Published in EMBO J on March 01, 1993
The Arabidopsis HY5 gene encodes a bZIP protein that regulates stimulus-induced development of root and hypocotyl. Genes Dev (1997) 5.18
Stress-induced binding of the transcriptional factor CHOP to a novel DNA control element. Mol Cell Biol (1996) 2.98
Compilation of sequence-specific DNA-binding proteins implicated in transcriptional control in fungi. Nucleic Acids Res (1993) 1.98
DNA recognition code of transcription factors in the helix-turn-helix, probe helix, hormone receptor, and zinc finger families. Proc Natl Acad Sci U S A (1994) 1.90
Genomic survey and gene expression analysis of the basic leucine zipper transcription factor family in rice. Plant Physiol (2007) 1.73
Predicting specificity-determining residues in two large eukaryotic transcription factor families. Nucleic Acids Res (2005) 1.30
Identification of C/EBP basic region residues involved in DNA sequence recognition and half-site spacing preference. Mol Cell Biol (1993) 1.29
Genetic analysis of the leucine heptad repeats of Lac repressor: evidence for a 4-helical bundle. EMBO J (1993) 1.27
Genome-wide analysis of bZIP-encoding genes in maize. DNA Res (2012) 1.14
DNA-binding specificity of the PAR basic leucine zipper protein VBP partially overlaps those of the C/EBP and CREB/ATF families and is influenced by domains that flank the core basic region. Mol Cell Biol (1995) 1.09
A single amino-acid substitution in the Ets domain alters core DNA binding specificity of Ets1 to that of the related transcription factors Elf1 and E74. Nucleic Acids Res (1993) 1.07
Assessment of the optimization of affinity and specificity at protein-DNA interfaces. Nucleic Acids Res (2009) 1.07
The Sko1p repressor and Gcn4p activator antagonistically modulate stress-regulated transcription in Saccharomyces cerevisiae. Mol Cell Biol (2001) 1.03
Replacement of invariant bZip residues within the basic region of the yeast transcriptional activator GCN4 can change its DNA binding specificity. Nucleic Acids Res (1994) 1.03
Genome-wide analysis and expression profile of the bZIP transcription factor gene family in grapevine (Vitis vinifera). BMC Genomics (2014) 1.03
SKN-1 domain folding and basic region monomer stabilization upon DNA binding. Genes Dev (1997) 0.98
Creating new DNA binding specificities in the yeast transcriptional activator GCN4 by combining selected amino acid substitutions. Nucleic Acids Res (1994) 0.91
Design and calibration of a semi-synthetic DNA phasing assay. Nucleic Acids Res (2000) 0.88
Analysis of the involvement of ocs-like bZip-binding elements in the differential strength of the bidirectional mas1'2' promoter. Plant Physiol (1994) 0.85
Genomic surveys and expression analysis of bZIP gene family in castor bean (Ricinus communis L.). Planta (2013) 0.85
The VBP and a1/EBP leucine zipper factors bind overlapping subsets of avian retroviral long terminal repeat CCAAT/enhancer elements. J Virol (1994) 0.84
A comparison of the different DNA binding specificities of the bZip proteins C/EBP and GCN4. Nucleic Acids Res (1995) 0.84
Single exchanges of amino acids in the basic region change the specificity of N-Myc. Nucleic Acids Res (1993) 0.82
DNA-binding specificity of the IDI-4 basic leucine zipper factor of Podospora anserina defined by systematic evolution of ligands by exponential enrichment (SELEX). Eukaryot Cell (2005) 0.80
Solution structure and dynamics of GCN4 cognate DNA: NMR investigations. Nucleic Acids Res (2001) 0.79
Genome-wide systematic characterization of the bZIP transcriptional factor family in tomato (Solanum lycopersicum L.). BMC Genomics (2015) 0.78
Genome-wide analysis of the basic leucine zipper (bZIP) transcription factor gene family in six legume genomes. BMC Genomics (2015) 0.78
Rosette-forming glioneuronal tumor in the pineal gland and the third ventricle: a case with radiological and clinical implications. Quant Imaging Med Surg (2012) 0.76
Electrostatic control of half-site spacing preferences by the cyclic AMP response element-binding protein CREB. Nucleic Acids Res (2001) 0.76
Nup100 regulates Saccharomyces cerevisiae replicative life span by mediating the nuclear export of specific tRNAs. RNA (2016) 0.75
