Outer membrane protein YadA of enteropathogenic yersiniae mediates specific binding to cellular but not plasma fibronectin.

PubWeight™: 1.41‹?› | Rank: Top 5%

🔗 View Article (PMC 280877)

Published in Infect Immun on June 01, 1993

Authors

H Schulze-Koops1, H Burkhardt, J Heesemann, T Kirsch, B Swoboda, C Bull, S Goodman, F Emmrich

Author Affiliations

1: Max-Planck-Society, Clinical Research Unit for Rheumatology/Immunology, University Erlangen-Nürnberg, Germany.

Articles citing this

Common themes in microbial pathogenicity revisited. Microbiol Mol Biol Rev (1997) 10.52

The virulence plasmid of Yersinia, an antihost genome. Microbiol Mol Biol Rev (1998) 5.78

Structure and sequence analysis of Yersinia YadA and Moraxella UspAs reveal a novel class of adhesins. EMBO J (2000) 3.23

The Yersinia adhesin YadA collagen-binding domain structure is a novel left-handed parallel beta-roll. EMBO J (2004) 2.15

Molecular analysis of transport and oligomerization of the Yersinia enterocolitica adhesin YadA. J Bacteriol (2003) 1.96

A protective epitope of Moraxella catarrhalis is encoded by two different genes. Infect Immun (1997) 1.89

Differential contribution of Yersinia enterocolitica virulence factors to evasion of microbicidal action of neutrophils. Infect Immun (1996) 1.69

Expression of invasin and motility are coordinately regulated in Yersinia enterocolitica. J Bacteriol (1998) 1.35

Deletion of amino acids 29 to 81 in adhesion protein YadA of Yersinia enterocolitica serotype O:8 results in selective abrogation of adherence to neutrophils. Infect Immun (1996) 1.30

Adherence of Streptococcus pneumoniae to immobilized fibronectin. Infect Immun (1995) 1.27

Identification of a fibronectin binding protein from Streptococcus mutans. Infect Immun (2000) 1.15

Treponema pallidum fibronectin-binding proteins. J Bacteriol (2004) 1.14

Role of YadA-mediated collagen binding in arthritogenicity of Yersinia enterocolitica serotype O:8: experimental studies with rats. Infect Immun (1995) 1.09

In vitro and in vivo characterization of an ail mutant of Yersinia enterocolitica. Infect Immun (1995) 1.08

Yersinia enterocolitica adhesin A induces production of interleukin-8 in epithelial cells. Infect Immun (2004) 1.04

Arthritogenicity of genetically manipulated Yersinia enterocolitica serotype O8 for Lewis rats. Infect Immun (1995) 1.02

Role of YadA in arthritogenicity of Yersinia enterocolitica serotype O:8: experimental studies with rats. Infect Immun (1994) 1.01

Staphylococcus saprophyticus hemagglutinin binds fibronectin. Infect Immun (1994) 0.99

YadA mediates specific binding of enteropathogenic Yersinia enterocolitica to human intestinal submucosa. Infect Immun (1994) 0.98

Oligomeric coiled-coil adhesin YadA is a double-edged sword. PLoS One (2010) 0.94

Trimeric autotransporter adhesin-dependent adherence of Bartonella henselae, Bartonella quintana, and Yersinia enterocolitica to matrix components and endothelial cells under static and dynamic flow conditions. Infect Immun (2011) 0.91

Actinobacillus actinomycetemcomitans outer membrane protein 100 triggers innate immunity and production of beta-defensin and the 18-kilodalton cationic antimicrobial protein through the fibronectin-integrin pathway in human gingival epithelial cells. Infect Immun (2006) 0.89

Yersinia infection tools-characterization of structure and function of adhesins. Front Cell Infect Microbiol (2013) 0.88

The cellular form of human fibronectin as an adhesion target for the S fimbriae of meningitis-associated Escherichia coli. Infect Immun (1999) 0.84

In vivo-induced InvA-like autotransporters Ifp and InvC of Yersinia pseudotuberculosis promote interactions with intestinal epithelial cells and contribute to virulence. Infect Immun (2011) 0.83

Rational live oral carrier vaccine design by mutating virulence-associated genes of Yersinia enterocolitica. Infect Immun (1999) 0.81

Articles cited by this

Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature (1970) 1528.65

Integrins: versatility, modulation, and signaling in cell adhesion. Cell (1992) 34.06

