Published in J Biol Chem on April 25, 1980
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Size determination of an equilibrium enzymic system by radiation inactivation: theoretical considerations. Biochem J (1982) 1.16
Radiation inactivation of oligomeric enzyme systems: theoretical considerations. Proc Natl Acad Sci U S A (1984) 1.01
Qualitative abnormalities in insulin binding in a patient with extreme insulin resistance: decreased sensitivity to alterations in temperature and pH. Proc Natl Acad Sci U S A (1981) 0.96
Stimulation of glucose incorporation and amino acid transport by insulin and an insulin-like growth factor in fibroblasts with defective insulin receptors cultured from a patient with leprechaunism. Proc Natl Acad Sci U S A (1981) 0.95
Antibody against the insulin receptor causes disappearance of insulin receptors in 3T3-L1 cells: a possible explanation of antibody-induced insulin resistance. Proc Natl Acad Sci U S A (1984) 0.94
Determination of molecular mass of the aroid alternative oxidase by radiation-inactivation analysis. Biochem J (1988) 0.94
Evidence for distinct functional molecular sizes of carnitine palmitoyltransferases I and II in rat liver mitochondria. Biochem J (1988) 0.92
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Defect in cooperativity in insulin receptors from a patient with a congenital form of extreme insulin resistance. J Clin Invest (1983) 0.88
Functional unit of the low density lipoprotein receptor of fibroblasts: a 100,000-dalton structure with multiple binding sites. Proc Natl Acad Sci U S A (1981) 0.87
Mouse macrophage receptor for acetylated low density lipoprotein: demonstration of a fully functional subunit in the membrane and with purified receptor. Proc Natl Acad Sci U S A (1992) 0.81
The structure of the hepatic insulin receptor and insulin binding. Biochem J (1986) 0.80
Simulation of an inhibitory equilibrium system. Aberrant proteinic target sizes as obtained by radiation inactivation. Biochem J (1984) 0.79
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Alternative pathway of insulin signalling in mice with targeted disruption of the IRS-1 gene. Nature (1994) 6.50
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Insulin stimulates tyrosine phosphorylation of the insulin receptor in a cell-free system. Nature (1982) 3.90
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Insulin rapidly stimulates tyrosine phosphorylation of a Mr-185,000 protein in intact cells. Nature (1985) 3.57
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Targeted disruption of the glucose transporter 4 selectively in muscle causes insulin resistance and glucose intolerance. Nat Med (2000) 3.53
The changing natural history of nephropathy in type I diabetes. Am J Med (1985) 3.50
Identification of the gene altered in Berardinelli-Seip congenital lipodystrophy on chromosome 11q13. Nat Genet (2001) 3.50
Protein-protein interaction in insulin signaling and the molecular mechanisms of insulin resistance. J Clin Invest (1999) 3.36
Direct demonstration that receptor crosslinking or aggregation is important in insulin action. Proc Natl Acad Sci U S A (1978) 3.15
A physiological role for titin and nebulin in skeletal muscle. Nature (1986) 3.15
beta-cell-specific deletion of the Igf1 receptor leads to hyperinsulinemia and glucose intolerance but does not alter beta-cell mass. Nat Genet (2002) 3.12
Quantitative aspects of the insulin-receptor interaction in liver plasma membranes. J Biol Chem (1974) 3.04
Tissue-specific insulin resistance in mice with mutations in the insulin receptor, IRS-1, and IRS-2. J Clin Invest (2000) 3.01
Antibodies that impair insulin receptor binding in an unusual diabetic syndrome with severe insulin resistance. Science (1975) 2.97
Bidirectional modulation of insulin action by amino acids. J Clin Invest (1998) 2.92
A cascade of tyrosine autophosphorylation in the beta-subunit activates the phosphotransferase of the insulin receptor. J Biol Chem (1988) 2.90
