Published in Gene on December 22, 1993
Reverse biochemistry: use of macromolecular protease inhibitors to dissect complex biological processes and identify a membrane-type serine protease in epithelial cancer and normal tissue. Proc Natl Acad Sci U S A (1999) 2.01
Human mesotrypsin is a unique digestive protease specialized for the degradation of trypsin inhibitors. J Biol Chem (2003) 1.44
Expression of trypsin by epithelial cells of various tissues, leukocytes, and neurons in human and mouse. Am J Pathol (1998) 1.17
High expression of tumour-associated trypsin inhibitor correlates with liver metastasis and poor prognosis in colorectal cancer. Br J Cancer (2009) 1.11
Resuscitating mutations in a furin cleavage-deficient mutant of the flavivirus tick-borne encephalitis virus. J Virol (2005) 1.02
Determinants of affinity and proteolytic stability in interactions of Kunitz family protease inhibitors with mesotrypsin. J Biol Chem (2010) 0.97
The P(2)' residue is a key determinant of mesotrypsin specificity: engineering a high-affinity inhibitor with anticancer activity. Biochem J (2011) 0.95
Human mesotrypsin defies natural trypsin inhibitors: from passive resistance to active destruction. Protein Pept Lett (2005) 0.95
PRSS3/mesotrypsin is a therapeutic target for metastatic prostate cancer. Mol Cancer Res (2012) 0.93
In vivo monitoring of neuronal loss in traumatic brain injury: a microdialysis study. Brain (2011) 0.91
The amyloid precursor protein/protease nexin 2 Kunitz inhibitor domain is a highly specific substrate of mesotrypsin. J Biol Chem (2009) 0.91
Activity of recombinant trypsin isoforms on human proteinase-activated receptors (PAR): mesotrypsin cannot activate epithelial PAR-1, -2, but weakly activates brain PAR-1. Br J Pharmacol (2005) 0.90
Serine proteases mediate inflammatory pain in acute pancreatitis. Am J Physiol Gastrointest Liver Physiol (2011) 0.86
Genetic and biochemical characterization of the E32del polymorphism in human mesotrypsinogen. Pancreatology (2005) 0.85
Expression and characterization of trypsinogen produced in the human male genital tract. Am J Pathol (2000) 0.83
Serine proteases, serine protease inhibitors, and protease-activated receptors: roles in synaptic function and behavior. Brain Res (2011) 0.82
Proteolytic activation of the human epithelial sodium channel by trypsin IV and trypsin I involves distinct cleavage sites. J Biol Chem (2014) 0.81
The effects of stimulating protease-activated receptor-1 and -2 in A172 human glioblastoma. J Neural Transm (Vienna) (2001) 0.81
Sequence and conformational specificity in substrate recognition: several human Kunitz protease inhibitor domains are specific substrates of mesotrypsin. J Biol Chem (2014) 0.80
Biochemical and structural insights into mesotrypsin: an unusual human trypsin. Int J Biochem Mol Biol (2013) 0.80
Isolation and characterization of the chicken trypsinogen gene family. Biochem J (1995) 0.79
Serine proteases and protease-activated receptor 2 mediate the proinflammatory and algesic actions of diverse stimulants. Br J Pharmacol (2014) 0.79
Combinatorial protein engineering of proteolytically resistant mesotrypsin inhibitors as candidates for cancer therapy. Biochem J (2016) 0.77
Trypsinogen 4 boosts tumor endothelial cells migration through proteolysis of tissue factor pathway inhibitor-2. Oncotarget (2015) 0.76
Filamentous coliphage M13 as a cloning vehicle: insertion of a HindII fragment of the lac regulatory region in M13 replicative form in vitro. Proc Natl Acad Sci U S A (1977) 18.85
The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor. Nature (1987) 17.08
Isolation of the lac repressor. Proc Natl Acad Sci U S A (1966) 10.20
