Published in J Mol Biol on August 20, 1993
Crystal structure of a deletion mutant of human thymidylate synthase Delta (7-29) and its ternary complex with Tomudex and dUMP. Protein Sci (2001) 1.21
The role of protein dynamics in thymidylate synthase catalysis: variants of conserved 2'-deoxyuridine 5'-monophosphate (dUMP)-binding Tyr-261. Biochemistry (2006) 1.14
Seeking an ancient enzyme in Methanococcus jannaschii using ORF, a program based on predicted secondary structure comparisons. Proc Natl Acad Sci U S A (1998) 0.96
Relative free energies of binding to thymidylate synthase of 2- and/or 4-thio and/or 5-fluoro analogues of dUMP. J Comput Aided Mol Des (2003) 0.85
Promotion of purine nucleotide binding to thymidylate synthase by a potent folate analogue inhibitor, 1843U89. Proc Natl Acad Sci U S A (1995) 0.78
Structure of the Varicella Zoster Virus Thymidylate Synthase Establishes Functional and Structural Similarities as the Human Enzyme and Potentiates Itself as a Target of Brivudine. PLoS One (2015) 0.77
Structure of a glycerol-conducting channel and the basis for its selectivity. Science (2000) 6.64
Ribosomal RNA sequence shows Pneumocystis carinii to be a member of the fungi. Nature (1988) 5.21
Clq: rapid purification method for preparation of monospecific antisera and for biochemical studies. J Immunol (1971) 5.06
Kinetic and catalytic mechanism of HhaI methyltransferase. J Biol Chem (1987) 4.84
Amphipathic analysis and possible formation of the ion channel in an acetylcholine receptor. Proc Natl Acad Sci U S A (1984) 4.70
The catalytic mechanism and structure of thymidylate synthase. Annu Rev Biochem (1995) 4.57
The signal recognition particle. Annu Rev Biochem (2001) 4.47
On the mechanism of inhibition of DNA-cytosine methyltransferases by cytosine analogs. Cell (1983) 3.56
Crystal structure of the HIV-1 integrase catalytic core and C-terminal domains: a model for viral DNA binding. Proc Natl Acad Sci U S A (2000) 3.26
Covalent bond formation between a DNA-cytosine methyltransferase and DNA containing 5-azacytosine. Proc Natl Acad Sci U S A (1984) 3.22
Crystal structure of Yersinia protein tyrosine phosphatase at 2.5 A and the complex with tungstate. Nature (1994) 3.10
Antifolate-resistant mutants of Plasmodium falciparum dihydrofolate reductase. Proc Natl Acad Sci U S A (1997) 3.07
Structure and function of an acetylcholine receptor. Biophys J (1982) 2.92
Stable amplified DNA in drug-resistant Leishmania exists as extrachromosomal circles. Science (1986) 2.84
Efficiency of signalling through cytokine receptors depends critically on receptor orientation. Nature (1998) 2.65
Bias in phylogenetic estimation and its relevance to the choice between parsimony and likelihood methods. Syst Biol (2001) 2.62
Overproduction of a bifunctional thymidylate synthetase-dihydrofolate reductase and DNA amplification in methotrexate-resistant Leishmania tropica. Proc Natl Acad Sci U S A (1983) 2.59
Site-directed ligand discovery. Proc Natl Acad Sci U S A (2000) 2.58
RNA methylation under heat shock control. Mol Cell (2000) 2.58
Crystal structure of colicin Ia. Nature (1997) 2.57
Structure of the conserved GTPase domain of the signal recognition particle. Nature (1997) 2.52
Atomic structure of thymidylate synthase: target for rational drug design. Science (1987) 2.48
Crystal structure of the signal sequence binding subunit of the signal recognition particle. Cell (1998) 2.44
Mechanism of action of the C3b inactivator: requirement for a high molecular weight cofactor (C3b-C4bINA cofactor) and production of a new C3b derivative (C3b'). Immunochemistry (1978) 2.43
Mechanism of interaction of thymidylate synthetase with 5-fluorodeoxyuridylate. Biochemistry (1974) 2.42
C'2ad, an inactive derivative of C'2 released during decay of EAC'4,2a. Immunochemistry (1966) 2.37
Ultrastructure of the human complement component, Clq (negative staining-glutamine synthetase-biologically active Clq). Proc Natl Acad Sci U S A (1972) 2.32
