 0.78

Phosphatidylethanolamine N-methyltransferase and choline dehydrogenase gene polymorphisms are associated with human sperm concentration. Asian J Androl (2012) 0.77

Phospholipid makeup of the breast adipose tissue is impacted by obesity and mammary cancer in the mouse: Results of a pilot study. Biochimie (2014) 0.77

Targeting Phospholipid Metabolism in Cancer. Front Oncol (2016) 0.77

Choline and betaine intake and colorectal cancer risk in Chinese population: a case-control study. PLoS One (2015) 0.76

Nutrient pathways and breast cancer risk: the Long Island Breast Cancer Study Project. Nutr Cancer (2013) 0.76

Increased phosphatidylethanolamine N-methyltransferase gene expression in non-small-cell lung cancer tissue predicts shorter patient survival. Oncol Lett (2014) 0.76

Genetic Variation in Choline-Metabolizing Enzymes Alters Choline Metabolism in Young Women Consuming Choline Intakes Meeting Current Recommendations. Int J Mol Sci (2017) 0.75

Association between BHMT gene rs3733890 polymorphism and cancer risk: evidence from a meta-analysis. Onco Targets Ther (2016) 0.75

Choline metabolic pathway gene polymorphisms and risk for Down syndrome: An association study in a population with folate-homocysteine metabolic impairment. Eur J Clin Nutr (2016) 0.75

Association between MTHFR gene 1298A>C polymorphism and breast cancer susceptibility: a meta-analysis based on 38 case-control studies with 40,985 subjects. World J Surg Oncol (2016) 0.75

Non-targeted and targeted metabolomics approaches to diagnosing lung cancer and predicting patient prognosis. Oncotarget (2016) 0.75

Pubertal supplementation of lipotropes in female rats reduces mammary cancer risk by suppressing histone deacetylase 1. Eur J Nutr (2013) 0.75

Serum betaine but not choline is inversely associated with breast cancer risk: a case-control study in China. Eur J Nutr (2016) 0.75

Articles cited by this

A data-based approach to diet questionnaire design and testing. Am J Epidemiol (1986) 12.68

On measures of gametic disequilibrium. Genetics (1988) 7.16

Concentrations of choline-containing compounds and betaine in common foods. J Nutr (2003) 4.12

Choline and human nutrition. Annu Rev Nutr (1994) 3.09

Choline: critical role during fetal development and dietary requirements in adults. Annu Rev Nutr (2006) 2.83

Environmental toxins and breast cancer on Long Island. I. Polycyclic aromatic hydrocarbon DNA adducts. Cancer Epidemiol Biomarkers Prev (2002) 2.83

The Long Island Breast Cancer Study Project: description of a multi-institutional collaboration to identify environmental risk factors for breast cancer. Breast Cancer Res Treat (2002) 2.71

Choline, an essential nutrient for humans. FASEB J (1991) 2.68

Periconceptional dietary intake of choline and betaine and neural tube defects in offspring. Am J Epidemiol (2004) 2.49

Polymorphism of the PEMT gene and susceptibility to nonalcoholic fatty liver disease (NAFLD). FASEB J (2005) 2.34

Diet, methyl donors and DNA methylation: interactions between dietary folate, methionine and choline. J Nutr (2002) 2.33

Choline phospholipid metabolism: a target in cancer cells? J Cell Biochem (2003) 2.12

Dietary choline and betaine and the risk of distal colorectal adenoma in women. J Natl Cancer Inst (2007) 2.07

Meta-analyses of observational and genetic association studies of folate intakes or levels and breast cancer risk. J Natl Cancer Inst (2006) 2.01

Common genetic polymorphisms affect the human requirement for the nutrient choline. FASEB J (2006) 1.88

Folate and risk of breast cancer: a meta-analysis. J Natl Cancer Inst (2007) 1.80

Dietary Reference Intakes: the new basis for recommendations for calcium and related nutrients, B vitamins, and choline. J Am Diet Assoc (1998) 1.79

Sex and menopausal status influence human dietary requirements for the nutrient choline. Am J Clin Nutr (2007) 1.76

Choline deficiency: a cause of hepatic steatosis during parenteral nutrition that can be reversed with intravenous choline supplementation. Hepatology (1995) 1.60

