CREB: a mediator of long-term memory from mollusks to mammals.

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Published in Cell on October 07, 1994

Authors

D A Frank1, M E Greenberg

Author Affiliations

1: Department of Neurology, Children's Hospital, Boston, Massachusetts 02115.

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Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor. Cell (1999) 32.32

Stimulation of 3T3 cells induces transcription of the c-fos proto-oncogene. Nature (1984) 24.45

Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery. Cell (1997) 21.42

Opposing effects of ERK and JNK-p38 MAP kinases on apoptosis. Science (1995) 17.76

Cellular survival: a play in three Akts. Genes Dev (1999) 17.05

Regulation of neuronal survival by the serine-threonine protein kinase Akt. Science (1997) 11.48

CREB: a stimulus-induced transcription factor activated by a diverse array of extracellular signals. Annu Rev Biochem (1999) 7.94

Two distinct destabilizing elements in the c-fos message trigger deadenylation as a first step in rapid mRNA decay. Genes Dev (1991) 7.51

Cell survival promoted by the Ras-MAPK signaling pathway by transcription-dependent and -independent mechanisms. Science (1999) 7.37

Huntingtin acts in the nucleus to induce apoptosis but death does not correlate with the formation of intranuclear inclusions. Cell (1998) 7.13

The c-fos transcript is targeted for rapid decay by two distinct mRNA degradation pathways. Genes Dev (1989) 7.03

c-Jun dimerizes with itself and with c-Fos, forming complexes of different DNA binding affinities. Cell (1988) 6.24

Protein kinase SGK mediates survival signals by phosphorylating the forkhead transcription factor FKHRL1 (FOXO3a). Mol Cell Biol (2001) 5.78

E2F-1 functions in mice to promote apoptosis and suppress proliferation. Cell (1996) 5.26

The regulation and function of c-fos and other immediate early genes in the nervous system. Neuron (1990) 5.19

Effect of protein synthesis inhibitors on growth factor activation of c-fos, c-myc, and actin gene transcription. Mol Cell Biol (1986) 5.07

Ca2+ influx regulates BDNF transcription by a CREB family transcription factor-dependent mechanism. Neuron (1998) 5.05

Coupling of the RAS-MAPK pathway to gene activation by RSK2, a growth factor-regulated CREB kinase. Science (1996) 4.96

Nerve growth factor and epidermal growth factor induce rapid transient changes in proto-oncogene transcription in PC12 cells. J Biol Chem (1985) 4.87

Signaling to the nucleus by an L-type calcium channel-calmodulin complex through the MAP kinase pathway. Science (2001) 4.81

A critical role for DNA end-joining proteins in both lymphogenesis and neurogenesis. Cell (1998) 4.78

The nonamer UUAUUUAUU is the key AU-rich sequence motif that mediates mRNA degradation. Mol Cell Biol (1995) 4.76

A cytoplasmic inhibitor of the JNK signal transduction pathway. Science (1997) 4.56

CREB: a Ca(2+)-regulated transcription factor phosphorylated by calmodulin-dependent kinases. Science (1991) 4.53

Transcription-dependent and -independent control of neuronal survival by the PI3K-Akt signaling pathway. Curr Opin Neurobiol (2001) 4.43

The E2F1-3 transcription factors are essential for cellular proliferation. Nature (2001) 4.37

EphB receptors interact with NMDA receptors and regulate excitatory synapse formation. Cell (2000) 4.34

Calcium regulation of neuronal gene expression. Proc Natl Acad Sci U S A (2001) 4.31

Regulation of gliogenesis in the central nervous system by the JAK-STAT signaling pathway. Science (1997) 4.26

Calcium signaling in neurons: molecular mechanisms and cellular consequences. Science (1995) 4.25

Calcium influx via the NMDA receptor induces immediate early gene transcription by a MAP kinase/ERK-dependent mechanism. J Neurosci (1996) 4.21

14-3-3 proteins and survival kinases cooperate to inactivate BAD by BH3 domain phosphorylation. Mol Cell (2000) 4.05

Regulation of gene expression in hippocampal neurons by distinct calcium signaling pathways. Science (1993) 3.71

Membrane depolarization and calcium induce c-fos transcription via phosphorylation of transcription factor CREB. Neuron (1990) 3.70

