Published in Cell on April 01, 1982
Mitochondrial DNA mutations in human disease. Nat Rev Genet (2005) 8.51
Normal oxidative damage to mitochondrial and nuclear DNA is extensive. Proc Natl Acad Sci U S A (1988) 5.52
A new mitochondrial disease associated with mitochondrial DNA heteroplasmy. Am J Hum Genet (1990) 4.96
Stable DNA replication: interplay between DNA replication, homologous recombination, and transcription. Microbiol Mol Biol Rev (1997) 3.90
Analyzing genomes with cumulative skew diagrams. Nucleic Acids Res (1998) 3.71
Detection of a specific mitochondrial DNA deletion in tissues of older humans. Nucleic Acids Res (1990) 3.13
Priming of human mitochondrial DNA replication occurs at the light-strand promoter. Proc Natl Acad Sci U S A (1985) 3.05
The role of mitochondria in aging. J Clin Invest (2013) 2.71
The mitochondrial genomes of two nematodes, Caenorhabditis elegans and Ascaris suum. Genetics (1992) 2.71
Spontaneous Kearns-Sayre/chronic external ophthalmoplegia plus syndrome associated with a mitochondrial DNA deletion: a slip-replication model and metabolic therapy. Proc Natl Acad Sci U S A (1989) 2.63
A novel endoribonuclease cleaves at a priming site of mouse mitochondrial DNA replication. EMBO J (1987) 2.63
Comparisons of ape and human sequences that regulate mitochondrial DNA transcription and D-loop DNA synthesis. Nucleic Acids Res (1988) 2.54
mtDNA depletion with variable tissue expression: a novel genetic abnormality in mitochondrial diseases. Am J Hum Genet (1991) 2.53
Structural insight into processive human mitochondrial DNA synthesis and disease-related polymerase mutations. Cell (2009) 2.51
Reconstitution of a minimal mtDNA replisome in vitro. EMBO J (2004) 2.49
Pervasive CpG suppression in animal mitochondrial genomes. Proc Natl Acad Sci U S A (1994) 2.35
Parkinson's disease is associated with oxidative damage to cytoplasmic DNA and RNA in substantia nigra neurons. Am J Pathol (1999) 2.31
Length heterogeneity of a conserved displacement-loop sequence in human mitochondrial DNA. Nucleic Acids Res (1985) 2.28
Recombination via flanking direct repeats is a major cause of large-scale deletions of human mitochondrial DNA. Nucleic Acids Res (1990) 2.28
A novel mitochondrial genome organization for the blue mussel, Mytilus edulis. Genetics (1992) 2.25
Replication priming and transcription initiate from precisely the same site in mouse mitochondrial DNA. EMBO J (1985) 2.03
Mitochondrial translation and beyond: processes implicated in combined oxidative phosphorylation deficiencies. J Biomed Biotechnol (2010) 2.01
Nucleotide sequence preservation of human mitochondrial DNA. Proc Natl Acad Sci U S A (1985) 1.88
Tandem duplications in animal mitochondrial DNAs: variation in incidence and gene content among lizards. Proc Natl Acad Sci U S A (1987) 1.85
Recombination associated with replication of malarial mitochondrial DNA. EMBO J (1996) 1.84
The initiation of DNA replication in the mitochondrial genome of yeast. EMBO J (1984) 1.82
Expression and maintenance of mitochondrial DNA: new insights into human disease pathology. Am J Pathol (2008) 1.78
Complementation of mutant and wild-type human mitochondrial DNAs coexisting since the mutation event and lack of complementation of DNAs introduced separately into a cell within distinct organelles. Mol Cell Biol (1994) 1.75
Revisiting the mouse mitochondrial DNA sequence. Nucleic Acids Res (2003) 1.70
Identification of small non-coding RNAs from mitochondria and chloroplasts. Nucleic Acids Res (2006) 1.69
Expression of catalytic mutants of the mtDNA helicase Twinkle and polymerase POLG causes distinct replication stalling phenotypes. Nucleic Acids Res (2007) 1.69
The development of mitochondrial medicine. Proc Natl Acad Sci U S A (1994) 1.68