Dietary relationships with early onset (under age 45) breast cancer in a case-control study in the United States: influence of chemotherapy treatment. Cancer Causes Control (1997) 1.59

Fruits, vegetables, and micronutrients in relation to breast cancer modified by menopause and hormone receptor status. Cancer Epidemiol Biomarkers Prev (2004) 1.52

Pregnancy and lactation are associated with diminished concentrations of choline and its metabolites in rat liver. J Nutr (1995) 1.49

Phosphatidylethanolamine N-methyltransferase (PEMT) gene expression is induced by estrogen in human and mouse primary hepatocytes. FASEB J (2007) 1.42

Betaine: a key modulator of one-carbon metabolism and homocysteine status. Clin Chem Lab Med (2005) 1.38

Therapeutic targets and biomarkers identified in cancer choline phospholipid metabolism. Pharmacogenomics (2006) 1.38

One-carbon metabolism, MTHFR polymorphisms, and risk of breast cancer. Cancer Res (2005) 1.38

Investigations of a common genetic variant in betaine-homocysteine methyltransferase (BHMT) in coronary artery disease. Atherosclerosis (2003) 1.17

The association between betaine and choline intakes and the plasma concentrations of homocysteine in women. Am J Clin Nutr (2007) 1.16

Prospective study on dietary intakes of folate, betaine, and choline and cardiovascular disease risk in women. Eur J Clin Nutr (2007) 1.15

Genotype transposer: automated genotype manipulation for linkage disequilibrium analysis. Bioinformatics (2001) 1.14

Hypomethylation of CpG sites and c-myc gene overexpression in hepatocellular carcinomas, but not hyperplastic nodules, induced by a choline-deficient L-amino acid-defined diet in rats. Jpn J Cancer Res (1999) 1.13

Ad libitum choline intake in healthy individuals meets or exceeds the proposed adequate intake level. J Nutr (2005) 1.10

Polymorphisms of one-carbon-metabolizing genes and risk of breast cancer in a population-based study. Carcinogenesis (2007) 1.06

Labile methyl groups and the promotion of cancer. Annu Rev Nutr (1986) 1.01

Articles by these authors

Effect of selenium and vitamin E on risk of prostate cancer and other cancers: the Selenium and Vitamin E Cancer Prevention Trial (SELECT). JAMA (2008) 13.35

Epidemiology of gastric cancer. World J Gastroenterol (2006) 7.67

Acute myeloid leukemia or myelodysplastic syndrome following use of granulocyte colony-stimulating factors during breast cancer adjuvant chemotherapy. J Natl Cancer Inst (2007) 4.97

A cis-regulatory map of the Drosophila genome. Nature (2011) 4.80

Robotically assisted vs laparoscopic hysterectomy among women with benign gynecologic disease. JAMA (2013) 4.67

The Breast Cancer Family Registry: an infrastructure for cooperative multinational, interdisciplinary and translational studies of the genetic epidemiology of breast cancer. Breast Cancer Res (2004) 4.54

Early discontinuation and nonadherence to adjuvant hormonal therapy in a cohort of 8,769 early-stage breast cancer patients. J Clin Oncol (2010) 4.43

Association of frequency and duration of aspirin use and hormone receptor status with breast cancer risk. JAMA (2004) 4.31

Risk of perforation after colonoscopy and sigmoidoscopy: a population-based study. J Natl Cancer Inst (2003) 3.71

Increased risk of noncardia gastric cancer associated with proinflammatory cytokine gene polymorphisms. Gastroenterology (2003) 3.58

Early discontinuation and non-adherence to adjuvant hormonal therapy are associated with increased mortality in women with breast cancer. Breast Cancer Res Treat (2010) 3.35

Population attributable risks of esophageal and gastric cancers. J Natl Cancer Inst (2003) 3.07

Racial disparities in treatment and survival among women with early-stage breast cancer. J Clin Oncol (2005) 3.02

Designing the Selenium and Vitamin E Cancer Prevention Trial (SELECT). J Natl Cancer Inst (2005) 2.99

In utero pesticide exposure, maternal paraoxonase activity, and head circumference. Environ Health Perspect (2004) 2.85

Environmental toxins and breast cancer on Long Island. I. Polycyclic aromatic hydrocarbon DNA adducts. Cancer Epidemiol Biomarkers Prev (2002) 2.83

