PubRank

D J Loskutoff

Author PubWeight™ 166.33‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 An assay for transforming growth factor-beta using cells transfected with a plasminogen activator inhibitor-1 promoter-luciferase construct. Anal Biochem 1994 6.31
2 Bacterial lipopolysaccharide and inflammatory mediators augment IL-6 secretion by human endothelial cells. J Immunol 1989 3.01
3 Synthesis of a fibrinolytic activator and inhibitor by endothelial cells. Proc Natl Acad Sci U S A 1977 2.83
4 Identification of regulatory sequences in the type 1 plasminogen activator inhibitor gene responsive to transforming growth factor beta. J Biol Chem 1991 2.52
5 Endothelial cells produce a latent inhibitor of plasminogen activators that can be activated by denaturants. J Biol Chem 1985 2.23
6 Purification of an inhibitor of plasminogen activator (antiactivator) synthesized by endothelial cells. J Biol Chem 1984 2.22
7 Is plasminogen activator inhibitor-1 the molecular switch that governs urokinase receptor-mediated cell adhesion and release? J Cell Biol 1996 2.21
8 Detection of an unusually stable fibrinolytic inhibitor produced by bovine endothelial cells. Proc Natl Acad Sci U S A 1983 2.20
9 Cytokine activation of vascular endothelium. Effects on tissue-type plasminogen activator and type 1 plasminogen activator inhibitor. J Biol Chem 1988 2.04
10 Regulation of mRNAs for type-1 plasminogen activator inhibitor, fibronectin, and type I procollagen by transforming growth factor-beta. Divergent responses in lung fibroblasts and carcinoma cells. J Biol Chem 1988 1.93
11 Regulation of type 1 plasminogen activator inhibitor gene expression in cultured bovine aortic endothelial cells. Induction by transforming growth factor-beta, lipopolysaccharide, and tumor necrosis factor-alpha. J Biol Chem 1989 1.92
12 Elevated expression of transforming growth factor-beta in adipose tissue from obese mice. Mol Med 1997 1.92
13 Regulation of the fibrinolytic system of cultured human vascular endothelium by interleukin 1. J Clin Invest 1986 1.89
14 Cloning and sequence of a cDNA coding for the human beta-migrating endothelial-cell-type plasminogen activator inhibitor. Proc Natl Acad Sci U S A 1986 1.85
15 Regulation of murine type 1 plasminogen activator inhibitor gene expression in vivo. Tissue specificity and induction by lipopolysaccharide, tumor necrosis factor-alpha, and transforming growth factor-beta. J Clin Invest 1991 1.85
16 Cultured bovine endothelial cells produce both urokinase and tissue-type plasminogen activators. J Cell Biol 1982 1.77
17 Increased type 1 plasminogen activator inhibitor gene expression in atherosclerotic human arteries. Proc Natl Acad Sci U S A 1992 1.76
18 Distribution and regulation of plasminogen activator inhibitor-1 in murine adipose tissue in vivo. Induction by tumor necrosis factor-alpha and lipopolysaccharide. J Clin Invest 1996 1.65
19 Type 1 plasminogen activator inhibitor gene: functional analysis and glucocorticoid regulation of its promoter. Proc Natl Acad Sci U S A 1988 1.64
20 Reverse fibrin autography: a method to detect and partially characterize protease inhibitors after sodium dodecyl sulfate--polyacrylamide gel electrophoresis. Anal Biochem 1984 1.59
21 Activation of rabbit Hageman factor by homogenates of cultured rabbit endothelial cells. J Clin Invest 1980 1.53
22 Cellular localization of type 1 plasminogen activator inhibitor messenger RNA and protein in murine renal tissue. Am J Pathol 1993 1.52
23 Changes in procoagulant and fibrinolytic gene expression during bleomycin-induced lung injury in the mouse. J Clin Invest 1995 1.52
24 Detection and partial characterization of an inhibitor of plasminogen activator in human platelets. J Clin Invest 1984 1.50
25 Type 1 plasminogen activator inhibitor. Prog Hemost Thromb 1989 1.49
26 Murine CD14 gene expression in vivo: extramyeloid synthesis and regulation by lipopolysaccharide. J Exp Med 1995 1.46
27 The primary plasminogen-activator inhibitors in endothelial cells, platelets, serum, and plasma are immunologically related. Proc Natl Acad Sci U S A 1985 1.46