Mutation of the c-fos gene dyad symmetry element inhibits serum inducibility of transcription in vivo and the nuclear regulatory factor binding in vitro. Mol Cell Biol (1987) 3.53

Nerve growth factor activates a Ras-dependent protein kinase that stimulates c-fos transcription via phosphorylation of CREB. Cell (1994) 3.30

EphA receptors regulate growth cone dynamics through the novel guanine nucleotide exchange factor ephexin. Cell (2001) 3.20

Neuronal activity-dependent cell survival mediated by transcription factor MEF2. Science (1999) 3.19

CREB: a major mediator of neuronal neurotrophin responses. Neuron (1997) 3.04

Regulation of CREB phosphorylation in the suprachiasmatic nucleus by light and a circadian clock. Science (1993) 3.03

Intracellular signaling pathways activated by neurotrophic factors. Annu Rev Neurosci (1996) 2.98

Neurogenin promotes neurogenesis and inhibits glial differentiation by independent mechanisms. Cell (2001) 2.93

Distinct roles for bFGF and NT-3 in the regulation of cortical neurogenesis. Neuron (1995) 2.90

Requirement for BDNF in activity-dependent survival of cortical neurons. Science (1994) 2.64

Calcium activation of Ras mediated by neuronal exchange factor Ras-GRF. Nature (1995) 2.47

Stimulation of neuronal acetylcholine receptors induces rapid gene transcription. Science (1986) 2.43

Calcium and growth factor pathways of c-fos transcriptional activation require distinct upstream regulatory sequences. Mol Cell Biol (1988) 2.40

Membrane depolarization and calcium influx stimulate MEK and MAP kinase via activation of Ras. Neuron (1994) 2.34

Myc requires distinct E2F activities to induce S phase and apoptosis. Mol Cell (2001) 2.29

Growth factors and membrane depolarization activate distinct programs of early response gene expression: dissociation of fos and jun induction. Genes Dev (1989) 2.17

Stimulation of protein tyrosine phosphorylation by NMDA receptor activation. Science (1991) 2.17

A growth factor-induced kinase phosphorylates the serum response factor at a site that regulates its DNA-binding activity. Mol Cell Biol (1993) 2.15

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Mutation of E2F2 in mice causes enhanced T lymphocyte proliferation, leading to the development of autoimmunity. Immunity (2001) 2.09

The inner core of the serum response element mediates both the rapid induction and subsequent repression of c-fos transcription following serum stimulation. Genes Dev (1990) 2.03

FosB mutant mice: loss of chronic cocaine induction of Fos-related proteins and heightened sensitivity to cocaine's psychomotor and rewarding effects. Proc Natl Acad Sci U S A (1997) 1.98

Beta-amyloid induces neuronal apoptosis via a mechanism that involves the c-Jun N-terminal kinase pathway and the induction of Fas ligand. J Neurosci (2001) 1.93

Multiple elements in the c-fos protein-coding region facilitate mRNA deadenylation and decay by a mechanism coupled to translation. J Biol Chem (1994) 1.90

The 34 kd pp60src substrate is located at the inner face of the plasma membrane. Cell (1983) 1.84

Regulation of proto-oncogene mRNA stability. Biochim Biophys Acta (1992) 1.84

Targeting of nonexpressed genes in embryonic stem cells via homologous recombination. Science (1989) 1.75

Growth factor-induced gene expression: the ups and downs of c-fos regulation. New Biol (1990) 1.72

Serine 133-phosphorylated CREB induces transcription via a cooperative mechanism that may confer specificity to neurotrophin signals. Mol Cell Neurosci (1995) 1.68

A defect in nurturing in mice lacking the immediate early gene fosB. Cell (1996) 1.63

Fos family members induce cell cycle entry by activating cyclin D1. Mol Cell Biol (1998) 1.61

Calcium regulation of gene expression in neuronal cells. J Neurobiol (1994) 1.57

Characterization of the protein kinase activity of avian sarcoma virus src gene product. Proc Natl Acad Sci U S A (1979) 1.46

Calcium activates serum response factor-dependent transcription by a Ras- and Elk-1-independent mechanism that involves a Ca2+/calmodulin-dependent kinase. Mol Cell Biol (1995) 1.46

Two elements target SIV Nef to the AP-2 clathrin adaptor complex, but only one is required for the induction of CD4 endocytosis. EMBO J (1999) 1.45

