Published in J Biol Chem on September 15, 1995
Association of the yeast poly(A) tail binding protein with translation initiation factor eIF-4G. EMBO J (1996) 7.28
Canonical eukaryotic initiation factors determine initiation of translation by internal ribosomal entry. Mol Cell Biol (1996) 6.35
Rapamycin blocks the phosphorylation of 4E-BP1 and inhibits cap-dependent initiation of translation. EMBO J (1996) 6.01
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A newly identified N-terminal amino acid sequence of human eIF4G binds poly(A)-binding protein and functions in poly(A)-dependent translation. EMBO J (1998) 5.18
The roles of individual eukaryotic translation initiation factors in ribosomal scanning and initiation codon selection. Genes Dev (2002) 4.96
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Functional dissection of eukaryotic initiation factor 4F: the 4A subunit and the central domain of the 4G subunit are sufficient to mediate internal entry of 43S preinitiation complexes. Mol Cell Biol (1996) 4.42
Mutations in translation initiation factors lead to increased rates of deadenylation and decapping of mRNAs in Saccharomyces cerevisiae. Mol Cell Biol (1999) 4.35
Foot-and-mouth disease. Clin Microbiol Rev (2004) 4.34
Human eukaryotic translation initiation factor 4G (eIF4G) possesses two separate and independent binding sites for eIF4A. Mol Cell Biol (1997) 3.61
A novel functional human eukaryotic translation initiation factor 4G. Mol Cell Biol (1998) 3.49
Phosphorylation of the cap-binding protein eukaryotic translation initiation factor 4E by protein kinase Mnk1 in vivo. Mol Cell Biol (1999) 3.46
RNA-protein interactions in regulation of picornavirus RNA translation. Microbiol Rev (1996) 3.36
Rotavirus RNA-binding protein NSP3 interacts with eIF4GI and evicts the poly(A) binding protein from eIF4F. EMBO J (1998) 3.16
Cap-independent polysomal association of natural mRNAs encoding c-myc, BiP, and eIF4G conferred by internal ribosome entry sites. RNA (1998) 3.00
Proteolysis of human eukaryotic translation initiation factor eIF4GII, but not eIF4GI, coincides with the shutoff of host protein synthesis after poliovirus infection. Proc Natl Acad Sci U S A (1998) 2.93
Identification of a translation initiation factor 3 (eIF3) core complex, conserved in yeast and mammals, that interacts with eIF5. Mol Cell Biol (1998) 2.91
Eukaryotic translation initiation factor 4E (eIF4E) binding site and the middle one-third of eIF4GI constitute the core domain for cap-dependent translation, and the C-terminal one-third functions as a modulatory region. Mol Cell Biol (2000) 2.89
The C-terminal domain of eukaryotic protein synthesis initiation factor (eIF) 4G is sufficient to support cap-independent translation in the absence of eIF4E. EMBO J (1996) 2.75
A new translational regulator with homology to eukaryotic translation initiation factor 4G. EMBO J (1997) 2.66
Translational control of viral gene expression in eukaryotes. Microbiol Mol Biol Rev (2000) 2.63
Topology and regulation of the human eIF4A/4G/4H helicase complex in translation initiation. Cell (2009) 2.60
Physical association of eukaryotic initiation factor 4G (eIF4G) with eIF4A strongly enhances binding of eIF4G to the internal ribosomal entry site of encephalomyocarditis virus and is required for internal initiation of translation. Mol Cell Biol (2000) 2.58
Posttranscriptional control of gene expression in yeast. Microbiol Mol Biol Rev (1998) 2.54
Picornavirus IRESes and the poly(A) tail jointly promote cap-independent translation in a mammalian cell-free system. RNA (2000) 2.53
Molecular mechanism of scanning and start codon selection in eukaryotes. Microbiol Mol Biol Rev (2011) 2.51
Eukaryotic translation initiation factor 4GI is a cellular target for NS1 protein, a translational activator of influenza virus. Mol Cell Biol (2000) 2.48
Serum-stimulated, rapamycin-sensitive phosphorylation sites in the eukaryotic translation initiation factor 4GI. EMBO J (2000) 2.40
A novel shuttling protein, 4E-T, mediates the nuclear import of the mRNA 5' cap-binding protein, eIF4E. EMBO J (2000) 2.37
Inhibition of endoplasmic reticulum-to-Golgi traffic by poliovirus protein 3A: genetic and ultrastructural analysis. J Virol (1997) 2.28
