Published in EMBO J on July 15, 1994
Independent and tight regulation of transcriptional units in Escherichia coli via the LacR/O, the TetR/O and AraC/I1-I2 regulatory elements. Nucleic Acids Res (1997) 13.15
Probing transcription factor dynamics at the single-molecule level in a living cell. Science (2007) 6.85
Transcriptional regulation by the numbers: models. Curr Opin Genet Dev (2005) 5.20
Detailed map of a cis-regulatory input function. Proc Natl Acad Sci U S A (2003) 4.30
Transcriptional regulation by the numbers: applications. Curr Opin Genet Dev (2005) 3.40
Programming gene expression with combinatorial promoters. Mol Syst Biol (2007) 3.29
Combinatorial transcriptional control of the lactose operon of Escherichia coli. Proc Natl Acad Sci U S A (2007) 2.51
Tools for functional postgenomic analysis of listeria monocytogenes. Appl Environ Microbiol (2008) 1.78
Modeling the Lac repressor-operator assembly: the influence of DNA looping on Lac repressor conformation. Proc Natl Acad Sci U S A (2006) 1.75
Spatial effects on the speed and reliability of protein-DNA search. Nucleic Acids Res (2008) 1.48
Concentration and length dependence of DNA looping in transcriptional regulation. PLoS One (2009) 1.46
Gene location and DNA density determine transcription factor distributions in Escherichia coli. Mol Syst Biol (2012) 1.43
Influence of catabolite repression and inducer exclusion on the bistable behavior of the lac operon. Biophys J (2004) 1.36
Inducible control of virulence gene expression in Listeria monocytogenes: temporal requirement of listeriolysin O during intracellular infection. J Bacteriol (2002) 1.31
The transcription factor titration effect dictates level of gene expression. Cell (2014) 1.30
Analysis of in-vivo LacR-mediated gene repression based on the mechanics of DNA looping. PLoS One (2006) 1.30
Optimizing information flow in small genetic networks. Phys Rev E Stat Nonlin Soft Matter Phys (2009) 1.23
Quantitative dissection of the simple repression input-output function. Proc Natl Acad Sci U S A (2011) 1.23
First-principles calculation of DNA looping in tethered particle experiments. Phys Biol (2009) 1.20
Regulation of sialic acid catabolism by the DNA binding protein NanR in Escherichia coli. J Bacteriol (2003) 1.20
Comparison of deterministic and stochastic models of the lac operon genetic network. Biophys J (2009) 1.17
Induction of the lac promoter in the absence of DNA loops and the stoichiometry of induction. Nucleic Acids Res (2006) 1.16
Single-molecule spectroscopic determination of lac repressor-DNA loop conformation. Biophys J (2005) 1.14
Atomistic simulations reveal bubbles, kinks and wrinkles in supercoiled DNA. Nucleic Acids Res (2011) 1.12
Sequence dependence of transcription factor-mediated DNA looping. Nucleic Acids Res (2012) 1.11
Tension-dependent DNA cleavage by restriction endonucleases: two-site enzymes are "switched off" at low force. Proc Natl Acad Sci U S A (2006) 1.06
Effects of the nucleoid protein HU on the structure, flexibility, and ring-closure properties of DNA deduced from Monte Carlo simulations. J Mol Biol (2008) 1.05
DNA looping in prokaryotes: experimental and theoretical approaches. J Bacteriol (2013) 1.03
DNA looping by two-site restriction endonucleases: heterogeneous probability distributions for loop size and unbinding force. Nucleic Acids Res (2006) 1.02
Stochastic dynamics of macromolecular-assembly networks. Mol Syst Biol (2006) 1.00
Conditional lethality yields a new vaccine strain of Listeria monocytogenes for the induction of cell-mediated immunity. Infect Immun (2005) 0.95
One is not enough. J Mol Biol (2009) 0.93
Ab initio thermodynamic modeling of distal multisite transcription regulation. Nucleic Acids Res (2007) 0.93
Transcription by the numbers redux: experiments and calculations that surprise. Trends Cell Biol (2010) 0.91
