Published in Proc Natl Acad Sci U S A on October 31, 2006
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Overlapping roles and collective requirement for the coreceptors GAS1, CDO, and BOC in SHH pathway function. Dev Cell (2011) 1.77
Boc and Gas1 each form distinct Shh receptor complexes with Ptch1 and are required for Shh-mediated cell proliferation. Dev Cell (2011) 1.55
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Genetic and biochemical definition of the Hedgehog receptor. Genes Dev (2010) 1.47
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Sulfation of chondroitin sulfate proteoglycans is necessary for proper Indian hedgehog signaling in the developing growth plate. Development (2009) 1.27
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All mammalian Hedgehog proteins interact with cell adhesion molecule, down-regulated by oncogenes (CDO) and brother of CDO (BOC) in a conserved manner. J Biol Chem (2010) 1.17
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Dual roles of the Cardin-Weintraub motif in multimeric Sonic hedgehog. J Biol Chem (2011) 0.84
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Crystal structure of a hemojuvelin-binding fragment of neogenin at 1.8Å. J Struct Biol (2010) 0.83
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New components of Drosophila leg development identified through genome wide association studies. PLoS One (2013) 0.78
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Design and characterization of a photo-activatable hedgehog probe that mimics the natural lipidated form. Arch Biochem Biophys (2014) 0.75
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Patched acts catalytically to suppress the activity of Smoothened. Nature (2002) 4.69
Lipoprotein particles are required for Hedgehog and Wingless signalling. Nature (2005) 4.38
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Identification of Hedgehog pathway components by RNAi in Drosophila cultured cells. Science (2003) 3.63
The ihog cell-surface proteins bind Hedgehog and mediate pathway activation. Cell (2006) 2.92
The cell surface membrane proteins Cdo and Boc are components and targets of the Hedgehog signaling pathway and feedback network in mice. Dev Cell (2006) 2.62
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Cdo functions at multiple points in the Sonic Hedgehog pathway, and Cdo-deficient mice accurately model human holoprosencephaly. Dev Cell (2006) 2.13
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An optimized system for expression and purification of secreted bacterial proteins. Protein Expr Purif (2005) 1.96
A potential catalytic site revealed by the 1.7-A crystal structure of the amino-terminal signalling domain of Sonic hedgehog. Nature (1995) 1.95
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Hedgehog acts as a somatic stem cell factor in the Drosophila ovary. Nature (2001) 1.89
Structural analysis of glycosaminoglycans in Drosophila and Caenorhabditis elegans and demonstration that tout-velu, a Drosophila gene related to EXT tumor suppressors, affects heparan sulfate in vivo. J Biol Chem (2000) 1.89
Hedgehog movement is regulated through tout velu-dependent synthesis of a heparan sulfate proteoglycan. Mol Cell (1999) 1.84
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The glypican Dally-like is required for Hedgehog signalling in the embryonic epidermis of Drosophila. Development (2003) 1.55
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Inhibition of Hedgehog signaling by direct binding of cyclopamine to Smoothened. Genes Dev (2002) 8.56
Widespread requirement for Hedgehog ligand stimulation in growth of digestive tract tumours. Nature (2003) 8.14
Hedgehog signalling in prostate regeneration, neoplasia and metastasis. Nature (2004) 6.82
Structure of the extracellular region of HER2 alone and in complex with the Herceptin Fab. Nature (2003) 6.78
Small molecule modulation of Smoothened activity. Proc Natl Acad Sci U S A (2002) 6.55
Medulloblastoma growth inhibition by hedgehog pathway blockade. Science (2002) 6.53
Insights into ErbB signaling from the structure of the ErbB2-pertuzumab complex. Cancer Cell (2004) 6.12
Hedgehog signalling within airway epithelial progenitors and in small-cell lung cancer. Nature (2003) 6.07
Minimizing the risk of reporting false positives in large-scale RNAi screens. Nat Methods (2006) 5.96
The Hedgehog response network: sensors, switches, and routers. Science (2004) 5.20
Functionally significant insulin-like growth factor I receptor mutations in centenarians. Proc Natl Acad Sci U S A (2008) 5.14
An open-and-shut case? Recent insights into the activation of EGF/ErbB receptors. Mol Cell (2003) 5.06
Hedgehog signalling is essential for maintenance of cancer stem cells in myeloid leukaemia. Nature (2009) 4.99