Cell attachment activity of fibronectin can be duplicated by small synthetic fragments of the molecule. Nature (1984) 14.25

Common themes in microbial pathogenicity. Microbiol Rev (1989) 7.78

Cell surface interactions with extracellular materials. Annu Rev Biochem (1983) 6.76

Three different fibronectin mRNAs arise by alternative splicing within the coding region. Cell (1983) 6.27

Protein tyrosine phosphatase activity of an essential virulence determinant in Yersinia. Science (1990) 5.21

The cold-insoluble globulin of human plasma. I. Purification, primary characterization, and relationship to fibrinogen and other cold-insoluble fraction components. J Biol Chem (1970) 4.49

Fibronectin binds to Staphylococcus aureus. Nature (1978) 4.39

Expression of the temperature-inducible outer membrane proteins of yersiniae. Infect Immun (1985) 4.36

Measurement of cell numbers by means of the endogenous enzyme hexosaminidase. Applications to detection of lymphokines and cell surface antigens. J Immunol Methods (1984) 4.16

Yersinia enterocolitica. N Engl J Med (1989) 4.00

Genetically manipulated virulence of Yersinia enterocolitica. Infect Immun (1984) 3.81

Binding and factor XIIIa-mediated cross-linking of a 27-kilodalton fragment of fibronectin to Staphylococcus aureus. Science (1980) 3.68

Location of the cell-attachment site in fibronectin with monoclonal antibodies and proteolytic fragments of the molecule. Cell (1981) 3.64

Discrimination between intracellular uptake and surface adhesion of bacterial pathogens. Science (1991) 3.64

Role of a plasmid in the pathogenicity of Yersinia species. Curr Top Microbiol Immunol (1985) 3.13

Preparation and characterization of the different types of collagen. Methods Enzymol (1982) 3.12

Human fibronectin: molecular cloning evidence for two mRNA species differing by an internal segment coding for a structural domain. EMBO J (1984) 2.88

Genetic analysis of virulence plasmid from a serogroup 9 Yersinia enterocolitica strain: role of outer membrane protein P1 in resistance to human serum and autoagglutination. Infect Immun (1985) 2.81

Presence of laminin receptors in Staphylococcus aureus. Science (1985) 2.79

The Yersinia yop regulon. Mol Microbiol (1989) 2.63

Plasmid-mediated surface fibrillae of Yersinia pseudotuberculosis and Yersinia enterocolitica: relationship to the outer membrane protein YOP1 and possible importance for pathogenesis. Infect Immun (1987) 2.40

Binding to collagen by Yersinia enterocolitica and Yersinia pseudotuberculosis: evidence for yopA-mediated and chromosomally encoded mechanisms. J Bacteriol (1989) 2.36

Fibronectin binds to some bacteria but does not promote their uptake by phagocytic cells. Science (1983) 2.31

Binding of Escherichia coli to fibronectin. A mechanism of tissue adherence. J Biol Chem (1984) 2.26

Fibronectin adsorption on hydrophilic and hydrophobic surfaces detected by antibody binding and analyzed during cell adhesion in serum-containing medium. J Biol Chem (1982) 2.12

Multiple sites of alternative splicing of the rat fibronectin gene transcript. EMBO J (1987) 2.03

Structure and biological role of vitronectin. Annu Rev Cell Biol (1991) 2.02

In vitro binding of Candida albicans yeast cells to human fibronectin. Can J Microbiol (1984) 1.98

Attachment of staphylococci and streptococci on fibronectin, fibronectin fragments, and fibrinogen bound to a solid phase. Infect Immun (1985) 1.86

The location of proteins labeled by the 125I-lactoperoxidase system in the NIL 8 hamster fibroblast. Cell (1975) 1.84

Synthesis and extracellular deposition of fibronectin in chondrocyte cultures. Response to the removal of extracellular cartilage matrix. J Cell Biol (1978) 1.81

Binding of Streptococcus pyogenes to laminin. J Biol Chem (1984) 1.71

Plasmid-encoded outer membrane protein YadA mediates specific binding of enteropathogenic yersiniae to various types of collagen. Infect Immun (1992) 1.68

Adhesion protein YadA of Yersinia species mediates binding of bacteria to fibronectin. Infect Immun (1992) 1.66

