Published in J Exp Med on December 01, 1974
Constrained diffusion or immobile fraction on cell surfaces: a new interpretation. Biophys J (1996) 5.78
The kinetics of antibody binding to membrane antigens in solution and at the cell surface. Biochem J (1980) 4.37
Actin restricts FcepsilonRI diffusion and facilitates antigen-induced receptor immobilization. Nat Cell Biol (2008) 3.15
Dimeric immunoglobulin E serves as a unit signal for mast cell degranulation. Proc Natl Acad Sci U S A (1977) 3.07
Growth of a pure population of mouse mast cells in vitro with conditioned medium derived from concanavalin A-stimulated splenocytes. Proc Natl Acad Sci U S A (1981) 2.33
Mast cell clones: a model for the analysis of cellular maturation. J Cell Biol (1982) 1.91
Precursor role of arachidonic acid in release of slow reacting substance from rat basophilic leukemia cells. Proc Natl Acad Sci U S A (1977) 1.86
Temporally resolved interactions between antigen-stimulated IgE receptors and Lyn kinase on living cells. J Cell Biol (2005) 1.80
IgE receptors on human basophils. Relationship to serum IgE concentration. J Clin Invest (1978) 1.71
Cross-linking of receptor-bound IgE to aggregates larger than dimers leads to rapid immobilization. J Cell Biol (1986) 1.61
Possible orientational constraints determine secretory signals induced by aggregation of IgE receptors on mast cells. EMBO J (1988) 1.50
Suspension culture of human mast cells/basophils from umbilical cord blood mononuclear cells. Proc Natl Acad Sci U S A (1983) 1.44
Preferential signaling and induction of allergy-promoting lymphokines upon weak stimulation of the high affinity IgE receptor on mast cells. J Exp Med (2003) 1.42
Crosslinking of the receptors for immunoglobulin E depolarizes the plasma membrane of rat basophilic leukemia cells. Proc Natl Acad Sci U S A (1983) 1.41
Small oligomers of immunoglobulin E (IgE) cause large-scale clustering of IgE receptors on the surface of rat basophilic leukemia cells. J Cell Biol (1984) 1.35
Development of human mast cells from umbilical cord blood cells by recombinant human and murine c-kit ligand. Proc Natl Acad Sci U S A (1993) 1.30
Cell cycle-associated changes in receptors for IgE during growth and differentiation of a rat basophilic leukemia cell line. J Exp Med (1975) 1.29
The RBL-2H3 cell line: its provenance and suitability as a model for the mast cell. Inflamm Res (2009) 1.25
The receptor for immunoglobulin E on rat basophilic leukemia cells: effect of ligand binding on receptor expression. Proc Natl Acad Sci U S A (1985) 1.21
Equilibrium theory for the clustering of bivalent cell surface receptors by trivalent ligands. Application to histamine release from basophils. Biophys J (1984) 1.21
Anaphylatoxin-induced histamine release with human leukocytes: studies of C3a leukocyte binding and histamine release. J Clin Invest (1979) 1.20
The Src homology 2 domain of Vav is required for its compartmentation to the plasma membrane and activation of c-Jun NH(2)-terminal kinase 1. J Exp Med (2000) 1.11
Dynamics of signal transduction after aggregation of cell-surface receptors: studies on the type I receptor for IgE. Proc Natl Acad Sci U S A (1994) 1.09
Kinetic proofreading models for cell signaling predict ways to escape kinetic proofreading. Proc Natl Acad Sci U S A (2001) 1.09
Modeling multivalent ligand-receptor interactions with steric constraints on configurations of cell-surface receptor aggregates. Biophys J (2010) 1.09
Guidelines for visualizing and annotating rule-based models. Mol Biosyst (2011) 1.05
Adapters in the organization of mast cell signaling. Immunol Rev (2009) 1.03