Sequence of the lactose permease gene. Nature (1980) 9.67
Easy identification of cDNA clones. EMBO J (1983) 9.18
pUR222, a vector for cloning and rapid chemical sequencing of DNA. Nucleic Acids Res (1981) 6.55
Sequence of the lacZ gene of Escherichia coli. EMBO J (1983) 6.46
Mutants that make more lac repressor. Proc Natl Acad Sci U S A (1968) 6.26
Lac repressor can be fused to beta-galactosidase. Nature (1974) 5.84
The three operators of the lac operon cooperate in repression. EMBO J (1990) 5.45
The lac operator is DNA. Proc Natl Acad Sci U S A (1967) 5.24
ABFs, a family of ABA-responsive element binding factors. J Biol Chem (2000) 4.98
Connexins regulate calcium signaling by controlling ATP release. Proc Natl Acad Sci U S A (1998) 4.35
In vitro neurogenesis by progenitor cells isolated from the adult human hippocampus. Nat Med (2000) 4.18
lac repressor forms loops with linear DNA carrying two suitably spaced lac operators. EMBO J (1987) 4.02
How lac repressor binds to DNA. Nature (1972) 3.72
Lac repressor and lac operator. Prog Biophys Mol Biol (1975) 3.08
Repression of lac promoter as a function of distance, phase and quality of an auxiliary lac operator. J Mol Biol (1996) 3.08
Cereblon is a direct protein target for immunomodulatory and antiproliferative activities of lenalidomide and pomalidomide. Leukemia (2012) 3.04
Genetic studies of the Lac repressor. XV: 4000 single amino acid substitutions and analysis of the resulting phenotypes on the basis of the protein structure. J Mol Biol (1996) 2.98
Quality and position of the three lac operators of E. coli define efficiency of repression. EMBO J (1994) 2.90
Activating SRC mutation in a subset of advanced human colon cancers. Nat Genet (1999) 2.84
Sequence of galR gene indicates a common evolutionary origin of lac and gal repressor in Escherichia coli. Proc Natl Acad Sci U S A (1982) 2.77
Possible ideal lac operator: Escherichia coli lac operator-like sequences from eukaryotic genomes lack the central G X C pair. Proc Natl Acad Sci U S A (1984) 2.64
Amplification of the lactose carrier protein in Escherichia coli using a plasmid vector. Mol Gen Genet (1978) 2.48
p53 transcriptional activity is essential for p53-dependent apoptosis following DNA damage. EMBO J (2000) 2.38
Suppressible regulator constitutive mutants of the lactose system in Escherichia coli. J Mol Biol (1966) 2.36
Immunoenzymatic detection of expressed gene fragments cloned in the lac Z gene of E. coli. EMBO J (1982) 2.29
Construction, isolation and implications of repressor-galactosidase - beta-galactosidase hybrid molecules. Eur J Biochem (1977) 2.24
Inhibition of the synthesis of beta-galactosidase in Escherichia coli by 2-nitrophenyl-beta-D-fucoside. J Mol Biol (1966) 2.24
Identification, transmembrane orientation and biogenesis of the amyloid A4 precursor of Alzheimer's disease. EMBO J (1988) 2.23
The interaction of the recognition helix of lac repressor with lac operator. EMBO J (1987) 2.19
Exon cloning: immunoenzymatic identification of exons of the chicken lysozyme gene. Proc Natl Acad Sci U S A (1982) 2.07
Diagnosis of nonpsychotic patients in community clinics. Am J Psychiatry (2000) 2.06
A novel gene, hKCa4, encodes the calcium-activated potassium channel in human T lymphocytes. J Biol Chem (1997) 2.05
Multiple coronary occlusions associated with ST-segment elevation. Clin Cardiol (1999) 2.02
Nucleotide sequences of the gal E gene and the gal T gene of E. coli. Nucleic Acids Res (1986) 2.00
Vascular patterning and leaf shape. Curr Opin Plant Biol (2001) 1.99
On the conservation of protein sequences in evolution. Trends Biochem Sci (2000) 1.91
