Nitric oxide acts directly in the presynaptic neuron to produce long-term potentiation in cultured hippocampal neurons.

PubWeight™: 1.63‹?› | Rank: Top 4%

🔗 View Article (PMID 8978607)

Published in Cell on December 13, 1996

Authors

O Arancio1, M Kiebler, C J Lee, V Lev-Ram, R Y Tsien, E R Kandel, R D Hawkins

Author Affiliations

1: Center for Neurobiology and Behavior, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA.

Articles citing this

Silent synapses and the emergence of a postsynaptic mechanism for LTP. Nat Rev Neurosci (2008) 3.52

Ivy cells: a population of nitric-oxide-producing, slow-spiking GABAergic neurons and their involvement in hippocampal network activity. Neuron (2008) 2.08

Inhibition of calpains improves memory and synaptic transmission in a mouse model of Alzheimer disease. J Clin Invest (2008) 1.79

NMDA receptor-dependent long-term potentiation and long-term depression (LTP/LTD). Cold Spring Harb Perspect Biol (2012) 1.67

alpha-Synuclein produces a long-lasting increase in neurotransmitter release. EMBO J (2004) 1.54

Nitric oxide mediates N-methyl-D-aspartate receptor-induced activation of p21ras. Proc Natl Acad Sci U S A (1998) 1.51

Nitric oxide S-nitrosylates serine racemase, mediating feedback inhibition of D-serine formation. Proc Natl Acad Sci U S A (2007) 1.27

The NO-cGMP-PKG signaling pathway regulates synaptic plasticity and fear memory consolidation in the lateral amygdala via activation of ERK/MAP kinase. Learn Mem (2008) 1.26

The specific role of cGMP in hippocampal LTP. Learn Mem (1999) 1.19

Coordinate action of pre- and postsynaptic brain-derived neurotrophic factor is required for AMPAR trafficking and acquisition of in vitro classical conditioning. Neuroscience (2008) 1.13

The past, the future and the biology of memory storage. Philos Trans R Soc Lond B Biol Sci (1999) 1.12

Increased neurotransmitter release during long-term potentiation at mossy fibre-granule cell synapses in rat cerebellum. J Physiol (2004) 1.12

The role of nitric oxide in pre-synaptic plasticity and homeostasis. Front Cell Neurosci (2013) 1.11

Involvement of reactive oxygen species in long-term potentiation in the spinal cord dorsal horn. J Neurophysiol (2009) 1.10

Modulation of oxidative stress and mitochondrial function by the ketogenic diet. Epilepsy Res (2011) 1.09

Retrograde signaling at central synapses. Proc Natl Acad Sci U S A (2001) 1.08

Nitric oxide is required for the induction and heterosynaptic spread of long-term potentiation in rat cerebellar slices. J Physiol (2001) 1.01

Synaptic plasticity and NO-cGMP-PKG signaling regulate pre- and postsynaptic alterations at rat lateral amygdala synapses following fear conditioning. PLoS One (2010) 1.00

Mutant mice deficient in NOS-1 exhibit attenuated long-term facilitation and short-term potentiation in breathing. J Physiol (2002) 0.99

Is the amyloid hypothesis of Alzheimer's disease therapeutically relevant? Biochem J (2012) 0.97

Toward an Integration of Deep Learning and Neuroscience. Front Comput Neurosci (2016) 0.97

Long-Term Potentiation at CA3-CA1 Hippocampal Synapses with Special Emphasis on Aging, Disease, and Stress. Front Aging Neurosci (2011) 0.94

Two sides to long-term potentiation: a view towards reconciliation. Philos Trans R Soc Lond B Biol Sci (2013) 0.93

Catalytic antioxidants and neurodegeneration. Antioxid Redox Signal (2009) 0.93

Essential control of an endothelial cell ISOC by the spectrin membrane skeleton. J Cell Biol (2001) 0.92

Amyloid-β inhibits No-cGMP signaling in a CD36- and CD47-dependent manner. PLoS One (2010) 0.91

Presynaptic long-term plasticity. Front Synaptic Neurosci (2013) 0.91

Nos2 inactivation promotes the development of medulloblastoma in Ptch1(+/-) mice by deregulation of Gap43-dependent granule cell precursor migration. PLoS Genet (2012) 0.89

Eps8 controls dendritic spine density and synaptic plasticity through its actin-capping activity. EMBO J (2013) 0.89

Concentration dynamics of nitric oxide in rat hippocampal subregions evoked by stimulation of the NMDA glutamate receptor. Proc Natl Acad Sci U S A (2005) 0.87

Presynaptic and postsynaptic Ca(2+) and CamKII contribute to long-term potentiation at synapses between individual CA3 neurons. Proc Natl Acad Sci U S A (2006) 0.87