Binding constants of IgE receptors on human blood basophils for IgE. Immunology (1986) 1.00
Self-reactive IgE exacerbates interferon responses associated with autoimmunity. Nat Immunol (2015) 0.99
Rat basophilic leukemia cell lines defective in phospholipid methyltransferase enzymes, Ca2+ influx, and histamine release: reconstitution by hybridization. Proc Natl Acad Sci U S A (1981) 0.98
In vitro production of IgE by human peripheral blood mononuclear cells. III. Demonstration of a circulating IgE-bearing cell involved in the spontaneous IgE biosynthesis. Clin Exp Immunol (1982) 0.97
The binding of rabbit basophil-derived platelet-activating factor to rabbit platelets. Am J Pathol (1980) 0.95
Quantifying aggregation of IgE-FcepsilonRI by multivalent antigen. Biophys J (1999) 0.93
Structural evidence for distinct IgG subclass-specific Fc receptors on mouse peritoneal macrophages. J Exp Med (1980) 0.92
Properties of a human immunoglobulin epsilon-chain fragment synthesized in Escherichia coli. Proc Natl Acad Sci U S A (1984) 0.91
Study of the transit of an integral membrane protein from secretory granules through the plasma membrane of secreting rat basophilic leukemia cells using a specific monoclonal antibody. J Cell Biol (1986) 0.91
Generation of monoclonal murine anti-DNP-IgE, IgM and IgG1 antibodies: biochemical and biological characterization. Immunology (1982) 0.90
Shuttling of initiating kinase between discrete aggregates of the high affinity receptor for IgE regulates the cellular response. Proc Natl Acad Sci U S A (1997) 0.90
One lyn molecule is sufficient to initiate phosphorylation of aggregated high-affinity IgE receptors. Proc Natl Acad Sci U S A (1999) 0.90
The number and affinity of IgE receptors on dispersed human lung mast cells. Immunology (1981) 0.89
Cell surface expression of murine, rat, and human Fc receptors by Xenopus oocytes. J Exp Med (1984) 0.88
Biological properties of a recombinant human immunoglobulin epsilon-chain fragment. Proc Natl Acad Sci U S A (1986) 0.88
Enrichment and expansion of cells using antibody-coated micropallet arrays. Cytometry A (2009) 0.88
Mast cells and company. Front Immunol (2012) 0.87
Necessity of the stalk region for immunoglobulin E interaction with CD23. Immunology (2002) 0.86
IgE-antigen complexes enhance Fc epsilon R and Ia expression by murine B lymphocytes. J Exp Med (1988) 0.84
Polymorphism of Fc receptor on murine B cells is Igh-linked. J Exp Med (1985) 0.84
Selective phosphorylation of the IgE receptor in antigen-stimulated rat mast cells. Proc Natl Acad Sci U S A (1983) 0.84
Expression of a biologically active fragment of human IgE epsilon chain in Escherichia coli. Proc Natl Acad Sci U S A (1984) 0.84
A kinetic analysis of the in vitro sensitization of murine peritoneal mast cells with monoclonal IgE anti-DNP antibody. Immunology (1988) 0.83
A detailed mathematical model predicts that serial engagement of IgE-Fc epsilon RI complexes can enhance Syk activation in mast cells. J Immunol (2010) 0.83
Shaping the response: the role of FcεRI and Syk expression levels in mast cell signaling. IET Syst Biol (2010) 0.83
Pulmonary function changes in normal rats induced by antibody against rat IgE. Clin Exp Immunol (1979) 0.83
The functional activity of human monocytes passively sensitized with monoclonal anti-D suggests a novel role for Fc gamma RI in the immune destruction of blood cells. Immunology (1994) 0.81
Immune reactions and allergy in experimental anisakiasis. Korean J Parasitol (2006) 0.81
Passive cutaneous anaphylaxis inhibition: evidence for heterogeneity in IgE mast cell interaction. Immunology (1981) 0.81
