PubRank

D A Clayton

Author PubWeight™ 269.70‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Sequence and gene organization of mouse mitochondrial DNA. Cell 1981 13.14
2 Mitochondrial transcription factor A is necessary for mtDNA maintenance and embryogenesis in mice. Nat Genet 1998 7.89
3 Replication of animal mitochondrial DNA. Cell 1982 7.79
4 DNA of a human hepatitis B virus candidate. J Virol 1974 5.90
5 Mitochondrial DNA maintenance in vertebrates. Annu Rev Biochem 1997 4.96
6 The number of mitochondrial deoxyribonucleic acid genomes in mouse L and human HeLa cells. Quantitative isolation of mitochondrial deoxyribonucleic acid. J Biol Chem 1974 4.71
7 Precise localization and nucleotide sequence of the two mouse mitochondrial rRNA genes and three immediately adjacent novel tRNA genes. Cell 1980 4.41
8 Transcription of the mammalian mitochondrial genome. Annu Rev Biochem 1984 4.35
9 Similarity of human mitochondrial transcription factor 1 to high mobility group proteins. Science 1991 4.26
10 Yeast mitochondrial RNA polymerase is homologous to those encoded by bacteriophages T3 and T7. Cell 1987 3.83
11 The absence of a pyrimidine dimer repair mechanism in mammalian mitochondria. Proc Natl Acad Sci U S A 1974 3.58
12 Structure of hepatitis B Dane particle DNA before and after the Dane particle DNA polymerase reaction. J Virol 1977 3.57
13 Circular dimer and catenate forms of mitochondrial DNA in human leukaemic leucocytes. Nature 1967 3.48
14 Complex mitochondrial DNA. Cold Spring Harb Symp Quant Biol 1968 3.31
15 Nuclear RNase MRP is required for correct processing of pre-5.8S rRNA in Saccharomyces cerevisiae. Mol Cell Biol 1993 3.29
16 Homology and structural relationships between the dimeric and monomeric circular forms of mitochondrial DNA from human leukemic leukocytes. J Mol Biol 1970 3.07
17 Priming of human mitochondrial DNA replication occurs at the light-strand promoter. Proc Natl Acad Sci U S A 1985 3.05
18 Sequence and properties of the human KB cell and mouse L cell D-loop regions of mitochondrial DNA. Nucleic Acids Res 1981 2.90
19 Molecular genetic aspects of human mitochondrial disorders. Annu Rev Genet 1995 2.82
20 Studies of mouse mitochondrial DNA in Escherichia coli: structure and function of the eucaryotic-procaryotic chimeric plasmids. Cell 1975 2.80
21 Purification and characterization of human mitochondrial transcription factor 1. Mol Cell Biol 1988 2.78
22 Precise identification of individual promoters for transcription of each strand of human mitochondrial DNA. Cell 1984 2.69
23 DNA wrapping and bending by a mitochondrial high mobility group-like transcriptional activator protein. J Biol Chem 1992 2.64
24 A mammalian mitochondrial RNA processing activity contains nucleus-encoded RNA. Science 1987 2.63
25 A novel endoribonuclease cleaves at a priming site of mouse mitochondrial DNA replication. EMBO J 1987 2.63
26 Dilated cardiomyopathy and atrioventricular conduction blocks induced by heart-specific inactivation of mitochondrial DNA gene expression. Nat Genet 1999 2.57
27 The transcription map of mouse mitochondrial DNA. Cell 1978 2.52
28 Mouse RNAase MRP RNA is encoded by a nuclear gene and contains a decamer sequence complementary to a conserved region of mitochondrial RNA substrate. Cell 1989 2.49
29 Replication of mitochondrial DNA in mouse L cells and their thymidine kinase - derivatives: displacement replication on a covalently-closed circular template. Proc Natl Acad Sci U S A 1972 2.49
30 Promoter selection in human mitochondria involves binding of a transcription factor to orientation-independent upstream regulatory elements. Cell 1987 2.44
31 Pervasive CpG suppression in animal mitochondrial genomes. Proc Natl Acad Sci U S A 1994 2.35
32 Length heterogeneity of a conserved displacement-loop sequence in human mitochondrial DNA. Nucleic Acids Res 1985 2.28
33 A human mitochondrial transcriptional activator can functionally replace a yeast mitochondrial HMG-box protein both in vivo and in vitro. Mol Cell Biol 1993 2.27
