A family of lysozyme-like virulence factors in bacterial pathogens of plants and animals.

PubWeight™: 1.70‹?› | Rank: Top 3%

🔗 View Article (PMC 38982)

Published in Proc Natl Acad Sci U S A on July 09, 1996

Authors

A R Mushegian1, K J Fullner, E V Koonin, E W Nester

Author Affiliations

1: Department of Microbiology, University of Washington, Seattle, WA 98195, USA.

Articles citing this

Biogenesis, architecture, and function of bacterial type IV secretion systems. Annu Rev Microbiol (2005) 6.16

Conjugative plasmid transfer in gram-positive bacteria. Microbiol Mol Biol Rev (2003) 3.33

Agrobacterium tumefaciens T-complex transport apparatus: a paradigm for a new family of multifunctional transporters in eubacteria. J Bacteriol (1997) 3.31

The bases of crown gall tumorigenesis. J Bacteriol (2000) 2.81

The Pseudomonas syringae Hrp pathogenicity island has a tripartite mosaic structure composed of a cluster of type III secretion genes bounded by exchangeable effector and conserved effector loci that contribute to parasitic fitness and pathogenicity in plants. Proc Natl Acad Sci U S A (2000) 2.26

Genetic analysis of assembly of the Salmonella enterica serovar Typhimurium type III secretion-associated needle complex. J Bacteriol (2001) 2.24

Processed VirB2 is the major subunit of the promiscuous pilus of Agrobacterium tumefaciens. J Bacteriol (1998) 2.08

Peptide linkage mapping of the Agrobacterium tumefaciens vir-encoded type IV secretion system reveals protein subassemblies. Proc Natl Acad Sci U S A (2002) 2.06

Peptidoglycan as a barrier to transenvelope transport. J Bacteriol (1996) 1.96

Vir proteins stabilize VirB5 and mediate its association with the T pilus of Agrobacterium tumefaciens. J Bacteriol (1999) 1.93

VirB1, a component of the T-complex transfer machinery of Agrobacterium tumefaciens, is processed to a C-terminal secreted product, VirB1. J Bacteriol (1997) 1.72

Pseudomonas syringae Hrp type III secretion system and effector proteins. Proc Natl Acad Sci U S A (2000) 1.66

Two novel type III-secreted proteins of Xanthomonas campestris pv. vesicatoria are encoded within the hrp pathogenicity island. J Bacteriol (2002) 1.53

Identification of two novel hrp-associated genes in the hrp gene cluster of Xanthomonas oryzae pv. oryzae. J Bacteriol (2000) 1.44

A type IV-secretion-like system is required for conjugative DNA transport of broad-host-range plasmid pIP501 in gram-positive bacteria. J Bacteriol (2007) 1.42

VirB6 is required for stabilization of VirB5 and VirB3 and formation of VirB7 homodimers in Agrobacterium tumefaciens. J Bacteriol (2000) 1.40

Membrane-bound lytic endotransglycosylase in Escherichia coli. J Bacteriol (1998) 1.27

An anomalous type IV secretion system in Rickettsia is evolutionarily conserved. PLoS One (2009) 1.26

Role of Agrobacterium virB genes in transfer of T complexes and RSF1010. J Bacteriol (1998) 1.24

The N- and C-terminal portions of the Agrobacterium VirB1 protein independently enhance tumorigenesis. J Bacteriol (2000) 1.19

The genetic organization and evolution of the broad host range mercury resistance plasmid pSB102 isolated from a microbial population residing in the rhizosphere of alfalfa. Nucleic Acids Res (2001) 1.19

Phylogenomics reveals a diverse Rickettsiales type IV secretion system. Infect Immun (2010) 1.17

Elevated temperature differentially affects virulence, VirB protein accumulation, and T-pilus formation in different Agrobacterium tumefaciens and Agrobacterium vitis strains. J Bacteriol (2001) 1.17

VirB1* promotes T-pilus formation in the vir-Type IV secretion system of Agrobacterium tumefaciens. J Bacteriol (2007) 1.13

Functional subsets of the virB type IV transport complex proteins involved in the capacity of Agrobacterium tumefaciens to serve as a recipient in virB-mediated conjugal transfer of plasmid RSF1010. J Bacteriol (2003) 1.12

Stability of the Agrobacterium tumefaciens VirB10 protein is modulated by growth temperature and periplasmic osmoadaption. J Bacteriol (1998) 1.11