FRET studies of a landscape of Lac repressor-mediated DNA loops. Nucleic Acids Res (2012) 0.91
Mechanism of transcriptional repression at a bacterial promoter by analysis of single molecules. EMBO J (2011) 0.91
Enhancement of DNA flexibility in vitro and in vivo by HMGB box A proteins carrying box B residues. Biochemistry (2009) 0.90
Design and analysis of LacI-repressed promoters and DNA-looping in a cyanobacterium. J Biol Eng (2014) 0.90
Quantitation of the DNA tethering effect in long-range DNA looping in vivo and in vitro using the Lac and λ repressors. Proc Natl Acad Sci U S A (2013) 0.89
Statistical mechanical model of coupled transcription from multiple promoters due to transcription factor titration. Phys Rev E Stat Nonlin Soft Matter Phys (2014) 0.87
Bacterial promoter repression by DNA looping without protein-protein binding competition. Nucleic Acids Res (2014) 0.86
Napoleon Is in Equilibrium. Annu Rev Condens Matter Phys (2015) 0.86
Dynamics of single DNA looping and cleavage by Sau3AI and effect of tension applied to the DNA. Biophys J (2006) 0.85
Bending the rules of transcriptional repression: tightly looped DNA directly represses T7 RNA polymerase. Biophys J (2010) 0.84
Accurate prediction of gene expression by integration of DNA sequence statistics with detailed modeling of transcription regulation. Biophys J (2010) 0.84
Comparison and calibration of different reporters for quantitative analysis of gene expression. Biophys J (2011) 0.84
DNA sequence-dependent mechanics and protein-assisted bending in repressor-mediated loop formation. Phys Biol (2013) 0.84
The RpiR-like repressor IolR regulates inositol catabolism in Sinorhizobium meliloti. J Bacteriol (2011) 0.83
Thermodynamics of biological processes. Methods Enzymol (2011) 0.82
Breaking evolutionary constraint with a tradeoff ratchet. Proc Natl Acad Sci U S A (2015) 0.82
Multi-input regulation and logic with T7 promoters in cells and cell-free systems. PLoS One (2013) 0.81
DNA supercoiling, a critical signal regulating the basal expression of the lac operon in Escherichia coli. Sci Rep (2016) 0.81
Scaling of gene expression with transcription-factor fugacity. Phys Rev Lett (2014) 0.81
In silico design and in vivo implementation of yeast gene Boolean gates. J Biol Eng (2014) 0.81
Systems biophysics of gene expression. Biophys J (2013) 0.80
Perspectives: using polymer modeling to understand the formation and function of nuclear compartments. Chromosome Res (2017) 0.79
Revisiting the Anomalous Bending Elasticity of Sharply Bent DNA. Biophys J (2015) 0.78
A functional assay in Escherichia coli to detect non-assisted interaction between galactose repressor dimers. Nucleic Acids Res (2000) 0.78
Comparison of the theoretical and real-world evolutionary potential of a genetic circuit. Phys Biol (2014) 0.78
Feedback regulation of Lac repressor expression in Escherichia coli. J Bacteriol (2009) 0.77
Oligomeric properties and DNA binding specificities of repressor isoforms from the Streptomyces bacteriophage phiC31. Nucleic Acids Res (1998) 0.77
Direct observation of a 91 bp LacI-mediated, negatively supercoiled DNA loop by atomic force microscope. FEBS Lett (2016) 0.76
Genome-wide comprehensive analysis of transcriptional regulation by ArgR in Thermus thermophilus. Extremophiles (2014) 0.76
In vitro transcription accurately predicts lac repressor phenotype in vivo in Escherichia coli. PeerJ (2014) 0.76
Substitutions at auxiliary operator O3 enhance repression by nitrate-responsive regulator NarL at synthetic lac control regions in Escherichia coli K-12. J Bacteriol (2007) 0.76
Minimal effect of gene clustering on expression in Escherichia coli. Genetics (2012) 0.76
Protein distributions from a stochastic model of the lac operon of E. coli with DNA looping: analytical solution and comparison with experiments. PLoS One (2014) 0.76