Mechanism of YadA-mediated serum resistance of Yersinia enterocolitica serotype O3. Infect Immun (1992) 1.61

Fibronectin binding to a Streptococcus pyogenes strain. J Bacteriol (1984) 1.60

Binding of Streptococcus pyogenes to soluble and insoluble fibronectin. Infect Immun (1986) 1.58

Identification of a third region of cell-specific alternative splicing in human fibronectin mRNA. Proc Natl Acad Sci U S A (1987) 1.55

Binding of collagen to Staphylococcus aureus Cowan 1. J Bacteriol (1986) 1.51

Binding of the basement membrane protein laminin to Escherichia coli. FEBS Lett (1982) 1.51

Binding sites for streptococci and staphylococci in fibronectin. Infect Immun (1984) 1.41

Association of fibril structure formation with cell surface properties of Yersinia enterocolitica. Infect Immun (1984) 1.39

Specific attachment of Staphylococcus aureus to immobilized fibronectin. Infect Immun (1986) 1.31

Skeletal myoblasts utilize a novel beta 1-series integrin and not alpha 6 beta 1 for binding to the E8 and T8 fragments of laminin. J Biol Chem (1991) 1.26

Fibronectin in synovial fluid and tissue in rheumatoid arthritis. Eur J Clin Invest (1981) 1.07

Genetic manipulation of virulence of Yersinia enterocolitica. Contrib Microbiol Immunol (1987) 1.03

Evidence for the presence of a free N-terminal fibronectin 30-kDa domain in human plasma by quantitative determination with an indirect immunosorbent assay. Anal Biochem (1988) 0.79

Articles by these authors

EULAR Recommendations 2003: an evidence based approach to the management of knee osteoarthritis: Report of a Task Force of the Standing Committee for International Clinical Studies Including Therapeutic Trials (ESCISIT). Ann Rheum Dis (2003) 7.95

Total cavopulmonary connection: a logical alternative to atriopulmonary connection for complex Fontan operations. Experimental studies and early clinical experience. J Thorac Cardiovasc Surg (1988) 6.83

A comparison of low-molecular-weight heparin with unfractionated heparin for unstable coronary artery disease. Efficacy and Safety of Subcutaneous Enoxaparin in Non-Q-Wave Coronary Events Study Group. N Engl J Med (1997) 6.19

EULAR evidence based recommendations for the management of hip osteoarthritis: report of a task force of the EULAR Standing Committee for International Clinical Studies Including Therapeutics (ESCISIT). Ann Rheum Dis (2004) 4.94

Cigarette smoking is associated with dose-related and potentially reversible impairment of endothelium-dependent dilation in healthy young adults. Circulation (1993) 4.53

EULAR recommendations for the management of knee osteoarthritis: report of a task force of the Standing Committee for International Clinical Studies Including Therapeutic Trials (ESCISIT). Ann Rheum Dis (2000) 4.37

Analysis of a cluster of surgical failures. Application to a series of neonatal arterial switch operations. J Thorac Cardiovasc Surg (1994) 4.28

Characterization of transposon mutants of biofilm-producing Staphylococcus epidermidis impaired in the accumulative phase of biofilm production: genetic identification of a hexosamine-containing polysaccharide intercellular adhesin. Infect Immun (1994) 3.95

A recombinant 64 kilodalton protein of Mycobacterium bovis bacillus Calmette-Guerin specifically stimulates human T4 clones reactive to mycobacterial antigens. J Exp Med (1986) 3.92

Genetically manipulated virulence of Yersinia enterocolitica. Infect Immun (1984) 3.81

A plasmid of enterohemorrhagic Escherichia coli O157:H7 is required for expression of a new fimbrial antigen and for adhesion to epithelial cells. Infect Immun (1987) 3.76

Endothelium-dependent dilation in the systemic arteries of asymptomatic subjects relates to coronary risk factors and their interaction. J Am Coll Cardiol (1994) 3.71

Frequent loss of Shiga-like toxin genes in clinical isolates of Escherichia coli upon subcultivation. Infect Immun (1992) 3.47

Structure and sequence analysis of Yersinia YadA and Moraxella UspAs reveal a novel class of adhesins. EMBO J (2000) 3.23

Prevalence of the "high-pathogenicity island" of Yersinia species among Escherichia coli strains that are pathogenic to humans. Infect Immun (1998) 3.17