Epidermal growth factor receptor activation in glioblastoma through novel missense mutations in the extracellular domain. PLoS Med (2006) 4.63
Disruption of the basal body compromises proteasomal function and perturbs intracellular Wnt response. Nat Genet (2007) 4.24
Complement evasion by human pathogens. Nat Rev Microbiol (2008) 4.24
EGF activates its receptor by removing interactions that autoinhibit ectodomain dimerization. Mol Cell (2003) 4.23
Sae2 is an endonuclease that processes hairpin DNA cooperatively with the Mre11/Rad50/Xrs2 complex. Mol Cell (2007) 3.86
Identification of Hedgehog pathway components by RNAi in Drosophila cultured cells. Science (2003) 3.63
Prevalence of off-target effects in Drosophila RNA interference screens. Nature (2006) 3.38
Hedgehog signaling maintains a tumor stem cell compartment in multiple myeloma. Proc Natl Acad Sci U S A (2007) 3.23
Structure of the extracellular region of HER3 reveals an interdomain tether. Science (2002) 3.19
Hedgehog/Wnt feedback supports regenerative proliferation of epithelial stem cells in bladder. Nature (2011) 3.15
Mechanism of activation and inhibition of the HER4/ErbB4 kinase. Structure (2008) 2.79
Structure of human RNase H1 complexed with an RNA/DNA hybrid: insight into HIV reverse transcription. Mol Cell (2007) 2.71
ATP control of dynamic P1 ParA-DNA interactions: a key role for the nucleoid in plasmid partition. Mol Microbiol (2010) 2.65
Itraconazole and arsenic trioxide inhibit Hedgehog pathway activation and tumor growth associated with acquired resistance to smoothened antagonists. Cancer Cell (2013) 2.62
Recorded scan times can limit the accuracy of sedimentation coefficients in analytical ultracentrifugation. Anal Biochem (2013) 2.57
Itraconazole, a commonly used antifungal that inhibits Hedgehog pathway activity and cancer growth. Cancer Cell (2010) 2.54
Transmembrane/juxtamembrane domain-dependent Dscam distribution and function during mushroom body neuronal morphogenesis. Neuron (2004) 2.44
Gli2 trafficking links Hedgehog-dependent activation of Smoothened in the primary cilium to transcriptional activation in the nucleus. Proc Natl Acad Sci U S A (2009) 2.43
Novel lipid modifications of secreted protein signals. Annu Rev Biochem (2004) 2.37
A defective response to Hedgehog signaling in disorders of cholesterol biosynthesis. Nat Genet (2003) 2.29
Mechanism of ubiquitin recognition by the CUE domain of Vps9p. Cell (2003) 2.25
Midbody targeting of the ESCRT machinery by a noncanonical coiled coil in CEP55. Science (2008) 2.23
Molecular architecture and functional model of the complete yeast ESCRT-I heterotetramer. Cell (2007) 2.21
Activity-dependent internalization of smoothened mediated by beta-arrestin 2 and GRK2. Science (2004) 2.19
Glucose and weight control in mice with a designed ghrelin O-acyltransferase inhibitor. Science (2010) 2.12
The TLR3 signaling complex forms by cooperative receptor dimerization. Proc Natl Acad Sci U S A (2008) 2.06
A genomewide screen for components of the RNAi pathway in Drosophila cultured cells. Proc Natl Acad Sci U S A (2006) 2.04
Hedgehog signal transduction via Smoothened association with a cytoplasmic complex scaffolded by the atypical kinesin, Costal-2. Mol Cell (2003) 2.02
Arsenic antagonizes the Hedgehog pathway by preventing ciliary accumulation and reducing stability of the Gli2 transcriptional effector. Proc Natl Acad Sci U S A (2010) 2.00
A conserved mechanism for centromeric nucleosome recognition by centromere protein CENP-C. Science (2013) 2.00
Structural basis for recognition of centromere histone variant CenH3 by the chaperone Scm3. Nature (2011) 1.99
A structural basis for complement inhibition by Staphylococcus aureus. Nat Immunol (2007) 1.95
Characterization of neuropilin-1 structural features that confer binding to semaphorin 3A and vascular endothelial growth factor 165. J Biol Chem (2002) 1.89
Lipid-regulated sterol transfer between closely apposed membranes by oxysterol-binding protein homologues. J Cell Biol (2009) 1.88
Open-label, exploratory phase II trial of oral itraconazole for the treatment of basal cell carcinoma. J Clin Oncol (2014) 1.86
Hedgehog-responsive candidate cell of origin for diffuse intrinsic pontine glioma. Proc Natl Acad Sci U S A (2011) 1.86
The extracellular region of ErbB4 adopts a tethered conformation in the absence of ligand. Proc Natl Acad Sci U S A (2005) 1.84
Scube/You activity mediates release of dually lipid-modified Hedgehog signal in soluble form. Genes Dev (2012) 1.84
Oxysterols are novel activators of the hedgehog signaling pathway in pluripotent mesenchymal cells. J Biol Chem (2007) 1.83
Mechanistic insights into active site-associated polyubiquitination by the ubiquitin-conjugating enzyme Ube2g2. Proc Natl Acad Sci U S A (2009) 1.82
Extensive phosphorylation of Smoothened in Hedgehog pathway activation. Proc Natl Acad Sci U S A (2004) 1.81