Development of a mast cell-based biosensor. Biosens Bioelectron (2007) 0.80
Mice genetically deficient in immunoglobulin E are more permissive hosts than wild-type mice to a primary, but not secondary, infection with the filarial nematode Brugia malayi. Infect Immun (2003) 0.78
Use of humanised rat basophilic leukaemia cell line RS-ATL8 for the assessment of allergenicity of Schistosoma mansoni proteins. PLoS Negl Trop Dis (2014) 0.78
Isolation from human chronic-lymphocytic-leukaemia cells of membrane glycoproteins associated with Fc-receptor functions. Physical parameters and production of polyclonal antibodies. Biochem J (1987) 0.77
Number and affinity of receptors for IgE on enriched populations of isolated rat intestinal mast cells. Immunology (1985) 0.75
The Role and Function of Fcγ Receptors on Myeloid Cells. Microbiol Spectr (2016) 0.75
Membrane-bound IgE receptor complexes fused with rat basophilic leukemia cells mediate degranulation. J Cell Biol (1987) 0.75
Allergen Valency, Dose, and FcεRI Occupancy Set Thresholds for Secretory Responses to Pen a 1 and Motivate Design of Hypoallergens. J Immunol (2016) 0.75
From IgE to Omalizumab. J Immunol (2016) 0.75
Purification and characterization of a lysosomal form and a variant form of beta-glucuronidase from the rat basophil leukaemia tumour. Biochem J (1981) 0.75
Amino acid metabolism in mammalian cell cultures. Science (1959) 55.21
A method of trace iodination of proteins for immunologic studies. Int Arch Allergy Appl Immunol (1966) 43.66
Three classes and four (sub)classes of rat immunoglobulins: IgM, IgA, IgE and IgG1, IgG2a, IgG2b, IgG2c. Eur J Immunol (1974) 3.86
Phosphatidylserine: selective enhancer of histamine release. Science (1971) 2.76
Transplantable immunoglobulin-secreting tumours in rats. IV. Sixty-three IgE-secreting immunocytoma tumours. Immunology (1974) 2.36
The interaction of IgE with rat basophilic leukemia cells. I. Evidence for specific binding of IgE. J Exp Med (1974) 2.30
Mechanisms of passive sensitization. 3. Number of IgE molecules and their receptor sites on human basophil granulocytes. J Immunol (1973) 1.87
Studies on the mechanisms of hypersensitivity phenomena. XIV. Passive sensitization in vitro of human leukocytes to ragweed pollen antigen. J Immunol (1966) 1.75
IgE and IgGa antibody-mediated release of histamine from rat peritoneal cells. I. Optimum conditions for in vitro preparation of target cells with antibody and and challenge with antigen. J Exp Med (1971) 1.64
Mechanisms of passive sensitization. IV. Dissociation of IgE molecules from basophil receptors at acid pH. J Immunol (1974) 1.62
In vitro studies of human reaginic allergy. Adv Immunol (1968) 1.50
On the nature of the presumed receptor for IgE on mast cells. II. Demonstration of the specific binding of IgE to cell-free particulate preparations from rat peritoneal mast cells. J Immunol (1973) 1.43
The kinetics of the reactions between antibodies to the 2,4 dinitrophenyl group and specific haptens. Ann N Y Acad Sci (1963) 1.36
Investigation of antigen-antibody kinetics by fluorescence polarization. Immunochemistry (1968) 1.32
IgE and reaginic hypersensitivity. Ann N Y Acad Sci (1971) 1.23
Interaction of IgE with rat basophilic leukemia cells. IV. Antibody-induced redistribution of IgE receptors. J Immunol (1974) 1.15
Affinity labeling of a phosphorylcholine binding mouse myeloma protein. Biochemistry (1972) 4.26
Characterization of a human macroglobulin. II. Distribution of the disulfide bonds. J Biol Chem (1965) 3.64
The receptor with high affinity for immunoglobulin E. Annu Rev Immunol (1986) 3.53
Structural basis of antibody function. Annu Rev Immunol (1983) 3.41