Reduction in intraventricular hemorrhage by elimination of fluctuating cerebral blood-flow velocity in preterm infants with respiratory distress syndrome. N Engl J Med (1985) 2.76

Double immunofluorescence microscopic technique for accurate differentiation of extracellularly and intracellularly located bacteria in cell culture. J Clin Microbiol (1985) 2.72

A ribonucleotide reductase homolog of cytomegalovirus and endothelial cell tropism. Science (2001) 2.70

Development of PCR for screening of enteroaggregative Escherichia coli. J Clin Microbiol (1995) 2.66

Shiga-like toxin II-related cytotoxins in Citrobacter freundii strains from humans and beef samples. Infect Immun (1993) 2.47

Psychopathology associated with suicidal ideation and attempts among children and adolescents. J Am Acad Child Adolesc Psychiatry (1998) 2.46

Immune responses to Yersinia enterocolitica in susceptible BALB/c and resistant C57BL/6 mice: an essential role for gamma interferon. Infect Immun (1994) 2.45

Enumeration of T cells reactive with Mycobacterium tuberculosis organisms and specific for the recombinant mycobacterial 64-kDa protein. Eur J Immunol (1987) 2.45

Cleavage of Chordin by Xolloid metalloprotease suggests a role for proteolytic processing in the regulation of Spemann organizer activity. Cell (1997) 2.44

Clonal structure and pathogenicity of Shiga-like toxin-producing, sorbitol-fermenting Escherichia coli O157:H-. J Clin Microbiol (1993) 2.43

Immunochemical analysis of plasmid-encoded proteins released by enteropathogenic Yersinia sp. grown in calcium-deficient media. Infect Immun (1986) 2.42

An essential role for HLA-DM in antigen presentation by class II major histocompatibility molecules. Nature (1994) 2.41

Binding to collagen by Yersinia enterocolitica and Yersinia pseudotuberculosis: evidence for yopA-mediated and chromosomally encoded mechanisms. J Bacteriol (1989) 2.36

Construction of a mobilizable Yersinia enterocolitica virulence plasmid. J Bacteriol (1983) 2.33

Reduced replication of Toxoplasma gondii is necessary for induction of bradyzoite-specific antigens: a possible role for nitric oxide in triggering stage conversion. Infect Immun (1994) 2.26

Yersinia enterocolitica impairs activation of transcription factor NF-kappaB: involvement in the induction of programmed cell death and in the suppression of the macrophage tumor necrosis factor alpha production. J Exp Med (1998) 2.24

Plasmids of human strains of Yersinia enterocolitica: molecular relatedness and possible importance for pathogenesis. J Infect Dis (1983) 2.20

The yersiniabactin biosynthetic gene cluster of Yersinia enterocolitica: organization and siderophore-dependent regulation. J Bacteriol (1998) 2.18

Molecular cloning and further characterization of a probable plant vacuolar sorting receptor. Plant Physiol (1997) 2.16

Differentiation in virulence patterns of Escherichia coli possessing eae genes. Med Microbiol Immunol (1994) 2.16

The pesticin receptor of Yersinia enterocolitica: a novel virulence factor with dual function. Mol Microbiol (1994) 2.15

Development of rRNA-targeted PCR and in situ hybridization with fluorescently labelled oligonucleotides for detection of Yersinia species. J Clin Microbiol (1998) 2.13

Young, gifted.and spurned. Nature (2001) 2.13

Helper virus induced T cell lymphoma in nonhuman primates after retroviral mediated gene transfer. J Exp Med (1992) 2.12

New advances in the management of acute coronary syndromes: 1. Matching treatment to risk. CMAJ (2001) 2.12

Type X collagen synthesis in human osteoarthritic cartilage. Indication of chondrocyte hypertrophy. Arthritis Rheum (1992) 2.10

Synergism in the activation of human CD8 T cells by cross-linking the T-cell receptor complex with the CD8 differentiation antigen. Proc Natl Acad Sci U S A (1986) 2.10

Variants of Shiga-like toxin II constitute a major toxin component in Escherichia coli O157 strains from patients with haemolytic uraemic syndrome. J Med Microbiol (1994) 2.08

Test-retest reliability of the Diagnostic Interview Schedule for Children (DISC 2.1). Parent, child, and combined algorithms. Arch Gen Psychiatry (1995) 2.05