The eIF4G-eIF4E complex is the target for direct cleavage by the rhinovirus 2A proteinase. J Virol (1996) 2.21
The TOR (target of rapamycin) signal transduction pathway regulates the stability of translation initiation factor eIF4G in the yeast Saccharomyces cerevisiae. Proc Natl Acad Sci U S A (1998) 2.15
Dual interactions of the translational repressor Paip2 with poly(A) binding protein. Mol Cell Biol (2001) 2.07
c-Myc protein synthesis is initiated from the internal ribosome entry segment during apoptosis. Mol Cell Biol (2000) 2.03
Translational activation of uncapped mRNAs by the central part of human eIF4G is 5' end-dependent. RNA (1998) 2.02
A region rich in aspartic acid, arginine, tyrosine, and glycine (DRYG) mediates eukaryotic initiation factor 4B (eIF4B) self-association and interaction with eIF3. Mol Cell Biol (1996) 2.01
Cleavage of Poly(A)-binding protein by coxsackievirus 2A protease in vitro and in vivo: another mechanism for host protein synthesis shutoff? J Virol (1999) 1.98
Eukaryotic translation initiation factor 4G is targeted for proteolytic cleavage by caspase 3 during inhibition of translation in apoptotic cells. Mol Cell Biol (1998) 1.97
The mitogen-activated protein kinase signal-integrating kinase Mnk2 is a eukaryotic initiation factor 4E kinase with high levels of basal activity in mammalian cells. Mol Cell Biol (2001) 1.93
A novel inhibitor of cap-dependent translation initiation in yeast: p20 competes with eIF4G for binding to eIF4E. EMBO J (1997) 1.92
DAP-5, a novel homolog of eukaryotic translation initiation factor 4G isolated as a putative modulator of gamma interferon-induced programmed cell death. Mol Cell Biol (1997) 1.90
Eukaryotic translation initiation factor 4AIII (eIF4AIII) is functionally distinct from eIF4AI and eIF4AII. Mol Cell Biol (1999) 1.85
Cleavage of poly(A)-binding protein by poliovirus 3C protease inhibits host cell translation: a novel mechanism for host translation shutoff. Mol Cell Biol (2004) 1.84
Computational modeling of eukaryotic mRNA turnover. RNA (2001) 1.79
Translation of polioviral mRNA is inhibited by cleavage of polypyrimidine tract-binding proteins executed by polioviral 3C(pro). J Virol (2002) 1.77
Eukaryotic translation initiation factor 3 (eIF3) and eIF2 can promote mRNA binding to 40S subunits independently of eIF4G in yeast. Mol Cell Biol (2006) 1.75
Translation initiation factor eIF4G-1 binds to eIF3 through the eIF3e subunit. J Biol Chem (2006) 1.74
Eukaryotic initiation factor 4GII (eIF4GII), but not eIF4GI, cleavage correlates with inhibition of host cell protein synthesis after human rhinovirus infection. J Virol (1999) 1.72
A novel form of DAP5 protein accumulates in apoptotic cells as a result of caspase cleavage and internal ribosome entry site-mediated translation. Mol Cell Biol (2000) 1.72
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The eukaryotic mRNA decapping protein Dcp1 interacts physically and functionally with the eIF4F translation initiation complex. EMBO J (2000) 1.70
Recognition of picornavirus internal ribosome entry sites within cells; influence of cellular and viral proteins. RNA (1998) 1.65
Regulation of gene expression by internal ribosome entry sites or cryptic promoters: the eIF4G story. Mol Cell Biol (2002) 1.64
Cooperative modulation by eIF4G of eIF4E-binding to the mRNA 5' cap in yeast involves a site partially shared by p20. EMBO J (1998) 1.63
Efficient cleavage of ribosome-associated poly(A)-binding protein by enterovirus 3C protease. J Virol (2002) 1.59
The proteolytic cleavage of eukaryotic initiation factor (eIF) 4G is prevented by eIF4E binding protein (PHAS-I; 4E-BP1) in the reticulocyte lysate. EMBO J (1997) 1.54
Direct functional interaction of initiation factor eIF4G with type 1 internal ribosomal entry sites. Proc Natl Acad Sci U S A (2009) 1.54
HSP101 functions as a specific translational regulatory protein whose activity is regulated by nutrient status. Genes Dev (1998) 1.52
Poly(A)-tail-promoted translation in yeast: implications for translational control. RNA (1998) 1.52
Picornavirus internal ribosome entry site elements target RNA cleavage events induced by the herpes simplex virus virion host shutoff protein. J Virol (1999) 1.52