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Insulin-receptor interaction in the obese-hyperglycemic mouse. A model of insulin resistance. J Biol Chem (1973) 2.80
Redistribution of substrates to adipose tissue promotes obesity in mice with selective insulin resistance in muscle. J Clin Invest (2000) 2.75
Size determination of enzymes by radiation inactivation. Anal Biochem (1979) 2.66
Correlation between CT numbers and tissue parameters needed for Monte Carlo simulations of clinical dose distributions. Phys Med Biol (2000) 2.65
Insulin stimulation of phosphorylation of the beta subunit of the insulin receptor. Formation of both phosphoserine and phosphotyrosine. J Biol Chem (1982) 2.58
Dilated cardiomyopathy and atrioventricular conduction blocks induced by heart-specific inactivation of mitochondrial DNA gene expression. Nat Genet (1999) 2.57
Rad: a member of the Ras family overexpressed in muscle of type II diabetic humans. Science (1993) 2.57
Tyrosine-specific protein kinase activity is associated with the purified insulin receptor. Proc Natl Acad Sci U S A (1983) 2.49
Altered function of insulin receptor substrate-1-deficient mouse islets and cultured beta-cell lines. J Clin Invest (1999) 2.48
125I-insulin binding to cultured human lymphocytes. Initial localization and fate of hormone determined by quantitative electron microscopic autoradiography. J Clin Invest (1978) 2.47
Evidence for a circulating islet cell growth factor in insulin-resistant states. Proc Natl Acad Sci U S A (2001) 2.44
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Regulation of insulin receptor substrate-1 in liver and muscle of animal models of insulin resistance. J Clin Invest (1992) 2.31
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Differences in risk of insulin-dependent diabetes in offspring of diabetic mothers and diabetic fathers. N Engl J Med (1984) 2.26
Decreased muscle glucose transport/phosphorylation is an early defect in the pathogenesis of non-insulin-dependent diabetes mellitus. Proc Natl Acad Sci U S A (1995) 2.25
Adenosine analogs inhibit adipocyte adenylate cyclase by a GTP-dependent process: basis for actions of adenosine and methylxanthines on cyclic AMP production and lipolysis. Proc Natl Acad Sci U S A (1978) 2.24
Insulin-induced receptor loss in cultured human lymphocytes is due to accelerated receptor degradation. Proc Natl Acad Sci U S A (1981) 2.18
Direct demonstration of separate receptors for growth and metabolic activities of insulin and multiplication-stimulating activity (an insulinlike growth factor) using antibodies to the insulin receptor. J Clin Invest (1980) 2.15
Essential role of insulin receptor substrate 1 in differentiation of brown adipocytes. Mol Cell Biol (2001) 2.14
beta(3)-adrenergic stimulation differentially inhibits insulin signaling and decreases insulin-induced glucose uptake in brown adipocytes. J Biol Chem (1999) 2.13
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Differential regulation of insulin receptor substrates-1 and -2 (IRS-1 and IRS-2) and phosphatidylinositol 3-kinase isoforms in liver and muscle of the obese diabetic (ob/ob) mouse. J Clin Invest (1997) 2.11
Phorbol esters modulate insulin receptor phosphorylation and insulin action in cultured hepatoma cells. Proc Natl Acad Sci U S A (1984) 2.09
Insulin stimulation of phosphatidylinositol 3-kinase activity and association with insulin receptor substrate 1 in liver and muscle of the intact rat. J Biol Chem (1992) 2.06
Mutation of the insulin receptor at tyrosine 960 inhibits signal transmission but does not affect its tyrosine kinase activity. Cell (1988) 2.06
MKP-3, a novel cytosolic protein-tyrosine phosphatase that exemplifies a new class of mitogen-activated protein kinase phosphatase. J Biol Chem (1996) 2.03
Differential signaling by insulin receptor substrate 1 (IRS-1) and IRS-2 in IRS-1-deficient cells. Mol Cell Biol (1997) 2.02