34 Altered mobility of polydeoxyribonucleotides in high resolution polyacrylamide gels due to removal of terminal phosphates. Nucleic Acids Res 1981 2.23
35 Mechanism of replication of human mitochondrial DNA. Localization of the 5' ends of nascent daughter strands. J Biol Chem 1981 2.20
36 Occurrence of complex mitochondrial DNA in normal tissues. Nature 1968 2.18
37 Addition of a 29 residue carboxyl-terminal tail converts a simple HMG box-containing protein into a transcriptional activator. J Mol Biol 1995 2.17
38 LTP leads to rapid surface expression of NMDA but not AMPA receptors in adult rat CA1. Nat Neurosci 2002 2.14
39 Mouse L cell mitochondrial DNA molecules are selected randomly for replication throughout the cell cycle. Cell 1977 2.09
40 The RNA processing enzyme RNase MRP is identical to the Th RNP and related to RNase P. Science 1989 2.07
41 Mitochondrial DNA of chloramphenicol-resistant mouse cells contains a single nucleotide change in the region encoding the 3' end of the large ribosomal RNA. Proc Natl Acad Sci U S A 1981 2.03
42 Replication priming and transcription initiate from precisely the same site in mouse mitochondrial DNA. EMBO J 1985 2.03
43 Elongation of displacement-loop strands in human and mouse mitochondrial DNA is arrested near specific template sequences. Proc Natl Acad Sci U S A 1981 2.02
44 In situ localization of mitochondrial DNA replication in intact mammalian cells. J Cell Biol 1996 2.01
45 In vitro transcription of human mitochondrial DNA. Identification of specific light strand transcripts from the displacement loop region. J Biol Chem 1983 1.89
46 Yeast site-specific ribonucleoprotein endoribonuclease MRP contains an RNA component homologous to mammalian RNase MRP RNA and essential for cell viability. Genes Dev 1992 1.88
47 Displacement-loop replication initiation sequence in animal mitochondrial DNA exists as a family of discrete lengths. Proc Natl Acad Sci U S A 1978 1.86
48 A transcription factor required for promoter recognition by human mitochondrial RNA polymerase. Accurate initiation at the heavy- and light-strand promoters dissected and reconstituted in vitro. J Biol Chem 1985 1.86
49 Mechanism of mitochondrial DNA replication in mouse L-cells: RNA priming during the initiation of heavy-strand synthesis. J Mol Biol 1979 1.86
50 Template-directed pausing in in vitro DNA synthesis by DNA polymerase a from Drosophila melanogaster embryos. Proc Natl Acad Sci U S A 1982 1.86
51 Initiation of mitochondrial DNA replication by transcription and R-loop processing. J Biol Chem 1998 1.83
52 Mechanism of mitochondrial DNA replication in mouse L-cells: asynchronous replication of strands, segregation of circular daughter molecules, aspects of topology and turnover of an initiation sequence. J Mol Biol 1974 1.80
53 Isolation of mammalian mitochondrial DNA and RNA and cloning of the mitochondrial genome. Methods Enzymol 1983 1.76
54 Secondary structure of RNase MRP RNA as predicted by phylogenetic comparison. FASEB J 1993 1.75
55 Mitochondrial transcription initiation. Variation and conservation. J Biol Chem 1993 1.74
56 In vitro replication of human mitochondrial DNA: accurate initiation at the origin of light-strand synthesis. Cell 1985 1.72
57 Pulse-labeled components in the replication of mitochondrial deoxyribonucleic acid. J Biol Chem 1973 1.69
58 Selective nicking of mammalian mitochondrial DNA in vivo: photosensitization by incorporation of 5-bromodeoxyuridine. J Mol Biol 1975 1.68
59 A genetically distinct thymidine kinase in mammalian mitochondria. Exclusive labeling of mitochondrial deoxyribonucleic acid. J Biol Chem 1973 1.64
60 Low levels of mitochondrial transcription factor A in mitochondrial DNA depletion. Biochem Biophys Res Commun 1994 1.63
61 Impairment of mitochondrial transcription termination by a point mutation associated with the MELAS subgroup of mitochondrial encephalomyopathies. Nature 1991 1.60
62 Characterization of a unique protein component of yeast RNase MRP: an RNA-binding protein with a zinc-cluster domain. Genes Dev 1994 1.57
63 DNA primase of human mitochondria is associated with structural RNA that is essential for enzymatic activity. Cell 1986 1.54