Nitric oxide synthase mediates the ability of darbepoetin alpha to improve the cognitive performance of STOP null mice. Neuropsychopharmacology (2010) 0.87

Heterocyclic N-Oxides - An Emerging Class of Therapeutic Agents. Curr Med Chem (2015) 0.87

Synaptic plasticity and NO-cGMP-PKG signaling coordinately regulate ERK-driven gene expression in the lateral amygdala and in the auditory thalamus following Pavlovian fear conditioning. Learn Mem (2010) 0.87

On the respective roles of nitric oxide and carbon monoxide in long-term potentiation in the hippocampus. Learn Mem (1999) 0.86

The origin of neocortical nitric oxide synthase-expressing inhibitory neurons. Front Neural Circuits (2012) 0.85

Nitric oxide signaling in invertebrates. Invert Neurosci (1997) 0.85

Cellular targets of nitric oxide in the hippocampus. PLoS One (2013) 0.85

A role for nitric oxide-driven retrograde signaling in the consolidation of a fear memory. Front Behav Neurosci (2010) 0.83

Long-term memory of visually cued fear conditioning: roles of the neuronal nitric oxide synthase gene and cyclic AMP response element-binding protein. Neuroscience (2010) 0.83

A role for cGMP-dependent protein kinase II in AMPA receptor trafficking and synaptic plasticity. Channels (Austin) (2008) 0.82

Dynamin 1 is required for memory formation. PLoS One (2014) 0.82

Role of phosphodiesterase 5 in synaptic plasticity and memory. Neuropsychiatr Dis Treat (2008) 0.82

Regulation of hippocampal synaptic plasticity thresholds and changes in exploratory and learning behavior in dominant negative NPR-B mutant rats. Front Mol Neurosci (2014) 0.82

Photolytically released nitric oxide produces a delayed but persistent suppression of LTP in area CA1 of the rat hippocampal slice. J Physiol (1999) 0.81

Monoclonal antibodies to 65kDa glutamate decarboxylase induce epitope specific effects on motor and cognitive functions in rats. Orphanet J Rare Dis (2013) 0.81

On the respective roles of nitric oxide and carbon monoxide in long-term potentiation in the hippocampus. Learn Mem (1999) 0.81

The relation of different-scale membrane processes under nitric oxide influence. J Biol Phys (2005) 0.79

Analysis of Proteins That Rapidly Change Upon Mechanistic/Mammalian Target of Rapamycin Complex 1 (mTORC1) Repression Identifies Parkinson Protein 7 (PARK7) as a Novel Protein Aberrantly Expressed in Tuberous Sclerosis Complex (TSC). Mol Cell Proteomics (2015) 0.79

Metaplastic effect of apamin on LTP and paired-pulse facilitation. Learn Mem (2007) 0.79

New perspectives in cyclic nucleotide-mediated functions in the CNS: the emerging role of cyclic nucleotide-gated (CNG) channels. Pflugers Arch (2013) 0.79

Nitric oxide-dependent long-term depression but not endocannabinoid-mediated long-term potentiation is crucial for visual recognition memory. J Physiol (2013) 0.78

Protein kinase G-dependent mechanisms modulate hypoglossal motoneuronal excitability and long-term facilitation. J Physiol (2010) 0.78

Response of the nitrergic system to activation of the neuroendocrine stress axis. Front Neurosci (2015) 0.77

Depressed nNOS expression during spine transition in the developing hippocampus of FMR1 KO mice. Braz J Med Biol Res (2012) 0.77

Enhanced nitric oxide production during lead (Pb²⁺) exposure recovers protein expression but not presynaptic localization of synaptic proteins in developing hippocampal neurons. Brain Res (2011) 0.77

BDNF-induced nitric oxide signals in cultured rat hippocampal neurons: time course, mechanism of generation, and effect on neurotrophin secretion. Front Cell Neurosci (2014) 0.77

Age-associated changes of nitric oxide concentration dynamics in the central nervous system of Fisher 344 rats. Cell Mol Neurobiol (2014) 0.76

The NO-cGMP-PKG signaling pathway coordinately regulates ERK and ERK-driven gene expression at pre- and postsynaptic sites following LTP-inducing stimulation of thalamo-amygdala synapses. Neural Plast (2011) 0.76

Furoxans (1,2,5-oxadiazole-N-oxides) as novel NO mimetic neuroprotective and procognitive agents. J Med Chem (2012) 0.76

Multicolor monitoring of the proteasome's catalytic signature. ACS Chem Biol (2014) 0.75

Suppression of synaptic plasticity by fullerenol in rat hippocampus in vitro. Int J Nanomedicine (2016) 0.75

Mutating three residues in the bovine rod cyclic nucleotide-activated channel can switch a nucleotide from inactive to active. Biophys J (2000) 0.75