28 Murine tissue factor gene expression in vivo. Tissue and cell specificity and regulation by lipopolysaccharide. Am J Pathol 1993 1.45
29 Tissue factor gene expression in the adipose tissues of obese mice. Proc Natl Acad Sci U S A 1998 1.44
30 Leptin-dependent platelet aggregation and arterial thrombosis suggests a mechanism for atherothrombotic disease in obesity. J Clin Invest 2001 1.41
31 Plasminogen activator inhibitor-1 and its cofactor vitronectin stabilize arterial thrombi after vascular injury in mice. Circulation 2001 1.39
32 Gene expression during the development of Bacillus subtilis bacteriophage phi 29. I. Analysis of viral-specific transcription by deoxyribonucleic acid-ribonucleic acid competition hybridization. J Virol 1973 1.38
33 Structural and functional analysis of the plasminogen activator inhibitor-1 binding motif in the somatomedin B domain of vitronectin. J Biol Chem 1996 1.31
34 Tissue distribution and regulation of murine von Willebrand factor gene expression in vivo. Blood 1998 1.29
35 Fibrin deposition in tissues from endotoxin-treated mice correlates with decreases in the expression of urokinase-type but not tissue-type plasminogen activator. J Clin Invest 1996 1.29
36 Distinct antithrombotic consequences of platelet glycoprotein Ibalpha and VI deficiency in a mouse model of arterial thrombosis. J Thromb Haemost 2006 1.28
37 Activated protein C stimulates the fibrinolytic activity of cultured endothelial cells and decreases antiactivator activity. Proc Natl Acad Sci U S A 1985 1.27
38 Human melanoma cells derived from lymphatic metastases use integrin alpha v beta 3 to adhere to lymph node vitronectin. J Clin Invest 1992 1.26
39 The fibrinolytic system of the vascular wall. Clin Haematol 1985 1.25
40 Tissue distribution of factor VIII gene expression in vivo--a closer look. Thromb Haemost 2001 1.24
41 Plasminogen activator inhibitor-1 regulates cell adhesion by binding to the somatomedin B domain of vitronectin. J Cell Physiol 2001 1.23
42 Tumor necrosis factor alpha is a key component in the obesity-linked elevation of plasminogen activator inhibitor 1. Proc Natl Acad Sci U S A 1999 1.23
43 Comparative studies of the fibrinolytic activity of cultured vascular cells. Thromb Res 1979 1.22
44 Evidence that type 1 plasminogen activator inhibitor binds to the somatomedin B domain of vitronectin. J Biol Chem 1991 1.21
45 Coordinated induction of plasminogen activator inhibitor-1 (PAI-1) and inhibition of plasminogen activator gene expression by hypoxia promotes pulmonary vascular fibrin deposition. J Clin Invest 1998 1.20
46 Extracellular matrix of cultured bovine aortic endothelial cells contains functionally active type 1 plasminogen activator inhibitor. Blood 1987 1.20
47 Purification of a protein from bovine plasma that binds to type 1 plasminogen activator inhibitor and prevents its interaction with extracellular matrix. Evidence that the protein is vitronectin. J Biol Chem 1989 1.20
48 Effect of thrombin on the fibrinolytic activity of cultured bovine endothelial cells. J Clin Invest 1979 1.20
49 Tissue factor expression during human and mouse development. Am J Pathol 1996 1.19
50 The somatomedin B domain of vitronectin. Structural requirements for the binding and stabilization of active type 1 plasminogen activator inhibitor. J Biol Chem 1994 1.18
51 Mechanism of protein C-dependent clot lysis: role of plasminogen activator inhibitor. Blood 1986 1.15
52 Human endothelial cells produce IL-6. Lack of responses to exogenous IL-6. Ann N Y Acad Sci 1989 1.12
53 Replication of dengue and junin viruses in cultured rabbit and human endothelial cells. Infect Immun 1978 1.12
54 Gene expression during the development of Bacillus subtilis bacteriophage phi29. II. Resolution of viral-specific ribonucleic acid molecules. J Virol 1973 1.12
55 Serum-mediated suppression of cell-associated plasminogen activator activity in cultured endothelial cells. Cell 1980 1.11
56 Tissue distribution and regulation of plasminogen activator inhibitor-1 in obese mice. Mol Med 1996 1.10
