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B Müller-Hill

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Top papers

Rank Title Journal Year PubWeight™‹?›
1 Filamentous coliphage M13 as a cloning vehicle: insertion of a HindII fragment of the lac regulatory region in M13 replicative form in vitro. Proc Natl Acad Sci U S A 1977 18.85
2 The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor. Nature 1987 17.08
3 Isolation of the lac repressor. Proc Natl Acad Sci U S A 1966 10.20
4 Sequence of the lactose permease gene. Nature 1980 9.67
5 Easy identification of cDNA clones. EMBO J 1983 9.18
6 pUR222, a vector for cloning and rapid chemical sequencing of DNA. Nucleic Acids Res 1981 6.55
7 Sequence of the lacZ gene of Escherichia coli. EMBO J 1983 6.46
8 Mutants that make more lac repressor. Proc Natl Acad Sci U S A 1968 6.26
9 Lac repressor can be fused to beta-galactosidase. Nature 1974 5.84
10 The three operators of the lac operon cooperate in repression. EMBO J 1990 5.45
11 The lac operator is DNA. Proc Natl Acad Sci U S A 1967 5.24
12 lac repressor forms loops with linear DNA carrying two suitably spaced lac operators. EMBO J 1987 4.02
13 How lac repressor binds to DNA. Nature 1972 3.72
14 Lac repressor and lac operator. Prog Biophys Mol Biol 1975 3.08
15 Repression of lac promoter as a function of distance, phase and quality of an auxiliary lac operator. J Mol Biol 1996 3.08
16 Genetic studies of the Lac repressor. XV: 4000 single amino acid substitutions and analysis of the resulting phenotypes on the basis of the protein structure. J Mol Biol 1996 2.98
17 Quality and position of the three lac operators of E. coli define efficiency of repression. EMBO J 1994 2.90
18 Sequence of galR gene indicates a common evolutionary origin of lac and gal repressor in Escherichia coli. Proc Natl Acad Sci U S A 1982 2.77
19 Possible ideal lac operator: Escherichia coli lac operator-like sequences from eukaryotic genomes lack the central G X C pair. Proc Natl Acad Sci U S A 1984 2.64
20 Amplification of the lactose carrier protein in Escherichia coli using a plasmid vector. Mol Gen Genet 1978 2.48
21 Suppressible regulator constitutive mutants of the lactose system in Escherichia coli. J Mol Biol 1966 2.36
22 Immunoenzymatic detection of expressed gene fragments cloned in the lac Z gene of E. coli. EMBO J 1982 2.29
23 Construction, isolation and implications of repressor-galactosidase - beta-galactosidase hybrid molecules. Eur J Biochem 1977 2.24
24 Inhibition of the synthesis of beta-galactosidase in Escherichia coli by 2-nitrophenyl-beta-D-fucoside. J Mol Biol 1966 2.24
25 Identification, transmembrane orientation and biogenesis of the amyloid A4 precursor of Alzheimer's disease. EMBO J 1988 2.23
26 The interaction of the recognition helix of lac repressor with lac operator. EMBO J 1987 2.19
27 Exon cloning: immunoenzymatic identification of exons of the chicken lysozyme gene. Proc Natl Acad Sci U S A 1982 2.07
28 Nucleotide sequences of the gal E gene and the gal T gene of E. coli. Nucleic Acids Res 1986 2.00
29 On the conservation of protein sequences in evolution. Trends Biochem Sci 2000 1.91
30 Synthetic lac operator mediates repression through lac repressor when introduced upstream and downstream from lac promoter. EMBO J 1986 1.80
31 Mutant lac repressors with new specificities hint at rules for protein--DNA recognition. EMBO J 1990 1.77
32 DNA supercoiling changes the spacing requirement of two lac operators for DNA loop formation with lac repressor. EMBO J 1988 1.70
33 Recognition helices of lac and lambda repressor are oriented in opposite directions and recognize similar DNA sequences. Proc Natl Acad Sci U S A 1988 1.64
34 Four dimers of lambda repressor bound to two suitably spaced pairs of lambda operators form octamers and DNA loops over large distances. Curr Biol 1999 1.63
35 Specific destruction of the second lac operator decreases repression of the lac operon in Escherichia coli fivefold. J Mol Biol 1987 1.62
36 beta-Galactosidase chimeras: primary structure of a lac repressor-beta-galactosidase protein. Proc Natl Acad Sci U S A 1978 1.60
37 Synthetic multifunctional proteins: isolation of covalently linked tryptophan synthetase alpha-subunit-lac-repressor-beta-galactosidase chimeras. Mol Gen Genet 1977 1.57
38 How Trp repressor binds to its operator. EMBO J 1990 1.53
39 Human antisera detect a Plasmodium falciparum genomic clone encoding a nonapeptide repeat. Nature 1984 1.51