Mitochondrial DNA mutations in disease and aging. J Cell Biol (2011) 1.67
Molecular population genetics of mtDNA size variation in crickets. Genetics (1989) 1.67
Extensive variation and heteroplasmy in size of mitochondrial DNA among geographic populations of Drosophila melanogaster. Proc Natl Acad Sci U S A (1986) 1.66
Electrophile and oxidant damage of mitochondrial DNA leading to rapid evolution of homoplasmic mutations. Proc Natl Acad Sci U S A (2003) 1.66
DNA sequence of the Xenopus laevis mitochondrial heavy and light strand replication origins and flanking tRNA genes. Nucleic Acids Res (1983) 1.65
Length heteroplasmy of sturgeon mitochondrial DNA: an illegitimate elongation model. Genetics (1990) 1.65
Mitochondrial biology. Replication-transcription switch in human mitochondria. Science (2015) 1.64
Organization of the mitochondrial genome of Atlantic cod, Gadus morhua. Nucleic Acids Res (1990) 1.59
Age-associated decline in mitochondrial respiration and electron transport in Drosophila melanogaster. Biochem J (2005) 1.59
Length and sequence variation in evening bat D-loop mtDNA. Genetics (1991) 1.58
Replication of a plasmid bearing a human Alu-family repeat in monkey COS-7 cells. Proc Natl Acad Sci U S A (1986) 1.54
Genes for cytochrome c oxidase subunit I, URF2, and three tRNAs in Drosophila mitochondrial DNA. Nucleic Acids Res (1983) 1.53
Transient overexpression of mitochondrial transcription factor A (TFAM) is sufficient to stimulate mitochondrial DNA transcription, but not sufficient to increase mtDNA copy number in cultured cells. Nucleic Acids Res (2004) 1.53
The AAA+ protein ATAD3 has displacement loop binding properties and is involved in mitochondrial nucleoid organization. J Cell Biol (2007) 1.53
Alterations to the expression level of mitochondrial transcription factor A, TFAM, modify the mode of mitochondrial DNA replication in cultured human cells. Nucleic Acids Res (2006) 1.51
Ultra-sensitive sequencing reveals an age-related increase in somatic mitochondrial mutations that are inconsistent with oxidative damage. PLoS Genet (2013) 1.51
Mammalian mitochondrial DNA replication intermediates are essentially duplex but contain extensive tracts of RNA/DNA hybrid. J Mol Biol (2010) 1.50
Mitochondrial DNA deletion mutations are concomitant with ragged red regions of individual, aged muscle fibers: analysis by laser-capture microdissection. Nucleic Acids Res (2001) 1.48
Nature of mitochondrial DNA deletions in substantia nigra neurons. Am J Hum Genet (2008) 1.48
Human mitochondrial DNA with large deletions repopulates organelles faster than full-length genomes under relaxed copy number control. Nucleic Acids Res (2002) 1.47
Saccharomyces cerevisiae contains an RNase MRP that cleaves at a conserved mitochondrial RNA sequence implicated in replication priming. Mol Cell Biol (1992) 1.45
Cellular and molecular events leading to mitochondrial toxicity of 1-(2-deoxy-2-fluoro-1-beta-D-arabinofuranosyl)-5-iodouracil in human liver cells. J Clin Invest (1995) 1.42
Origins and functional consequences of somatic mitochondrial DNA mutations in human cancer. Elife (2014) 1.39
The mitochondrial transcription termination factor mTERF modulates replication pausing in human mitochondrial DNA. Nucleic Acids Res (2007) 1.38
Replication origin of mitochondrial DNA in insects. Genetics (2005) 1.37
Nucleus-driven multiple large-scale deletions of the human mitochondrial genome: a new autosomal dominant disease. Am J Hum Genet (1990) 1.36
Release of replication termination controls mitochondrial DNA copy number after depletion with 2',3'-dideoxycytidine. Nucleic Acids Res (2002) 1.36
RNA-DNA hybrid formation at the human mitochondrial heavy-strand origin ceases at replication start sites: an implication for RNA-DNA hybrids serving as primers. EMBO J (1996) 1.35
