Published in J Biol Chem on September 15, 1985
Purification and characterization of human mitochondrial transcription factor 1. Mol Cell Biol (1988) 2.78
The mitochondrial transcription factor TFAM coordinates the assembly of multiple DNA molecules into nucleoid-like structures. Mol Biol Cell (2007) 2.42
A human mitochondrial transcriptional activator can functionally replace a yeast mitochondrial HMG-box protein both in vivo and in vitro. Mol Cell Biol (1993) 2.27
Human mitochondrial transcription factor B1 interacts with the C-terminal activation region of h-mtTFA and stimulates transcription independently of its RNA methyltransferase activity. Mol Cell Biol (2003) 1.80
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Assignment of a yeast protein necessary for mitochondrial transcription initiation. Nucleic Acids Res (1992) 1.40
In organello footprint analysis of human mitochondrial DNA: human mitochondrial transcription factor A interactions at the origin of replication. Mol Cell Biol (1994) 1.37
RNA-DNA hybrid formation at the human mitochondrial heavy-strand origin ceases at replication start sites: an implication for RNA-DNA hybrids serving as primers. EMBO J (1996) 1.35
Core human mitochondrial transcription apparatus is a regulated two-component system in vitro. Proc Natl Acad Sci U S A (2010) 1.34
A compendium of human mitochondrial gene expression machinery with links to disease. Environ Mol Mutagen (2010) 1.26
Accurate in vitro transcription of Xenopus laevis mitochondrial DNA from two bidirectional promoters. Mol Cell Biol (1986) 1.21
Precise assignment of the light-strand promoter of mouse mitochondrial DNA: a functional promoter consists of multiple upstream domains. Mol Cell Biol (1986) 1.21
Purification of Xenopus laevis mitochondrial RNA polymerase and identification of a dissociable factor required for specific transcription. Mol Cell Biol (1988) 1.13
Intra- and inter-molecular recombination of mitochondrial DNA after in vivo induction of multiple double-strand breaks. Nucleic Acids Res (2009) 1.13
Identification of multiple rate-limiting steps during the human mitochondrial transcription cycle in vitro. J Biol Chem (2010) 1.09
Mechanism of mammalian mitochondrial DNA replication: import of mitochondrial transcription factor A into isolated mitochondria stimulates 7S DNA synthesis. Nucleic Acids Res (2001) 1.09
A disease-associated G5703A mutation in human mitochondrial DNA causes a conformational change and a marked decrease in steady-state levels of mitochondrial tRNA(Asn). Mol Cell Biol (1997) 1.08
Accurate transcription of a plant mitochondrial gene in vitro. Mol Cell Biol (1991) 1.06
Template sequences required for transcription of Xenopus laevis mitochondrial DNA from two bidirectional promoters. Mol Cell Biol (1988) 1.04
LRP130 protein remodels mitochondria and stimulates fatty acid oxidation. J Biol Chem (2011) 1.03
Characterization of a DNA-binding protein implicated in transcription in wheat mitochondria. Mol Cell Biol (1999) 1.03
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Arabidopsis phage-type RNA polymerases: accurate in vitro transcription of organellar genes. Plant Cell (2007) 1.01
Precise assignment of the heavy-strand promoter of mouse mitochondrial DNA: cognate start sites are not required for transcriptional initiation. Mol Cell Biol (1986) 0.99
Identification of two homologous mitochondrial DNA sequences, which bind strongly and specifically to a mitochondrial protein of Paracentrotus lividus. Nucleic Acids Res (1991) 0.98
Replication-competent human mitochondrial DNA lacking the heavy-strand promoter region. Mol Cell Biol (1991) 0.98
Identification of primary transcriptional start sites of mouse mitochondrial DNA: accurate in vitro initiation of both heavy- and light-strand transcripts. Mol Cell Biol (1986) 0.97
Minor transcription initiation events indicate that both human mitochondrial promoters function bidirectionally. Mol Cell Biol (1986) 0.96
