Mitochondrial DNA maintenance in vertebrates.

Mitochondrial DNA mutations in human colonic crypt stem cells. J Clin Invest (2003) 3.84

Alzheimer's brains harbor somatic mtDNA control-region mutations that suppress mitochondrial transcription and replication. Proc Natl Acad Sci U S A (2004) 2.77

Reconstitution of a minimal mtDNA replisome in vitro. EMBO J (2004) 2.49

Control of mitochondrial transcription specificity factors (TFB1M and TFB2M) by nuclear respiratory factors (NRF-1 and NRF-2) and PGC-1 family coactivators. Mol Cell Biol (2005) 2.46

Base excision repair of oxidative DNA damage and association with cancer and aging. Carcinogenesis (2008) 2.42

Genome signature comparisons among prokaryote, plasmid, and mitochondrial DNA. Proc Natl Acad Sci U S A (1999) 2.38

Compositional differences within and between eukaryotic genomes. Proc Natl Acad Sci U S A (1997) 2.35

Depressed mitochondrial transcription factors and oxidative capacity in rat failing cardiac and skeletal muscles. J Physiol (2003) 2.32

Random intracellular drift explains the clonal expansion of mitochondrial DNA mutations with age. Am J Hum Genet (2001) 2.31

The functional organization of mitochondrial genomes in human cells. BMC Biol (2004) 2.20

The role of mitochondrial DNA copy number in mammalian fertility. Biol Reprod (2010) 2.15

Human DNA2 is a mitochondrial nuclease/helicase for efficient processing of DNA replication and repair intermediates. Mol Cell (2008) 2.12

Ataxia-telangiectasia mutated kinase regulates ribonucleotide reductase and mitochondrial homeostasis. J Clin Invest (2007) 2.03

Mitochondrial translation and beyond: processes implicated in combined oxidative phosphorylation deficiencies. J Biomed Biotechnol (2010) 2.01

Human mitochondrial DNA is packaged with TFAM. Nucleic Acids Res (2003) 2.01

Architectural role of mitochondrial transcription factor A in maintenance of human mitochondrial DNA. Mol Cell Biol (2004) 1.97

Cyclin D1 repression of nuclear respiratory factor 1 integrates nuclear DNA synthesis and mitochondrial function. Proc Natl Acad Sci U S A (2006) 1.96

Replication of mitochondrial DNA occurs by strand displacement with alternative light-strand origins, not via a strand-coupled mechanism. Genes Dev (2005) 1.94

The human DNA ligase III gene encodes nuclear and mitochondrial proteins. Mol Cell Biol (1999) 1.94

A human mitochondrial transcription factor is related to RNA adenine methyltransferases and binds S-adenosylmethionine. Mol Cell Biol (2002) 1.85

Mitochondrial DNA instability and peri-implantation lethality associated with targeted disruption of nuclear respiratory factor 1 in mice. Mol Cell Biol (2001) 1.83

The mitochondrial RNA polymerase contributes critically to promoter specificity in mammalian cells. EMBO J (2004) 1.81

Human mitochondrial transcription factor B1 interacts with the C-terminal activation region of h-mtTFA and stimulates transcription independently of its RNA methyltransferase activity. Mol Cell Biol (2003) 1.80

Expression and maintenance of mitochondrial DNA: new insights into human disease pathology. Am J Pathol (2008) 1.78

Identification of a novel human nuclear-encoded mitochondrial poly(A) polymerase. Nucleic Acids Res (2004) 1.73

Identification of 5'-deoxyribose phosphate lyase activity in human DNA polymerase gamma and its role in mitochondrial base excision repair in vitro. Proc Natl Acad Sci U S A (1998) 1.71

Mitochondrial defects and oxidative stress in Alzheimer disease and Parkinson disease. Free Radic Biol Med (2012) 1.67

Polyadenylation and degradation of human mitochondrial RNA: the prokaryotic past leaves its mark. Mol Cell Biol (2005) 1.67

Electrophile and oxidant damage of mitochondrial DNA leading to rapid evolution of homoplasmic mutations. Proc Natl Acad Sci U S A (2003) 1.66