Yeast as a model for human mtDNA replication. Am J Hum Genet (1999) 1.35
Heteroplasmy of short tandem repeats in mitochondrial DNA of Atlantic cod, Gadus morhua. Genetics (1992) 1.35
Replication origins are associated with transcription initiation sequences in the mitochondrial genome of yeast. EMBO J (1982) 1.34
Repeated sequence sets in mitochondrial DNA molecules of root knot nematodes (Meloidogyne): nucleotide sequences, genome location and potential for host-race identification. Nucleic Acids Res (1991) 1.34
Electron microscopic localization of the chloroplast DNA replicative origins in Chlamydomonas reinhardii. Nucleic Acids Res (1984) 1.32
A variable domain of delayed replication in FRAXA fragile X chromosomes: X inactivation-like spread of late replication. Proc Natl Acad Sci U S A (1997) 1.32
Multiple deletions of mitochondrial DNA in several tissues of a patient with severe retarded depression and familial progressive external ophthalmoplegia. J Clin Invest (1992) 1.30
Mitochondrial genetics. Br Med Bull (2013) 1.30
A compendium of human mitochondrial gene expression machinery with links to disease. Environ Mol Mutagen (2010) 1.26
The mitochondrial genome of the screamer louse Bothriometopus (phthiraptera: ischnocera): effects of extensive gene rearrangements on the evolution of the genome. J Mol Evol (2007) 1.26
Deletions of muscle mitochondrial DNA in mitochondrial myopathies: sequence analysis and possible mechanisms. Nucleic Acids Res (1989) 1.25
DNA supercoiling suppresses real-time PCR: a new approach to the quantification of mitochondrial DNA damage and repair. Nucleic Acids Res (2007) 1.23
The complete sequence of the zebrafish (Danio rerio) mitochondrial genome and evolutionary patterns in vertebrate mitochondrial DNA. Genome Res (2001) 1.23
New views on strand asymmetry in insect mitochondrial genomes. PLoS One (2010) 1.21
Initiation of transcription from each of the two human mitochondrial promoters requires unique nucleotides at the transcriptional start sites. Proc Natl Acad Sci U S A (1985) 1.21
A small DNA molecule containing covalently-linked ribonucleotides originates from the large intergenic region of the cauliflower mosaic virus genome. Nucleic Acids Res (1983) 1.21
Mitochondrial DNA copy number is regulated in a tissue specific manner by DNA methylation of the nuclear-encoded DNA polymerase gamma A. Nucleic Acids Res (2012) 1.21
Physical and functional interactions between human mitochondrial single-stranded DNA-binding protein and tumour suppressor p53. Nucleic Acids Res (2008) 1.18
The accessory subunit of mtDNA polymerase shares structural homology with aminoacyl-tRNA synthetases: implications for a dual role as a primer recognition factor and processivity clamp. Proc Natl Acad Sci U S A (1999) 1.18
Mechanisms of human mitochondrial DNA maintenance: the determining role of primary sequence and length over function. Mol Biol Cell (1999) 1.17
Mitochondrial DNA and nuclear DNA from normal rat liver have a common sequence. Proc Natl Acad Sci U S A (1983) 1.16
Heterochromatin on the inactive X chromosome delays replication timing without affecting origin usage. Proc Natl Acad Sci U S A (2004) 1.16
The accessory subunit of mitochondrial DNA polymerase gamma determines the DNA content of mitochondrial nucleoids in human cultured cells. Nucleic Acids Res (2009) 1.16
TWINKLE is an essential mitochondrial helicase required for synthesis of nascent D-loop strands and complete mtDNA replication. Hum Mol Genet (2013) 1.16
Human mitochondrial DNA replication. Cold Spring Harb Perspect Biol (2012) 1.15
Nuclear complementation restores mtDNA levels in cultured cells from a patient with mtDNA depletion. Am J Hum Genet (1993) 1.14