Hedgehog-mediated patterning of the mammalian embryo requires transporter-like function of dispatched. Cell (2002) 1.77
Structure and Notch receptor binding of the tandem WWE domain of Deltex. Structure (2005) 1.76
Dystroglycan organizes axon guidance cue localization and axonal pathfinding. Neuron (2012) 1.76
Interaction of yeast RNA-binding proteins Nrd1 and Nab3 with RNA polymerase II terminator elements. RNA (2007) 1.72
Atomic-resolution dynamics on the surface of amyloid-β protofibrils probed by solution NMR. Nature (2011) 1.70
Structural basis for ligand and heparin binding to neuropilin B domains. Proc Natl Acad Sci U S A (2007) 1.66
FK506 activates BMPR2, rescues endothelial dysfunction, and reverses pulmonary hypertension. J Clin Invest (2013) 1.65
Molecular architecture of a eukaryotic DNA transposase. Nat Struct Mol Biol (2005) 1.64
Structure of the MutL C-terminal domain: a model of intact MutL and its roles in mismatch repair. EMBO J (2004) 1.61
Patterning axon targeting of olfactory receptor neurons by coupled hedgehog signaling at two distinct steps. Cell (2010) 1.57
Design of a novel peptide inhibitor of HIV fusion that disrupts the internal trimeric coiled-coil of gp41. J Biol Chem (2002) 1.57
Interactions between Hedgehog proteins and their binding partners come into view. Genes Dev (2010) 1.54
Structure and stability of the ankyrin domain of the Drosophila Notch receptor. Protein Sci (2003) 1.54
Solution structure of the 128 kDa enzyme I dimer from Escherichia coli and its 146 kDa complex with HPr using residual dipolar couplings and small- and wide-angle X-ray scattering. J Am Chem Soc (2010) 1.53
Efficient secretion of a folded protein domain by a monomeric bacterial autotransporter. Mol Microbiol (2005) 1.53
Regulation of Mre11/Rad50 by Nbs1: effects on nucleotide-dependent DNA binding and association with ataxia-telangiectasia-like disorder mutant complexes. J Biol Chem (2003) 1.52
Structural and functional organization of the ESCRT-I trafficking complex. Cell (2006) 1.51
Roles for Hedgehog signaling in androgen production and prostate ductal morphogenesis. Dev Biol (2004) 1.50
Acyldepsipeptide antibiotics induce the formation of a structured axial channel in ClpP: A model for the ClpX/ClpA-bound state of ClpP. Chem Biol (2010) 1.48
Mutational analysis of Norrin-Frizzled4 recognition. J Biol Chem (2006) 1.48
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Defective cerebellar response to mitogenic Hedgehog signaling in Down [corrected] syndrome mice. Proc Natl Acad Sci U S A (2006) 1.47
The mode of Hedgehog binding to Ihog homologues is not conserved across different phyla. Nature (2008) 1.47
Crystal structure of the CaV2 IQ domain in complex with Ca2+/calmodulin: high-resolution mechanistic implications for channel regulation by Ca2+. Structure (2008) 1.44
RAD51AP1 is a structure-specific DNA binding protein that stimulates joint molecule formation during RAD51-mediated homologous recombination. Mol Cell (2007) 1.43
Active site sharing and subterminal hairpin recognition in a new class of DNA transposases. Mol Cell (2005) 1.42
Structural basis for DNA bridging by barrier-to-autointegration factor. Nat Struct Mol Biol (2005) 1.41
Overview of current methods in sedimentation velocity and sedimentation equilibrium analytical ultracentrifugation. Curr Protoc Protein Sci (2013) 1.41
Molecular mechanisms of Sonic hedgehog mutant effects in holoprosencephaly. Proc Natl Acad Sci U S A (2005) 1.40
Structural basis for recruitment of the adaptor protein APS to the activated insulin receptor. Mol Cell (2003) 1.38
The dynamin-like GTPase Sey1p mediates homotypic ER fusion in S. cerevisiae. J Cell Biol (2012) 1.38
Netrin binds discrete subdomains of DCC and UNC5 and mediates interactions between DCC and heparin. J Biol Chem (2003) 1.37
Allosteric inhibition of complement function by a staphylococcal immune evasion protein. Proc Natl Acad Sci U S A (2010) 1.37
The crystal structures of EAP domains from Staphylococcus aureus reveal an unexpected homology to bacterial superantigens. J Biol Chem (2005) 1.37
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Two 14-3-3 binding motifs are required for stable association of Forkhead transcription factor FOXO4 with 14-3-3 proteins and inhibition of DNA binding. Biochemistry (2003) 1.35
Solution NMR structure of the barrier-to-autointegration factor-Emerin complex. J Biol Chem (2007) 1.34
Characterization of Ehp, a secreted complement inhibitory protein from Staphylococcus aureus. J Biol Chem (2007) 1.32
Identification of a cKit(+) colonic crypt base secretory cell that supports Lgr5(+) stem cells in mice. Gastroenterology (2012) 1.32
Structure of colicin I receptor bound to the R-domain of colicin Ia: implications for protein import. EMBO J (2007) 1.27