PubRank

R L Geahlen

Author PubWeight™ 84.11‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Perinatal lethality and blocked B-cell development in mice lacking the tyrosine kinase Syk. Nature 1995 4.84
2 Association of the 72-kDa protein-tyrosine kinase PTK72 with the B cell antigen receptor. J Biol Chem 1992 2.12
3 DAP12-mediated signal transduction in natural killer cells. A dominant role for the Syk protein-tyrosine kinase. J Biol Chem 1998 2.10
4 Cloning and expression of a protein-tyrosine-phosphatase. Proc Natl Acad Sci U S A 1990 2.07
5 Inhibition of mast cell Fc epsilon R1-mediated signaling and effector function by the Syk-selective inhibitor, piceatannol. J Biol Chem 1994 1.90
6 Mechanisms of p34cdc2 regulation. Mol Cell Biol 1993 1.89
7 Fc epsilon RI-mediated tyrosine phosphorylation and activation of the 72-kDa protein-tyrosine kinase, PTK72, in RBL-2H3 rat tumor mast cells. Proc Natl Acad Sci U S A 1992 1.77
8 Visualization of Syk-antigen receptor interactions using green fluorescent protein: differential roles for Syk and Lyn in the regulation of receptor capping and internalization. J Immunol 2001 1.69
9 B lymphocyte activation is accompanied by phosphorylation of a 72-kDa protein-tyrosine kinase. J Biol Chem 1991 1.68
10 Unexpected effects of FERM domain mutations on catalytic activity of Jak3: structural implication for Janus kinases. Mol Cell 2001 1.61
11 CD22 associates with the human surface IgM-B-cell antigen receptor complex. Proc Natl Acad Sci U S A 1993 1.60
12 Reversible palmitoylation of the protein-tyrosine kinase p56lck. J Biol Chem 1993 1.53
13 Syk- and Lyn-dependent phosphorylation of Syk on multiple tyrosines following B cell activation includes a site that negatively regulates signaling. J Immunol 1998 1.50
14 Role of band 3 tyrosine phosphorylation in the regulation of erythrocyte glycolysis. J Biol Chem 1991 1.46
15 Granulocyte colony-stimulating factor receptor signaling involves the formation of a three-component complex with Lyn and Syk protein-tyrosine kinases. Proc Natl Acad Sci U S A 1994 1.42
16 Syk, activated by cross-linking the B-cell antigen receptor, localizes to the cytosol where it interacts with and phosphorylates alpha-tubulin on tyrosine. J Biol Chem 1996 1.37
17 Tyrosine phosphorylation of band 3 inhibits peripheral protein binding. J Biol Chem 1987 1.35
18 Identification of the major sites of autophosphorylation of the murine protein-tyrosine kinase Syk. Biochim Biophys Acta 1997 1.31
19 Inhibition of beta 2 integrin receptor and Syk kinase signaling in monocytes by the Src family kinase Fgr. Immunity 2001 1.27
20 Emodin, a protein tyrosine kinase inhibitor from Polygonum cuspidatum. J Nat Prod 1992 1.24
21 Detection of protein kinase activity in sodium dodecyl sulfate-polyacrylamide gels. Anal Biochem 1986 1.24
22 Purification and characterization of a protein-tyrosine kinase from bovine thymus. J Biol Chem 1986 1.23
23 Use of a GTP photoaffinity probe to resolve aspects of the mechanism of tubulin polymerization. J Biol Chem 1979 1.23
24 Type II regulatory subunit of cAMP-dependent protein kinase. Phosphorylation by casein kinase II at a site that is also phosphorylated in vivo. J Biol Chem 1982 1.21
25 p72syk tyrosine kinase is activated by oxidizing conditions that induce lymphocyte tyrosine phosphorylation and Ca2+ signals. J Biol Chem 1993 1.19
26 Stimulation of macrophage Fc gamma RIIIA activates the receptor-associated protein tyrosine kinase Syk and induces phosphorylation of multiple proteins including p95Vav and p62/GAP-associated protein. J Immunol 1994 1.17