Unique features of animal mitochondrial translation systems. The non-universal genetic code, unusual features of the translational apparatus and their relevance to human mitochondrial diseases. Proc Jpn Acad Ser B Phys Biol Sci (2010) 1.14
The rat liver mitochondrial DNA-protein complex: displaced single strands of replicative intermediates are protein coated. J Cell Biol (1985) 1.14
Mapping of heteroplasmic mitochondrial DNA deletions in Kearns-Sayre syndrome. Nucleic Acids Res (1989) 1.13
Cloning and delimiting one chloroplast DNA replicative origin of Chlamydomonas. Nucleic Acids Res (1984) 1.13
Maintenance of human rearranged mitochondrial DNAs in long-term cultured transmitochondrial cell lines. Mol Biol Cell (2000) 1.11
Mitochondrial DNA replication proceeds via a 'bootlace' mechanism involving the incorporation of processed transcripts. Nucleic Acids Res (2013) 1.10
Mitochondrial biogenesis and turnover. Cell Calcium (2008) 1.10
Kinetoplast maxicircle DNA replication in Crithidia fasciculata and Trypanosoma brucei. Mol Cell Biol (1995) 1.10
Human heart mitochondrial DNA is organized in complex catenated networks containing abundant four-way junctions and replication forks. J Biol Chem (2009) 1.09
Evolution of the mitochondrial genome in mammals living at high altitude: new insights from a study of the tribe Caprini (Bovidae, Antilopinae). J Mol Evol (2009) 1.09
Mechanism of mammalian mitochondrial DNA replication: import of mitochondrial transcription factor A into isolated mitochondria stimulates 7S DNA synthesis. Nucleic Acids Res (2001) 1.09
A chemical enucleation method for the transfer of mitochondrial DNA to rho(o) cells. Nucleic Acids Res (2003) 1.08
Sea urchin egg mitochondrial DNA contains a short displacement loop (D-loop) in the replication origin region. Nucleic Acids Res (1989) 1.06
In vivo mutagenesis reveals that OriL is essential for mitochondrial DNA replication. EMBO Rep (2012) 1.06
Sequence and gene organization of mouse mitochondrial DNA. Cell (1981) 13.14
Mitochondrial transcription factor A is necessary for mtDNA maintenance and embryogenesis in mice. Nat Genet (1998) 7.89
DNA of a human hepatitis B virus candidate. J Virol (1974) 5.90
Mitochondrial DNA maintenance in vertebrates. Annu Rev Biochem (1997) 4.96
The number of mitochondrial deoxyribonucleic acid genomes in mouse L and human HeLa cells. Quantitative isolation of mitochondrial deoxyribonucleic acid. J Biol Chem (1974) 4.71
Precise localization and nucleotide sequence of the two mouse mitochondrial rRNA genes and three immediately adjacent novel tRNA genes. Cell (1980) 4.41
Transcription of the mammalian mitochondrial genome. Annu Rev Biochem (1984) 4.35
Similarity of human mitochondrial transcription factor 1 to high mobility group proteins. Science (1991) 4.26
Yeast mitochondrial RNA polymerase is homologous to those encoded by bacteriophages T3 and T7. Cell (1987) 3.83
The absence of a pyrimidine dimer repair mechanism in mammalian mitochondria. Proc Natl Acad Sci U S A (1974) 3.58
Structure of hepatitis B Dane particle DNA before and after the Dane particle DNA polymerase reaction. J Virol (1977) 3.57
Circular dimer and catenate forms of mitochondrial DNA in human leukaemic leucocytes. Nature (1967) 3.48
Complex mitochondrial DNA. Cold Spring Harb Symp Quant Biol (1968) 3.31
Nuclear RNase MRP is required for correct processing of pre-5.8S rRNA in Saccharomyces cerevisiae. Mol Cell Biol (1993) 3.29
Homology and structural relationships between the dimeric and monomeric circular forms of mitochondrial DNA from human leukemic leukocytes. J Mol Biol (1970) 3.07
Priming of human mitochondrial DNA replication occurs at the light-strand promoter. Proc Natl Acad Sci U S A (1985) 3.05
Sequence and properties of the human KB cell and mouse L cell D-loop regions of mitochondrial DNA. Nucleic Acids Res (1981) 2.90