Long-term shedding and clonal turnover of enterohemorrhagic Escherichia coli O157 in diarrheal diseases. J Clin Microbiol (1995) 2.04

Steady-state and transient-state kinetic studies on the oxidation of 3,4-dimethoxybenzyl alcohol catalyzed by the ligninase of Phanerocheate chrysosporium Burds. J Biol Chem (1986) 1.99

Interleukin-6 in synovial fluid is closely associated with chronic synovitis in rheumatoid arthritis. Rheumatol Int (1993) 1.96

Authentic matrix vesicles contain active metalloproteases (MMP). a role for matrix vesicle-associated MMP-13 in activation of transforming growth factor-beta. J Biol Chem (2001) 1.96

Ebstein's anomaly: presentation and outcome from fetus to adult. J Am Coll Cardiol (1994) 1.95

[HYGEA (Hygiene in gastroenterology--endoscope reprocessing): Study on quality of reprocessing flexible endoscopes in hospitals and in the practice setting]. Z Gastroenterol (2002) 1.93

The spectrum of immune responses to Campylobacter jejuni and glycoconjugates in Guillain-Barré syndrome and in other neuroimmunological disorders. Ann Neurol (1993) 1.92

[German 2012 guidelines for the sequential medical treatment of rheumatoid arthritis. Adapted EULAR recommendations and updated treatment algorithm]. Z Rheumatol (2012) 1.91

Specific and rapid detection by fluorescent in situ hybridization of bacteria in clinical samples obtained from cystic fibrosis patients. J Clin Microbiol (2000) 1.91

Substitution of two histidine residues in YadA protein of Yersinia enterocolitica abrogates collagen binding, cell adherence and mouse virulence. Mol Microbiol (1995) 1.91

Toll-like receptor (TLR) 2 and TLR4 are essential for Aspergillus-induced activation of murine macrophages. Cell Microbiol (2003) 1.86

Detection of Campylobacter pyloridis in patients with antrum gastritis and peptic ulcers by culture, complement fixation test, and immunoblot. J Clin Microbiol (1986) 1.85

Interaction of Yersinia enterocolitica with macrophages leads to macrophage cell death through apoptosis. Infect Immun (1997) 1.85

Persistence of Yersinia enterocolitica in man. Infection (1988) 1.83

Phage-associated cytotoxin production by and enteroadhesiveness of enteropathogenic Escherichia coli isolated from infants with diarrhea in West Germany. J Infect Dis (1987) 1.79

High incidence of serum antibodies to Escherichia coli O157 lipopolysaccharide in children with hemolytic-uremic syndrome. J Pediatr (1991) 1.78

Natural history of supravalvular aortic stenosis and pulmonary artery stenosis. J Am Coll Cardiol (1990) 1.78

Cloning and characterization of a bradyzoite-specifically expressed gene (hsp30/bag1) of Toxoplasma gondii, related to genes encoding small heat-shock proteins of plants. Mol Microbiol (1995) 1.75

Delayed diagnosis of congenital heart disease worsens preoperative condition and outcome of surgery in neonates. Heart (2006) 1.75

IL-18 (IFN-gamma-inducing factor) regulates early cytokine production in, and promotes resolution of, bacterial infection in mice. J Immunol (1998) 1.73

In vivo neutralization of tumor necrosis factor-alpha and interferon-gamma abrogates resistance to Yersinia enterocolitica infection in mice. Med Microbiol Immunol (1992) 1.73

Induction of bradyzoite-specific Toxoplasma gondii antigens in gamma interferon-treated mouse macrophages. Infect Immun (1993) 1.72

Association of BK virus with failure of prophylaxis against hemorrhagic cystitis following bone marrow transplantation. J Clin Oncol (1995) 1.71

Inter-regional differences and outcome in unstable angina; analysis of the international ESSENCE trial. Efficacy and Safety of Subcutaneous Enoxaparin in Non-Q-wave Coronary Events. Eur Heart J (2000) 1.71

Differential contribution of Yersinia enterocolitica virulence factors to evasion of microbicidal action of neutrophils. Infect Immun (1996) 1.69

Prevalence of attaching and effacing Escherichia coli in stool samples from patients and controls. Zentralbl Bakteriol (1994) 1.69

Abiotrophia elegans sp. nov., a possible pathogen in patients with culture-negative endocarditis. J Clin Microbiol (1998) 1.68