Modulation of mitochondrial transcription in response to mtDNA depletion and repletion in HeLa cells. Nucleic Acids Res (2002) 1.64

Regulation of mitochondrial D-loops by transcription factor A and single-stranded DNA-binding protein. EMBO Rep (2002) 1.61

Site-specific somatic mitochondrial DNA point mutations in patients with thymidine phosphorylase deficiency. J Clin Invest (2003) 1.60

Mitochondrial DNA replication and disease: insights from DNA polymerase γ mutations. Cell Mol Life Sci (2010) 1.58

Nam1p, a protein involved in RNA processing and translation, is coupled to transcription through an interaction with yeast mitochondrial RNA polymerase. J Biol Chem (2000) 1.58

Tracking replication enzymology in vivo by genome-wide mapping of ribonucleotide incorporation. Nat Struct Mol Biol (2015) 1.56

Human mitochondrial ribosomal protein MRPL12 interacts directly with mitochondrial RNA polymerase to modulate mitochondrial gene expression. J Biol Chem (2007) 1.54

Transient overexpression of mitochondrial transcription factor A (TFAM) is sufficient to stimulate mitochondrial DNA transcription, but not sufficient to increase mtDNA copy number in cultured cells. Nucleic Acids Res (2004) 1.53

Comparative and phylogenomic studies on the mitochondrial genomes of Pentatomomorpha (Insecta: Hemiptera: Heteroptera). BMC Genomics (2008) 1.52

Likelihood analysis of asymmetrical mutation bias gradients in vertebrate mitochondrial genomes. Genetics (2003) 1.50

Defective mitochondrial gene expression results in reactive oxygen species-mediated inhibition of respiration and reduction of yeast life span. Mol Cell Biol (2006) 1.47

Human mitochondrial DNA with large deletions repopulates organelles faster than full-length genomes under relaxed copy number control. Nucleic Acids Res (2002) 1.47

The conserved Mec1/Rad53 nuclear checkpoint pathway regulates mitochondrial DNA copy number in Saccharomyces cerevisiae. Mol Biol Cell (2005) 1.45

Mitochondrial single-stranded DNA-binding protein is required for mitochondrial DNA replication and development in Drosophila melanogaster. Mol Biol Cell (2001) 1.44

DNA polymerase gamma and mitochondrial disease: understanding the consequence of POLG mutations. Biochim Biophys Acta (2008) 1.43

Okazaki fragment maturation: nucleases take centre stage. J Mol Cell Biol (2011) 1.42

The dynamics of mitochondrial DNA heteroplasmy: implications for human health and disease. Nat Rev Genet (2015) 1.40

Replication origin of mitochondrial DNA in insects. Genetics (2005) 1.37

Release of replication termination controls mitochondrial DNA copy number after depletion with 2',3'-dideoxycytidine. Nucleic Acids Res (2002) 1.36

Yeast as a model for human mtDNA replication. Am J Hum Genet (1999) 1.35

Mitochondrial dysfunction due to oxidative mitochondrial DNA damage is reduced through cooperative actions of diverse proteins. Mol Cell Biol (2002) 1.35

Core human mitochondrial transcription apparatus is a regulated two-component system in vitro. Proc Natl Acad Sci U S A (2010) 1.34

The complete sequence of the mitochondrial genome of Nautilus macromphalus (Mollusca: Cephalopoda). BMC Genomics (2006) 1.24

Stability of the mitochondrial genome requires an amino-terminal domain of yeast mitochondrial RNA polymerase. Proc Natl Acad Sci U S A (1999) 1.24

The complete sequence of the zebrafish (Danio rerio) mitochondrial genome and evolutionary patterns in vertebrate mitochondrial DNA. Genome Res (2001) 1.23

Human mitochondrial complex I in health and disease. Am J Hum Genet (1999) 1.23

Mitochondrial ROS Signaling in Organismal Homeostasis. Cell (2015) 1.23

Sls1p is a membrane-bound regulator of transcription-coupled processes involved in Saccharomyces cerevisiae mitochondrial gene expression. Genetics (2002) 1.22