From adjacent activation in Escherichia coli and DNA cyclization to eukaryotic enhancers: the elements of a puzzle. Front Genet (2014) 0.76
Identification of an intestine-specific promoter and inducible expression of bacterial α-galactosidase in mammalian cells by a lac operon system. J Anim Sci Biotechnol (2012) 0.75
An IPTG Inducible Conditional Expression System for Mycobacteria. PLoS One (2015) 0.75
Proteins mediating DNA loops effectively block transcription. Protein Sci (2017) 0.75
Supercoiling Effects on Short-Range DNA Looping in E. coli. PLoS One (2016) 0.75
A simple model for Lutz and Bujard's controllable promoters and its application for analyzing a simple genetic oscillator. In Silico Biol (2015) 0.75
Evaluation of novel inducible promoter/repressor systems for recombinant protein expression in Lactobacillus plantarum. Microb Cell Fact (2016) 0.75
Protein-induced DNA linking number change by sequence-specific DNA binding proteins and its biological effects. Biophys Rev (2016) 0.75
Using synthetic biology to make cells tomorrow's test tubes. Integr Biol (Camb) (2016) 0.75
pBR322 vectors having tetracycline-dependent replication. Plasmid (2016) 0.75
Protein-induced DNA linking number change by sequence-specific DNA binding proteins and its biological effects. Biophys Rev (2016) 0.75
Self-consistent theory of transcriptional control in complex regulatory architectures. PLoS One (2017) 0.75
Equilibria and kinetics of lac repressor-operator interactions by polyacrylamide gel electrophoresis. Nucleic Acids Res (1981) 35.39
Protein-DNA recognition. Annu Rev Biochem (1984) 22.02
THE PROPERTIES OF REPRESSOR AND THE KINETICS OF ITS ACTION. J Mol Biol (1965) 7.29
The interaction of RNA polymerase and lac repressor with the lac control region. Nucleic Acids Res (1979) 6.17
The operator-binding domain of lambda repressor: structure and DNA recognition. Nature (1982) 6.03
Transcription of glnA in E. coli is stimulated by activator bound to sites far from the promoter. Cell (1986) 5.81
The three operators of the lac operon cooperate in repression. EMBO J (1990) 5.45
An operator at -280 base pairs that is required for repression of araBAD operon promoter: addition of DNA helical turns between the operator and promoter cyclically hinders repression. Proc Natl Acad Sci U S A (1984) 5.42
DNA looping. Annu Rev Biochem (1992) 5.26
A perfectly symmetric lac operator binds the lac repressor very tightly. Proc Natl Acad Sci U S A (1983) 4.24
Promoters largely determine the efficiency of repressor action. Proc Natl Acad Sci U S A (1988) 4.18
lac repressor forms loops with linear DNA carrying two suitably spaced lac operators. EMBO J (1987) 4.02
Initiation of transcription at the bacterial glnAp2 promoter by purified E. coli components is facilitated by enhancers. Cell (1987) 3.85
DNA looping and unlooping by AraC protein. Science (1990) 3.85
DNA supercoiling promotes formation of a bent repression loop in lac DNA. J Mol Biol (1987) 3.81
Use of polymerase chain reaction catalyzed by Taq DNA polymerase for site-specific mutagenesis. Gene (1989) 3.11
Diffusion-driven mechanisms of protein translocation on nucleic acids. 2. The Escherichia coli repressor--operator interaction: equilibrium measurements. Biochemistry (1981) 2.98
Multipartite genetic control elements: communication by DNA loop. Annu Rev Genet (1989) 2.75
DNA binding by proteins. Science (1988) 2.66
Possible ideal lac operator: Escherichia coli lac operator-like sequences from eukaryotic genomes lack the central G X C pair. Proc Natl Acad Sci U S A (1984) 2.64
The location of the repressor binding sites in the lac operon. Proc Natl Acad Sci U S A (1974) 2.64
Upstream operators enhance repression of the lac promoter. Science (1986) 2.58
"Second" and "third operator" of the lac operon: an investigation of their role in the regulatory mechanism. J Mol Biol (1979) 2.56