The impact of suboptimal bowel preparation on adenoma miss rates and the factors associated with early repeat colonoscopy. Gastrointest Endosc (2011) 2.73

The Long Island Breast Cancer Study Project: description of a multi-institutional collaboration to identify environmental risk factors for breast cancer. Breast Cancer Res Treat (2002) 2.71

Short telomere length and breast cancer risk: a study in sister sets. Cancer Res (2007) 2.70

Racial disparities in utilization of liver transplantation for hepatocellular carcinoma in the United States, 1998-2002. Am J Gastroenterol (2007) 2.69

Comparative effectiveness of robotic versus laparoscopic hysterectomy for endometrial cancer. J Clin Oncol (2012) 2.59

Prenatal exposure to organophosphates, paraoxonase 1, and cognitive development in childhood. Environ Health Perspect (2011) 2.56

Genomic DNA methylation among women in a multiethnic New York City birth cohort. Cancer Epidemiol Biomarkers Prev (2008) 2.52

DNA methylation in white blood cells: association with risk factors in epidemiologic studies. Epigenetics (2011) 2.51

Prenatal organophosphate metabolite and organochlorine levels and performance on the Brazelton Neonatal Behavioral Assessment Scale in a multiethnic pregnancy cohort. Am J Epidemiol (2007) 2.51

Use of the Internet by women with breast cancer. J Med Internet Res (2003) 2.46

Timing of adjuvant chemotherapy initiation after surgery for stage III colon cancer. Cancer (2006) 2.36

Increased influence of genetic variation on PON1 activity in neonates. Environ Health Perspect (2003) 2.36

Quantitation of choline and its metabolites in tissues and foods by liquid chromatography/electrospray ionization-isotope dilution mass spectrometry. Anal Chem (2002) 2.35

Polymorphism of the PEMT gene and susceptibility to nonalcoholic fatty liver disease (NAFLD). FASEB J (2005) 2.34

Diet, methyl donors and DNA methylation: interactions between dietary folate, methionine and choline. J Nutr (2002) 2.33

Dopaminergic differentiation of human embryonic stem cells. Stem Cells (2004) 2.30

Association between composition of the human gastrointestinal microbiome and development of fatty liver with choline deficiency. Gastroenterology (2010) 2.30

Delay of adjuvant chemotherapy initiation following breast cancer surgery among elderly women. Breast Cancer Res Treat (2006) 2.26

Prostate cancer in fathers with fewer male offspring: the Jerusalem Perinatal Study cohort. J Natl Cancer Inst (2007) 2.24

Persistence of multiple illnesses in World Trade Center rescue and recovery workers: a cohort study. Lancet (2011) 2.24

Trends in relative survival for ovarian cancer from 1975 to 2011. Obstet Gynecol (2015) 2.22

Uptake and economic impact of first-cycle colony-stimulating factor use during adjuvant treatment of breast cancer. J Clin Oncol (2012) 2.21

DNA repair capacity of lymphoblastoid cell lines from sisters discordant for breast cancer. J Natl Cancer Inst (2005) 2.20

Significant differences in global genomic DNA methylation by gender and race/ethnicity in peripheral blood. Epigenetics (2011) 2.12

Chemotherapy and cardiotoxicity in older breast cancer patients: a population-based study. J Clin Oncol (2005) 2.11

Epidemiology of upper gastrointestinal malignancies. Semin Oncol (2004) 2.10

Elevated preoperative neutrophil:lymphocyte ratio as a predictor of postoperative disease recurrence in esophageal cancer. Ann Surg Oncol (2011) 2.10

Carbonated soft drink consumption and risk of esophageal adenocarcinoma. J Natl Cancer Inst (2006) 2.08

Dietary choline deficiency alters global and gene-specific DNA methylation in the developing hippocampus of mouse fetal brains. FASEB J (2006) 2.07

Dietary choline and betaine and the risk of distal colorectal adenoma in women. J Natl Cancer Inst (2007) 2.07

Electric blanket use and breast cancer on Long Island. Epidemiology (2003) 2.06

Nationwide trends in the performance of inpatient hysterectomy in the United States. Obstet Gynecol (2013) 2.05

Socioeconomic and other predictors of colonoscopy preparation quality. Dig Dis Sci (2010) 2.04

