Published in Proc Natl Acad Sci U S A on November 08, 1994
Compartmentalized IgE receptor-mediated signal transduction in living cells. J Cell Biol (1997) 2.91
Observing FcepsilonRI signaling from the inside of the mast cell membrane. J Cell Biol (2000) 2.69
Fc epsilon RI-mediated recruitment of p53/56lyn to detergent-resistant membrane domains accompanies cellular signaling. Proc Natl Acad Sci U S A (1995) 2.30
Negative regulation of immunoglobulin E-dependent allergic responses by Lyn kinase. J Exp Med (2004) 1.91
Temporally resolved interactions between antigen-stimulated IgE receptors and Lyn kinase on living cells. J Cell Biol (2005) 1.80
Transfection of Syk protein tyrosine kinase reconstitutes high affinity IgE receptor-mediated degranulation in a Syk-negative variant of rat basophilic leukemia RBL-2H3 cells. J Exp Med (1996) 1.77
Transphosphorylation as the mechanism by which the high-affinity receptor for IgE is phosphorylated upon aggregation. Proc Natl Acad Sci U S A (1994) 1.58
G protein-coupled receptors and the modification of FcepsilonRI-mediated mast cell activation. Immunol Lett (2007) 1.33
Positive and negative regulation of mast cell activation by Lyn via the FcepsilonRI. J Immunol (2005) 1.25
The four distal tyrosines are required for LAT-dependent signaling in FcepsilonRI-mediated mast cell activation. J Exp Med (2003) 1.21
Quantitative time-resolved phosphoproteomic analysis of mast cell signaling. J Immunol (2007) 1.16
The Src homology 2 domain of Vav is required for its compartmentation to the plasma membrane and activation of c-Jun NH(2)-terminal kinase 1. J Exp Med (2000) 1.11
Kinetic proofreading models for cell signaling predict ways to escape kinetic proofreading. Proc Natl Acad Sci U S A (2001) 1.09
Early activation of sphingosine kinase in mast cells and recruitment to FcepsilonRI are mediated by its interaction with Lyn kinase. Mol Cell Biol (2004) 1.09
Mast cell chemotaxis - chemoattractants and signaling pathways. Front Immunol (2012) 1.07
Lyn kinase promotes erythroblast expansion and late-stage development. Blood (2006) 1.06
Adapters in the organization of mast cell signaling. Immunol Rev (2009) 1.03
Quantitative nanoscale analysis of IgE-FcεRI clustering and coupling to early signaling proteins. J Phys Chem B (2012) 1.01
A mechanism for SRC kinase-dependent signaling by noncatalytic receptors. Biochemistry (2008) 1.00
B cell antigen receptor desensitization: disruption of receptor coupling to tyrosine kinase activation. J Immunol (1997) 0.99
Phosphorylation of Tyr342 in the linker region of Syk is critical for Fc epsilon RI signaling in mast cells. Mol Cell Biol (2002) 0.95
Activation of RBL-2H3 mast cells is dependent on tyrosine phosphorylation of phospholipase D2 by Fyn and Fgr. Mol Cell Biol (2004) 0.95
Transgenic mice expressing the human high-affinity immunoglobulin (Ig) E receptor alpha chain respond to human IgE in mast cell degranulation and in allergic reactions. J Exp Med (1996) 0.93
One lyn molecule is sufficient to initiate phosphorylation of aggregated high-affinity IgE receptors. Proc Natl Acad Sci U S A (1999) 0.90
Shuttling of initiating kinase between discrete aggregates of the high affinity receptor for IgE regulates the cellular response. Proc Natl Acad Sci U S A (1997) 0.90
Sequential requirements of the N-terminal palmitoylation site and SH2 domain of Src family kinases in the initiation and progression of FcepsilonRI signaling. Mol Cell Biol (2000) 0.87
Differential dephosphorylation of the FcRgamma immunoreceptor tyrosine-based activation motif tyrosines with dissimilar potential for activating Syk. J Biol Chem (2008) 0.87
Transmembrane adaptor protein PAG/CBP is involved in both positive and negative regulation of mast cell signaling. Mol Cell Biol (2014) 0.86