Mutant bZip-DNA complexes with four quasi-identical protein-DNA interfaces. EMBO J (1996) 0.75
Genome-Wide Identification of bZIP Family Genes Involved in Drought and Heat Stresses in Strawberry (Fragaria vesca). Int J Genomics (2017) 0.75
Tricine-sodium dodecyl sulfate-polyacrylamide gel electrophoresis for the separation of proteins in the range from 1 to 100 kDa. Anal Biochem (1987) 59.79
The leucine zipper: a hypothetical structure common to a new class of DNA binding proteins. Science (1988) 27.01
GCN4 protein, synthesized in vitro, binds HIS3 regulatory sequences: implications for general control of amino acid biosynthetic genes in yeast. Cell (1985) 11.63
Functional dissection of a eukaryotic transcriptional activator protein, GCN4 of yeast. Cell (1986) 11.42
Plasmid vectors for high-efficiency expression controlled by the PL promoter of coliphage lambda. Gene (1981) 9.44
Scissors-grip model for DNA recognition by a family of leucine zipper proteins. Science (1989) 8.98
The GCN4 basic region leucine zipper binds DNA as a dimer of uninterrupted alpha helices: crystal structure of the protein-DNA complex. Cell (1992) 6.47
Saturation mutagenesis of the yeast his3 regulatory site: requirements for transcriptional induction and for binding by GCN4 activator protein. Science (1986) 6.36
GCN4, a eukaryotic transcriptional activator protein, binds as a dimer to target DNA. EMBO J (1987) 5.32
Defining the sequence specificity of DNA-binding proteins by selecting binding sites from random-sequence oligonucleotides: analysis of yeast GCN4 protein. Mol Cell Biol (1989) 5.23
Cloning and analysis of strong promoters is made possible by the downstream placement of a RNA termination signal. Proc Natl Acad Sci U S A (1981) 3.77
A tobacco bZip transcription activator (TAF-1) binds to a G-box-like motif conserved in plant genes. EMBO J (1991) 3.25
Fos-Jun heterodimers and Jun homodimers bend DNA in opposite orientations: implications for transcription factor cooperativity. Cell (1991) 3.09
Design of DNA-binding peptides based on the leucine zipper motif. Science (1990) 2.84
DNA bending by Fos and Jun: the flexible hinge model. Science (1991) 2.53
Cognate DNA binding specificity retained after leucine zipper exchange between GCN4 and C/EBP. Science (1989) 2.44
The interaction of the recognition helix of lac repressor with lac operator. EMBO J (1987) 2.19
Mutations that define the optimal half-site for binding yeast GCN4 activator protein and identify an ATF/CREB-like repressor that recognizes similar DNA sites. Mol Cell Biol (1990) 2.00
Mutant lac repressors with new specificities hint at rules for protein--DNA recognition. EMBO J (1990) 1.77
Highly conserved residues in the bZIP domain of yeast GCN4 are not essential for DNA binding. Mol Cell Biol (1991) 1.42
Identification of an amino acid-base contact in the GCN4-DNA complex by bromouracil-mediated photocrosslinking. Nature (1992) 1.31
lac repressor mutants with double or triple exchanges in the recognition helix bind specifically to lac operator variants with multiple exchanges. EMBO J (1989) 1.18
Mutations in the bZIP domain of yeast GCN4 that alter DNA-binding specificity. Proc Natl Acad Sci U S A (1992) 1.09
A model of the lac repressor-operator complex based on physical and genetic data. Eur J Biochem (1991) 0.99
Lac repressor with the helix-turn-helix motif of lambda cro binds to lac operator. EMBO J (1992) 0.95
A synthetic operon containing 14 bovine pancreatic trypsin inhibitor genes is expressed in E. coli. EMBO J (1986) 0.92
The roles of residues 5 and 9 of the recognition helix of Lac repressor in lac operator binding. J Mol Biol (1991) 0.90
The interaction of lac repressor headpiece with its operator: an NMR view. Protein Seq Data Anal (1988) 0.84
A sense of smell. Curr Biol (1992) 0.80
Filamentous coliphage M13 as a cloning vehicle: insertion of a HindII fragment of the lac regulatory region in M13 replicative form in vitro. Proc Natl Acad Sci U S A (1977) 18.85
The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor. Nature (1987) 17.08
Isolation of the lac repressor. Proc Natl Acad Sci U S A (1966) 10.20
Sequence of the lactose permease gene. Nature (1980) 9.67
Easy identification of cDNA clones. EMBO J (1983) 9.18