Construction, isolation and implications of repressor-galactosidase - beta-galactosidase hybrid molecules. Eur J Biochem (1977) 2.24
The interaction of the recognition helix of lac repressor with lac operator. EMBO J (1987) 2.19
A new class of promoter mutations in the lactose operon of Escherichia coli. J Mol Biol (1974) 2.05
Lac repressor is a transient gene-activating protein. Cell (1987) 2.04
Structure of the complex of lac repressor headpiece and an 11 base-pair half-operator determined by nuclear magnetic resonance spectroscopy and restrained molecular dynamics. J Mol Biol (1993) 1.92
Long-range cooperativity between gene regulatory sequences in a prokaryote. Nature (1987) 1.84
DNA supercoiling changes the spacing requirement of two lac operators for DNA loop formation with lac repressor. EMBO J (1988) 1.70
Recognition helices of lac and lambda repressor are oriented in opposite directions and recognize similar DNA sequences. Proc Natl Acad Sci U S A (1988) 1.64
Specific destruction of the second lac operator decreases repression of the lac operon in Escherichia coli fivefold. J Mol Biol (1987) 1.62
Interaction of spatially separated protein-DNA complexes for control of gene expression: operator conversions. Proc Natl Acad Sci U S A (1988) 1.58
Lac repressor - lac operator interaction. Circular dichroism study. Nucleic Acids Res (1981) 1.56
DNA binding characteristics of lactose repressor and the trypsin-resistant core repressor. J Biol Chem (1980) 1.51
Single and double loop formation when deoR repressor binds to its natural operator sites. Cell (1989) 1.41
Dimer-to-tetramer assembly of Lac repressor involves a leucine heptad repeat. New Biol (1991) 1.35
Interaction of the Escherichia coli Gal repressor protein with its DNA operators in vitro. Biochemistry (1990) 1.32
Genetic analysis of the leucine heptad repeats of Lac repressor: evidence for a 4-helical bundle. EMBO J (1993) 1.27
Deletions fusing the i and lac regions of the chromosome in E. coli: isolation and mapping. Mol Gen Genet (1974) 1.24
Structural aspects of protein-DNA recognition. Biochem J (1991) 1.21
A versatile phage lambda expression vector system for cloning in Escherichia coli. Gene (1989) 1.13
Repression of the E. coli lactose operon by cooperation between two individually unproductive "half-operator" sites. C R Acad Sci III (1992) 0.84
Filamentous coliphage M13 as a cloning vehicle: insertion of a HindII fragment of the lac regulatory region in M13 replicative form in vitro. Proc Natl Acad Sci U S A (1977) 18.85
The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor. Nature (1987) 17.08
Isolation of the lac repressor. Proc Natl Acad Sci U S A (1966) 10.20
Sequence of the lactose permease gene. Nature (1980) 9.67
Easy identification of cDNA clones. EMBO J (1983) 9.18
pUR222, a vector for cloning and rapid chemical sequencing of DNA. Nucleic Acids Res (1981) 6.55
Sequence of the lacZ gene of Escherichia coli. EMBO J (1983) 6.46
Mutants that make more lac repressor. Proc Natl Acad Sci U S A (1968) 6.26
Lac repressor can be fused to beta-galactosidase. Nature (1974) 5.84
The three operators of the lac operon cooperate in repression. EMBO J (1990) 5.45
The lac operator is DNA. Proc Natl Acad Sci U S A (1967) 5.24
lac repressor forms loops with linear DNA carrying two suitably spaced lac operators. EMBO J (1987) 4.02
How lac repressor binds to DNA. Nature (1972) 3.72
Lac repressor and lac operator. Prog Biophys Mol Biol (1975) 3.08
Repression of lac promoter as a function of distance, phase and quality of an auxiliary lac operator. J Mol Biol (1996) 3.08
Genetic studies of the Lac repressor. XV: 4000 single amino acid substitutions and analysis of the resulting phenotypes on the basis of the protein structure. J Mol Biol (1996) 2.98