Generation of multiple isoforms of eukaryotic translation initiation factor 4GI by use of alternate translation initiation codons. Mol Cell Biol (2002) 1.51
Interaction of the eIF4G initiation factor with the aphthovirus IRES is essential for internal translation initiation in vivo. RNA (2000) 1.51
Activity of the hepatitis A virus IRES requires association between the cap-binding translation initiation factor (eIF4E) and eIF4G. J Virol (2001) 1.50
Eukaryote-specific domains in translation initiation factors: implications for translation regulation and evolution of the translation system. Genome Res (2000) 1.48
The histone 3'-terminal stem-loop-binding protein enhances translation through a functional and physical interaction with eukaryotic initiation factor 4G (eIF4G) and eIF3. Mol Cell Biol (2002) 1.48
The yeast eukaryotic initiation factor 4G (eIF4G) HEAT domain interacts with eIF1 and eIF5 and is involved in stringent AUG selection. Mol Cell Biol (2003) 1.46
Calicivirus 3C-like proteinase inhibits cellular translation by cleavage of poly(A)-binding protein. J Virol (2004) 1.44
Characterization of a novel RNA-binding region of eIF4GI critical for ribosomal scanning. EMBO J (2003) 1.43
Truncated initiation factor eIF4G lacking an eIF4E binding site can support capped mRNA translation. EMBO J (2001) 1.41
Sum1, a component of the fission yeast eIF3 translation initiation complex, is rapidly relocalized during environmental stress and interacts with components of the 26S proteasome. Mol Biol Cell (2002) 1.41
Eukaryotic initiation factors 4G and 4A mediate conformational changes downstream of the initiation codon of the encephalomyocarditis virus internal ribosomal entry site. Mol Cell Biol (2003) 1.40
Eukaryotic translation initiation factors 4G and 4A from Saccharomyces cerevisiae interact physically and functionally. Mol Cell Biol (1999) 1.39
Essential role of NAT1/p97/DAP5 in embryonic differentiation and the retinoic acid pathway. EMBO J (2000) 1.39
Binding of eukaryotic translation initiation factor 4E (eIF4E) to eIF4G represses translation of uncapped mRNA. Mol Cell Biol (1997) 1.36
Poliovirus 2A protease induces apoptotic cell death. Mol Cell Biol (2000) 1.36
The 5'-7-methylguanosine cap on eukaryotic mRNAs serves both to stimulate canonical translation initiation and to block an alternative pathway. Mol Cell (2010) 1.35
Herpes simplex virus virion host shutoff protein is stimulated by translation initiation factors eIF4B and eIF4H. J Virol (2004) 1.35
Impaired binding of standard initiation factors mediates poliovirus translation attenuation. J Virol (2003) 1.33
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IRES interaction with translation initiation factors: functional characterization of novel RNA contacts with eIF3, eIF4B, and eIF4GII. RNA (2001) 1.30
HIV-1 protease cleaves eukaryotic initiation factor 4G and inhibits cap-dependent translation. Proc Natl Acad Sci U S A (2001) 1.30
p97/DAP5 is a ribosome-associated factor that facilitates protein synthesis and cell proliferation by modulating the synthesis of cell cycle proteins. EMBO J (2006) 1.28
SQT1, which encodes an essential WD domain protein of Saccharomyces cerevisiae, suppresses dominant-negative mutations of the ribosomal protein gene QSR1. Mol Cell Biol (1997) 1.28
Requirement of RNA binding of mammalian eukaryotic translation initiation factor 4GI (eIF4GI) for efficient interaction of eIF4E with the mRNA cap. Mol Cell Biol (2008) 1.27
'Ribozoomin'--translation initiation from the perspective of the ribosome-bound eukaryotic initiation factors (eIFs). Curr Protein Pept Sci (2012) 1.25
The 39-kilodalton subunit of eukaryotic translation initiation factor 3 is essential for the complex's integrity and for cell viability in Saccharomyces cerevisiae. Mol Cell Biol (1997) 1.25
Functional overlap between eIF4G isoforms in Saccharomyces cerevisiae. PLoS One (2010) 1.21
Cap-independent translation conferred by the 5' leader of tobacco etch virus is eukaryotic initiation factor 4G dependent. J Virol (2001) 1.19
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Identification of partners of TIF34, a component of the yeast eIF3 complex, required for cell proliferation and translation initiation. EMBO J (1997) 1.16
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