pUR222, a vector for cloning and rapid chemical sequencing of DNA. Nucleic Acids Res (1981) 6.55
Sequence of the lacZ gene of Escherichia coli. EMBO J (1983) 6.46
Mutants that make more lac repressor. Proc Natl Acad Sci U S A (1968) 6.26
Lac repressor can be fused to beta-galactosidase. Nature (1974) 5.84
The three operators of the lac operon cooperate in repression. EMBO J (1990) 5.45
The lac operator is DNA. Proc Natl Acad Sci U S A (1967) 5.24
lac repressor forms loops with linear DNA carrying two suitably spaced lac operators. EMBO J (1987) 4.02
How lac repressor binds to DNA. Nature (1972) 3.72
Lac repressor and lac operator. Prog Biophys Mol Biol (1975) 3.08
Repression of lac promoter as a function of distance, phase and quality of an auxiliary lac operator. J Mol Biol (1996) 3.08
Genetic studies of the Lac repressor. XV: 4000 single amino acid substitutions and analysis of the resulting phenotypes on the basis of the protein structure. J Mol Biol (1996) 2.98
Quality and position of the three lac operators of E. coli define efficiency of repression. EMBO J (1994) 2.90
Sequence of galR gene indicates a common evolutionary origin of lac and gal repressor in Escherichia coli. Proc Natl Acad Sci U S A (1982) 2.77
Possible ideal lac operator: Escherichia coli lac operator-like sequences from eukaryotic genomes lack the central G X C pair. Proc Natl Acad Sci U S A (1984) 2.64
Amplification of the lactose carrier protein in Escherichia coli using a plasmid vector. Mol Gen Genet (1978) 2.48
Suppressible regulator constitutive mutants of the lactose system in Escherichia coli. J Mol Biol (1966) 2.36
Immunoenzymatic detection of expressed gene fragments cloned in the lac Z gene of E. coli. EMBO J (1982) 2.29
Construction, isolation and implications of repressor-galactosidase - beta-galactosidase hybrid molecules. Eur J Biochem (1977) 2.24
Inhibition of the synthesis of beta-galactosidase in Escherichia coli by 2-nitrophenyl-beta-D-fucoside. J Mol Biol (1966) 2.24
Identification, transmembrane orientation and biogenesis of the amyloid A4 precursor of Alzheimer's disease. EMBO J (1988) 2.23
The interaction of the recognition helix of lac repressor with lac operator. EMBO J (1987) 2.19
Exon cloning: immunoenzymatic identification of exons of the chicken lysozyme gene. Proc Natl Acad Sci U S A (1982) 2.07
Nucleotide sequences of the gal E gene and the gal T gene of E. coli. Nucleic Acids Res (1986) 2.00
On the conservation of protein sequences in evolution. Trends Biochem Sci (2000) 1.91
Synthetic lac operator mediates repression through lac repressor when introduced upstream and downstream from lac promoter. EMBO J (1986) 1.80
Mutant lac repressors with new specificities hint at rules for protein--DNA recognition. EMBO J (1990) 1.77
DNA supercoiling changes the spacing requirement of two lac operators for DNA loop formation with lac repressor. EMBO J (1988) 1.70
Recognition helices of lac and lambda repressor are oriented in opposite directions and recognize similar DNA sequences. Proc Natl Acad Sci U S A (1988) 1.64
Four dimers of lambda repressor bound to two suitably spaced pairs of lambda operators form octamers and DNA loops over large distances. Curr Biol (1999) 1.63
Specific destruction of the second lac operator decreases repression of the lac operon in Escherichia coli fivefold. J Mol Biol (1987) 1.62
beta-Galactosidase chimeras: primary structure of a lac repressor-beta-galactosidase protein. Proc Natl Acad Sci U S A (1978) 1.60
Synthetic multifunctional proteins: isolation of covalently linked tryptophan synthetase alpha-subunit-lac-repressor-beta-galactosidase chimeras. Mol Gen Genet (1977) 1.57
How Trp repressor binds to its operator. EMBO J (1990) 1.53
Human antisera detect a Plasmodium falciparum genomic clone encoding a nonapeptide repeat. Nature (1984) 1.51
Dimer-to-tetramer assembly of Lac repressor involves a leucine heptad repeat. New Biol (1991) 1.35
lac repressor forms stable loops in vitro with supercoiled wild-type lac DNA containing all three natural lac operators. J Mol Biol (1990) 1.31
Genetic analysis of transpositions in the lac region of Escherichia coli. J Mol Biol (1980) 1.29
Isolation, genetic analysis, and characterization of Escherichia coli mutants with defects in the lacY gene. J Bacteriol (1977) 1.28