Sequence of galR gene indicates a common evolutionary origin of lac and gal repressor in Escherichia coli. Proc Natl Acad Sci U S A (1982) 2.77
Possible ideal lac operator: Escherichia coli lac operator-like sequences from eukaryotic genomes lack the central G X C pair. Proc Natl Acad Sci U S A (1984) 2.64
Amplification of the lactose carrier protein in Escherichia coli using a plasmid vector. Mol Gen Genet (1978) 2.48
Suppressible regulator constitutive mutants of the lactose system in Escherichia coli. J Mol Biol (1966) 2.36
Immunoenzymatic detection of expressed gene fragments cloned in the lac Z gene of E. coli. EMBO J (1982) 2.29
Construction, isolation and implications of repressor-galactosidase - beta-galactosidase hybrid molecules. Eur J Biochem (1977) 2.24
Inhibition of the synthesis of beta-galactosidase in Escherichia coli by 2-nitrophenyl-beta-D-fucoside. J Mol Biol (1966) 2.24
Identification, transmembrane orientation and biogenesis of the amyloid A4 precursor of Alzheimer's disease. EMBO J (1988) 2.23
The interaction of the recognition helix of lac repressor with lac operator. EMBO J (1987) 2.19
Exon cloning: immunoenzymatic identification of exons of the chicken lysozyme gene. Proc Natl Acad Sci U S A (1982) 2.07
Nucleotide sequences of the gal E gene and the gal T gene of E. coli. Nucleic Acids Res (1986) 2.00
On the conservation of protein sequences in evolution. Trends Biochem Sci (2000) 1.91
Synthetic lac operator mediates repression through lac repressor when introduced upstream and downstream from lac promoter. EMBO J (1986) 1.80
Mutant lac repressors with new specificities hint at rules for protein--DNA recognition. EMBO J (1990) 1.77
DNA supercoiling changes the spacing requirement of two lac operators for DNA loop formation with lac repressor. EMBO J (1988) 1.70
Recognition helices of lac and lambda repressor are oriented in opposite directions and recognize similar DNA sequences. Proc Natl Acad Sci U S A (1988) 1.64
Four dimers of lambda repressor bound to two suitably spaced pairs of lambda operators form octamers and DNA loops over large distances. Curr Biol (1999) 1.63
Specific destruction of the second lac operator decreases repression of the lac operon in Escherichia coli fivefold. J Mol Biol (1987) 1.62
beta-Galactosidase chimeras: primary structure of a lac repressor-beta-galactosidase protein. Proc Natl Acad Sci U S A (1978) 1.60
Synthetic multifunctional proteins: isolation of covalently linked tryptophan synthetase alpha-subunit-lac-repressor-beta-galactosidase chimeras. Mol Gen Genet (1977) 1.57
How Trp repressor binds to its operator. EMBO J (1990) 1.53
Human antisera detect a Plasmodium falciparum genomic clone encoding a nonapeptide repeat. Nature (1984) 1.51
Identification of three residues in the basic regions of the bZIP proteins GCN4, C/EBP and TAF-1 that are involved in specific DNA binding. EMBO J (1993) 1.46
Dimer-to-tetramer assembly of Lac repressor involves a leucine heptad repeat. New Biol (1991) 1.35
lac repressor forms stable loops in vitro with supercoiled wild-type lac DNA containing all three natural lac operators. J Mol Biol (1990) 1.31
Genetic analysis of transpositions in the lac region of Escherichia coli. J Mol Biol (1980) 1.29
Isolation, genetic analysis, and characterization of Escherichia coli mutants with defects in the lacY gene. J Bacteriol (1977) 1.28
Genetic analysis of the leucine heptad repeats of Lac repressor: evidence for a 4-helical bundle. EMBO J (1993) 1.27
How AraC interacts specifically with its target DNAs. J Mol Biol (1996) 1.24
Cloning and characterization of the MboII restriction-modification system. Nucleic Acids Res (1991) 1.19
lac repressor mutants with double or triple exchanges in the recognition helix bind specifically to lac operator variants with multiple exchanges. EMBO J (1989) 1.18