Activation/Inhibition of mast cells by supra-optimal antigen concentrations. Cell Commun Signal (2013) 0.86
Transmembrane adaptor proteins in the high-affinity IgE receptor signaling. Front Immunol (2012) 0.84
A detailed mathematical model predicts that serial engagement of IgE-Fc epsilon RI complexes can enhance Syk activation in mast cells. J Immunol (2010) 0.83
Functional analysis of Lyn kinase A and B isoforms reveals redundant and distinct roles in Fc epsilon RI-dependent mast cell activation. J Immunol (2010) 0.83
The SCHOOL of nature: I. Transmembrane signaling. Self Nonself (2010) 0.82
Antigen binding characteristics of immunoglobulin free light chains: crosslinking by antigen is essential to induce allergic inflammation. PLoS One (2012) 0.82
Functional nanoscale coupling of Lyn kinase with IgE-FcεRI is restricted by the actin cytoskeleton in early antigen-stimulated signaling. Mol Biol Cell (2016) 0.75
Differential Lyn-dependence of the SHIP1-deficient mast cell phenotype. Cell Commun Signal (2016) 0.75
Dimeric immunoglobulin E serves as a unit signal for mast cell degranulation. Proc Natl Acad Sci U S A (1977) 3.07
Complete structure and expression in transfected cells of high affinity IgE receptor. Nature (1989) 2.97
Engagement of the high-affinity IgE receptor activates src protein-related tyrosine kinases. Nature (1992) 2.95
Tyrosine phosphorylation coupled to IgE receptor-mediated signal transduction and histamine release. Proc Natl Acad Sci U S A (1990) 1.98
Phosphorylation and dephosphorylation of the high-affinity receptor for immunoglobulin E immediately after receptor engagement and disengagement. Nature (1991) 1.96
Larger oligomers of IgE are more effective than dimers in stimulating rat basophilic leukemia cells. J Immunol (1980) 1.92
Protein-tyrosine kinase p72syk in high affinity IgE receptor signaling. Identification as a component of pp72 and association with the receptor gamma chain after receptor aggregation. J Biol Chem (1993) 1.91
Multichain immune recognition receptors: similarities in structure and signaling pathways. Immunol Today (1992) 1.90
Fc epsilon RI-mediated tyrosine phosphorylation and activation of the 72-kDa protein-tyrosine kinase, PTK72, in RBL-2H3 rat tumor mast cells. Proc Natl Acad Sci U S A (1992) 1.77
Transphosphorylation as the mechanism by which the high-affinity receptor for IgE is phosphorylated upon aggregation. Proc Natl Acad Sci U S A (1994) 1.58
Further characterization of the beta-component of the receptor for immunoglobulin E. Mol Immunol (1982) 1.51
Distinct p53/56lyn and p59fyn domains associate with nonphosphorylated and phosphorylated Ig-alpha. Proc Natl Acad Sci U S A (1994) 1.49
Analysis of Ig-alpha-tyrosine kinase interaction reveals two levels of binding specificity and tyrosine phosphorylated Ig-alpha stimulation of Fyn activity. EMBO J (1994) 1.43
Protein-tyrosine phosphorylation: an essential component of Fc epsilon RI signaling. Immunol Today (1992) 1.37
Qualitative characteristics of histamine release from human basophils by covalently cross-linked IgE. J Immunol (1981) 1.13
Dynamics of signal transduction after aggregation of cell-surface receptors: studies on the type I receptor for IgE. Proc Natl Acad Sci U S A (1994) 1.09
Transmembrane signaling by the high-affinity IgE receptor on membrane preparations. Proc Natl Acad Sci U S A (1992) 1.02
Affinity labeling of a phosphorylcholine binding mouse myeloma protein. Biochemistry (1972) 4.26
Characterization of a human macroglobulin. II. Distribution of the disulfide bonds. J Biol Chem (1965) 3.64
The receptor with high affinity for immunoglobulin E. Annu Rev Immunol (1986) 3.53