Molecular genetic aspects of human mitochondrial disorders. Annu Rev Genet (1995) 2.82
Studies of mouse mitochondrial DNA in Escherichia coli: structure and function of the eucaryotic-procaryotic chimeric plasmids. Cell (1975) 2.80
Purification and characterization of human mitochondrial transcription factor 1. Mol Cell Biol (1988) 2.78
Precise identification of individual promoters for transcription of each strand of human mitochondrial DNA. Cell (1984) 2.69
DNA wrapping and bending by a mitochondrial high mobility group-like transcriptional activator protein. J Biol Chem (1992) 2.64
A mammalian mitochondrial RNA processing activity contains nucleus-encoded RNA. Science (1987) 2.63
A novel endoribonuclease cleaves at a priming site of mouse mitochondrial DNA replication. EMBO J (1987) 2.63
Dilated cardiomyopathy and atrioventricular conduction blocks induced by heart-specific inactivation of mitochondrial DNA gene expression. Nat Genet (1999) 2.57
The transcription map of mouse mitochondrial DNA. Cell (1978) 2.52
Mouse RNAase MRP RNA is encoded by a nuclear gene and contains a decamer sequence complementary to a conserved region of mitochondrial RNA substrate. Cell (1989) 2.49
Replication of mitochondrial DNA in mouse L cells and their thymidine kinase - derivatives: displacement replication on a covalently-closed circular template. Proc Natl Acad Sci U S A (1972) 2.49
Promoter selection in human mitochondria involves binding of a transcription factor to orientation-independent upstream regulatory elements. Cell (1987) 2.44
Pervasive CpG suppression in animal mitochondrial genomes. Proc Natl Acad Sci U S A (1994) 2.35
Length heterogeneity of a conserved displacement-loop sequence in human mitochondrial DNA. Nucleic Acids Res (1985) 2.28
A human mitochondrial transcriptional activator can functionally replace a yeast mitochondrial HMG-box protein both in vivo and in vitro. Mol Cell Biol (1993) 2.27
Altered mobility of polydeoxyribonucleotides in high resolution polyacrylamide gels due to removal of terminal phosphates. Nucleic Acids Res (1981) 2.23
Mechanism of replication of human mitochondrial DNA. Localization of the 5' ends of nascent daughter strands. J Biol Chem (1981) 2.20
Occurrence of complex mitochondrial DNA in normal tissues. Nature (1968) 2.18
Addition of a 29 residue carboxyl-terminal tail converts a simple HMG box-containing protein into a transcriptional activator. J Mol Biol (1995) 2.17
LTP leads to rapid surface expression of NMDA but not AMPA receptors in adult rat CA1. Nat Neurosci (2002) 2.14
Mouse L cell mitochondrial DNA molecules are selected randomly for replication throughout the cell cycle. Cell (1977) 2.09
The RNA processing enzyme RNase MRP is identical to the Th RNP and related to RNase P. Science (1989) 2.07
Mitochondrial DNA of chloramphenicol-resistant mouse cells contains a single nucleotide change in the region encoding the 3' end of the large ribosomal RNA. Proc Natl Acad Sci U S A (1981) 2.03
Replication priming and transcription initiate from precisely the same site in mouse mitochondrial DNA. EMBO J (1985) 2.03
Elongation of displacement-loop strands in human and mouse mitochondrial DNA is arrested near specific template sequences. Proc Natl Acad Sci U S A (1981) 2.02
In situ localization of mitochondrial DNA replication in intact mammalian cells. J Cell Biol (1996) 2.01
In vitro transcription of human mitochondrial DNA. Identification of specific light strand transcripts from the displacement loop region. J Biol Chem (1983) 1.89
Yeast site-specific ribonucleoprotein endoribonuclease MRP contains an RNA component homologous to mammalian RNase MRP RNA and essential for cell viability. Genes Dev (1992) 1.88
Displacement-loop replication initiation sequence in animal mitochondrial DNA exists as a family of discrete lengths. Proc Natl Acad Sci U S A (1978) 1.86