Rearrangements of human mitochondrial DNA (mtDNA): new insights into the regulation of mtDNA copy number and gene expression. Mol Biol Cell (2000) 1.21

G-quadruplex structures in RNA stimulate mitochondrial transcription termination and primer formation. Proc Natl Acad Sci U S A (2010) 1.21

Dual localization of human DNA topoisomerase IIIalpha to mitochondria and nucleus. Proc Natl Acad Sci U S A (2002) 1.19

Direct regulation of mitochondrial RNA synthesis by thyroid hormone. Mol Cell Biol (1999) 1.19

Mitochondrial genome instability and ROS enhance intestinal tumorigenesis in APC(Min/+) mice. Am J Pathol (2011) 1.18

The relationship between the rate of molecular evolution and the rate of genome rearrangement in animal mitochondrial genomes. J Mol Evol (2006) 1.18

Mechanisms of human mitochondrial DNA maintenance: the determining role of primary sequence and length over function. Mol Biol Cell (1999) 1.17

Import of mitochondrial transcription factor A (TFAM) into rat liver mitochondria stimulates transcription of mitochondrial DNA. Nucleic Acids Res (2003) 1.12

Changes in organization of Crithidia fasciculata kinetoplast DNA replication proteins during the cell cycle. J Cell Biol (1998) 1.11

Initiation of bacteriophage T4 DNA replication and replication fork dynamics: a review in the Virology Journal series on bacteriophage T4 and its relatives. Virol J (2010) 1.11

Maintenance of human rearranged mitochondrial DNAs in long-term cultured transmitochondrial cell lines. Mol Biol Cell (2000) 1.11

Mitochondrial biogenesis and turnover. Cell Calcium (2008) 1.10

Mechanism of mammalian mitochondrial DNA replication: import of mitochondrial transcription factor A into isolated mitochondria stimulates 7S DNA synthesis. Nucleic Acids Res (2001) 1.09

Expression of a novel non-coding mitochondrial RNA in human proliferating cells. Nucleic Acids Res (2007) 1.07

Replication and preferential inheritance of hypersuppressive petite mitochondrial DNA. EMBO J (2001) 1.07

Developmentally-regulated packaging of mitochondrial DNA by the HMG-box protein mtTFA during Xenopus oogenesis. Nucleic Acids Res (2001) 1.06

The accessory subunit B of DNA polymerase gamma is required for mitochondrial replisome function. Nucleic Acids Res (2007) 1.06

Mitochondrial topoisomerase I sites in the regulatory D-loop region of mitochondrial DNA. Biochemistry (2008) 1.04

The mitochondrial genome structure of Xenoturbella bocki (phylum Xenoturbellida) is ancestral within the deuterostomes. BMC Evol Biol (2009) 1.03

Accessorizing the human mitochondrial transcription machinery. Trends Biochem Sci (2013) 1.03

Nuclear HMGA1 nonhistone chromatin proteins directly influence mitochondrial transcription, maintenance, and function. Exp Cell Res (2006) 1.02

Naturally occurring mitochondrial DNA heteroplasmy in the MRL mouse. Mitochondrion (2008) 1.01

Ribonucleotide discrimination and reverse transcription by the human mitochondrial DNA polymerase. J Biol Chem (2011) 1.00

UvsW protein regulates bacteriophage T4 origin-dependent replication by unwinding R-loops. Mol Cell Biol (2001) 1.00

Mitochondrial DNA mutations may contribute to aging via cell death caused by peptides that induce cytochrome c release. Rejuvenation Res (2008) 1.00

Quality of Cell Products: Authenticity, Identity, Genomic Stability and Status of Differentiation. Transfus Med Hemother (2010) 1.00

Carbon monoxide, skeletal muscle oxidative stress, and mitochondrial biogenesis in humans. Am J Physiol Heart Circ Physiol (2009) 0.99

The mitochondrial genome of the hemichordate Balanoglossus carnosus and the evolution of deuterostome mitochondria. Genetics (1998) 0.99

A new paradigm for MAPK: structural interactions of hERK1 with mitochondria in HeLa cells. PLoS One (2009) 0.99