Dimeric immunoglobulin E serves as a unit signal for mast cell degranulation. Proc Natl Acad Sci U S A (1977) 3.07
Complete structure and expression in transfected cells of high affinity IgE receptor. Nature (1989) 2.97
Affinity labeling of a mouse myeloma protein which binds nitrophenyl ligands. Kinetics of labeling and isolation of a labeled peptide. Biochemistry (1970) 2.88
Interaction between proteins localized in membranes. Proc Natl Acad Sci U S A (1986) 2.74
Lateral motion and valence of Fc receptors on rat peritoneal mast cells. Nature (1976) 2.69
The influence of polyvalency on the binding properties of antibodies. Immunochemistry (1972) 2.67
The interaction of IgE with rat basophilic leukemia cells. I. Evidence for specific binding of IgE. J Exp Med (1974) 2.30
Assessment of compositional relatedness between proteins. Nature (1968) 2.30
Characterization of gene expression in resting and activated mast cells. J Exp Med (1998) 2.24
Studies of the mechanism of tunicamycin in hibition of IgA and IgE secretion by plasma cells. J Biol Chem (1977) 2.06
Signal transduction by Fc receptors: the Fc epsilon RI case. Immunol Today (1993) 2.04
Larger oligomers of IgE are more effective than dimers in stimulating rat basophilic leukemia cells. J Immunol (1980) 1.92
A cDNA presumptively coding for the alpha subunit of the receptor with high affinity for immunoglobulin E. Biochemistry (1987) 1.81
Distribution and valency of receptor for IgE on rodent mast cells and related tumour cells. Nature (1976) 1.78
Structure and function of gamma M macroglobulins. Adv Immunol (1970) 1.73
Characterization of a human macroglobulin. 3. The products of tryptic digestion. J Biol Chem (1966) 1.72
An unusual mechanism for ligand antagonism. Science (1998) 1.69
The IgE-mast cell system as a paradigm for the study of antibody mechanisms. Immunol Rev (1978) 1.68
Medical problems of civil disorders. Organization of a volunteer group of health professionals to provide medical services in a riot. N Engl J Med (1969) 1.63
Transphosphorylation as the mechanism by which the high-affinity receptor for IgE is phosphorylated upon aggregation. Proc Natl Acad Sci U S A (1994) 1.58
Release of slow reacting substance (SRS) from rat basophilic leukemia (RBL-1) cells. J Immunol (1977) 1.58
Characterization of a human macroglobulin. V. A Waldenström macroglobulin with antibody activity. Proc Natl Acad Sci U S A (1967) 1.56
Effect of antigen binding on the properties of antibody. Adv Immunol (1974) 1.55
Structural features of gamma-immunoglobulin, antibody, and their fragments. Circular dichroism studies. Biochemistry (1968) 1.55
Further characterization of the beta-component of the receptor for immunoglobulin E. Mol Immunol (1982) 1.51
Surface IgE on human basophils during histamine release. J Exp Med (1973) 1.48
Aggregation of the high-affinity IgE receptor and enhanced activity of p53/56lyn protein-tyrosine kinase. Proc Natl Acad Sci U S A (1994) 1.47
Guide to physical urticarias. J Allergy Clin Immunol (1988) 1.44
Crosslinking of the receptors for immunoglobulin E depolarizes the plasma membrane of rat basophilic leukemia cells. Proc Natl Acad Sci U S A (1983) 1.41
Triggering of cultured neoplastic mast cells by antibodies to the receptor for IgE. J Immunol (1978) 1.40
The positive inotropic-acting forskolin, a potent adenylate cyclase activator. Arzneimittelforschung (1981) 1.40
Colic in breast-milk-fed infants: treatment by temporary substitution of neocate infant formula. Acta Paediatr (2000) 1.39
Expression of high-affinity binding of human immunoglobulin E by transfected cells. Science (1989) 1.36