A transcription factor required for promoter recognition by human mitochondrial RNA polymerase. Accurate initiation at the heavy- and light-strand promoters dissected and reconstituted in vitro. J Biol Chem (1985) 1.86
Mechanism of mitochondrial DNA replication in mouse L-cells: RNA priming during the initiation of heavy-strand synthesis. J Mol Biol (1979) 1.86
Template-directed pausing in in vitro DNA synthesis by DNA polymerase a from Drosophila melanogaster embryos. Proc Natl Acad Sci U S A (1982) 1.86
Initiation of mitochondrial DNA replication by transcription and R-loop processing. J Biol Chem (1998) 1.83
Mechanism of mitochondrial DNA replication in mouse L-cells: asynchronous replication of strands, segregation of circular daughter molecules, aspects of topology and turnover of an initiation sequence. J Mol Biol (1974) 1.80
Isolation of mammalian mitochondrial DNA and RNA and cloning of the mitochondrial genome. Methods Enzymol (1983) 1.76
Secondary structure of RNase MRP RNA as predicted by phylogenetic comparison. FASEB J (1993) 1.75
Mitochondrial transcription initiation. Variation and conservation. J Biol Chem (1993) 1.74
In vitro replication of human mitochondrial DNA: accurate initiation at the origin of light-strand synthesis. Cell (1985) 1.72
Pulse-labeled components in the replication of mitochondrial deoxyribonucleic acid. J Biol Chem (1973) 1.69
Selective nicking of mammalian mitochondrial DNA in vivo: photosensitization by incorporation of 5-bromodeoxyuridine. J Mol Biol (1975) 1.68
A genetically distinct thymidine kinase in mammalian mitochondria. Exclusive labeling of mitochondrial deoxyribonucleic acid. J Biol Chem (1973) 1.64
Low levels of mitochondrial transcription factor A in mitochondrial DNA depletion. Biochem Biophys Res Commun (1994) 1.63
Impairment of mitochondrial transcription termination by a point mutation associated with the MELAS subgroup of mitochondrial encephalomyopathies. Nature (1991) 1.60
Characterization of a unique protein component of yeast RNase MRP: an RNA-binding protein with a zinc-cluster domain. Genes Dev (1994) 1.57
DNA primase of human mitochondria is associated with structural RNA that is essential for enzymatic activity. Cell (1986) 1.54
A persistent RNA-DNA hybrid is formed during transcription at a phylogenetically conserved mitochondrial DNA sequence. Mol Cell Biol (1995) 1.53
Complex mitochondrial DNA in leukemic and normal human myeloid cells. Proc Natl Acad Sci U S A (1969) 1.52
Flexible recognition of rapidly evolving promoter sequences by mitochondrial transcription factor 1. Genes Dev (1989) 1.52
Nuclear RNase MRP processes RNA at multiple discrete sites: interaction with an upstream G box is required for subsequent downstream cleavages. Genes Dev (1991) 1.47
Mechanism of mitochondrial DNA replication in mouse L-cells: topology of circular daughter molecules and dynamics of catenated oligomer formation. J Mol Biol (1976) 1.46
Saccharomyces cerevisiae contains an RNase MRP that cleaves at a conserved mitochondrial RNA sequence implicated in replication priming. Mol Cell Biol (1992) 1.45
Cleavage of replicating forms of mitochondrial DNA by EcoRI endonuclease. Proc Natl Acad Sci U S A (1974) 1.44
A tridecamer DNA sequence supports human mitochondrial RNA 3'-end formation in vitro. Mol Cell Biol (1988) 1.44
Human mitochondrial transcription factor A and promoter spacing integrity are required for transcription initiation. Biochim Biophys Acta (1995) 1.43
Characterization of human MRP/Th RNA and its nuclear gene: full length MRP/Th RNA is an active endoribonuclease when assembled as an RNP. Nucleic Acids Res (1990) 1.42
Assignment of a yeast protein necessary for mitochondrial transcription initiation. Nucleic Acids Res (1992) 1.40