64 A persistent RNA-DNA hybrid is formed during transcription at a phylogenetically conserved mitochondrial DNA sequence. Mol Cell Biol 1995 1.53
65 Complex mitochondrial DNA in leukemic and normal human myeloid cells. Proc Natl Acad Sci U S A 1969 1.52
66 Flexible recognition of rapidly evolving promoter sequences by mitochondrial transcription factor 1. Genes Dev 1989 1.52
67 Nuclear RNase MRP processes RNA at multiple discrete sites: interaction with an upstream G box is required for subsequent downstream cleavages. Genes Dev 1991 1.47
68 Mechanism of mitochondrial DNA replication in mouse L-cells: topology of circular daughter molecules and dynamics of catenated oligomer formation. J Mol Biol 1976 1.46
69 Saccharomyces cerevisiae contains an RNase MRP that cleaves at a conserved mitochondrial RNA sequence implicated in replication priming. Mol Cell Biol 1992 1.45
70 Cleavage of replicating forms of mitochondrial DNA by EcoRI endonuclease. Proc Natl Acad Sci U S A 1974 1.44
71 A tridecamer DNA sequence supports human mitochondrial RNA 3'-end formation in vitro. Mol Cell Biol 1988 1.44
72 Human mitochondrial transcription factor A and promoter spacing integrity are required for transcription initiation. Biochim Biophys Acta 1995 1.43
73 Characterization of human MRP/Th RNA and its nuclear gene: full length MRP/Th RNA is an active endoribonuclease when assembled as an RNP. Nucleic Acids Res 1990 1.42
74 Assignment of a yeast protein necessary for mitochondrial transcription initiation. Nucleic Acids Res 1992 1.40
75 Intracellular mosaicism (nuclear - -mitochondrial + ) for thymidine kinase in mouse L cells. J Cell Sci 1972 1.38
76 Mechanism of mitochondrial DNA replication in mouse L-cells: localization and sequence of the light-strand origin of replication. J Mol Biol 1979 1.37
77 RNA-DNA hybrid formation at the human mitochondrial heavy-strand origin ceases at replication start sites: an implication for RNA-DNA hybrids serving as primers. EMBO J 1996 1.35
78 Mechanism of mitochondrial DNA replication in mouse L-cells: kinetics of synthesis and turnover of the initiation sequence. J Mol Biol 1978 1.30
79 A rapid, efficient method for purifying DNA-binding proteins. Denaturation-renaturation chromatography of human and yeast mitochondrial extracts. J Biol Chem 1991 1.30
80 The transcription map of human mitochondrial DNA implicates transfer RNA excision as a major processing event. J Biol Chem 1980 1.30
81 A role for RNAase MRP in mitochondrial RNA processing. Cell 1992 1.27
82 RNase mitochondrial RNA processing correctly cleaves a novel R loop at the mitochondrial DNA leading-strand origin of replication. Genes Dev 1997 1.27
83 A Saccharomyces cerevisiae mitochondrial transcription factor, sc-mtTFB, shares features with sigma factors but is functionally distinct. Mol Cell Biol 1995 1.27
84 In vitro transcription of human mitochondrial DNA: accurate termination requires a region of DNA sequence that can function bidirectionally. Proc Natl Acad Sci U S A 1986 1.25
85 The mitochondrial DNA of Drosophila melanogaster exists in two distinct and stable superhelical forms. Cell 1977 1.25
86 Both the conserved stem-loop and divergent 5'-flanking sequences are required for initiation at the human mitochondrial origin of light-strand DNA replication. J Biol Chem 1986 1.23
87 Properties of a primer RNA-DNA hybrid at the mouse mitochondrial DNA leading-strand origin of replication. J Biol Chem 1996 1.21
88 Initiation of transcription from each of the two human mitochondrial promoters requires unique nucleotides at the transcriptional start sites. Proc Natl Acad Sci U S A 1985 1.21
89 Precise assignment of the light-strand promoter of mouse mitochondrial DNA: a functional promoter consists of multiple upstream domains. Mol Cell Biol 1986 1.21
90 Electron microscopic studies on substrate specificity of T4 excision repair endonuclease. Nature 1972 1.20
91 Mutational analysis of the RNA component of Saccharomyces cerevisiae RNase MRP reveals distinct nuclear phenotypes. Gene 2000 1.20
