Proton currents in human granulocytes: regulation by membrane potential and intracellular pH.

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Published in J Physiol on July 01, 1993

Authors

N Demaurex1, S Grinstein, M Jaconi, W Schlegel, D P Lew, K H Krause

Author Affiliations

1: Infectious Diseases Division, University Hospital Geneva, Switzerland.

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Surveillance for rotavirus in Argentina. J Med Virol (2001) 1.47

A novel flagellar Ca2+-binding protein in trypanosomes. J Biol Chem (1989) 1.47

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