Identification of transcriptional regulatory elements in human mitochondrial DNA by linker substitution analysis. Mol Cell Biol (1989) 0.94
X-ray crystal structure of the polymerase domain of the bacteriophage N4 virion RNA polymerase. Proc Natl Acad Sci U S A (2008) 0.90
Mitochondrial transcription factor A and its downstream targets are up-regulated in a rat hepatoma. J Biol Chem (2002) 0.89
A time to reap, a time to sow: mitophagy and biogenesis in cardiac pathophysiology. J Mol Cell Cardiol (2014) 0.89
TFAM forces mtDNA to make a U-turn. Nat Struct Mol Biol (2011) 0.89
DNA curvature in front of the human mitochondrial L-strand replication origin with specific protein binding. Nucleic Acids Res (1989) 0.89
Phage N4 RNA polymerase II recruitment to DNA by a single-stranded DNA-binding protein. Genes Dev (2003) 0.88
Nutrient sensing by the mitochondrial transcription machinery dictates oxidative phosphorylation. J Clin Invest (2014) 0.86
Mitochondrial signaling: forwards, backwards, and in between. Oxid Med Cell Longev (2013) 0.86
Mitochondrial quality control: Easy come, easy go. Biochim Biophys Acta (2015) 0.85
Identification of a putative mitochondrial RNA polymerase from Physarum polycephalum: characterization, expression, purification, and transcription in vitro. Curr Genet (2006) 0.84
Hitting the brakes: termination of mitochondrial transcription. Biochim Biophys Acta (2011) 0.84
The mitochondrial nucleoid: integrating mitochondrial DNA into cellular homeostasis. Cold Spring Harb Perspect Biol (2013) 0.84
Calcineurin A and CaMKIV transactivate PGC-1alpha promoter, but differentially regulate cytochrome c promoter in rat skeletal muscle. Pflugers Arch (2007) 0.83
Contrasting effects of in vitro fertilization and nuclear transfer on the expression of mtDNA replication factors. Genetics (2007) 0.83
Evidence for site-specific occupancy of the mitochondrial genome by nuclear transcription factors. PLoS One (2014) 0.81
A DNA binding protein showing sequence specificity for a region containing the replication origin of Xenopus laevis mitochondrial DNA. Nucleic Acids Res (1987) 0.81
In vitro replication of heavy strand DNA in permeabilized human mitochondria. Nucleic Acids Res (1991) 0.81
Arrest of human mitochondrial RNA polymerase transcription by the biological aldehyde adduct of DNA, M1dG. Nucleic Acids Res (2010) 0.79
Role of the mitochondrial DNA replication machinery in mitochondrial DNA mutagenesis, aging and age-related diseases. Ageing Res Rev (2016) 0.78
Functional and structural features of a tandem duplication of the human mtDNA promoter region. Am J Hum Genet (1997) 0.77
The strictly aerobic yeast Yarrowia lipolytica tolerates loss of a mitochondrial DNA-packaging protein. Eukaryot Cell (2014) 0.77
Yeast mitochondrial HMG proteins: DNA-binding properties of the most evolutionarily divergent component of mitochondrial nucleoids. Biosci Rep (2015) 0.76
Specific requirement for ATP at an early step of in vitro transcription of human mitochondrial DNA. Proc Natl Acad Sci U S A (1987) 0.76
Sequence and gene organization of mouse mitochondrial DNA. Cell (1981) 13.14
Mitochondrial transcription factor A is necessary for mtDNA maintenance and embryogenesis in mice. Nat Genet (1998) 7.89
Replication of animal mitochondrial DNA. Cell (1982) 7.79
DNA of a human hepatitis B virus candidate. J Virol (1974) 5.90
Mitochondrial DNA maintenance in vertebrates. Annu Rev Biochem (1997) 4.96
The number of mitochondrial deoxyribonucleic acid genomes in mouse L and human HeLa cells. Quantitative isolation of mitochondrial deoxyribonucleic acid. J Biol Chem (1974) 4.71
Precise localization and nucleotide sequence of the two mouse mitochondrial rRNA genes and three immediately adjacent novel tRNA genes. Cell (1980) 4.41
Transcription of the mammalian mitochondrial genome. Annu Rev Biochem (1984) 4.35
Similarity of human mitochondrial transcription factor 1 to high mobility group proteins. Science (1991) 4.26
Yeast mitochondrial RNA polymerase is homologous to those encoded by bacteriophages T3 and T7. Cell (1987) 3.83