57 Immunoradiometric assay to measure the binding of a specific inhibitor to tissue-type plasminogen activator. J Lab Clin Med 1985 1.09
58 Detection of vitronectin mRNA in tissues and cells of the mouse. Proc Natl Acad Sci U S A 1991 1.09
59 Kinetic analysis of the interactions between plasminogen activator inhibitor 1 and both urokinase and tissue plasminogen activator. Arch Biochem Biophys 1988 1.08
60 Insulin continues to induce plasminogen activator inhibitor 1 gene expression in insulin-resistant mice and adipocytes. Mol Med 2000 1.08
61 Effects of acidified fetal bovine serum on the fibrinolytic activity and growth of cells in culture. J Cell Physiol 1978 1.06
62 Astrocytes are the primary source of tissue factor in the murine central nervous system. A role for astrocytes in cerebral hemostasis. J Clin Invest 1993 1.04
63 Expression of type 1 plasminogen activator inhibitor in chronic pulmonary thromboemboli. Circulation 1994 1.04
64 Inactivation of plasminogen activator inhibitor by oxidants. Biochemistry 1986 1.04
65 SPARC induces the expression of type 1 plasminogen activator inhibitor in cultured bovine aortic endothelial cells. J Biol Chem 1991 1.02
66 An inhibitor of plasminogen activator in rabbit endothelial cells. J Biol Chem 1981 1.01
67 Binding of type 1 plasminogen activator inhibitor to the extracellular matrix of cultured bovine endothelial cells. J Biol Chem 1989 1.01
68 Kinetic analysis of the interaction between type 1 plasminogen activator inhibitor and vitronectin and evidence that the bovine inhibitor binds to a thrombin-derived amino-terminal fragment of bovine vitronectin. Biochim Biophys Acta 1991 1.00
69 Expression of fibrinolytic genes in atherosclerotic abdominal aortic aneurysm wall. A possible mechanism for aneurysm expansion. J Clin Invest 1995 1.00
70 Disruption of the plasminogen activator inhibitor 1 gene reduces the adiposity and improves the metabolic profile of genetically obese and diabetic ob/ob mice. FASEB J 2001 0.99
71 Induction of plasminogen activator inhibitor 1 gene expression in murine liver by lipopolysaccharide. Cellular localization and role of endogenous tumor necrosis factor-alpha. Am J Pathol 1997 0.99
72 Cultured granulosa cells produce two plasminogen activators and an antiactivator, each regulated differently by gonadotropins. Endocrinology 1985 0.99
73 Fibrinolytic system of vascular endothelial cells. Role of plasminogen activator inhibitors. Haemostasis 1988 0.99
74 The majority of type 1 plasminogen activator inhibitor associated with cultured human endothelial cells is located under the cells and is accessible to solution-phase tissue-type plasminogen activator. J Cell Biol 1990 0.98
75 Characterization of two monoclonal antibodies against human tissue-type plasminogen activator. Thromb Haemost 1985 0.96
76 Distribution of vitronectin mRNA during murine development. Dev Dyn 1995 0.95
77 Altered expression of plasminogen activator inhibitor type 1 in placentas from pregnant women with preeclampsia and/or intrauterine fetal growth retardation. Blood 1994 0.94
78 Dysfunction of glomerular fibrinolysis in experimental antiglomerular basement membrane antibody glomerulonephritis. J Am Soc Nephrol 1993 0.93
79 Messenger RNA for plasminogen activator inhibitor. Thromb Res 1986 0.92
80 The dexamethasone-induced inhibitor of plasminogen activator in hepatoma cells is antigenically-related to an inhibitor produced by bovine aortic endothelial cells. Thromb Haemost 1986 0.92
81 Abnormal expression of type 1 plasminogen activator inhibitor and tissue factor in severe preeclampsia. Thromb Haemost 1998 0.91
82 Interactions between type 1 plasminogen activator inhibitor, extracellular matrix and vitronectin. Cell Differ Dev 1990 0.91
83 Endotoxin stimulates expression of the murine urokinase receptor gene in vivo. Am J Pathol 1995 0.91
84 Role of tumor necrosis factor alpha in induction of murine CD14 gene expression by lipopolysaccharide. Infect Immun 1997 0.91