Functional and mutational analysis of p19, a DNA transfer protein with muramidase activity. J Bacteriol (2001) 1.10

Agrobacterium type IV secretion system and its substrates form helical arrays around the circumference of virulence-induced cells. Proc Natl Acad Sci U S A (2010) 1.07

The PtlE protein of Bordetella pertussis has peptidoglycanase activity required for Ptl-mediated pertussis toxin secretion. J Bacteriol (2002) 1.02

VirB1 orthologs from Brucella suis and pKM101 complement defects of the lytic transglycosylase required for efficient type IV secretion from Agrobacterium tumefaciens. J Bacteriol (2004) 1.00

TraG encoded by the pIP501 type IV secretion system is a two-domain peptidoglycan-degrading enzyme essential for conjugative transfer. J Bacteriol (2013) 0.91

Agrobacterium: nature's genetic engineer. Front Plant Sci (2015) 0.89

Hpa2 required by HrpF to translocate Xanthomonas oryzae transcriptional activator-like effectors into rice for pathogenicity. Appl Environ Microbiol (2011) 0.88

Subcellular location of the soluble lytic transglycosylase homologue in Staphylococcus aureus. Curr Microbiol (2004) 0.88

The P5 protein from bacteriophage phi-6 is a distant homolog of lytic transglycosylases. Protein Sci (2005) 0.86

The flagellar muramidase from the photosynthetic bacterium Rhodobacter sphaeroides. J Bacteriol (2007) 0.83

Mating pair formation homologue TraG is a variable membrane protein essential for contact-independent type IV secretion of chromosomal DNA by Neisseria gonorrhoeae. J Bacteriol (2013) 0.82

PrgK, a multidomain peptidoglycan hydrolase, is essential for conjugative transfer of the pheromone-responsive plasmid pCF10. J Bacteriol (2013) 0.81

A functional peptidoglycan hydrolase characterized from T4SS in 89K pathogenicity island of epidemic Streptococcus suis serotype 2. BMC Microbiol (2014) 0.78

Domestication of a housekeeping transglycosylase for assembly of a Type VI secretion system. EMBO Rep (2016) 0.78

Phylogenomic analyses reveal a molecular signature linked to subterranean adaptation in rodents. BMC Evol Biol (2015) 0.75

Analysis of complete genome sequence and major surface antigens of Neorickettsia helminthoeca, causative agent of salmon poisoning disease. Microb Biotechnol (2017) 0.75

Draft Genome Sequences of Salmonella Lysozyme Gene Knockout Mutants. Genome Announc (2017) 0.75

Articles cited by this

Basic local alignment search tool. J Mol Biol (1990) 659.07

Rapid and efficient site-specific mutagenesis without phenotypic selection. Methods Enzymol (1987) 66.52

Issues in searching molecular sequence databases. Nat Genet (1994) 19.28

Detection of conserved segments in proteins: iterative scanning of sequence databases with alignment blocks. Proc Natl Acad Sci U S A (1994) 18.46

Prediction of protein secondary structure at better than 70% accuracy. J Mol Biol (1993) 17.53

A workbench for multiple alignment construction and analysis. Proteins (1991) 16.96

Assessment of protein models with three-dimensional profiles. Nature (1992) 12.64

The genetic and transcriptional organization of the vir region of the A6 Ti plasmid of Agrobacterium tumefaciens. EMBO J (1986) 7.90

Structures and mechanisms of glycosyl hydrolases. Structure (1995) 5.96

Two-way chemical signaling in Agrobacterium-plant interactions. Microbiol Rev (1992) 4.37

Molecular characterization of an operon required for pertussis toxin secretion. Proc Natl Acad Sci U S A (1993) 4.12

Genetic complementation analysis of the Agrobacterium tumefaciens virB operon: virB2 through virB11 are essential virulence genes. J Bacteriol (1994) 3.72

Characterization of the virB operon from an Agrobacterium tumefaciens Ti plasmid. J Biol Chem (1988) 3.40

Common mechanisms in bacterial conjugation and Ti-mediated T-DNA transfer to plant cells. Cell (1994) 3.34

Sequence similarities between the RP4 Tra2 and the Ti VirB region strongly support the conjugation model for T-DNA transfer. J Biol Chem (1992) 3.15

Nuclear localization of Agrobacterium VirE2 protein in plant cells. Science (1992) 3.12

Association of the virD2 protein with the 5' end of T strands in Agrobacterium tumefaciens. J Bacteriol (1988) 2.44