Activating transcription factor-1 can mediate Ca(2+)- and cAMP-inducible transcriptional activation. J Biol Chem (1993) 1.39

Characterization of a pathway for ciliary neurotrophic factor signaling to the nucleus. Science (1993) 1.37

The destabilizing elements in the coding region of c-fos mRNA are recognized as RNA. Mol Cell Biol (1993) 1.34

Interleukin 2 signaling involves the phosphorylation of Stat proteins. Proc Natl Acad Sci U S A (1995) 1.32

Structure and modulation of neural cell adhesion molecules in early and late embryogenesis. Cold Spring Harb Symp Quant Biol (1983) 1.32

Ca2+ channel-regulated neuronal gene expression. J Neurobiol (1998) 1.30

14-3-3 inhibits Bad-induced cell death through interaction with serine-136. Mol Pharmacol (2001) 1.27

Growth and differentiation of embryonic stem cells that lack an intact c-fos gene. Proc Natl Acad Sci U S A (1992) 1.25

Essential role of the fosB gene in molecular, cellular, and behavioral actions of chronic electroconvulsive seizures. J Neurosci (1998) 1.24

Changes in the distribution of the 34-kdalton tyrosine kinase substrate during differentiation and maturation of chicken tissues. J Cell Biol (1984) 1.22

Serum- and glucocorticoid-inducible kinase SGK phosphorylates and negatively regulates B-Raf. J Biol Chem (2001) 1.21

The serum response factor is extensively modified by phosphorylation following its synthesis in serum-stimulated fibroblasts. Mol Cell Biol (1991) 1.21

N-methyl-D-aspartate receptors are critical for mediating the effects of glutamate on intracellular calcium concentration and immediate early gene expression in cultured hippocampal neurons. Neuroscience (1995) 1.20

Stimulation of growth factor receptor signal transduction by activation of voltage-sensitive calcium channels. Proc Natl Acad Sci U S A (1996) 1.20

Alternative modes of c-myc regulation in growth factor-stimulated and differentiating cells. Oncogene (1987) 1.19

Comparison of the 34,000-Da pp60src substrate and a 38,000-Da phosphoprotein identified by monoclonal antibodies. J Biol Chem (1983) 1.19

Nur77 is differentially modified in PC12 cells upon membrane depolarization and growth factor treatment. Mol Cell Biol (1991) 1.18

Increased phosphorylation of tyrosine in vinculin does not occur upon transformation by some avian sarcoma viruses. Mol Cell Biol (1985) 1.18

Ca(2+)-dependent routes to Ras: mechanisms for neuronal survival, differentiation, and plasticity? Neuron (1996) 1.12

Magnitude of the CREB-dependent transcriptional response is determined by the strength of the interaction between the kinase-inducible domain of CREB and the KIX domain of CREB-binding protein. Mol Cell Biol (2000) 1.11

L-type voltage-sensitive calcium channel activation stimulates gene expression by a serum response factor-dependent pathway. J Biol Chem (1994) 1.10

Calcium regulation of gene expression in neurons: the mode of entry matters. Curr Opin Neurobiol (1995) 1.09

L-type voltage-sensitive Ca2+ channel activation regulates c-fos transcription at multiple levels. J Biol Chem (1995) 1.08

Orchestral maneuvers in the axon: trio and the control of axon guidance. Cell (2000) 1.08

Regulation of cyclic AMP response element-binding protein (CREB) phosphorylation by acute and chronic morphine in the rat locus coeruleus. J Neurochem (1992) 1.06

A kinase to remember: dual roles for MAP kinase in long-term memory. Neuron (1997) 1.06

Phenotypic changes and loss of N-CAM-mediated adhesion in transformed embryonic chicken retinal cells. J Cell Biol (1984) 1.05

Calcium phosphate transfection of DNA into neurons in primary culture. Curr Protoc Neurosci (2001) 1.03

Nonhomologous end-joining proteins are required for V(D)J recombination, normal growth, and neurogenesis. Cold Spring Harb Symp Quant Biol (1999) 1.00

HIV and SIV Nef modulate signal transduction and protein sorting in T cells. Cold Spring Harb Symp Quant Biol (1999) 0.96

Alteration of neural cell adhesion molecule (N-CAM) expression after neuronal cell transformation by Rous sarcoma virus. Proc Natl Acad Sci U S A (1984) 0.96