Mitochondrial dysfunction in cancer cells due to aberrant mitochondrial replication. J Biol Chem (2011) 0.98

Unusual conservation of mitochondrial gene order in Crassostrea oysters: evidence for recent speciation in Asia. BMC Evol Biol (2010) 0.98

Germline bottlenecks, biparental inheritance and selection on mitochondrial variants: a two-level selection model. Genetics (2005) 0.98

Identification of sequence polymorphism in the D-Loop region of mitochondrial DNA as a risk factor for hepatocellular carcinoma with distinct etiology. J Exp Clin Cancer Res (2010) 0.97

Herpes simplex virus UL12.5 targets mitochondria through a mitochondrial localization sequence proximal to the N terminus. J Virol (2009) 0.97

Single nucleotide polymorphisms in the mitochondrial displacement loop and outcome of esophageal squamous cell carcinoma. J Exp Clin Cancer Res (2010) 0.96

Two-dimensional intact mitochondrial DNA agarose electrophoresis reveals the structural complexity of the mammalian mitochondrial genome. Nucleic Acids Res (2012) 0.96

Mitochondrial DNA alterations and mitochondrial dysfunction in the progression of hepatocellular carcinoma. World J Gastroenterol (2013) 0.95

Mitochondrial nuclear receptors and transcription factors: who's minding the cell? J Neurosci Res (2008) 0.95

Bacteriophage T4 helicase loader protein gp59 functions as gatekeeper in origin-dependent replication in vivo. J Biol Chem (2005) 0.94

CREB-1alpha is recruited to and mediates upregulation of the cytochrome c promoter during enhanced mitochondrial biogenesis accompanying skeletal muscle differentiation. Mol Cell Biol (2008) 0.94

Effects of benzo[a]pyrene on mitochondrial and nuclear DNA damage in Atlantic killifish (Fundulus heteroclitus) from a creosote-contaminated and reference site. Aquat Toxicol (2009) 0.93

Nucleotide incorporation by human DNA polymerase gamma opposite benzo[a]pyrene and benzo[c]phenanthrene diol epoxide adducts of deoxyguanosine and deoxyadenosine. Nucleic Acids Res (2004) 0.93

Conflict between translation initiation and elongation in vertebrate mitochondrial genomes. PLoS One (2007) 0.93

Sequence and gene organization of mouse mitochondrial DNA. Cell (1981) 13.14

Mitochondrial transcription factor A is necessary for mtDNA maintenance and embryogenesis in mice. Nat Genet (1998) 7.89

Replication of animal mitochondrial DNA. Cell (1982) 7.79

DNA of a human hepatitis B virus candidate. J Virol (1974) 5.90

The number of mitochondrial deoxyribonucleic acid genomes in mouse L and human HeLa cells. Quantitative isolation of mitochondrial deoxyribonucleic acid. J Biol Chem (1974) 4.71

Precise localization and nucleotide sequence of the two mouse mitochondrial rRNA genes and three immediately adjacent novel tRNA genes. Cell (1980) 4.41

Transcription of the mammalian mitochondrial genome. Annu Rev Biochem (1984) 4.35

Similarity of human mitochondrial transcription factor 1 to high mobility group proteins. Science (1991) 4.26

Yeast mitochondrial RNA polymerase is homologous to those encoded by bacteriophages T3 and T7. Cell (1987) 3.83

The absence of a pyrimidine dimer repair mechanism in mammalian mitochondria. Proc Natl Acad Sci U S A (1974) 3.58

Structure of hepatitis B Dane particle DNA before and after the Dane particle DNA polymerase reaction. J Virol (1977) 3.57

Circular dimer and catenate forms of mitochondrial DNA in human leukaemic leucocytes. Nature (1967) 3.48

Complex mitochondrial DNA. Cold Spring Harb Symp Quant Biol (1968) 3.31

Nuclear RNase MRP is required for correct processing of pre-5.8S rRNA in Saccharomyces cerevisiae. Mol Cell Biol (1993) 3.29

Homology and structural relationships between the dimeric and monomeric circular forms of mitochondrial DNA from human leukemic leukocytes. J Mol Biol (1970) 3.07