Computer analysis of bacterial haloacid dehalogenases defines a large superfamily of hydrolases with diverse specificity. Application of an iterative approach to database search. J Mol Biol (1994) 2.41

The regulatory VirG protein specifically binds to a cis-acting regulatory sequence involved in transcriptional activation of Agrobacterium tumefaciens virulence genes. J Bacteriol (1990) 2.24

Common ancestry between IncN conjugal transfer genes and macromolecular export systems of plant and animal pathogens. Mol Microbiol (1994) 2.22

Subcellular localization of seven VirB proteins of Agrobacterium tumefaciens: implications for the formation of a T-DNA transport structure. J Bacteriol (1993) 2.10

The Agrobacterium tumefaciens virB4 gene product is an essential virulence protein requiring an intact nucleoside triphosphate-binding domain. J Bacteriol (1993) 2.09

Membrane location of the Ti plasmid VirB proteins involved in the biosynthesis of a pilin-like conjugative structure on Agrobacterium tumefaciens. FEMS Microbiol Lett (1993) 2.06

Chitinases, chitosanases, and lysozymes can be divided into procaryotic and eucaryotic families sharing a conserved core. Nat Struct Biol (1996) 1.94

A 3-D model for the CD40 ligand predicts that it is a compact trimer similar to the tumor necrosis factors. Int Immunol (1993) 1.93

Site-specific cleavage and joining of single-stranded DNA by VirD2 protein of Agrobacterium tumefaciens Ti plasmids: analogy to bacterial conjugation. Proc Natl Acad Sci U S A (1993) 1.84

Characterization of the Shigella flexneri ipgD and ipgF genes, which are located in the proximal part of the mxi locus. Infect Immun (1993) 1.84

Complementation analysis of Agrobacterium tumefaciens Ti plasmid virB genes by use of a vir promoter expression vector: virB9, virB10, and virB11 are essential virulence genes. J Bacteriol (1990) 1.83

Agrobacterium tumefaciens VirB11 protein requires a consensus nucleotide-binding site for function in virulence. J Bacteriol (1995) 1.72

Correction: characterization of the virB operon from Agrobacterium tumefaciens Ti plasmid. J Biol Chem (1990) 1.60

Gene 19 of plasmid R1 is required for both efficient conjugative DNA transfer and bacteriophage R17 infection. J Bacteriol (1995) 1.57

Localization and topology of VirB proteins of Agrobacterium tumefaciens. Plasmid (1994) 1.55

Site-directed mutagenesis of the catalytic residues Asp-52 and Glu-35 of chicken egg white lysozyme. Proc Natl Acad Sci U S A (1989) 1.54

An essential virulence protein of Agrobacterium tumefaciens, VirB4, requires an intact mononucleotide binding domain to function in transfer of T-DNA. Mol Gen Genet (1994) 1.48

Mechanism and stereoelectronic effects in the lysozyme reaction. CRC Crit Rev Biochem (1987) 1.46

Doughnut-shaped structure of a bacterial muramidase revealed by X-ray crystallography. Nature (1994) 1.45

Initiation of Agrobacterium tumefaciens T-DNA processing. Purified proteins VirD1 and VirD2 catalyze site- and strand-specific cleavage of superhelical T-border DNA in vitro. J Biol Chem (1995) 1.33

Protein-oligosaccharide interactions: lysozyme, phosphorylase, amylases. Curr Top Microbiol Immunol (1988) 1.30

The refined structures of goose lysozyme and its complex with a bound trisaccharide show that the "goose-type" lysozymes lack a catalytic aspartate residue. J Mol Biol (1995) 1.29

A conserved domain in putative bacterial and bacteriophage transglycosylases. Trends Biochem Sci (1994) 1.19

Structural similarity of plant chitinase and lysozymes from animals and phage. An evolutionary connection. FEBS Lett (1994) 1.12

Nucleotide sequence of iagA and iagB genes involved in invasion of HeLa cells by Salmonella enterica subsp. enterica ser. Typhi. Res Microbiol (1995) 1.09

'Holy' proteins. II: The soluble lytic transglycosylase. Curr Opin Struct Biol (1994) 1.00

Cloning and characterization of a potentially protective chitinase-like recombinant antigen from Wuchereria bancrofti. Infect Immun (1994) 0.94

The sequence of the leading region of the resistance plasmid R1. Nucleic Acids Res (1990) 0.92