Synthetic lac operator mediates repression through lac repressor when introduced upstream and downstream from lac promoter. EMBO J (1986) 1.80
Mutant lac repressors with new specificities hint at rules for protein--DNA recognition. EMBO J (1990) 1.77
Interventions to reduce the burden of caregiving for an adult with dementia: a meta-analysis. Res Nurs Health (2001) 1.70
DNA supercoiling changes the spacing requirement of two lac operators for DNA loop formation with lac repressor. EMBO J (1988) 1.70
Interaction of an adenovirus E3 14.7-kilodalton protein with a novel tumor necrosis factor alpha-inducible cellular protein containing leucine zipper domains. Mol Cell Biol (1998) 1.68
Recognition helices of lac and lambda repressor are oriented in opposite directions and recognize similar DNA sequences. Proc Natl Acad Sci U S A (1988) 1.64
Four dimers of lambda repressor bound to two suitably spaced pairs of lambda operators form octamers and DNA loops over large distances. Curr Biol (1999) 1.63
Specific destruction of the second lac operator decreases repression of the lac operon in Escherichia coli fivefold. J Mol Biol (1987) 1.62
Dexamethasone synergizes with lenalidomide to inhibit multiple myeloma tumor growth, but reduces lenalidomide-induced immunomodulation of T and NK cell function. Curr Cancer Drug Targets (2010) 1.60
beta-Galactosidase chimeras: primary structure of a lac repressor-beta-galactosidase protein. Proc Natl Acad Sci U S A (1978) 1.60
Dose-dependent regulation of the early promoter of human papillomavirus type 18 by the viral E2 protein. J Virol (1997) 1.59
Synthetic multifunctional proteins: isolation of covalently linked tryptophan synthetase alpha-subunit-lac-repressor-beta-galactosidase chimeras. Mol Gen Genet (1977) 1.57
How Trp repressor binds to its operator. EMBO J (1990) 1.53
Treadmill training with body weight support: its effect on Parkinson's disease. Arch Phys Med Rehabil (2000) 1.53
COPD in Chinese nonsmokers. Eur Respir J (2009) 1.52
Human antisera detect a Plasmodium falciparum genomic clone encoding a nonapeptide repeat. Nature (1984) 1.51
Comparison of chloral hydrate and midazolam for sedation of neonates for neuroimaging studies. J Pediatr (1996) 1.50
Neuronal-glial interactions mediated by interleukin-1 enhance neuronal acetylcholinesterase activity and mRNA expression. J Neurosci (2000) 1.48
Identification of three residues in the basic regions of the bZIP proteins GCN4, C/EBP and TAF-1 that are involved in specific DNA binding. EMBO J (1993) 1.46
A custom-made nasal implant: prefabrication from curing of silicone adhesive. Plast Reconstr Surg (1996) 1.43
Localization of the putative precursor of Alzheimer's disease-specific amyloid at nuclear envelopes of adult human muscle. EMBO J (1988) 1.43
Identification of N-terminal residues on P-selectin glycoprotein ligand-1 required for binding to P-selectin. J Biol Chem (1998) 1.42
Identification of a cell protein (FIP-3) as a modulator of NF-kappaB activity and as a target of an adenovirus inhibitor of tumor necrosis factor alpha-induced apoptosis. Proc Natl Acad Sci U S A (1999) 1.42
Wallerian degeneration of the pyramidal tract does not affect stroke rehabilitation outcome. Neurology (1998) 1.42
Observation of B(0)(s)-->Psi(2S)Phi and measurement of the ratio of branching fractions Beta(B(0)(s)-->Psi(2S)Phi)/Beta(B(0)(s)-->J/PsiPhi). Phys Rev Lett (2006) 1.40
Astrocytic gap junctions remain open during ischemic conditions. J Neurosci (1998) 1.39
Dimer-to-tetramer assembly of Lac repressor involves a leucine heptad repeat. New Biol (1991) 1.35
lac repressor forms stable loops in vitro with supercoiled wild-type lac DNA containing all three natural lac operators. J Mol Biol (1990) 1.31