The absence of a pyrimidine dimer repair mechanism in mammalian mitochondria. Proc Natl Acad Sci U S A (1974) 3.58
Structure of hepatitis B Dane particle DNA before and after the Dane particle DNA polymerase reaction. J Virol (1977) 3.57
Circular dimer and catenate forms of mitochondrial DNA in human leukaemic leucocytes. Nature (1967) 3.48
Complex mitochondrial DNA. Cold Spring Harb Symp Quant Biol (1968) 3.31
Nuclear RNase MRP is required for correct processing of pre-5.8S rRNA in Saccharomyces cerevisiae. Mol Cell Biol (1993) 3.29
Homology and structural relationships between the dimeric and monomeric circular forms of mitochondrial DNA from human leukemic leukocytes. J Mol Biol (1970) 3.07
Priming of human mitochondrial DNA replication occurs at the light-strand promoter. Proc Natl Acad Sci U S A (1985) 3.05
Cdk-activating kinase complex is a component of human transcription factor TFIIH. Nature (1995) 3.05
Sequence and properties of the human KB cell and mouse L cell D-loop regions of mitochondrial DNA. Nucleic Acids Res (1981) 2.90
Molecular genetic aspects of human mitochondrial disorders. Annu Rev Genet (1995) 2.82
Studies of mouse mitochondrial DNA in Escherichia coli: structure and function of the eucaryotic-procaryotic chimeric plasmids. Cell (1975) 2.80
Purification and characterization of human mitochondrial transcription factor 1. Mol Cell Biol (1988) 2.78
Precise identification of individual promoters for transcription of each strand of human mitochondrial DNA. Cell (1984) 2.69
DNA wrapping and bending by a mitochondrial high mobility group-like transcriptional activator protein. J Biol Chem (1992) 2.64
A mammalian mitochondrial RNA processing activity contains nucleus-encoded RNA. Science (1987) 2.63
A novel endoribonuclease cleaves at a priming site of mouse mitochondrial DNA replication. EMBO J (1987) 2.63
Dilated cardiomyopathy and atrioventricular conduction blocks induced by heart-specific inactivation of mitochondrial DNA gene expression. Nat Genet (1999) 2.57
The transcription map of mouse mitochondrial DNA. Cell (1978) 2.52
Mouse RNAase MRP RNA is encoded by a nuclear gene and contains a decamer sequence complementary to a conserved region of mitochondrial RNA substrate. Cell (1989) 2.49
Replication of mitochondrial DNA in mouse L cells and their thymidine kinase - derivatives: displacement replication on a covalently-closed circular template. Proc Natl Acad Sci U S A (1972) 2.49
Promoter selection in human mitochondria involves binding of a transcription factor to orientation-independent upstream regulatory elements. Cell (1987) 2.44
Pervasive CpG suppression in animal mitochondrial genomes. Proc Natl Acad Sci U S A (1994) 2.35
Length heterogeneity of a conserved displacement-loop sequence in human mitochondrial DNA. Nucleic Acids Res (1985) 2.28
A human mitochondrial transcriptional activator can functionally replace a yeast mitochondrial HMG-box protein both in vivo and in vitro. Mol Cell Biol (1993) 2.27
Altered mobility of polydeoxyribonucleotides in high resolution polyacrylamide gels due to removal of terminal phosphates. Nucleic Acids Res (1981) 2.23
Mechanism of replication of human mitochondrial DNA. Localization of the 5' ends of nascent daughter strands. J Biol Chem (1981) 2.20
Occurrence of complex mitochondrial DNA in normal tissues. Nature (1968) 2.18
Addition of a 29 residue carboxyl-terminal tail converts a simple HMG box-containing protein into a transcriptional activator. J Mol Biol (1995) 2.17
LTP leads to rapid surface expression of NMDA but not AMPA receptors in adult rat CA1. Nat Neurosci (2002) 2.14
Mouse L cell mitochondrial DNA molecules are selected randomly for replication throughout the cell cycle. Cell (1977) 2.09
The RNA processing enzyme RNase MRP is identical to the Th RNP and related to RNase P. Science (1989) 2.07
Mitochondrial DNA of chloramphenicol-resistant mouse cells contains a single nucleotide change in the region encoding the 3' end of the large ribosomal RNA. Proc Natl Acad Sci U S A (1981) 2.03