Illuminating the ancient retainer. Nat Struct Biol (1996) 0.78

Articles by these authors

(truncated to the top 100)

Initial sequencing and analysis of the human genome. Nature (2001) 212.86

A genomic perspective on protein families. Science (1997) 50.51

The COG database: a tool for genome-scale analysis of protein functions and evolution. Nucleic Acids Res (2000) 49.22

The COG database: new developments in phylogenetic classification of proteins from complete genomes. Nucleic Acids Res (2001) 43.17

Isolation of covalently closed circular DNA of high molecular weight from bacteria. Anal Biochem (1976) 25.02

Protein sequence similarity searches using patterns as seeds. Nucleic Acids Res (1998) 23.87

Improving the accuracy of PSI-BLAST protein database searches with composition-based statistics and other refinements. Nucleic Acids Res (2001) 22.33

Detection of conserved segments in proteins: iterative scanning of sequence databases with alignment blocks. Proc Natl Acad Sci U S A (1994) 18.46

A superfamily of conserved domains in DNA damage-responsive cell cycle checkpoint proteins. FASEB J (1997) 15.10

Genome sequence of an obligate intracellular pathogen of humans: Chlamydia trachomatis. Science (1998) 13.64

Plasmid required for virulence of Agrobacterium tumefaciens. J Bacteriol (1975) 12.83

Wide host range cloning vectors: a cosmid clone bank of an Agrobacterium Ti plasmid. Plasmid (1982) 11.97

BRCA1 protein products ... Functional motifs... Nat Genet (1996) 11.50

AAA+: A class of chaperone-like ATPases associated with the assembly, operation, and disassembly of protein complexes. Genome Res (1999) 11.30

Stable incorporation of plasmid DNA into higher plant cells: the molecular basis of crown gall tumorigenesis. Cell (1977) 11.22

Genetic analysis of crown gall: fine structure map of the T-DNA by site-directed mutagenesis. Cell (1981) 10.83

Bacterial rhodopsin: evidence for a new type of phototrophy in the sea. Science (2000) 10.82

Two related superfamilies of putative helicases involved in replication, recombination, repair and expression of DNA and RNA genomes. Nucleic Acids Res (1989) 10.03

A Tn3 lacZ transposon for the random generation of beta-galactosidase gene fusions: application to the analysis of gene expression in Agrobacterium. EMBO J (1985) 9.03

Agrobacterium tumefaciens mutants affected in crown gall tumorigenesis and octopine catabolism. J Bacteriol (1980) 8.86

Integration and organization of Ti plasmid sequences in crown gall tumors. Cell (1980) 8.60

Agrobacterium tumefaciens DNA and PS8 bacteriophage DNA not detected in crown gall tumors. Proc Natl Acad Sci U S A (1974) 8.54

Novel domains of the prokaryotic two-component signal transduction systems. FEMS Microbiol Lett (2001) 8.45

Iterated profile searches with PSI-BLAST--a tool for discovery in protein databases. Trends Biochem Sci (1998) 8.01

Microbial culturomics: paradigm shift in the human gut microbiome study. Clin Microbiol Infect (2012) 7.97

The genetic and transcriptional organization of the vir region of the A6 Ti plasmid of Agrobacterium tumefaciens. EMBO J (1986) 7.90

IMPALA: matching a protein sequence against a collection of PSI-BLAST-constructed position-specific score matrices. Bioinformatics (1999) 6.91

The genome of the natural genetic engineer Agrobacterium tumefaciens C58. Science (2001) 6.90

Towards understanding the first genome sequence of a crenarchaeon by genome annotation using clusters of orthologous groups of proteins (COGs). Genome Biol (2000) 6.50

Genome sequence and comparative analysis of the solvent-producing bacterium Clostridium acetobutylicum. J Bacteriol (2001) 6.46

A minimal gene set for cellular life derived by comparison of complete bacterial genomes. Proc Natl Acad Sci U S A (1996) 6.38

Comparison of the complete protein sets of worm and yeast: orthology and divergence. Science (1998) 6.28

Sources of systematic error in functional annotation of genomes: domain rearrangement, non-orthologous gene displacement and operon disruption. In Silico Biol (1998) 6.22

Gleaning non-trivial structural, functional and evolutionary information about proteins by iterative database searches. J Mol Biol (1999) 5.90

Identification and genetic analysis of an Agrobacterium tumefaciens chromosomal virulence region. J Bacteriol (1985) 5.84