Structural basis of antibody function. Annu Rev Immunol (1983) 3.41
The interaction of IgE with rat basophilic leukemia cells. II. Quantitative aspects of the binding reaction. J Exp Med (1974) 3.33
Dimeric immunoglobulin E serves as a unit signal for mast cell degranulation. Proc Natl Acad Sci U S A (1977) 3.07
Complete structure and expression in transfected cells of high affinity IgE receptor. Nature (1989) 2.97
Affinity labeling of a mouse myeloma protein which binds nitrophenyl ligands. Kinetics of labeling and isolation of a labeled peptide. Biochemistry (1970) 2.88
Interaction between proteins localized in membranes. Proc Natl Acad Sci U S A (1986) 2.74
Lateral motion and valence of Fc receptors on rat peritoneal mast cells. Nature (1976) 2.69
The influence of polyvalency on the binding properties of antibodies. Immunochemistry (1972) 2.67
The interaction of IgE with rat basophilic leukemia cells. I. Evidence for specific binding of IgE. J Exp Med (1974) 2.30
Assessment of compositional relatedness between proteins. Nature (1968) 2.30
Characterization of gene expression in resting and activated mast cells. J Exp Med (1998) 2.24
Signal transduction by Fc receptors: the Fc epsilon RI case. Immunol Today (1993) 2.04
Larger oligomers of IgE are more effective than dimers in stimulating rat basophilic leukemia cells. J Immunol (1980) 1.92
A cDNA presumptively coding for the alpha subunit of the receptor with high affinity for immunoglobulin E. Biochemistry (1987) 1.81
Distribution and valency of receptor for IgE on rodent mast cells and related tumour cells. Nature (1976) 1.78
Structure and function of gamma M macroglobulins. Adv Immunol (1970) 1.73
Characterization of a human macroglobulin. 3. The products of tryptic digestion. J Biol Chem (1966) 1.72
An unusual mechanism for ligand antagonism. Science (1998) 1.69
The IgE-mast cell system as a paradigm for the study of antibody mechanisms. Immunol Rev (1978) 1.68
Medical problems of civil disorders. Organization of a volunteer group of health professionals to provide medical services in a riot. N Engl J Med (1969) 1.63
Transphosphorylation as the mechanism by which the high-affinity receptor for IgE is phosphorylated upon aggregation. Proc Natl Acad Sci U S A (1994) 1.58
Characterization of a human macroglobulin. V. A Waldenström macroglobulin with antibody activity. Proc Natl Acad Sci U S A (1967) 1.56
Effect of antigen binding on the properties of antibody. Adv Immunol (1974) 1.55
Further characterization of the beta-component of the receptor for immunoglobulin E. Mol Immunol (1982) 1.51
Surface IgE on human basophils during histamine release. J Exp Med (1973) 1.48
Crosslinking of the receptors for immunoglobulin E depolarizes the plasma membrane of rat basophilic leukemia cells. Proc Natl Acad Sci U S A (1983) 1.41
Triggering of cultured neoplastic mast cells by antibodies to the receptor for IgE. J Immunol (1978) 1.40
The positive inotropic-acting forskolin, a potent adenylate cyclase activator. Arzneimittelforschung (1981) 1.40
Expression of high-affinity binding of human immunoglobulin E by transfected cells. Science (1989) 1.36
Studies with a monoclonal antibody to the beta subunit of the receptor with high affinity for immunoglobulin E. Mol Immunol (1988) 1.35
Isolation and characterization of cDNAs coding for the beta subunit of the high-affinity receptor for immunoglobulin E. Proc Natl Acad Sci U S A (1988) 1.32
Cell cycle-associated changes in receptors for IgE during growth and differentiation of a rat basophilic leukemia cell line. J Exp Med (1975) 1.29
A Waldenström macroglobulin which binds nitrophenyl ligands. J Biol Chem (1969) 1.26
Noncytotoxic IgE-mediated release of histamine and serotonin from murine mastocytoma cells. J Immunol (1977) 1.22