85 Regulation of tissue factor gene expression in obesity. Blood 2001 0.90
86 Intracellular plasminogen activator activity in growing and quiescent cells. J Cell Physiol 1978 0.89
87 The kidneys of mice with autoimmune disease acquire a hypofibrinolytic/procoagulant state that correlates with the development of glomerulonephritis and tissue microthrombosis. Am J Pathol 1997 0.89
88 Serum-derived vitronectin influences the pericellular distribution of type 1 plasminogen activator inhibitor. J Cell Biol 1990 0.89
89 Changes in the plasma levels of type 1 and type 2 plasminogen activator inhibitors in normal pregnancy and in patients with severe preeclampsia. Blood 1989 0.89
90 The leptin receptor system of human platelets. J Thromb Haemost 2005 0.88
91 Expression of transforming growth factor-beta and tumor necrosis factor-alpha in the plasma and tissues of mice with lupus nephritis. Lab Invest 2000 0.88
92 Type 1 plasminogen activator inhibitor induces multimerization of plasma vitronectin. A suggested mechanism for the generation of the tissue form of vitronectin in vivo. J Biol Chem 1996 0.87
93 Interactions between fibrin and the plasminogen activators produced by cultured endothelial cells. Blood 1983 0.87
94 Localization of vitronectin in the normal and atherosclerotic human vessel wall. Histochem Cell Biol 1997 0.87
95 Protein C inhibitor is expressed in tubular cells of human kidney. J Clin Invest 1994 0.86
96 Extrahepatic expression and regulation of protein C in the mouse. Am J Pathol 1998 0.86
97 Fibrinolytic pathways and the endothelium. Semin Thromb Hemost 1987 0.86
98 Expression and cellular localization of messenger RNA for plasminogen activator inhibitor type 1 in human astrocytomas in vivo. Cancer Res 1994 0.85
99 Vitronectin gene expression in vivo. Evidence for extrahepatic synthesis and acute phase regulation. J Biol Chem 1994 0.85
100 Platelets stimulate endothelial cells to synthesize type 1 plasminogen activator inhibitor. Evaluation of the role of transforming growth factor beta. Blood 1991 0.85
101 The PAI-1/vitronectin interaction: two cats in a bag? Thromb Haemost 1995 0.85
102 Bovine plasminogen activator inhibitor 1: specificity determinations and comparison of the active, latent, and guanidine-activated forms. Biochemistry 1988 0.85
103 Human hepatoma cell line plasminogen activator. J Lab Clin Med 1983 0.84
104 Regulation of plasminogen activator production by cultured endothelial cells. Ann N Y Acad Sci 1982 0.84
105 Plasminogen activator inhibitor-type I is a major biosynthetic product of retinal microvascular endothelial cells and pericytes in culture. Biochem J 1989 0.84
106 A comparison between activated protein C and des-1-41-light chain-activated protein C in reactions with type 1 plasminogen activator inhibitor. Blood 1989 0.83
107 Expression of type 1 plasminogen activator inhibitor in renal tissue in murine lupus nephritis. Kidney Int 1995 0.83
108 Patterns of expression of fibrinolytic genes and matrix metalloproteinase-9 in dissecting aortic aneurysms. Am J Pathol 1998 0.83
109 Abnormal expression of plasminogen activator inhibitors in patients with gestational trophoblastic disease. Am J Pathol 1996 0.83
110 A slice of PAI. J Clin Invest 1993 0.82
111 Highly sulfated glycosaminoglycans augment the cross-linking of vitronectin by guinea pig liver transglutaminase. Functional studies of the cross-linked vitronectin multimers. J Biol Chem 1990 0.82
112 Regulation of murine protein C gene expression in vivo: effects of tumor necrosis factor-alpha, interleukin-1, and transforming growth factor-beta. Thromb Haemost 1999 0.81
113 Recommendations for the nomenclature of mutant fibrinolytic genes and their proteins. Report of the SSC Fibrinolysis Subcommittee 1990. Thromb Haemost 1990 0.81
114 Plasminogen activators and their inhibitors. Methods Enzymol 1988 0.80
115 Hemostatic gene expression and vascular disease in obesity: insights from studies of genetically obese mice. Thromb Haemost 1999 0.80
116 Effects of energy intake on type 1 plasminogen activator inhibitor levels in glomeruli of lupus-prone B/W mice. Am J Pathol 1995 0.80