Priming of human mitochondrial DNA replication occurs at the light-strand promoter. Proc Natl Acad Sci U S A (1985) 3.05

Sequence and properties of the human KB cell and mouse L cell D-loop regions of mitochondrial DNA. Nucleic Acids Res (1981) 2.90

Molecular genetic aspects of human mitochondrial disorders. Annu Rev Genet (1995) 2.82

Studies of mouse mitochondrial DNA in Escherichia coli: structure and function of the eucaryotic-procaryotic chimeric plasmids. Cell (1975) 2.80

Purification and characterization of human mitochondrial transcription factor 1. Mol Cell Biol (1988) 2.78

Precise identification of individual promoters for transcription of each strand of human mitochondrial DNA. Cell (1984) 2.69

DNA wrapping and bending by a mitochondrial high mobility group-like transcriptional activator protein. J Biol Chem (1992) 2.64

A mammalian mitochondrial RNA processing activity contains nucleus-encoded RNA. Science (1987) 2.63

A novel endoribonuclease cleaves at a priming site of mouse mitochondrial DNA replication. EMBO J (1987) 2.63

Dilated cardiomyopathy and atrioventricular conduction blocks induced by heart-specific inactivation of mitochondrial DNA gene expression. Nat Genet (1999) 2.57

The transcription map of mouse mitochondrial DNA. Cell (1978) 2.52

Mouse RNAase MRP RNA is encoded by a nuclear gene and contains a decamer sequence complementary to a conserved region of mitochondrial RNA substrate. Cell (1989) 2.49

Replication of mitochondrial DNA in mouse L cells and their thymidine kinase - derivatives: displacement replication on a covalently-closed circular template. Proc Natl Acad Sci U S A (1972) 2.49

Promoter selection in human mitochondria involves binding of a transcription factor to orientation-independent upstream regulatory elements. Cell (1987) 2.44

Pervasive CpG suppression in animal mitochondrial genomes. Proc Natl Acad Sci U S A (1994) 2.35

Length heterogeneity of a conserved displacement-loop sequence in human mitochondrial DNA. Nucleic Acids Res (1985) 2.28

A human mitochondrial transcriptional activator can functionally replace a yeast mitochondrial HMG-box protein both in vivo and in vitro. Mol Cell Biol (1993) 2.27

Altered mobility of polydeoxyribonucleotides in high resolution polyacrylamide gels due to removal of terminal phosphates. Nucleic Acids Res (1981) 2.23

Mechanism of replication of human mitochondrial DNA. Localization of the 5' ends of nascent daughter strands. J Biol Chem (1981) 2.20

Occurrence of complex mitochondrial DNA in normal tissues. Nature (1968) 2.18

Addition of a 29 residue carboxyl-terminal tail converts a simple HMG box-containing protein into a transcriptional activator. J Mol Biol (1995) 2.17

LTP leads to rapid surface expression of NMDA but not AMPA receptors in adult rat CA1. Nat Neurosci (2002) 2.14

Mouse L cell mitochondrial DNA molecules are selected randomly for replication throughout the cell cycle. Cell (1977) 2.09

The RNA processing enzyme RNase MRP is identical to the Th RNP and related to RNase P. Science (1989) 2.07

Mitochondrial DNA of chloramphenicol-resistant mouse cells contains a single nucleotide change in the region encoding the 3' end of the large ribosomal RNA. Proc Natl Acad Sci U S A (1981) 2.03

Replication priming and transcription initiate from precisely the same site in mouse mitochondrial DNA. EMBO J (1985) 2.03

Elongation of displacement-loop strands in human and mouse mitochondrial DNA is arrested near specific template sequences. Proc Natl Acad Sci U S A (1981) 2.02

In situ localization of mitochondrial DNA replication in intact mammalian cells. J Cell Biol (1996) 2.01

In vitro transcription of human mitochondrial DNA. Identification of specific light strand transcripts from the displacement loop region. J Biol Chem (1983) 1.89

Yeast site-specific ribonucleoprotein endoribonuclease MRP contains an RNA component homologous to mammalian RNase MRP RNA and essential for cell viability. Genes Dev (1992) 1.88