27 Phosphorylation of human erythrocyte band 3 by endogenous p72syk. J Biol Chem 1994 1.15
28 Immunochemical detection of adenine nucleotide-binding proteins with antibodies to 5'-p-fluorosulfonylbenzoyladenosine. Anal Biochem 1990 1.14
29 T and B lymphocytes express distinct tyrosine protein kinases. J Biol Chem 1984 1.14
30 Metabolic activation of 2-substituted derivatives of myristic acid to form potent inhibitors of myristoyl CoA:protein N-myristoyltransferase. Biochemistry 1990 1.13
31 Kinase inhibitors from Polygonum cuspidatum. J Nat Prod 1993 1.10
32 Generation of an active protein-tyrosine kinase from lymphocytes by proteolysis. J Biol Chem 1988 1.09
33 Matrix valency regulates integrin-mediated lymphoid adhesion via Syk kinase. J Cell Biol 1999 1.08
34 Inhibition of signaling through the B cell antigen receptor by the protooncogene product, c-Cbl, requires Syk tyrosine 317 and the c-Cbl phosphotyrosine-binding domain. J Immunol 1999 1.08
35 The protein-tyrosine kinase Syk interacts with TRAF-interacting protein TRIP in breast epithelial cells. Oncogene 2009 1.07
36 Syk activation and dissociation from the B-cell antigen receptor is mediated by phosphorylation of tyrosine 130. J Biol Chem 1997 1.06
37 Cross-linking of integrins induces tyrosine phosphorylation of the proto-oncogene product Vav and the protein tyrosine kinase Syk in human factor-dependent myeloid cells. Cell Growth Differ 1997 1.06
38 Interactions of Lyn with the antigen receptor during B cell activation. J Biol Chem 1994 1.01
39 Hierarchy of protein tyrosine kinases in interleukin-2 (IL-2) signaling: activation of syk depends on Jak3; however, neither Syk nor Lck is required for IL-2-mediated STAT activation. Mol Cell Biol 2000 0.99
40 Treatment of T cells with 2-hydroxymyristic acid inhibits the myristoylation and alters the stability of p56lck. Biochemistry 1993 0.98
41 Interactions of a photoaffinity analog of GTP with the proteins of microtubules. Proc Natl Acad Sci U S A 1977 0.96
42 Syk-dependent phosphorylation of microtubules in activated B-lymphocytes. J Cell Sci 2000 0.96
43 Phosphorylation- and activation-independent association of the tyrosine kinase Syk and the tyrosine kinase substrates Cbl and Vav with tubulin in B-cells. J Biol Chem 1999 0.93
44 The engagement of beta1 integrins on promonocytic cells promotes phosphorylation of Syk and formation of a protein complex containing Lyn and beta1 integrin. Eur J Immunol 1999 0.91
45 Induction of a substrate for casein kinase II during lymphocyte mitogenesis. Biochim Biophys Acta 1984 0.91
46 Regulatory subunit of the type I cAMP-dependent protein kinase as an inhibitor and substrate of the cGMP-dependent protein kinase. J Biol Chem 1980 0.90
47 Synthesis and protein-tyrosine kinase inhibitory activities of flavonoid analogues. J Med Chem 1991 0.90
48 Synthesis and protein-tyrosine kinase inhibitory activity of polyhydroxylated stilbene analogues of piceatannol. J Med Chem 1993 0.89
49 Studies on the phosphorylation of the type I cAMP-dependent protein kinase. J Biol Chem 1980 0.86
50 Substrate recognition by the Lyn protein-tyrosine kinase. NMR structure of the immunoreceptor tyrosine-based activation motif signaling region of the B cell antigen receptor. J Biol Chem 2000 0.85
51 Renaturation and assay of protein kinases after electrophoresis in sodium dodecyl sulfate-polyacrylamide gels. Methods Enzymol 1991 0.85