Intracellular mosaicism (nuclear - -mitochondrial + ) for thymidine kinase in mouse L cells. J Cell Sci (1972) 1.38
Mechanism of mitochondrial DNA replication in mouse L-cells: localization and sequence of the light-strand origin of replication. J Mol Biol (1979) 1.37
RNA-DNA hybrid formation at the human mitochondrial heavy-strand origin ceases at replication start sites: an implication for RNA-DNA hybrids serving as primers. EMBO J (1996) 1.35
Mechanism of mitochondrial DNA replication in mouse L-cells: kinetics of synthesis and turnover of the initiation sequence. J Mol Biol (1978) 1.30
A rapid, efficient method for purifying DNA-binding proteins. Denaturation-renaturation chromatography of human and yeast mitochondrial extracts. J Biol Chem (1991) 1.30
The transcription map of human mitochondrial DNA implicates transfer RNA excision as a major processing event. J Biol Chem (1980) 1.30
A role for RNAase MRP in mitochondrial RNA processing. Cell (1992) 1.27
RNase mitochondrial RNA processing correctly cleaves a novel R loop at the mitochondrial DNA leading-strand origin of replication. Genes Dev (1997) 1.27
A Saccharomyces cerevisiae mitochondrial transcription factor, sc-mtTFB, shares features with sigma factors but is functionally distinct. Mol Cell Biol (1995) 1.27
The mitochondrial DNA of Drosophila melanogaster exists in two distinct and stable superhelical forms. Cell (1977) 1.25
In vitro transcription of human mitochondrial DNA: accurate termination requires a region of DNA sequence that can function bidirectionally. Proc Natl Acad Sci U S A (1986) 1.25
Both the conserved stem-loop and divergent 5'-flanking sequences are required for initiation at the human mitochondrial origin of light-strand DNA replication. J Biol Chem (1986) 1.23
Properties of a primer RNA-DNA hybrid at the mouse mitochondrial DNA leading-strand origin of replication. J Biol Chem (1996) 1.21
Initiation of transcription from each of the two human mitochondrial promoters requires unique nucleotides at the transcriptional start sites. Proc Natl Acad Sci U S A (1985) 1.21
Precise assignment of the light-strand promoter of mouse mitochondrial DNA: a functional promoter consists of multiple upstream domains. Mol Cell Biol (1986) 1.21
Electron microscopic studies on substrate specificity of T4 excision repair endonuclease. Nature (1972) 1.20
Mutational analysis of the RNA component of Saccharomyces cerevisiae RNase MRP reveals distinct nuclear phenotypes. Gene (2000) 1.20
A single mouse gene encodes the mitochondrial transcription factor A and a testis-specific nuclear HMG-box protein. Nat Genet (1996) 1.19
Precise nucleotide location of the 5' ends of RNA-primed nascent light strands of mouse mitochondrial DNA. J Mol Biol (1982) 1.16
Mitochondrial DNA polymerase gamma is expressed and translated in the absence of mitochondrial DNA maintenance and replication. Nucleic Acids Res (1996) 1.15
Thymidylate nucleotide supply for mitochondrial DNA synthesis in mouse L-cells. Effect of 5-fluorodeoxyuridine and methotrexate in thymidine kinase plus and thymidine kinase minus cells. J Biol Chem (1976) 1.11
Identification of the 3'-ends of the two mouse mitochondrial ribosomal RNAs. The 3'-end of 16 S ribosomal RNA contains nucleotides encoded by the gene for transfer RNALeuUUR. J Biol Chem (1983) 1.10
All eight unassigned reading frames of mouse mitochondrial DNA are expressed. EMBO J (1984) 1.07
Efficient incorporation of anti-HIV deoxynucleotides by recombinant yeast mitochondrial DNA polymerase. J Biol Chem (1995) 1.07
Analysis of glutamate receptor surface expression in acute hippocampal slices. Sci STKE (2002) 1.07
Mitochondrial DNA of human-mouse cell hybrids. Nature (1971) 1.05
Isolation and characterization of a DNA primase from human mitochondria. J Biol Chem (1985) 1.05