40 Identification of three residues in the basic regions of the bZIP proteins GCN4, C/EBP and TAF-1 that are involved in specific DNA binding. EMBO J 1993 1.46
41 Dimer-to-tetramer assembly of Lac repressor involves a leucine heptad repeat. New Biol 1991 1.35
42 lac repressor forms stable loops in vitro with supercoiled wild-type lac DNA containing all three natural lac operators. J Mol Biol 1990 1.31
43 Genetic analysis of transpositions in the lac region of Escherichia coli. J Mol Biol 1980 1.29
44 Isolation, genetic analysis, and characterization of Escherichia coli mutants with defects in the lacY gene. J Bacteriol 1977 1.28
45 Genetic analysis of the leucine heptad repeats of Lac repressor: evidence for a 4-helical bundle. EMBO J 1993 1.27
46 How AraC interacts specifically with its target DNAs. J Mol Biol 1996 1.24
47 Cloning and characterization of the MboII restriction-modification system. Nucleic Acids Res 1991 1.19
48 lac repressor mutants with double or triple exchanges in the recognition helix bind specifically to lac operator variants with multiple exchanges. EMBO J 1989 1.18
49 Cloning of the cDNA encoding human brain trypsinogen and characterization of its product. Gene 1993 1.18
50 Lac repressor. Angew Chem Int Ed Engl 1971 1.17
51 Mutations in the lacY gene of Escherichia coli define functional organization of lactose permease. Proc Natl Acad Sci U S A 1981 1.16
52 High local protein concentrations at promoters: strategies in prokaryotic and eukaryotic cells. Bioessays 2001 1.15
53 How Lac repressor finds lac operator in vitro. J Mol Biol 1992 1.13
54 A versatile phage lambda expression vector system for cloning in Escherichia coli. Gene 1989 1.13
55 A change of threonine 266 to isoleucine in the lac permease of Escherichia coli diminishes the transport of lactose and increases the transport of maltose. Mol Gen Genet 1985 1.12
56 The 11-1 gene of Plasmodium falciparum codes for distinct fast evolving repeats. EMBO J 1988 1.08
57 Dimeric lac repressors exhibit phase-dependent co-operativity. J Mol Biol 1998 1.07
58 The PreA4(695) precursor protein of Alzheimer's disease A4 amyloid is encoded by 16 exons. Nucleic Acids Res 1989 1.07
59 Does the lactose carrier of Escherichia coli function as a monomer? FEBS Lett 1983 1.07
60 Investigation of structure and function of lactose permease of Escherichia coli. Biochem Soc Trans 1980 1.04
61 Replacement of invariant bZip residues within the basic region of the yeast transcriptional activator GCN4 can change its DNA binding specificity. Nucleic Acids Res 1994 1.03
62 72 residues of gal repressor fused to beta-galactosidase repress the gal operon of E. coli. EMBO J 1983 1.03
63 The sequence of the two extra exons in rat preA4. Nucleic Acids Res 1989 1.01
64 Cross-reactive antigenic determinants present on different Plasmodium falciparum blood-stage antigens. Parasite Immunol 1989 1.01
65 Lactose permease of Escherichia coli: properties of mutants defective in substrate translocation. Proc Natl Acad Sci U S A 1987 1.00
66 A model of the lac repressor-operator complex based on physical and genetic data. Eur J Biochem 1991 0.99
67 Lambda cI repressor mutants altered in transcriptional activation. J Mol Biol 1994 0.98
68 Differential splicing of Alzheimer's disease amyloid A4 precursor RNA in rat tissues: PreA4(695) mRNA is predominantly produced in rat and human brain. Biochem Biophys Res Commun 1990 0.96
69 Lac repressor with the helix-turn-helix motif of lambda cro binds to lac operator. EMBO J 1992 0.95
70 gal4 transcription activator protein of yeast can function as a repressor in Escherichia coli. EMBO J 1987 0.94
71 Dimerisation mutants of Lac repressor. II. A single amino acid substitution, D278L, changes the specificity of dimerisation. J Mol Biol 2000 0.93
72 The DNA binding specificity of the basic region of the yeast transcriptional activator GCN4 can be changed by substitution of a single amino acid. Nucleic Acids Res 1993 0.93
73 A synthetic operon containing 14 bovine pancreatic trypsin inhibitor genes is expressed in E. coli. EMBO J 1986 0.92
74 Dimerisation mutants of Lac repressor. I. A monomeric mutant, L251A, that binds Lac operator DNA as a dimer. J Mol Biol 1999 0.92
75 The side-chain of the amino acid residue in position 110 of the Lac repressor influences its allosteric equilibrium. J Mol Biol 1996 0.91