92 A single mouse gene encodes the mitochondrial transcription factor A and a testis-specific nuclear HMG-box protein. Nat Genet 1996 1.19
93 Precise nucleotide location of the 5' ends of RNA-primed nascent light strands of mouse mitochondrial DNA. J Mol Biol 1982 1.16
94 Mitochondrial DNA polymerase gamma is expressed and translated in the absence of mitochondrial DNA maintenance and replication. Nucleic Acids Res 1996 1.15
95 Thymidylate nucleotide supply for mitochondrial DNA synthesis in mouse L-cells. Effect of 5-fluorodeoxyuridine and methotrexate in thymidine kinase plus and thymidine kinase minus cells. J Biol Chem 1976 1.11
96 Identification of the 3'-ends of the two mouse mitochondrial ribosomal RNAs. The 3'-end of 16 S ribosomal RNA contains nucleotides encoded by the gene for transfer RNALeuUUR. J Biol Chem 1983 1.10
97 All eight unassigned reading frames of mouse mitochondrial DNA are expressed. EMBO J 1984 1.07
98 Efficient incorporation of anti-HIV deoxynucleotides by recombinant yeast mitochondrial DNA polymerase. J Biol Chem 1995 1.07
99 Analysis of glutamate receptor surface expression in acute hippocampal slices. Sci STKE 2002 1.07
100 Mitochondrial DNA of human-mouse cell hybrids. Nature 1971 1.05
101 Isolation and characterization of a DNA primase from human mitochondria. J Biol Chem 1985 1.05
102 Conserved features of yeast and mammalian mitochondrial DNA replication. Curr Opin Genet Dev 1993 1.03
103 In vitro replication of mitochondrial DNA. Elongation of the endogenous primer sequence in D loop mitochondrial DNA by human DNA polymerase beta. J Biol Chem 1977 1.03
104 Roles for a promoter and RNA processing in the synthesis of mitochondrial displacement-loop strands. Biochim Biophys Acta 1987 1.02
105 Efficient site-specific cleavage by RNase MRP requires interaction with two evolutionarily conserved mitochondrial RNA sequences. Mol Cell Biol 1990 1.01
106 Precise assignment of the heavy-strand promoter of mouse mitochondrial DNA: cognate start sites are not required for transcriptional initiation. Mol Cell Biol 1986 0.99
107 Human mitochondrial transcription termination exhibits RNA polymerase independence and biased bipolarity in vitro. J Biol Chem 1994 0.98
108 Characterization of a Xenopus laevis ribonucleoprotein endoribonuclease. Isolation of the RNA component and its expression during development. J Biol Chem 1992 0.98
109 Identification of primary transcriptional start sites of mouse mitochondrial DNA: accurate in vitro initiation of both heavy- and light-strand transcripts. Mol Cell Biol 1986 0.97
110 Secondary structure of the RNA component of a nuclear/mitochondrial ribonucleoprotein. J Biol Chem 1990 0.97
111 Minor transcription initiation events indicate that both human mitochondrial promoters function bidirectionally. Mol Cell Biol 1986 0.96
112 Identification of transcriptional regulatory elements in human mitochondrial DNA by linker substitution analysis. Mol Cell Biol 1989 0.94
113 Mechanism of mitochondrial DNA replication in mouse L-cells: introduction of superhelical turns into newly replicated molecules. J Mol Biol 1978 0.94
114 Transcription-dependent DNA transactions in the mitochondrial genome of a yeast hypersuppressive petite mutant. Mol Cell Biol 1998 0.94
115 Functional conservation of yeast mtTFB despite extensive sequence divergence. Gene Expr 1996 0.93
116 Replication of mouse L-cell mitochondrial DNA. Cold Spring Harb Symp Quant Biol 1979 0.93
117 Structure and chromosomal localization of the mouse mitochondrial transcription factor A gene (Tfam). Mamm Genome 1997 0.92
118 Hypoxic coordinate regulation of mitochondrial enzymes in mammalian cells. Science 1984 0.92
119 A big development for a small RNA. Nature 2001 0.92
120 Mechanism of mitochondrial DNA replication in mouse L-cells. Replication of unicircular dimer molecules. J Mol Biol 1981 0.92
121 Mitochondrial protein synthesis in mouse L-cells: effect of selective nicking of mitochondrial DNA. J Mol Biol 1975 0.91