Studies with a monoclonal antibody to the beta subunit of the receptor with high affinity for immunoglobulin E. Mol Immunol (1988) 1.35
Isolation and characterization of cDNAs coding for the beta subunit of the high-affinity receptor for immunoglobulin E. Proc Natl Acad Sci U S A (1988) 1.32
Isolation and partial characterization of Fc gamma-binding proteins of human leukocytes. J Clin Invest (1981) 1.31
Improved cell surface radioiodination of macrophages. J Immunol Methods (1980) 1.30
Cell cycle-associated changes in receptors for IgE during growth and differentiation of a rat basophilic leukemia cell line. J Exp Med (1975) 1.29
Modulation of cyclic AMP in purified rat mast cells. III. Studies on the effects of concanavalin A and anti-IgE on cyclic AMP concentrations during histamine release. J Immunol (1976) 1.26
A Waldenström macroglobulin which binds nitrophenyl ligands. J Biol Chem (1969) 1.26
Isolation of a biologically active macrophage receptor for the third component of complement. Nature (1981) 1.24
Noncytotoxic IgE-mediated release of histamine and serotonin from murine mastocytoma cells. J Immunol (1977) 1.22
Quantitative relationships between aggregation of IgE receptors, generation of intracellular signals, and histamine secretion in rat basophilic leukemia (2H3) cells. Enhanced responses with heavy water. J Biol Chem (1986) 1.20
The receptor on mast cells and related cells with high affinity for IgE. Contemp Top Mol Immunol (1983) 1.19
Ligand binding specificity of a rabbit alveolar macrophage receptor for C3b. J Biol Chem (1982) 1.19
Binding properties of a Waldenström macroglobulin antibody. J Biol Chem (1968) 1.18
Myeloma proteins and antibodies. Am J Med (1969) 1.18
Human monocytes, B lymphocytes, and non-B lymphocytes each have structurally unique Fc gamma receptors. J Immunol (1983) 1.18
Initial characterization of the calcium channel activated by the cross-linking of the receptors for immunoglobulin E. J Biol Chem (1984) 1.17
Affinity labeling of a mouse myeloma protein which binds nitrophenyl ligands. Sequence and position of a labeled tryptic peptide. Biochemistry (1970) 1.17
The chemistry of the immunoglobulins. JAMA (1967) 1.17
Electron microscopic localization of immunoglobulin E on the surface membrane of human basophils. J Exp Med (1971) 1.15
Phospholipids stabilize the interaction between the alpha and beta subunits of the solubilized receptor for immunoglobulin E. Biochemistry (1982) 1.15
Human neutrophils and eosinophils have structurally distinct Fc gamma receptors. J Immunol (1984) 1.15
Interaction of IgE with rat basophilic leukemia cells. IV. Antibody-induced redistribution of IgE receptors. J Immunol (1974) 1.15
Isolation of IgE from reaginic rat serum. J Immunol (1974) 1.14
Identification of an IgE-binding protein by molecular cloning. Proc Natl Acad Sci U S A (1985) 1.13
Qualitative characteristics of histamine release from human basophils by covalently cross-linked IgE. J Immunol (1981) 1.13
The unique domain as the site on Lyn kinase for its constitutive association with the high affinity receptor for IgE. J Biol Chem (1997) 1.12
Structure-activity relationships for activation of adenylate cyclase by the diterpene forskolin and its derivatives. J Med Chem (1983) 1.12
Analysis of the rate-limiting step in a ligand-cell receptor interaction: the immunoglobulin E system. Biochemistry (1983) 1.12
A previously unrecognized subunit of the receptor for immunoglobulin E. Biochemistry (1983) 1.12
Reconstitution of the receptor for immunoglobulin E into liposomes. Conditions for incorporation of the receptor into vesicles. J Biol Chem (1982) 1.11