Plasmid-encoded outer membrane protein YadA mediates specific binding of enteropathogenic yersiniae to various types of collagen. Infect Immun (1992) 1.68

The natural and "unnatural" history of congenitally corrected transposition. Am J Cardiol (1990) 1.66

Use of A-type CpG oligodeoxynucleotides as an adjuvant in allergen-specific immunotherapy in humans: a phase I/IIa clinical trial. Clin Exp Allergy (2009) 1.66

T lymphocytes mediate protection against Yersinia enterocolitica in mice: characterization of murine T-cell clones specific for Y. enterocolitica. Infect Immun (1992) 1.66

High-pathogenicity island of Yersinia pestis in enterobacteriaceae isolated from blood cultures and urine samples: prevalence and functional expression. J Infect Dis (2000) 1.66

The product of the Herpesvirus saimiri open reading frame 1 (tip) interacts with T cell-specific kinase p56lck in transformed cells. J Biol Chem (1995) 1.65

Improved reperfusion and clinical outcome with enoxaparin as an adjunct to streptokinase thrombolysis in acute myocardial infarction. The AMI-SK study. Eur Heart J (2002) 1.65

Newborn screening for congenital heart defects: a systematic review and cost-effectiveness analysis. Health Technol Assess (2005) 1.64

Isolation and characterization of rheumatoid arthritis synovial fibroblasts from primary culture--primary culture cells markedly differ from fourth-passage cells. Arthritis Res (2000) 1.62

Rapid and specific detection of Helicobacter pylori macrolide resistance in gastric tissue by fluorescent in situ hybridisation. Gut (2000) 1.62

Mechanism of YadA-mediated serum resistance of Yersinia enterocolitica serotype O3. Infect Immun (1992) 1.61

Amelioration of rat experimental arthritides by treatment with the alkaloid sinomenine. Int J Immunopharmacol (1996) 1.61

Experimental Yersinia enterocolitica infection in euthymic and T-cell-deficient athymic nude C57BL/6 mice: comparison of time course, histomorphology, and immune response. Infect Immun (1993) 1.60

XuvTools: free, fast and reliable stitching of large 3D datasets. J Microsc (2009) 1.59

Congenital heart disease in the neonate: results of surgical treatment. Arch Dis Child (1983) 1.59

Pneumocystis carinii carriage in immunocompetent patients with primary pulmonary disorders as detected by single or nested PCR. J Clin Microbiol (1999) 1.58

Idiotype identity in a MALT-type lymphoma and B cells in Helicobacter pylori associated chronic gastritis. Lab Invest (1994) 1.58

Apoptotic cell death in activated monocytes following incorporation of clodronate-liposomes. J Leukoc Biol (1996) 1.57

Experimental Yersinia infection of human synovial cells: persistence of live bacteria and generation of bacterial antigen deposits including "ghosts," nucleic acid-free bacterial rods. Infect Immun (1996) 1.57

Cloning and sequencing of a Shiga-like toxin II-related gene from Escherichia coli O157:H7 strain 7279. Zentralbl Bakteriol (1992) 1.56

Time to treatment influences the impact of ST-segment resolution on one-year prognosis: insights from the assessment of the safety and efficacy of a new thrombolytic (ASSENT-2) trial. Circulation (2001) 1.56

Use of synthetic oligoribonucleotides to probe RNA-protein interactions in the MS2 translational operator complex. Nucleic Acids Res (1990) 1.54

Early gamma interferon mRNA expression is associated with resistance of mice against Yersinia enterocolitica. Infect Immun (1994) 1.53

The cytotoxin YopT of Yersinia enterocolitica induces modification and cellular redistribution of the small GTP-binding protein RhoA. J Biol Chem (1999) 1.52

Molecular approaches to diagnosis of pulmonary diseases due to Mycoplasma pneumoniae. J Clin Microbiol (1998) 1.52

Efficacy of postoperative blood salvage following total hip arthroplasty in patients with and without deposited autologous units. J Bone Joint Surg Am (2000) 1.51

Yersinia enterocolitica promotes deactivation of macrophage mitogen-activated protein kinases extracellular signal-regulated kinase-1/2, p38, and c-Jun NH2-terminal kinase. Correlation with its inhibitory effect on tumor necrosis factor-alpha production. J Biol Chem (1997) 1.51