122 A functional dominant mutation in Schizosaccharomyces pombe RNase MRP RNA affects nuclear RNA processing and requires the mitochondrial-associated nuclear mutation ptp1-1 for viability. EMBO J 1996 0.90
123 Bovine RNase MRP cleaves the divergent bovine mitochondrial RNA sequence at the displacement-loop region. J Mol Evol 1993 0.90
124 Mitochondrial medicine--recent advances. J Intern Med 1999 0.89
125 Backfoot is a novel homeobox gene expressed in the mesenchyme of developing hind limb. Dev Dyn 1997 0.88
126 The gene for the RNA component of the mitochondrial RNA-processing endoribonuclease is located on human chromosome 9p and on mouse chromosome 4. Genomics 1990 0.88
127 Complex mitochondrial DNA. Int Rev Exp Pathol 1975 0.88
128 Transcriptional mapping of the ribosomal RNA region of mouse L-cell mitochondrial DNA. Nucleic Acids Res 1980 0.87
129 Down-regulation of mitochondrial transcription factor A during spermatogenesis in humans. Hum Mol Genet 1997 0.87
130 Detection of circular DNA from mitochondria of Neurospora crassa. Biochem Biophys Res Commun 1972 0.86
131 Schizosaccharomyces pombe RNase MRP RNA is homologous to metazoan RNase MRP RNAs and may provide clues to interrelationships between RNase MRP and RNase P. Yeast 1995 0.85
132 Mitochondrial DNA gets the drift. Nat Genet 1996 0.84
133 Stimulation of mitochondrial gene expression and proliferation of mitochondria following impairment of cellular energy transfer by inhibition of the phosphocreatine circuit in rat hearts. J Bioenerg Biomembr 1999 0.83
134 Mutational analysis of the gene for Schizosaccharomyces pombe RNase MRP RNA, mrp1, using plasmid shuffle by counterselection on canavanine. Yeast 1996 0.83
135 Strand breakage in solutions of DNA and ethidium bromide exposed to visible light. Nucleic Acids Res 1977 0.80
136 Regulation and function of the mitochondrial genome. J Inherit Metab Dis 1996 0.78
137 Nucleotide assignment of alkali-sensitive sites in mouse mitochondrial DNA. J Biol Chem 1981 0.78
138 Mitochondrial-specific thymidine kinase. Arch Biochem Biophys 1973 0.78
139 Distribution of RNase MRP RNA during Xenopus laevis oogenesis. Mol Reprod Dev 1995 0.78
140 Absence of a pyrimidine dimer repair mechanism for mitochondrial DNA in mouse and human cells. Basic Life Sci 1975 0.78
141 The gene for ribosomal protein L7a-1 in Schizosaccharomyces pombe contains an intron after the initiation codon. Biochim Biophys Acta 1998 0.77
142 Backfoot, a novel homeobox gene, maps to human chromosome 5 (BFT) and mouse chromosome 13 (Bft). Genomics 1997 0.77
143 Isolation and characterization of vertebrate mitochondrial transcription factor A homologs. Methods Enzymol 1996 0.76
144 cDNA cloning, sequencing, and characterization of male and female rat liver aldehyde oxidase (rAOX1). Differences in redox status may distinguish male and female forms of hepatic APX. J Biol Chem 1999 0.76
145 Mechanism of mitochondrial DNA replication in mouse L cells: localization of alkali-sensitive sites at the two origins of replication. Plasmid 1981 0.76
146 Microheterogeneity detected in circular dimer mitochondrial DNA. Nucleic Acids Res 1977 0.75
147 Heavy traffic at a dual-purpose human mitochondrial tRNA gene. J Clin Invest 1993 0.75
148 Dark-field electron microscopy of unstained and unshadowed DNA. J Microsc 1971 0.75
149 Phi X 174 gene A protein does not cleave at a mouse mitochondrial DNA sequence homologous to the phi X and G4 cleavage site. Plasmid 1981 0.75
150 Effects of testosterone on investigation of stimulus change by the domestic chick. Behaviour 1979 0.75
151 Subtle determinants of the nucleocytoplasmic partitioning of in vivo-transcribed RNase MRP RNA in Xenopus laevis oocytes. Gene Expr 1996 0.75
152 Phases of inhibition and response during investigation of stimulus change by the domestic chick. Behaviour 1979 0.75
153 Properties of mitochondrial DNA metabolising enzymes; implications for chemotherapy. Adv Exp Med Biol 1994 0.75
154 Mapping promoters in displacement-loop region of vertebrate mitochondrial DNA. Methods Enzymol 1996 0.75
155 S1 nuclease-specific nicking of mitochondrial DNA containing displacement loops. Anal Biochem 1978 0.75