Genetic analysis of transpositions in the lac region of Escherichia coli. J Mol Biol (1980) 1.29
Clinical features, investigation and treatment of post-traumatic syringomyelia. J Neurol Neurosurg Psychiatry (1981) 1.29
Isolation, genetic analysis, and characterization of Escherichia coli mutants with defects in the lacY gene. J Bacteriol (1977) 1.28
Haloperidol, lorazepam, or both for psychotic agitation? A multicenter, prospective, double-blind, emergency department study. Am J Emerg Med (1997) 1.27
Genetic analysis of the leucine heptad repeats of Lac repressor: evidence for a 4-helical bundle. EMBO J (1993) 1.27
Sequences within the spacer region of yeast rRNA cistrons that stimulate 35S rRNA synthesis in vivo mediate RNA polymerase I-dependent promoter and terminator activities. Mol Cell Biol (1989) 1.24
How AraC interacts specifically with its target DNAs. J Mol Biol (1996) 1.24
Cloning and characterization of the MboII restriction-modification system. Nucleic Acids Res (1991) 1.19
lac repressor mutants with double or triple exchanges in the recognition helix bind specifically to lac operator variants with multiple exchanges. EMBO J (1989) 1.18
Lysophosphatidic acid augments human hepatocellular carcinoma cell invasion through LPA1 receptor and MMP-9 expression. Oncogene (2010) 1.18
Lac repressor. Angew Chem Int Ed Engl (1971) 1.17
The flavonoid baicalin exhibits anti-inflammatory activity by binding to chemokines. Immunopharmacology (2000) 1.17
Mutations in the lacY gene of Escherichia coli define functional organization of lactose permease. Proc Natl Acad Sci U S A (1981) 1.16
High local protein concentrations at promoters: strategies in prokaryotic and eukaryotic cells. Bioessays (2001) 1.15
A null mutation for Fmr1 in female mice: effects on regional cerebral metabolic rate for glucose and relationship to behavior. Neuroscience (2005) 1.15
New use of a three-dimensional pellet culture system for human intervertebral disc cells: initial characterization and potential use for tissue engineering. Spine (Phila Pa 1976) (2001) 1.14
Linker-free directed assembly of high-performance integrated devices based on nanotubes and nanowires. Nat Nanotechnol (2006) 1.13
How Lac repressor finds lac operator in vitro. J Mol Biol (1992) 1.13
A versatile phage lambda expression vector system for cloning in Escherichia coli. Gene (1989) 1.13
A change of threonine 266 to isoleucine in the lac permease of Escherichia coli diminishes the transport of lactose and increases the transport of maltose. Mol Gen Genet (1985) 1.12
Treatment of fluoxetine-induced anorgasmia with amantadine. J Clin Psychiatry (1992) 1.11
Chronic social instability stress in female rats: a potential animal model for female depression. Neuroscience (2009) 1.11
Cerebral protein synthesis in a genetic mouse model of phenylketonuria. Proc Natl Acad Sci U S A (2000) 1.09
The 11-1 gene of Plasmodium falciparum codes for distinct fast evolving repeats. EMBO J (1988) 1.08
Dimeric lac repressors exhibit phase-dependent co-operativity. J Mol Biol (1998) 1.07
The PreA4(695) precursor protein of Alzheimer's disease A4 amyloid is encoded by 16 exons. Nucleic Acids Res (1989) 1.07
Does the lactose carrier of Escherichia coli function as a monomer? FEBS Lett (1983) 1.07
Evidence for neurogenic transmission inducing degenerative cartilage damage distant from local inflammation. Arthritis Rheum (1999) 1.07
SpermCheck Fertility, an immunodiagnostic home test that detects normozoospermia and severe oligozoospermia. Hum Reprod (2010) 1.05
Mammalian ncRNA-disease repository: a global view of ncRNA-mediated disease network. Cell Death Dis (2013) 1.05