Pilot study of urinary biomarkers of phytoestrogens, phthalates, and phenols in girls. Environ Health Perspect (2007) 2.04

Study design: evaluating gene-environment interactions in the etiology of breast cancer - the WECARE study. Breast Cancer Res (2004) 2.03

Associations between breast cancer risk and the catalase genotype, fruit and vegetable consumption, and supplement use. Am J Epidemiol (2005) 2.03

Predicting hepatocellular carcinoma by detection of aberrant promoter methylation in serum DNA. Clin Cancer Res (2007) 2.02

The role for adjuvant radiotherapy in the treatment of hemangiopericytoma: a Surveillance, Epidemiology, and End Results analysis. J Neurosurg (2013) 2.01

An Arabidopsis glutathione peroxidase functions as both a redox transducer and a scavenger in abscisic acid and drought stress responses. Plant Cell (2006) 2.01

Prognostic significance of adenocarcinoma histology in women with cervical cancer. Gynecol Oncol (2012) 1.98

A functional polymorphism of toll-like receptor 4 gene increases risk of gastric carcinoma and its precursors. Gastroenterology (2006) 1.98

Fear, anxiety, worry, and breast cancer screening behavior: a critical review. Cancer Epidemiol Biomarkers Prev (2004) 1.96

Global methylation profiles in DNA from different blood cell types. Epigenetics (2011) 1.94

Survival associated with 5-fluorouracil-based adjuvant chemotherapy among elderly patients with node-positive colon cancer. Ann Intern Med (2002) 1.89

DNA methylation potential: dietary intake and blood concentrations of one-carbon metabolites and cofactors in rural African women. Am J Clin Nutr (2013) 1.88

Common genetic polymorphisms affect the human requirement for the nutrient choline. FASEB J (2006) 1.88

Lifetime alcohol intake and breast cancer risk. Ann Epidemiol (2005) 1.85

Risk of malignancy in patients with celiac disease. Am J Med (2003) 1.85

Effect of breast cancer radiotherapy and cigarette smoking on risk of second primary lung cancer. J Clin Oncol (2008) 1.83

Acid suppression therapy may not alter malignant progression in Barrett's metaplasia showing p53 protein accumulation. Am J Gastroenterol (2002) 1.81

Genome-wide DNA methylation profiles in hepatocellular carcinoma. Hepatology (2012) 1.81

Breast cancers among very young premenopausal women (United States). Cancer Causes Control (2003) 1.80

Hormone receptor status and survival in a population-based cohort of patients with breast carcinoma. Cancer (2005) 1.78

Delay in initiating adjuvant radiotherapy following breast conservation surgery and its impact on survival. Int J Radiat Oncol Biol Phys (2006) 1.77

Sex and menopausal status influence human dietary requirements for the nutrient choline. Am J Clin Nutr (2007) 1.76

High radical prostatectomy surgical volume is related to lower radical prostatectomy total hospital charges. Eur Urol (2006) 1.76

Adherence to biopsy guidelines for Barrett's esophagus surveillance in the community setting in the United States. Clin Gastroenterol Hepatol (2009) 1.76

Indium-111-capromab pendetide radioimmunoscintigraphy and prognosis for durable biochemical response to salvage radiation therapy in men after failed prostatectomy. J Clin Oncol (2003) 1.74

Structure of the APPL1 BAR-PH domain and characterization of its interaction with Rab5. EMBO J (2007) 1.74

Weight gain prior to diagnosis and survival from breast cancer. Cancer Epidemiol Biomarkers Prev (2007) 1.73

Genetic variation of folate-mediated one-carbon transfer pathway predicts susceptibility to choline deficiency in humans. Proc Natl Acad Sci U S A (2005) 1.73

Choline availability during embryonic development alters progenitor cell mitosis in developing mouse hippocampus. J Nutr (2003) 1.73

Trends in hospital volume and patterns of referral for women with gynecologic cancers. Obstet Gynecol (2013) 1.72

Colonoscopic screening in average-risk individuals ages 40 to 49 vs 50 to 59 years. Gastroenterology (2008) 1.71

Dietary choline and betaine assessed by food-frequency questionnaire in relation to plasma total homocysteine concentration in the Framingham Offspring Study. Am J Clin Nutr (2006) 1.71

Telomere length, oxidative damage, antioxidants and breast cancer risk. Int J Cancer (2009) 1.70