Using the COG database to improve gene recognition in complete genomes. Genetica (2000) 5.80

Cleavage of cohesin by the CD clan protease separin triggers anaphase in yeast. Cell (2000) 5.69

A gene essential for Agrobacterium virulence is homologous to a family of positive regulatory loci. Proc Natl Acad Sci U S A (1986) 5.61

Metabolism and evolution of Haemophilus influenzae deduced from a whole-genome comparison with Escherichia coli. Curr Biol (1996) 5.50

Genome alignment, evolution of prokaryotic genome organization, and prediction of gene function using genomic context. Genome Res (2001) 5.37

Octopine and nopaline metabolism in Agrobacterium tumefaciens and crown gall tumor cells: role of plasmid genes. J Bacteriol (1977) 5.11

Mutational analysis of the virulence region of an Agrobacterium tumefaciens Ti plasmid. J Bacteriol (1983) 4.82

Conserved domains in DNA repair proteins and evolution of repair systems. Nucleic Acids Res (1999) 4.80

Genome of the extremely radiation-resistant bacterium Deinococcus radiodurans viewed from the perspective of comparative genomics. Microbiol Mol Biol Rev (2001) 4.75

Purification of competent cells in the Bacillus subtilis transformation system. J Bacteriol (1968) 4.68

Genome trees constructed using five different approaches suggest new major bacterial clades. BMC Evol Biol (2001) 4.59

Agrobacterium tumefaciens mutants affected in attachment to plant cells. J Bacteriol (1982) 4.54

A plant cell factor induces Agrobacterium tumefaciens vir gene expression. Proc Natl Acad Sci U S A (1986) 4.46

Positionally cloned human disease genes: patterns of evolutionary conservation and functional motifs. Proc Natl Acad Sci U S A (1997) 4.40

The DNA-repair protein AlkB, EGL-9, and leprecan define new families of 2-oxoglutarate- and iron-dependent dioxygenases. Genome Biol (2001) 4.39

Conserved sequence motifs in the initiator proteins for rolling circle DNA replication encoded by diverse replicons from eubacteria, eucaryotes and archaebacteria. Nucleic Acids Res (1992) 4.39

T-DNA of Agrobacterium tumefaciens encodes an enzyme of cytokinin biosynthesis. Proc Natl Acad Sci U S A (1984) 4.37

Cysteine proteases of positive strand RNA viruses and chymotrypsin-like serine proteases. A distinct protein superfamily with a common structural fold. FEBS Lett (1989) 4.29

Common origin of four diverse families of large eukaryotic DNA viruses. J Virol (2001) 4.28

N-terminal domains of putative helicases of flavi- and pestiviruses may be serine proteases. Nucleic Acids Res (1989) 4.27

Characterization of the virA locus of Agrobacterium tumefaciens: a transcriptional regulator and host range determinant. EMBO J (1987) 4.22

The virD operon of Agrobacterium tumefaciens encodes a site-specific endonuclease. Cell (1986) 4.20

Identification of paracaspases and metacaspases: two ancient families of caspase-like proteins, one of which plays a key role in MALT lymphoma. Mol Cell (2000) 4.19

The HD domain defines a new superfamily of metal-dependent phosphohydrolases. Trends Biochem Sci (1998) 4.11

SAP - a putative DNA-binding motif involved in chromosomal organization. Trends Biochem Sci (2000) 4.10

Evidence for massive gene exchange between archaeal and bacterial hyperthermophiles. Trends Genet (1998) 4.10

Cytokinin/auxin balance in crown gall tumors is regulated by specific loci in the T-DNA. Proc Natl Acad Sci U S A (1983) 4.08

The complete sequence (22 kilobases) of murine coronavirus gene 1 encoding the putative proteases and RNA polymerase. Virology (1991) 4.07

Who's your neighbor? New computational approaches for functional genomics. Nat Biotechnol (2000) 4.04

Construction and analysis of bacterial artificial chromosome libraries from a marine microbial assemblage. Environ Microbiol (2000) 3.99

Viral proteins containing the purine NTP-binding sequence pattern. Nucleic Acids Res (1989) 3.96

Complementation analysis of Agrobacterium tumefaciens Ti plasmid mutations affecting oncogenicity. J Bacteriol (1982) 3.90

Chromosome 2 sequence of the human malaria parasite Plasmodium falciparum. Science (1998) 3.83