Displacement-loop replication initiation sequence in animal mitochondrial DNA exists as a family of discrete lengths. Proc Natl Acad Sci U S A (1978) 1.86

A transcription factor required for promoter recognition by human mitochondrial RNA polymerase. Accurate initiation at the heavy- and light-strand promoters dissected and reconstituted in vitro. J Biol Chem (1985) 1.86

Mechanism of mitochondrial DNA replication in mouse L-cells: RNA priming during the initiation of heavy-strand synthesis. J Mol Biol (1979) 1.86

Template-directed pausing in in vitro DNA synthesis by DNA polymerase a from Drosophila melanogaster embryos. Proc Natl Acad Sci U S A (1982) 1.86

Initiation of mitochondrial DNA replication by transcription and R-loop processing. J Biol Chem (1998) 1.83

Mechanism of mitochondrial DNA replication in mouse L-cells: asynchronous replication of strands, segregation of circular daughter molecules, aspects of topology and turnover of an initiation sequence. J Mol Biol (1974) 1.80

Isolation of mammalian mitochondrial DNA and RNA and cloning of the mitochondrial genome. Methods Enzymol (1983) 1.76

Secondary structure of RNase MRP RNA as predicted by phylogenetic comparison. FASEB J (1993) 1.75

Mitochondrial transcription initiation. Variation and conservation. J Biol Chem (1993) 1.74

In vitro replication of human mitochondrial DNA: accurate initiation at the origin of light-strand synthesis. Cell (1985) 1.72

Pulse-labeled components in the replication of mitochondrial deoxyribonucleic acid. J Biol Chem (1973) 1.69

Selective nicking of mammalian mitochondrial DNA in vivo: photosensitization by incorporation of 5-bromodeoxyuridine. J Mol Biol (1975) 1.68

A genetically distinct thymidine kinase in mammalian mitochondria. Exclusive labeling of mitochondrial deoxyribonucleic acid. J Biol Chem (1973) 1.64

Low levels of mitochondrial transcription factor A in mitochondrial DNA depletion. Biochem Biophys Res Commun (1994) 1.63

Impairment of mitochondrial transcription termination by a point mutation associated with the MELAS subgroup of mitochondrial encephalomyopathies. Nature (1991) 1.60

Characterization of a unique protein component of yeast RNase MRP: an RNA-binding protein with a zinc-cluster domain. Genes Dev (1994) 1.57

DNA primase of human mitochondria is associated with structural RNA that is essential for enzymatic activity. Cell (1986) 1.54

A persistent RNA-DNA hybrid is formed during transcription at a phylogenetically conserved mitochondrial DNA sequence. Mol Cell Biol (1995) 1.53

Complex mitochondrial DNA in leukemic and normal human myeloid cells. Proc Natl Acad Sci U S A (1969) 1.52

Flexible recognition of rapidly evolving promoter sequences by mitochondrial transcription factor 1. Genes Dev (1989) 1.52

Nuclear RNase MRP processes RNA at multiple discrete sites: interaction with an upstream G box is required for subsequent downstream cleavages. Genes Dev (1991) 1.47

Mechanism of mitochondrial DNA replication in mouse L-cells: topology of circular daughter molecules and dynamics of catenated oligomer formation. J Mol Biol (1976) 1.46

Saccharomyces cerevisiae contains an RNase MRP that cleaves at a conserved mitochondrial RNA sequence implicated in replication priming. Mol Cell Biol (1992) 1.45

Cleavage of replicating forms of mitochondrial DNA by EcoRI endonuclease. Proc Natl Acad Sci U S A (1974) 1.44

A tridecamer DNA sequence supports human mitochondrial RNA 3'-end formation in vitro. Mol Cell Biol (1988) 1.44

Human mitochondrial transcription factor A and promoter spacing integrity are required for transcription initiation. Biochim Biophys Acta (1995) 1.43

Characterization of human MRP/Th RNA and its nuclear gene: full length MRP/Th RNA is an active endoribonuclease when assembled as an RNP. Nucleic Acids Res (1990) 1.42

Assignment of a yeast protein necessary for mitochondrial transcription initiation. Nucleic Acids Res (1992) 1.40