Replication priming and transcription initiate from precisely the same site in mouse mitochondrial DNA. EMBO J (1985) 2.03
Elongation of displacement-loop strands in human and mouse mitochondrial DNA is arrested near specific template sequences. Proc Natl Acad Sci U S A (1981) 2.02
In situ localization of mitochondrial DNA replication in intact mammalian cells. J Cell Biol (1996) 2.01
In vitro transcription of human mitochondrial DNA. Identification of specific light strand transcripts from the displacement loop region. J Biol Chem (1983) 1.89
Yeast site-specific ribonucleoprotein endoribonuclease MRP contains an RNA component homologous to mammalian RNase MRP RNA and essential for cell viability. Genes Dev (1992) 1.88
Displacement-loop replication initiation sequence in animal mitochondrial DNA exists as a family of discrete lengths. Proc Natl Acad Sci U S A (1978) 1.86
Mechanism of mitochondrial DNA replication in mouse L-cells: RNA priming during the initiation of heavy-strand synthesis. J Mol Biol (1979) 1.86
Template-directed pausing in in vitro DNA synthesis by DNA polymerase a from Drosophila melanogaster embryos. Proc Natl Acad Sci U S A (1982) 1.86
Initiation of mitochondrial DNA replication by transcription and R-loop processing. J Biol Chem (1998) 1.83
Mechanism of mitochondrial DNA replication in mouse L-cells: asynchronous replication of strands, segregation of circular daughter molecules, aspects of topology and turnover of an initiation sequence. J Mol Biol (1974) 1.80
Isolation of mammalian mitochondrial DNA and RNA and cloning of the mitochondrial genome. Methods Enzymol (1983) 1.76
Secondary structure of RNase MRP RNA as predicted by phylogenetic comparison. FASEB J (1993) 1.75
Mitochondrial transcription initiation. Variation and conservation. J Biol Chem (1993) 1.74
In vitro replication of human mitochondrial DNA: accurate initiation at the origin of light-strand synthesis. Cell (1985) 1.72
Activation of cyclin-dependent kinase 4 (cdk4) by mouse MO15-associated kinase. Mol Cell Biol (1994) 1.71
Pulse-labeled components in the replication of mitochondrial deoxyribonucleic acid. J Biol Chem (1973) 1.69
Selective nicking of mammalian mitochondrial DNA in vivo: photosensitization by incorporation of 5-bromodeoxyuridine. J Mol Biol (1975) 1.68
A genetically distinct thymidine kinase in mammalian mitochondria. Exclusive labeling of mitochondrial deoxyribonucleic acid. J Biol Chem (1973) 1.64
Low levels of mitochondrial transcription factor A in mitochondrial DNA depletion. Biochem Biophys Res Commun (1994) 1.63
Cdk7 is essential for mitosis and for in vivo Cdk-activating kinase activity. Genes Dev (1998) 1.62
Impairment of mitochondrial transcription termination by a point mutation associated with the MELAS subgroup of mitochondrial encephalomyopathies. Nature (1991) 1.60
Characterization of a unique protein component of yeast RNase MRP: an RNA-binding protein with a zinc-cluster domain. Genes Dev (1994) 1.57
DNA primase of human mitochondria is associated with structural RNA that is essential for enzymatic activity. Cell (1986) 1.54
A persistent RNA-DNA hybrid is formed during transcription at a phylogenetically conserved mitochondrial DNA sequence. Mol Cell Biol (1995) 1.53
Complex mitochondrial DNA in leukemic and normal human myeloid cells. Proc Natl Acad Sci U S A (1969) 1.52
Flexible recognition of rapidly evolving promoter sequences by mitochondrial transcription factor 1. Genes Dev (1989) 1.52
Nuclear RNase MRP processes RNA at multiple discrete sites: interaction with an upstream G box is required for subsequent downstream cleavages. Genes Dev (1991) 1.47
Mechanism of mitochondrial DNA replication in mouse L-cells: topology of circular daughter molecules and dynamics of catenated oligomer formation. J Mol Biol (1976) 1.46
Saccharomyces cerevisiae contains an RNase MRP that cleaves at a conserved mitochondrial RNA sequence implicated in replication priming. Mol Cell Biol (1992) 1.45