Identification of a vibrio cholerae RTX toxin gene cluster that is tightly linked to the cholera toxin prophage. Proc Natl Acad Sci U S A (1999) 3.75

Comparative genomics of the Archaea (Euryarchaeota): evolution of conserved protein families, the stable core, and the variable shell. Genome Res (1999) 3.62

SURVEY AND SUMMARY: holliday junction resolvases and related nucleases: identification of new families, phyletic distribution and evolutionary trajectories. Nucleic Acids Res (2000) 3.56

Sugars induce the Agrobacterium virulence genes through a periplasmic binding protein and a transmembrane signal protein. Proc Natl Acad Sci U S A (1990) 3.48

Role for 2-linked-beta-D-glucan in the virulence of Agrobacterium tumefaciens. J Bacteriol (1985) 3.48

Transcriptional regulation of the virA and virG genes of Agrobacterium tumefaciens. J Bacteriol (1988) 3.48

Evolution of aminoacyl-tRNA synthetases--analysis of unique domain architectures and phylogenetic trees reveals a complex history of horizontal gene transfer events. Genome Res (1999) 3.44

Evidence for diverse types of large plasmids in tumor-inducing strains of Agrobacterium. J Bacteriol (1976) 3.42

Characterization of the virB operon from an Agrobacterium tumefaciens Ti plasmid. J Biol Chem (1988) 3.40

A role for the mannose-sensitive hemagglutinin in biofilm formation by Vibrio cholerae El Tor. J Bacteriol (1999) 3.38

Coronavirus genome: prediction of putative functional domains in the non-structural polyprotein by comparative amino acid sequence analysis. Nucleic Acids Res (1989) 3.38

Putative papain-related thiol proteases of positive-strand RNA viruses. Identification of rubi- and aphthovirus proteases and delineation of a novel conserved domain associated with proteases of rubi-, alpha- and coronaviruses. FEBS Lett (1991) 3.35

DNA polymerase beta-like nucleotidyltransferase superfamily: identification of three new families, classification and evolutionary history. Nucleic Acids Res (1999) 3.32

A new superfamily of putative NTP-binding domains encoded by genomes of small DNA and RNA viruses. FEBS Lett (1990) 3.30

Eukaryotic signalling domain homologues in archaea and bacteria. Ancient ancestry and horizontal gene transfer. J Mol Biol (1999) 3.28

Lineage-specific loss and divergence of functionally linked genes in eukaryotes. Proc Natl Acad Sci U S A (2000) 3.27

The Agrobacterium tumefaciens virE2 gene product is a single-stranded-DNA-binding protein that associates with T-DNA. J Bacteriol (1988) 3.21

New cloning vehicles for transformation of higher plants. EMBO J (1985) 3.15

Non-orthologous gene displacement. Trends Genet (1996) 3.12

Lineage-specific gene expansions in bacterial and archaeal genomes. Genome Res (2001) 3.10

A novel superfamily of nucleoside triphosphate-binding motif containing proteins which are probably involved in duplex unwinding in DNA and RNA replication and recombination. FEBS Lett (1988) 3.09

The VirA protein of Agrobacterium tumefaciens is autophosphorylated and is essential for vir gene regulation. J Bacteriol (1990) 3.04

Genetic analysis of Agrobacterium. Methods Enzymol (1991) 3.02

An NTP-binding motif is the most conserved sequence in a highly diverged monophyletic group of proteins involved in positive strand RNA viral replication. J Mol Evol (1989) 3.00

A conserved NTP-motif in putative helicases. Nature (1988) 2.94

Plasmids specifying plant hyperplasias. Annu Rev Microbiol (1981) 2.93

Novel families of putative protein kinases in bacteria and archaea: evolution of the "eukaryotic" protein kinase superfamily. Genome Res (1998) 2.91

Detection of new genes in a bacterial genome using Markov models for three gene classes. Nucleic Acids Res (1995) 2.89

Rickettsiae and Chlamydiae: evidence of horizontal gene transfer and gene exchange. Trends Genet (1999) 2.87

Predicting functions from protein sequences--where are the bottlenecks? Nat Genet (1998) 2.86

Molecular and genetic analysis of the transferred DNA regions of the root-inducing plasmid of Agrobacterium rhizogenes. J Bacteriol (1985) 2.85

DNA from the A6S/2 crown gall tumor contains scrambled Ti-plasmid sequences near its junctions with plant DNA. Cell (1982) 2.85