76 Creating new DNA binding specificities in the yeast transcriptional activator GCN4 by combining selected amino acid substitutions. Nucleic Acids Res 1994 0.91
77 The roles of residues 5 and 9 of the recognition helix of Lac repressor in lac operator binding. J Mol Biol 1991 0.90
78 In vitro phagocytosis inhibition assay for the screening of potential candidate antigens for sub-unit vaccines against the asexual blood stage of Plasmodium falciparum. J Immunol Methods 1993 0.90
79 Sequence homology between Lac and Gal repressors and three sugar-binding periplasmic proteins. Nature 1983 0.88
80 A positive selection vector for cloning of long polymerase chain reaction fragments based on a lethal mutant of the crp gene of Escherichia coli. Anal Biochem 1998 0.87
81 F'-coded, temperature-sensitive lambda cI857 repressor gene for easy construction and regulation of lambda promoter-dependent expression systems. J Bacteriol 1985 0.86
82 Enhanced GFAP expression in astrocytes of transgenic mice expressing the human brain-specific trypsinogen IV. Glia 1998 0.86
83 Identification of cDNAs encoding two novel rat pancreatic serine proteases. Gene 1992 0.86
84 Cloning and expression of genomic DNA sequences coding for putative erythrocyte membrane-associated antigens of Plasmodium falciparum. Res Immunol 1991 0.85
85 A comparison of the different DNA binding specificities of the bZip proteins C/EBP and GCN4. Nucleic Acids Res 1995 0.84
86 The polymorphic 11.1 locus of Plasmodium falciparum. Mol Biochem Parasitol 1987 0.84
87 lambda Immunity phase shift in a lambda N- -lacZ+ fusion. Mol Gen Genet 1981 0.84
88 Strengthening the dimerisation interface of Lac repressor increases its thermostability by 40 deg. C. J Mol Biol 2000 0.84
89 Linker mutagenesis in the lacZ gene of Escherichia coli yields variants of active beta-galactosidase. Eur J Biochem 1991 0.83
90 Single exchanges of amino acids in the basic region change the specificity of N-Myc. Nucleic Acids Res 1993 0.82
91 lacZ--Y+ fusions in Escherichia coli. DNA sequencing reveals the eight N-terminal residues of lac permease as non-essential. Eur J Biochem 1983 0.82
92 DNA recognition and the code. Nature 1994 0.80
93 A basic tail increases repression by dimeric lac repressor. J Mol Biol 1995 0.80
94 Insertion of d(pCpG)n.d(pCpG)n into the lacZ gene of Escherichia coli inhibits expression of beta-galactosidase in vivo. J Mol Biol 1988 0.79
95 Towards a mutant analysis of the tertiary structures of functional DNA-binding motifs. FEBS Lett 1998 0.79
96 How Trp repressor binds to its operator. EMBO J 1990 0.78
97 A highly abundant transcript in adult murine cerebellar granule cells contains repetitive sequences homologous to L1. J Neurosci 1987 0.78
98 Structure and function of a thymic peptide is mimicked by Plasmodium falciparum peptides. Ann Inst Pasteur Immunol 1989 0.77
99 The sequence of a third member of the heat shock protein family in Plasmodium falciparum. Nucleic Acids Res 1989 0.77
100 Characterization of beta-galactosidase--lactose-permease chimaeras of Escherichia coli. Eur J Biochem 1983 0.77
101 The fraud of Abderhalden's enzymes. Nature 1998 0.77
102 The possible roles of residues 79 and 80 of the Trp repressor from Escherichia coli K-12 in trp operator recognition. Mol Gen Genet 1995 0.76
103 Characterisation of P. falciparum antigenic determinants isolated from a genomic expression library by differential antibody screening. Nucleic Acids Res 1985 0.75
104 European research institutes. Science 1992 0.75
105 Fused lacZ genes code for di-, tri- and tetra-beta-galactosidase in Escherichia coli. EMBO J 1985 0.75
106 A lethal mutant of the catabolite gene activator protein CAP of Escherichia coli. Biol Chem 1997 0.75
107 The repeat of the same. Trends Biochem Sci 1989 0.75
108 Mutant bZip-DNA complexes with four quasi-identical protein-DNA interfaces. EMBO J 1996 0.75
109 Mutants in position 69 of the Trp repressor of Escherichia coli K12 with altered DNA-binding specificity. Mol Gen Genet 1996 0.75
110 [100 years of Escherichia coli]. Naturwissenschaften 1986 0.75
111 Mutants with substitutions for Glu171 in the catabolite activator protein (CAP) of Escherichia coli activate transcription from the lac promoter. Mol Gen Genet 1993 0.75
112 [How does the lac repressor recognize the lac operator?]. Hoppe Seylers Z Physiol Chem 1972 0.75
113 Co-operative binding of two Trp repressor dimers to alpha- or beta-centred trp operators. Mol Microbiol 1996 0.75