Cloning of the cDNA encoding human brain trypsinogen and characterization of its product. Gene (1993) 1.18
Lac repressor. Angew Chem Int Ed Engl (1971) 1.17
Mutations in the lacY gene of Escherichia coli define functional organization of lactose permease. Proc Natl Acad Sci U S A (1981) 1.16
High local protein concentrations at promoters: strategies in prokaryotic and eukaryotic cells. Bioessays (2001) 1.15
How Lac repressor finds lac operator in vitro. J Mol Biol (1992) 1.13
A versatile phage lambda expression vector system for cloning in Escherichia coli. Gene (1989) 1.13
A change of threonine 266 to isoleucine in the lac permease of Escherichia coli diminishes the transport of lactose and increases the transport of maltose. Mol Gen Genet (1985) 1.12
The 11-1 gene of Plasmodium falciparum codes for distinct fast evolving repeats. EMBO J (1988) 1.08
Dimeric lac repressors exhibit phase-dependent co-operativity. J Mol Biol (1998) 1.07
The PreA4(695) precursor protein of Alzheimer's disease A4 amyloid is encoded by 16 exons. Nucleic Acids Res (1989) 1.07
Does the lactose carrier of Escherichia coli function as a monomer? FEBS Lett (1983) 1.07
Investigation of structure and function of lactose permease of Escherichia coli. Biochem Soc Trans (1980) 1.04
72 residues of gal repressor fused to beta-galactosidase repress the gal operon of E. coli. EMBO J (1983) 1.03
Replacement of invariant bZip residues within the basic region of the yeast transcriptional activator GCN4 can change its DNA binding specificity. Nucleic Acids Res (1994) 1.03
Cross-reactive antigenic determinants present on different Plasmodium falciparum blood-stage antigens. Parasite Immunol (1989) 1.01
The sequence of the two extra exons in rat preA4. Nucleic Acids Res (1989) 1.01
Lactose permease of Escherichia coli: properties of mutants defective in substrate translocation. Proc Natl Acad Sci U S A (1987) 1.00
A model of the lac repressor-operator complex based on physical and genetic data. Eur J Biochem (1991) 0.99
Lambda cI repressor mutants altered in transcriptional activation. J Mol Biol (1994) 0.98
Differential splicing of Alzheimer's disease amyloid A4 precursor RNA in rat tissues: PreA4(695) mRNA is predominantly produced in rat and human brain. Biochem Biophys Res Commun (1990) 0.96
Pharmacological characterization of the first potent and selective antagonist at the cysteinyl leukotriene 2 (CysLT(2)) receptor. Br J Pharmacol (2010) 0.95
Lac repressor with the helix-turn-helix motif of lambda cro binds to lac operator. EMBO J (1992) 0.95
gal4 transcription activator protein of yeast can function as a repressor in Escherichia coli. EMBO J (1987) 0.94
Dimerisation mutants of Lac repressor. II. A single amino acid substitution, D278L, changes the specificity of dimerisation. J Mol Biol (2000) 0.93
The DNA binding specificity of the basic region of the yeast transcriptional activator GCN4 can be changed by substitution of a single amino acid. Nucleic Acids Res (1993) 0.93
A synthetic operon containing 14 bovine pancreatic trypsin inhibitor genes is expressed in E. coli. EMBO J (1986) 0.92
Dimerisation mutants of Lac repressor. I. A monomeric mutant, L251A, that binds Lac operator DNA as a dimer. J Mol Biol (1999) 0.92
The side-chain of the amino acid residue in position 110 of the Lac repressor influences its allosteric equilibrium. J Mol Biol (1996) 0.91
Creating new DNA binding specificities in the yeast transcriptional activator GCN4 by combining selected amino acid substitutions. Nucleic Acids Res (1994) 0.91
The roles of residues 5 and 9 of the recognition helix of Lac repressor in lac operator binding. J Mol Biol (1991) 0.90
In vitro phagocytosis inhibition assay for the screening of potential candidate antigens for sub-unit vaccines against the asexual blood stage of Plasmodium falciparum. J Immunol Methods (1993) 0.90