Quantitative relationships between aggregation of IgE receptors, generation of intracellular signals, and histamine secretion in rat basophilic leukemia (2H3) cells. Enhanced responses with heavy water. J Biol Chem (1986) 1.20
The receptor on mast cells and related cells with high affinity for IgE. Contemp Top Mol Immunol (1983) 1.19
Myeloma proteins and antibodies. Am J Med (1969) 1.18
Binding properties of a Waldenström macroglobulin antibody. J Biol Chem (1968) 1.18
Initial characterization of the calcium channel activated by the cross-linking of the receptors for immunoglobulin E. J Biol Chem (1984) 1.17
Affinity labeling of a mouse myeloma protein which binds nitrophenyl ligands. Sequence and position of a labeled tryptic peptide. Biochemistry (1970) 1.17
The chemistry of the immunoglobulins. JAMA (1967) 1.17
Electron microscopic localization of immunoglobulin E on the surface membrane of human basophils. J Exp Med (1971) 1.15
Phospholipids stabilize the interaction between the alpha and beta subunits of the solubilized receptor for immunoglobulin E. Biochemistry (1982) 1.15
Interaction of IgE with rat basophilic leukemia cells. IV. Antibody-induced redistribution of IgE receptors. J Immunol (1974) 1.15
Isolation of IgE from reaginic rat serum. J Immunol (1974) 1.14
Qualitative characteristics of histamine release from human basophils by covalently cross-linked IgE. J Immunol (1981) 1.13
The unique domain as the site on Lyn kinase for its constitutive association with the high affinity receptor for IgE. J Biol Chem (1997) 1.12
Structure-activity relationships for activation of adenylate cyclase by the diterpene forskolin and its derivatives. J Med Chem (1983) 1.12
Analysis of the rate-limiting step in a ligand-cell receptor interaction: the immunoglobulin E system. Biochemistry (1983) 1.12
A previously unrecognized subunit of the receptor for immunoglobulin E. Biochemistry (1983) 1.12
Reconstitution of the receptor for immunoglobulin E into liposomes. Conditions for incorporation of the receptor into vesicles. J Biol Chem (1982) 1.11
Translocation of protein kinase C in rat basophilic leukemic cells induced by phorbol ester or by aggregation of IgE receptors. J Immunol (1988) 1.10
Catalytic unit of adenlyate cyclase: purification and identification by affinity crosslinking. Proc Natl Acad Sci U S A (1985) 1.10
The effect of antigen on antibodies: recent studies. Contemp Top Mol Immunol (1978) 1.10
Dynamics of signal transduction after aggregation of cell-surface receptors: studies on the type I receptor for IgE. Proc Natl Acad Sci U S A (1994) 1.09
Kinetic proofreading models for cell signaling predict ways to escape kinetic proofreading. Proc Natl Acad Sci U S A (2001) 1.09
Ionophore A-23187 induced histamine release from rat mast cells and rat basophil leukemia (RBL-1) cells. J Immunol (1975) 1.09
Phase separation of the receptor for immunoglobulin E and its subunits in Triton X-114. J Biol Chem (1984) 1.07
Secretion from rat basophilic leukaemia cells induced by calcium ionophores. Effect of pH and metabolic inhibition. Biochim Biophys Acta (1981) 1.05
Isolation of homologous and heterologous complexes between catalytic and regulatory components of adenylate cyclase by forskolin-Sepharose. FEBS Lett (1983) 1.04
[Ultrastructure of the luminal surface of Fallopian tube in the scanning electron microscope]. Arch Gynakol (1972) 1.04
Interaction of aggregated native and mutant IgE receptors with the cellular skeleton. Proc Natl Acad Sci U S A (1992) 1.03
Unexpected signals in a system subject to kinetic proofreading. Proc Natl Acad Sci U S A (2001) 1.03
Transmembrane signaling by the high-affinity IgE receptor on membrane preparations. Proc Natl Acad Sci U S A (1992) 1.02