52 Properties of a tyrosine protein kinase from calf thymus. Response to ionic strength and divalent cations. Biochim Biophys Acta 1985 0.84
53 The protein-tyrosine kinase Lck associates with and is phosphorylated by Cdc2. J Biol Chem 1996 0.83
54 Design, synthesis, and biological evaluation of a series of lavendustin A analogues that inhibit EGFR and Syk tyrosine kinases, as well as tubulin polymerization. J Med Chem 2001 0.83
55 Identification of tyrosine 67 in bovine brain myelin basic protein as a specific phosphorylation site for thymus p56lck. Biochem Biophys Res Commun 1991 0.82
56 Synthesis and biochemical evaluation of a series of aminoflavones as potential inhibitors of protein-tyrosine kinases p56lck, EGFr, and p60v-src. J Med Chem 1994 0.82
57 Signaling-induced association of a tyrosine-phosphorylated 36-kDa protein with p50csk. J Biol Chem 1994 0.82
58 Activation of T cell Raf-1 at mitosis requires the protein-tyrosine kinase Lck. J Biol Chem 1996 0.81
59 S-(2-oxopentadecyl)-CoA, a nonhydrolyzable analogue of myristoyl-CoA, is a potent inhibitor of myristoyl-CoA:protein N-myristoyltransferase. J Med Chem 1989 0.80
60 Posttranslational acylation of the transferrin receptor in LSTRA cells with myristate, palmitate and stearate: evidence for distinct acyltransferases. Biochim Biophys Acta 1994 0.79
61 Detection of myristoyl CoA:protein N-myristoyltransferase activity by ion-exchange chromatography. Anal Biochem 1989 0.78
62 Synthesis and use of 8-azidoguanosine 3',5'-cyclic monophosphate as photoaffinity label for cyclic GMP-dependent protein kinase. Proc Natl Acad Sci U S A 1979 0.78
63 Partial purification and characterization of the lck protein-tyrosine kinase from bovine thymus. Biochem J 1991 0.78
64 Extracellular control of erythrocyte metabolism mediated by a cytoplasmic tyrosine kinase. Biomed Biochim Acta 1990 0.78
65 Selective inhibition of the growth of ras-transformed human bronchial epithelial cells by emodin, a protein-tyrosine kinase inhibitor. Biochem Biophys Res Commun 1993 0.78
66 Effect of phosphorylation on the regulatory subunit of the type I cAMP-dependent protein kinase. J Biol Chem 1981 0.78
67 Detection of a novel lymphocyte protein-tyrosine kinase by renaturation in polyacrylamide gels. Biochem Biophys Res Commun 1986 0.77
68 Synthesis and evaluation of hydroxylated flavones and related compounds as potential inhibitors of the protein-tyrosine kinase p56lck. J Nat Prod 1992 0.77
69 Cell cycle-specific activation of the PTK72 protein-tyrosine kinase in B lymphocytes. J Biol Chem 1993 0.77
70 Phosphorylation of cAMP-dependent protein kinase subunits. Adv Enzyme Regul 1982 0.76
71 Phosphorylation of glycogen synthase by a bovine thymus protein-tyrosine kinase, p40. Biochem Biophys Res Commun 1988 0.76
72 The effect of mild oxidants on glycolysis in human erythrocytes. Biochem J 1992 0.75
73 Flavonoids from Koelreuteria henryi and other sources as protein-tyrosine kinase inhibitors. J Nat Prod 1993 0.75
74 Oncogene signal transduction inhibitors from medicinal plants. In Vivo 1997 0.75
75 Synthesis of [beta-(4-pyridyl-1-oxide)-L-alanine4]-angiotensin I as a potential suicide substrate for protein-tyrosine kinases. Int J Pept Protein Res 1990 0.75
76 Protein-tyrosine kinase inhibition: mechanism-based discovery of antitumor agents. J Nat Prod 1992 0.75
77 Synthesis of myristoyl CoA analogues and myristoyl peptides as inhibitors of myristoyl CoA:protein N-myristoyltransferase. J Pharm Sci 1994 0.75