Unstable DNA amplifications in methotrexate-resistant Leishmania consist of extrachromosomal circles which relocalize during stabilization. Cell (1984) 2.28
Cleavage of C2 by C1s into the antigenically distinct fragments C2a and C2b: demonstration of binding of C2b to C4b. Proc Natl Acad Sci U S A (1977) 2.27
Domain structure of 3-hydroxy-3-methylglutaryl coenzyme A reductase, a glycoprotein of the endoplasmic reticulum. J Biol Chem (1985) 2.27
Cleavage products of C4b produced by enzymes in human serum. Immunochemistry (1975) 2.26
Regulation of an enzyme by phosphorylation at the active site. Science (1990) 2.25
Structure of a bacterial enzyme regulated by phosphorylation, isocitrate dehydrogenase. Proc Natl Acad Sci U S A (1989) 2.20
Structural studies of a membrane-bound acetylcholine receptor from Torpedo californica. J Mol Biol (1977) 2.17
Rabbit C1q: purification, functional and structural studies. J Immunol Methods (1972) 2.15
A rapid and sensitive high pressure liquid chromatography assay for deoxyribonucleoside triphosphates in cell extracts. Anal Biochem (1979) 2.13
A conserved aspartate of tRNA pseudouridine synthase is essential for activity and a probable nucleophilic catalyst. Biochemistry (1998) 2.12
Chemical studies of Clq; a modulator of immunoglobulin biology. Biochem Biophys Res Commun (1971) 2.05
Linking regions between helices in bacteriorhodopsin revealed. Biophys J (1982) 2.03
Stereochemical modeling of disulfide bridges. Criteria for introduction into proteins by site-directed mutagenesis. Protein Eng (1989) 1.98
Structure, multiple site binding, and segmental accommodation in thymidylate synthase on binding dUMP and an anti-folate. Biochemistry (1990) 1.98
Structural and functional conservation between yeast and human 3-hydroxy-3-methylglutaryl coenzyme A reductases, the rate-limiting enzyme of sterol biosynthesis. Mol Cell Biol (1988) 1.97
Cleavage of C4b by C3b inactivator: production of a nicked form of C4b, C4b', as an intermediate cleavage product of C4b by C3b inactivator. J Immunol (1980) 1.94
Catalytic mechanism of NADP(+)-dependent isocitrate dehydrogenase: implications from the structures of magnesium-isocitrate and NADP+ complexes. Biochemistry (1991) 1.91
Isolation and expression of the Pneumocystis carinii thymidylate synthase gene. Proc Natl Acad Sci U S A (1989) 1.88
The three-dimensional structure of Asn102 mutant of trypsin: role of Asp102 in serine protease catalysis. Science (1987) 1.87
Saturation site-directed mutagenesis of thymidylate synthase. J Biol Chem (1990) 1.85
Structural studies on human Clq: non-covalent and covalent subunits. Immunochemistry (1972) 1.83
Plasmid migration using orthogonal-field-alternation gel electrophoresis. Nucleic Acids Res (1987) 1.82
Structure of Cry2Aa suggests an unexpected receptor binding epitope. Structure (2001) 1.82
Immunospecific identification and three-dimensional structure of a membrane-bound acetylcholine receptor from Torpedo californica. J Mol Biol (1979) 1.82
Crystal structure of the macrocycle-forming thioesterase domain of the erythromycin polyketide synthase: versatility from a unique substrate channel. Proc Natl Acad Sci U S A (2001) 1.80
Structure at 2.5 A of a designed peptide that maintains solubility of membrane proteins. Science (1993) 1.76
Family of G protein alpha chains: amphipathic analysis and predicted structure of functional domains. Protein Eng (1989) 1.76
Domain flexibility in retroviral proteases: structural implications for drug resistant mutations. Biochemistry (1998) 1.75
Structure determination of asymmetric membrane profiles using an iterative Fourier method. Biophys J (1979) 1.75
Plastic adaptation toward mutations in proteins: structural comparison of thymidylate synthases. Proteins (1990) 1.75
Isolation and expression of the Pneumocystis carinii dihydrofolate reductase gene. Proc Natl Acad Sci U S A (1989) 1.74