Cleavage of replicating forms of mitochondrial DNA by EcoRI endonuclease. Proc Natl Acad Sci U S A (1974) 1.44
A tridecamer DNA sequence supports human mitochondrial RNA 3'-end formation in vitro. Mol Cell Biol (1988) 1.44
Effects of phosphorylation by CAK on cyclin binding by CDC2 and CDK2. Mol Cell Biol (1995) 1.44
Human mitochondrial transcription factor A and promoter spacing integrity are required for transcription initiation. Biochim Biophys Acta (1995) 1.43
Characterization of human MRP/Th RNA and its nuclear gene: full length MRP/Th RNA is an active endoribonuclease when assembled as an RNP. Nucleic Acids Res (1990) 1.42
Assignment of a yeast protein necessary for mitochondrial transcription initiation. Nucleic Acids Res (1992) 1.40
Intracellular mosaicism (nuclear - -mitochondrial + ) for thymidine kinase in mouse L cells. J Cell Sci (1972) 1.38
Mechanism of mitochondrial DNA replication in mouse L-cells: localization and sequence of the light-strand origin of replication. J Mol Biol (1979) 1.37
RNA-DNA hybrid formation at the human mitochondrial heavy-strand origin ceases at replication start sites: an implication for RNA-DNA hybrids serving as primers. EMBO J (1996) 1.35
The CDK7-cycH-p36 complex of transcription factor IIH phosphorylates p53, enhancing its sequence-specific DNA binding activity in vitro. Mol Cell Biol (1997) 1.34
Mechanism of mitochondrial DNA replication in mouse L-cells: kinetics of synthesis and turnover of the initiation sequence. J Mol Biol (1978) 1.30
A rapid, efficient method for purifying DNA-binding proteins. Denaturation-renaturation chromatography of human and yeast mitochondrial extracts. J Biol Chem (1991) 1.30
The transcription map of human mitochondrial DNA implicates transfer RNA excision as a major processing event. J Biol Chem (1980) 1.30
RNase mitochondrial RNA processing correctly cleaves a novel R loop at the mitochondrial DNA leading-strand origin of replication. Genes Dev (1997) 1.27
A role for RNAase MRP in mitochondrial RNA processing. Cell (1992) 1.27
A Saccharomyces cerevisiae mitochondrial transcription factor, sc-mtTFB, shares features with sigma factors but is functionally distinct. Mol Cell Biol (1995) 1.27
T-loop phosphorylation stabilizes the CDK7-cyclin H-MAT1 complex in vivo and regulates its CTD kinase activity. EMBO J (2001) 1.26
In vitro transcription of human mitochondrial DNA: accurate termination requires a region of DNA sequence that can function bidirectionally. Proc Natl Acad Sci U S A (1986) 1.25
The mitochondrial DNA of Drosophila melanogaster exists in two distinct and stable superhelical forms. Cell (1977) 1.25
Both the conserved stem-loop and divergent 5'-flanking sequences are required for initiation at the human mitochondrial origin of light-strand DNA replication. J Biol Chem (1986) 1.23
Properties of a primer RNA-DNA hybrid at the mouse mitochondrial DNA leading-strand origin of replication. J Biol Chem (1996) 1.21
Initiation of transcription from each of the two human mitochondrial promoters requires unique nucleotides at the transcriptional start sites. Proc Natl Acad Sci U S A (1985) 1.21
Precise assignment of the light-strand promoter of mouse mitochondrial DNA: a functional promoter consists of multiple upstream domains. Mol Cell Biol (1986) 1.21
Electron microscopic studies on substrate specificity of T4 excision repair endonuclease. Nature (1972) 1.20
Mutational analysis of the RNA component of Saccharomyces cerevisiae RNase MRP reveals distinct nuclear phenotypes. Gene (2000) 1.20
Cdc2 activation in fission yeast depends on Mcs6 and Csk1, two partially redundant Cdk-activating kinases (CAKs). Curr Biol (1999) 1.19
A single mouse gene encodes the mitochondrial transcription factor A and a testis-specific nuclear HMG-box protein. Nat Genet (1996) 1.19
Precise nucleotide location of the 5' ends of RNA-primed nascent light strands of mouse mitochondrial DNA. J Mol Biol (1982) 1.16