Genetic analysis of the leucine heptad repeats of Lac repressor: evidence for a 4-helical bundle. EMBO J (1993) 1.27
How AraC interacts specifically with its target DNAs. J Mol Biol (1996) 1.24
Cloning and characterization of the MboII restriction-modification system. Nucleic Acids Res (1991) 1.19
lac repressor mutants with double or triple exchanges in the recognition helix bind specifically to lac operator variants with multiple exchanges. EMBO J (1989) 1.18
Cloning of the cDNA encoding human brain trypsinogen and characterization of its product. Gene (1993) 1.18
Lac repressor. Angew Chem Int Ed Engl (1971) 1.17
Mutations in the lacY gene of Escherichia coli define functional organization of lactose permease. Proc Natl Acad Sci U S A (1981) 1.16
High local protein concentrations at promoters: strategies in prokaryotic and eukaryotic cells. Bioessays (2001) 1.15
How Lac repressor finds lac operator in vitro. J Mol Biol (1992) 1.13
A versatile phage lambda expression vector system for cloning in Escherichia coli. Gene (1989) 1.13
A change of threonine 266 to isoleucine in the lac permease of Escherichia coli diminishes the transport of lactose and increases the transport of maltose. Mol Gen Genet (1985) 1.12
The 11-1 gene of Plasmodium falciparum codes for distinct fast evolving repeats. EMBO J (1988) 1.08
Dimeric lac repressors exhibit phase-dependent co-operativity. J Mol Biol (1998) 1.07
The PreA4(695) precursor protein of Alzheimer's disease A4 amyloid is encoded by 16 exons. Nucleic Acids Res (1989) 1.07
Does the lactose carrier of Escherichia coli function as a monomer? FEBS Lett (1983) 1.07
Investigation of structure and function of lactose permease of Escherichia coli. Biochem Soc Trans (1980) 1.04
72 residues of gal repressor fused to beta-galactosidase repress the gal operon of E. coli. EMBO J (1983) 1.03
Replacement of invariant bZip residues within the basic region of the yeast transcriptional activator GCN4 can change its DNA binding specificity. Nucleic Acids Res (1994) 1.03
The sequence of the two extra exons in rat preA4. Nucleic Acids Res (1989) 1.01
Cross-reactive antigenic determinants present on different Plasmodium falciparum blood-stage antigens. Parasite Immunol (1989) 1.01
Lactose permease of Escherichia coli: properties of mutants defective in substrate translocation. Proc Natl Acad Sci U S A (1987) 1.00
A model of the lac repressor-operator complex based on physical and genetic data. Eur J Biochem (1991) 0.99
Lambda cI repressor mutants altered in transcriptional activation. J Mol Biol (1994) 0.98
Differential splicing of Alzheimer's disease amyloid A4 precursor RNA in rat tissues: PreA4(695) mRNA is predominantly produced in rat and human brain. Biochem Biophys Res Commun (1990) 0.96
Lac repressor with the helix-turn-helix motif of lambda cro binds to lac operator. EMBO J (1992) 0.95
gal4 transcription activator protein of yeast can function as a repressor in Escherichia coli. EMBO J (1987) 0.94
Dimerisation mutants of Lac repressor. II. A single amino acid substitution, D278L, changes the specificity of dimerisation. J Mol Biol (2000) 0.93
The DNA binding specificity of the basic region of the yeast transcriptional activator GCN4 can be changed by substitution of a single amino acid. Nucleic Acids Res (1993) 0.93
A synthetic operon containing 14 bovine pancreatic trypsin inhibitor genes is expressed in E. coli. EMBO J (1986) 0.92
Dimerisation mutants of Lac repressor. I. A monomeric mutant, L251A, that binds Lac operator DNA as a dimer. J Mol Biol (1999) 0.92
The side-chain of the amino acid residue in position 110 of the Lac repressor influences its allosteric equilibrium. J Mol Biol (1996) 0.91
Creating new DNA binding specificities in the yeast transcriptional activator GCN4 by combining selected amino acid substitutions. Nucleic Acids Res (1994) 0.91
The roles of residues 5 and 9 of the recognition helix of Lac repressor in lac operator binding. J Mol Biol (1991) 0.90
In vitro phagocytosis inhibition assay for the screening of potential candidate antigens for sub-unit vaccines against the asexual blood stage of Plasmodium falciparum. J Immunol Methods (1993) 0.90