Attachment site(s) of retinal in bacteriorhodopsin. Proc Natl Acad Sci U S A (1981) 1.73
A bifunctional thymidylate synthetase-dihydrofolate reductase in protozoa. Mol Biochem Parasitol (1984) 1.71
The dihydrofolate reductase domain of Plasmodium falciparum thymidylate synthase-dihydrofolate reductase. Gene synthesis, expression, and anti-folate-resistant mutants. J Biol Chem (1993) 1.71
Projected structure of purple membrane determined to 3.7 A resolution by low temperature electron microscopy. J Mol Biol (1981) 1.71
Purification and characterization of the bifunctional thymidylate synthetase-dihydrofolate reductase from methotrexate-resistant Leishmania tropica. Biochemistry (1985) 1.71
The mechanism of pseudouridine synthase I as deduced from its interaction with 5-fluorouracil-tRNA. Proc Natl Acad Sci U S A (1999) 1.69
Identification of new RNA modifying enzymes by iterative genome search using known modifying enzymes as probes. Nucleic Acids Res (1996) 1.68
Structure and content of the Entamoeba histolytica genome. Adv Parasitol (2007) 1.62
Structure and specific binding of trypsin: comparison of inhibited derivatives and a model for substrate binding. J Mol Biol (1974) 1.62
Structure-based discovery of inhibitors of thymidylate synthase. Science (1993) 1.61
5-Fluorocytosine in DNA is a mechanism-based inhibitor of HhaI methylase. Biochemistry (1988) 1.57
High-pressure liquid chromatography--ultraviolet analysis of intracellular nucleotides. Anal Biochem (1982) 1.56
The structure of bovine trypsin: electron density maps of the inhibited enzyme at 5 Angstrom and at 2-7 Angstron resolution. J Mol Biol (1974) 1.55
5-Fluoro-2'-deoxyuridylate: covalent complex with thymidylate synthetase. Proc Natl Acad Sci U S A (1972) 1.54
The Cys(X)5Arg catalytic motif in phosphoester hydrolysis. Biochemistry (1994) 1.54
Heterologous expression of active thymidylate synthase-dihydrofolate reductase from Plasmodium falciparum. Biochemistry (1990) 1.52
Folding of dihydrofolate reductase from Escherichia coli. Biochemistry (1986) 1.51
Mechanisms of zymogen activation. Annu Rev Biophys Bioeng (1977) 1.51
The molecular neurobiology of the acetylcholine receptor. Annu Rev Neurosci (1986) 1.50
Functional changes in the structure of the SRP GTPase on binding GDP and Mg2+GDP. Nat Struct Biol (1999) 1.47
Construction of a dihydrofolate reductase-deficient mutant of Escherichia coli by gene replacement. J Bacteriol (1988) 1.46
The crystal and molecular structure of DIP-inhibited bovine trypsin at2.7Angstrom resolution. Cold Spring Harb Symp Quant Biol (1972) 1.45
Biochemical studies on the mode of action of cytochalasin B. Preparation of (3H)cytochalasin B and studies on its binding of cells. J Biol Chem (1974) 1.43
Molecular recognition of tRNA by tRNA pseudouridine 55 synthase. Biochemistry (1998) 1.42
Epidermal growth factor (EGF) induces oligomerization of soluble, extracellular, ligand-binding domain of EGF receptor. A low resolution projection structure of the ligand-binding domain. J Biol Chem (1991) 1.41
Reversible adsorption of C'2 by EAC'4: role of Mg2+, enumeration of competent SAC'4, two-step nature of C'2a fixation and estimation of its efficiency. Immunochemistry (1966) 1.41
The structural basis for tRNA recognition and pseudouridine formation by pseudouridine synthase I. Nat Struct Biol (2000) 1.41
Production of a polyketide natural product in nonpolyketide-producing prokaryotic and eukaryotic hosts. Proc Natl Acad Sci U S A (1998) 1.37
Deficiency of C1r in human serum. Effects on the structure and function of macromolecular C1. J Exp Med (1970) 1.36
Structure of bovine trypsinogen at 1.9 A resolution. Biochemistry (1977) 1.36
Human factor D of the alternative complement pathway: purification and characterization. J Immunol (1977) 1.33
Crystal structure of human thymidylate synthase: a structural mechanism for guiding substrates into the active site. Biochemistry (1995) 1.32