Intracellular mosaicism (nuclear - -mitochondrial + ) for thymidine kinase in mouse L cells. J Cell Sci (1972) 1.38

Mechanism of mitochondrial DNA replication in mouse L-cells: localization and sequence of the light-strand origin of replication. J Mol Biol (1979) 1.37

RNA-DNA hybrid formation at the human mitochondrial heavy-strand origin ceases at replication start sites: an implication for RNA-DNA hybrids serving as primers. EMBO J (1996) 1.35

Mechanism of mitochondrial DNA replication in mouse L-cells: kinetics of synthesis and turnover of the initiation sequence. J Mol Biol (1978) 1.30

A rapid, efficient method for purifying DNA-binding proteins. Denaturation-renaturation chromatography of human and yeast mitochondrial extracts. J Biol Chem (1991) 1.30

The transcription map of human mitochondrial DNA implicates transfer RNA excision as a major processing event. J Biol Chem (1980) 1.30

A role for RNAase MRP in mitochondrial RNA processing. Cell (1992) 1.27

RNase mitochondrial RNA processing correctly cleaves a novel R loop at the mitochondrial DNA leading-strand origin of replication. Genes Dev (1997) 1.27

A Saccharomyces cerevisiae mitochondrial transcription factor, sc-mtTFB, shares features with sigma factors but is functionally distinct. Mol Cell Biol (1995) 1.27

The mitochondrial DNA of Drosophila melanogaster exists in two distinct and stable superhelical forms. Cell (1977) 1.25

In vitro transcription of human mitochondrial DNA: accurate termination requires a region of DNA sequence that can function bidirectionally. Proc Natl Acad Sci U S A (1986) 1.25

Both the conserved stem-loop and divergent 5'-flanking sequences are required for initiation at the human mitochondrial origin of light-strand DNA replication. J Biol Chem (1986) 1.23

Properties of a primer RNA-DNA hybrid at the mouse mitochondrial DNA leading-strand origin of replication. J Biol Chem (1996) 1.21

Initiation of transcription from each of the two human mitochondrial promoters requires unique nucleotides at the transcriptional start sites. Proc Natl Acad Sci U S A (1985) 1.21

Precise assignment of the light-strand promoter of mouse mitochondrial DNA: a functional promoter consists of multiple upstream domains. Mol Cell Biol (1986) 1.21

Electron microscopic studies on substrate specificity of T4 excision repair endonuclease. Nature (1972) 1.20

Mutational analysis of the RNA component of Saccharomyces cerevisiae RNase MRP reveals distinct nuclear phenotypes. Gene (2000) 1.20

A single mouse gene encodes the mitochondrial transcription factor A and a testis-specific nuclear HMG-box protein. Nat Genet (1996) 1.19

Precise nucleotide location of the 5' ends of RNA-primed nascent light strands of mouse mitochondrial DNA. J Mol Biol (1982) 1.16

Mitochondrial DNA polymerase gamma is expressed and translated in the absence of mitochondrial DNA maintenance and replication. Nucleic Acids Res (1996) 1.15

Thymidylate nucleotide supply for mitochondrial DNA synthesis in mouse L-cells. Effect of 5-fluorodeoxyuridine and methotrexate in thymidine kinase plus and thymidine kinase minus cells. J Biol Chem (1976) 1.11

Identification of the 3'-ends of the two mouse mitochondrial ribosomal RNAs. The 3'-end of 16 S ribosomal RNA contains nucleotides encoded by the gene for transfer RNALeuUUR. J Biol Chem (1983) 1.10

All eight unassigned reading frames of mouse mitochondrial DNA are expressed. EMBO J (1984) 1.07

Efficient incorporation of anti-HIV deoxynucleotides by recombinant yeast mitochondrial DNA polymerase. J Biol Chem (1995) 1.07

Analysis of glutamate receptor surface expression in acute hippocampal slices. Sci STKE (2002) 1.07

Mitochondrial DNA of human-mouse cell hybrids. Nature (1971) 1.05

Isolation and characterization of a DNA primase from human mitochondria. J Biol Chem (1985) 1.05