Multiple elevations of cytosolic-free Ca2+ in human neutrophils: initiation by adherence receptors of the integrin family. J Cell Biol (1991) 2.02
Glucose toxicity and the development of diabetes in mice with muscle-specific inactivation of GLUT4. J Clin Invest (2001) 2.01
Receptors and growth-promoting effects of insulin and insulinlike growth factors on cells from bovine retinal capillaries and aorta. J Clin Invest (1985) 2.00
Expression and function of IRS-1 in insulin signal transmission. J Biol Chem (1992) 1.98
Obesity associated with a mutation in a genetic regulator of adipocyte differentiation. N Engl J Med (1998) 1.93
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Angiotensin II inhibits insulin signaling in aortic smooth muscle cells at multiple levels. A potential role for serine phosphorylation in insulin/angiotensin II crosstalk. J Clin Invest (1997) 1.88
Effects of autoantibodies to the insulin receptor on isolated adipocytes. Studies of insulin binding and insulin action. J Clin Invest (1977) 1.85
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Demonstration that monocytes rather than lymphocytes are the insulin-binding cells in preparations of humah peripheral blood mononuclear leukocytes: implications for studies of insulin-resistant states in man. Proc Natl Acad Sci U S A (1975) 1.83
Glucose and carbachol generate 1,2-diacylglycerols by different mechanisms in pancreatic islets. J Clin Invest (1988) 1.82
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Insulin receptor deficiency in genetic and acquired obesity. J Clin Invest (1975) 1.79
Characterization of antibodies to the insulin receptor: a cause of insulin-resistant diabetes in man. J Clin Invest (1976) 1.74
Phorbol ester-induced serine phosphorylation of the insulin receptor decreases its tyrosine kinase activity. J Biol Chem (1988) 1.74
Activation of adenylate cyclase in hepatic membranes involves interactions of the catalytic unit with multimeric complexes of regulatory proteins. J Biol Chem (1979) 1.72
Intraoperative diagnostic and interventional magnetic resonance imaging in neurosurgery. Neurosurgery (1997) 1.69
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Insulin receptors, receptor antibodies, and the mechanism of insulin action. Recent Prog Horm Res (1981) 1.68
Essential role of insulin receptor substrate-2 in insulin stimulation of Glut4 translocation and glucose uptake in brown adipocytes. J Biol Chem (2000) 1.67
Selective insulin signaling through A and B insulin receptors regulates transcription of insulin and glucokinase genes in pancreatic beta cells. Mol Cell (2001) 1.65
Positive and negative regulation of phosphoinositide 3-kinase-dependent signaling pathways by three different gene products of the p85alpha regulatory subunit. Mol Cell Biol (2000) 1.65
Direct demonstration of glycosylation of insulin receptor subunits by biosynthetic and external labeling: evidence for heterogeneity. Proc Natl Acad Sci U S A (1981) 1.64
Characterization of insulin-mediated phosphorylation of the insulin receptor in a cell-free system. J Biol Chem (1983) 1.62
Biosynthesis and glycosylation of the insulin receptor. Evidence for a single polypeptide precursor of the two major subunits. J Biol Chem (1983) 1.62
Purification and partial sequence analysis of pp185, the major cellular substrate of the insulin receptor tyrosine kinase. J Biol Chem (1991) 1.62
Modulation of insulin receptor, insulin receptor substrate-1, and phosphatidylinositol 3-kinase in liver and muscle of dexamethasone-treated rats. J Clin Invest (1993) 1.61
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Proton currents in human granulocytes: regulation by membrane potential and intracellular pH. J Physiol (1993) 1.56
Kinetic properties and sites of autophosphorylation of the partially purified insulin receptor from hepatoma cells. J Biol Chem (1984) 1.56
A model to explore the interaction between muscle insulin resistance and beta-cell dysfunction in the development of type 2 diabetes. Diabetes (2000) 1.55