Catalytic unit of adenlyate cyclase: purification and identification by affinity crosslinking. Proc Natl Acad Sci U S A (1985) 1.10
Translocation of protein kinase C in rat basophilic leukemic cells induced by phorbol ester or by aggregation of IgE receptors. J Immunol (1988) 1.10
The rat basophilic leukemia cell receptor for IgE. I. Characterization as a glycoprotein. J Immunol (1976) 1.10
The effect of antigen on antibodies: recent studies. Contemp Top Mol Immunol (1978) 1.10
Dynamics of signal transduction after aggregation of cell-surface receptors: studies on the type I receptor for IgE. Proc Natl Acad Sci U S A (1994) 1.09
Kinetic proofreading models for cell signaling predict ways to escape kinetic proofreading. Proc Natl Acad Sci U S A (2001) 1.09
Ionophore A-23187 induced histamine release from rat mast cells and rat basophil leukemia (RBL-1) cells. J Immunol (1975) 1.09
Treatment of infant colic with amino acid-based infant formula: a preliminary study. Acta Paediatr (2000) 1.09
Phase separation of the receptor for immunoglobulin E and its subunits in Triton X-114. J Biol Chem (1984) 1.07
Secretion from rat basophilic leukaemia cells induced by calcium ionophores. Effect of pH and metabolic inhibition. Biochim Biophys Acta (1981) 1.05
The cell surface receptor for immunoglobulin E. I. The use of repetitive affinity chromatography for the purification of a mammalian receptor. J Biol Chem (1979) 1.04
[Ultrastructure of the luminal surface of Fallopian tube in the scanning electron microscope]. Arch Gynakol (1972) 1.04
Isolation of homologous and heterologous complexes between catalytic and regulatory components of adenylate cyclase by forskolin-Sepharose. FEBS Lett (1983) 1.04
Interaction of aggregated native and mutant IgE receptors with the cellular skeleton. Proc Natl Acad Sci U S A (1992) 1.03
Unexpected signals in a system subject to kinetic proofreading. Proc Natl Acad Sci U S A (2001) 1.03
Transmembrane signaling by the high-affinity IgE receptor on membrane preparations. Proc Natl Acad Sci U S A (1992) 1.02
Structure-function relationships in the mast cell high affinity receptor for IgE. Role of the cytoplasmic domains and of the beta subunit. J Biol Chem (1991) 1.01
Assay and partial characterization of the solubilized cell surface receptor for immunoglobulin E. J Biol Chem (1977) 1.00
The receptor for immunoglobulin E: examination for kinase activity and as a substrate for kinases. Mol Immunol (1986) 1.00
Association of the receptor for immunoglobulin E with an endogenous polypeptide on rat basophilic leukemia cells. J Recept Res (1980) 0.99
Affinity site labeling of a mouse myeloma protein which binds dinitrophenyl ligands. Science (1968) 0.99
Stimulation of adenylate cyclase by water-soluble analogues of forskolin. Mol Pharmacol (1987) 0.99
Simple radio-immunoassay for the measurement of human and rat IgE levels by ammonium sulfate precipitation. J Immunol (1975) 0.98
Exploiting the difference between intrinsic and extrinsic kinases: implications for regulation of signaling by immunoreceptors. J Immunol (1997) 0.98
Role of immunoglobulin E and immunoglobulin E receptors in bronchial asthma. J Allergy Clin Immunol (1981) 0.98
Preparative isolation of the cell receptor for immunoglobulin E. J Biol Chem (1979) 0.98
Binding of immunoglobulin E to the receptor on rat peritoneal macrophages. J Immunol (1982) 0.97
Dissociation of the receptor for immunoglobulin E in mild detergents. Biochemistry (1985) 0.97
Disparity of IgE binding between normal and tumor mouse mast cells. J Immunol (1976) 0.97
Early molecular events in antigen-antibody cell activation. Annu Rev Pharmacol Toxicol (1979) 0.97