Structure-function relationships in the mast cell high affinity receptor for IgE. Role of the cytoplasmic domains and of the beta subunit. J Biol Chem (1991) 1.01
Assay and partial characterization of the solubilized cell surface receptor for immunoglobulin E. J Biol Chem (1977) 1.00
The receptor for immunoglobulin E: examination for kinase activity and as a substrate for kinases. Mol Immunol (1986) 1.00
Association of the receptor for immunoglobulin E with an endogenous polypeptide on rat basophilic leukemia cells. J Recept Res (1980) 0.99
Stimulation of adenylate cyclase by water-soluble analogues of forskolin. Mol Pharmacol (1987) 0.99
Affinity site labeling of a mouse myeloma protein which binds dinitrophenyl ligands. Science (1968) 0.99
Simple radio-immunoassay for the measurement of human and rat IgE levels by ammonium sulfate precipitation. J Immunol (1975) 0.98
Exploiting the difference between intrinsic and extrinsic kinases: implications for regulation of signaling by immunoreceptors. J Immunol (1997) 0.98
Preparative isolation of the cell receptor for immunoglobulin E. J Biol Chem (1979) 0.98
Binding of immunoglobulin E to the receptor on rat peritoneal macrophages. J Immunol (1982) 0.97
Disparity of IgE binding between normal and tumor mouse mast cells. J Immunol (1976) 0.97
Dissociation of the receptor for immunoglobulin E in mild detergents. Biochemistry (1985) 0.97
Early molecular events in antigen-antibody cell activation. Annu Rev Pharmacol Toxicol (1979) 0.97
Evolution of immunoglobulin polypeptide chains: carboxy-terminal of an IgM heavy chain. Science (1966) 0.96
The specificity of a monoclonal macroglobulin (gamma M) antibody: reactivity with primate gamma G immunoglobulins. J Immunol (1969) 0.96
Cytophilic binding of IgE to the macrophage. III. Involvement of cyclic GMP and calcium in macrophage activation by dimeric or aggregated rat myeloma IgE. Cell Immunol (1980) 0.95
Functional comparison of Fc epsilon RI, Fc gamma RII, and Fc gamma RIII in mast cells. J Immunol (1992) 0.95
Tolerance and pharmacodynamics of the angiotensin converting enzyme inhibitor 2-[N-[(S)-1-ethoxycarbonyl-3-phenylpropyl]-L-alanyl]-(1S,3S,5S)-2- azabicyclo[3.3.0]octane-3-carboxylic acid (Hoe 498) in healthy volunteers. Arzneimittelforschung (1984) 0.95
Composition and subunit structure of the cell receptor for immunoglobulin E. J Biol Chem (1980) 0.94
Rumen chemical and bacterial changes during stepwise adaptation to a high-concentrate diet in goats. Animal (2010) 0.94
Detergent-resistant microdomains offer no refuge for proteins phosphorylated by the IgE receptor. J Biol Chem (2000) 0.94
The antigen receptor problem. Annu Rev Biochem (1970) 0.94
Geometric considerations in modeling transport processes in tissue. Adv Exp Med Biol (1973) 0.93
Characterization of a human macroglobulin. IV. Studies of its conformation by fluorescence polarization. J Biol Chem (1966) 0.93
Some physical chemical aspects of receptor-ligand interactions. Immunol Commun (1976) 0.93
Transmembrane signaling in P815 mastocytoma cells by transfected IgE receptors. J Biol Chem (1990) 0.92
Serum IgE levels during the potentiated reagin response to egg albumin in rats infected with Nippostrongylus brasiliensis. J Immunol (1975) 0.91
Reconstitution of the receptor for immunoglobulin E into liposomes. Reincorporation of purified receptors. J Biol Chem (1984) 0.91
Immobilization and internalization of mutated IgE receptors in transfected cells. J Immunol (1991) 0.91
Characterization of protein-tyrosine phosphatases that dephosphorylate the high affinity IgE receptor. J Biol Chem (1997) 0.91
Amino terminal sequences of human immunoglobulin heavy chains. Immunochemistry (1971) 0.91