117 The prothrombotic effects of leptin possible implications for the risk of cardiovascular disease in obesity. Ann N Y Acad Sci 2001 0.80
118 Detection of both type 1 and type 2 plasminogen activator inhibitors in human cells. J Cell Physiol 1988 0.80
119 Fibrinolytic system of cultured endothelial cells: regulation by plasminogen activator inhibitor. J Cell Biochem 1986 0.80
120 Immunoelectron microscopic localization of type 1 plasminogen activator inhibitor on the surface of activated endothelial cells. J Cell Biol 1991 0.80
121 Interaction of type 1 plasminogen activator inhibitor with the enzymes of the contact activation system. J Biol Chem 1989 0.79
122 Inhibitors of urokinase and thrombin in cultured neural cells. J Neurochem 1991 0.79
123 Denaturant-induced stimulation of the beta-migrating plasminogen activator inhibitor in endothelial cells and serum. Blood 1986 0.79
124 Characterization of a plasminogen activator secreted by cultured bovine aortic endothelial cells. Biochim Biophys Acta 1982 0.78
125 A monoclonal antibody that does not recognize tissue-type plasminogen activator bound to its naturally occurring inhibitor. Thromb Haemost 1986 0.78
126 Induction of plasminogen activator inhibitor 1 gene expression in adipocytes by thiazolidinediones. FASEB J 2001 0.78
127 Functional display of human plasminogen-activator inhibitor 1 (PAI-1) on phages: novel perspectives for structure-function analysis by error-prone DNA synthesis. Gene 1993 0.78
128 Plasminogen activator inhibitors. Trends Cardiovasc Med 1991 0.78
129 Glomerular extracellular matrix accumulation in experimental anti-GBM Ab glomerulonephritis. Nephron 2000 0.78
130 Thrombotic phenotype of mice with a combined deficiency in plasminogen activator inhibitor 1 and vitronectin. J Thromb Haemost 2005 0.78
131 Type 1 plasminogen activator inhibitor gene expression following partial hepatectomy. Am J Pathol 1993 0.78
132 The fat mouse: a powerful genetic model to study elevated plasminogen activator inhibitor 1 in obesity/NIDDM. Thromb Haemost 1997 0.78
133 A direct, plasmin-independent assay for plasminogen activator. Thromb Res 1984 0.78
134 Preparation of tissue culture serum lacking alpha2-macroglobulin. FEBS Lett 1978 0.77
135 PAI-1 inhibits neointimal formation after arterial injury in mice: a new target for controlling restenosis? Circulation 1997 0.77
136 Evidence that extrahepatic cells express vitronectin mRNA at rates approaching those of hepatocytes. Histochem Cell Biol 1996 0.77
137 Differential regulation of vitronectin in mice and humans in vitro. J Biol Chem 1996 0.77
138 Renal expression of fibrinolytic genes and tissue factor in a murine model of renal disease as a function of age. Semin Thromb Hemost 1998 0.77
139 A method for defining binding sites involved in protein-protein interactions: analysis of the binding of plasminogen activator inhibitor 1 to the somatomedin domain of vitronectin. Anal Biochem 2001 0.76
140 Immunoelectron microscopic localization of type 1 plasminogen activator inhibitor in the extracellular matrix of transforming growth factor-beta-activated endothelial cells. Ann N Y Acad Sci 1992 0.76
141 Carboxypeptidases: new regulators of plasminogen activation in vivo? J Clin Invest 1995 0.75
142 Medical control of abdominal aortic aneurysm expansion rate. J Vasc Surg 1996 0.75
143 Obesity enhances the induction of plasminogen activator inhibitor-1 by restraint stress: a possible mechanism of stress-induced renal fibrin deposition in obese mice. J Thromb Haemost 2005 0.75
144 Retinal pigment epithelial cells produce a latent fibrinolytic inhibitor that is antigenically and biochemically related to type 1 plasminogen activator inhibitor produced by vascular endothelial cells. Exp Eye Res 1989 0.75
145 The regulation of uterine tissue factor by estrogen. Endocrine 1995 0.75
146 Regulation of type I plasminogen activator inhibitor synthesis by protein kinase C and cAMP in bovine aortic endothelial cells. Biochim Biophys Acta 1991 0.75