Designing tools for assumption-proof brain mapping. Neuron (2014) 0.75

Evidence that nitric oxide does not directly contribute to methacholine-induced amylase secretion in rabbit parotid acinar cells. Pflugers Arch (2003) 0.75

Articles by these authors

A new generation of Ca2+ indicators with greatly improved fluorescence properties. J Biol Chem (1985) 90.20

Fluorescent indicators for Ca2+ based on green fluorescent proteins and calmodulin. Nature (1997) 18.83

Crystal structure of the Aequorea victoria green fluorescent protein. Science (1996) 16.81

Improved green fluorescence. Nature (1995) 12.65

Calcium homeostasis in intact lymphocytes: cytoplasmic free calcium monitored with a new, intracellularly trapped fluorescent indicator. J Cell Biol (1982) 11.87

New calcium indicators and buffers with high selectivity against magnesium and protons: design, synthesis, and properties of prototype structures. Biochemistry (1980) 11.70

Wavelength mutations and posttranslational autoxidation of green fluorescent protein. Proc Natl Acad Sci U S A (1994) 10.50

On/off blinking and switching behaviour of single molecules of green fluorescent protein. Nature (1997) 9.97

Identification of a signal for rapid export of proteins from the nucleus. Cell (1995) 9.92

Engineering green fluorescent protein for improved brightness, longer wavelengths and fluorescence resonance energy transfer. Curr Biol (1996) 9.72

Specific covalent labeling of recombinant protein molecules inside live cells. Science (1998) 9.32

Reducing the environmental sensitivity of yellow fluorescent protein. Mechanism and applications. J Biol Chem (2001) 9.27

Subregion- and cell type-restricted gene knockout in mouse brain. Cell (1996) 8.02

Biochemistry, mutagenesis, and oligomerization of DsRed, a red fluorescent protein from coral. Proc Natl Acad Sci U S A (2000) 7.68

Control of memory formation through regulated expression of a CaMKII transgene. Science (1996) 7.56

Circular permutation and receptor insertion within green fluorescent proteins. Proc Natl Acad Sci U S A (1999) 7.55

Understanding, improving and using green fluorescent proteins. Trends Biochem Sci (1995) 7.51

Fluorescent indicators for cytosolic calcium based on rhodamine and fluorescein chromophores. J Biol Chem (1989) 7.22

Fas preassociation required for apoptosis signaling and dominant inhibition by pathogenic mutations. Science (2000) 6.98

Measurement of cytosolic, mitochondrial, and Golgi pH in single living cells with green fluorescent proteins. Proc Natl Acad Sci U S A (1998) 6.73

Dynamic and quantitative Ca2+ measurements using improved cameleons. Proc Natl Acad Sci U S A (1999) 6.63

Cognitive neuroscience and the study of memory. Neuron (1998) 6.22

Considerations for formulating the second-generation pneumococcal capsular polysaccharide vaccine with emphasis on the cross-reactive types within groups. J Infect Dis (1983) 6.15

Calcium channels, stores, and oscillations. Annu Rev Cell Biol (1990) 6.12

The structure of the chromophore within DsRed, a red fluorescent protein from coral. Proc Natl Acad Sci U S A (2000) 5.88

A non-disruptive technique for loading calcium buffers and indicators into cells. Nature (1981) 5.72

Emptying of intracellular Ca2+ stores releases a novel small messenger that stimulates Ca2+ influx. Nature (1993) 5.55

Neutral carrier ion-selective microelectrodes for measurement of intracellular free calcium. Biochim Biophys Acta (1980) 5.34

Cytoplasmic pH and free Mg2+ in lymphocytes. J Cell Biol (1982) 5.30

Recombinant BDNF rescues deficits in basal synaptic transmission and hippocampal LTP in BDNF knockout mice. Neuron (1996) 5.19

Structural basis for dual excitation and photoisomerization of the Aequorea victoria green fluorescent protein. Proc Natl Acad Sci U S A (1997) 4.99

Cell-permeant caged InsP3 ester shows that Ca2+ spike frequency can optimize gene expression. Nature (1998) 4.93

Monitoring protein conformations and interactions by fluorescence resonance energy transfer between mutants of green fluorescent protein. Methods Enzymol (2000) 4.87

Genetic demonstration of a role for PKA in the late phase of LTP and in hippocampus-based long-term memory. Cell (1997) 4.83

T-cell mitogens cause early changes in cytoplasmic free Ca2+ and membrane potential in lymphocytes. Nature (1982) 4.83

Impaired long-term potentiation, spatial learning, and hippocampal development in fyn mutant mice. Science (1992) 4.58

Fluorescence ratio imaging of cyclic AMP in single cells. Nature (1991) 4.45

Molecular biology of learning: modulation of transmitter release. Science (1982) 4.44

Effects of cAMP simulate a late stage of LTP in hippocampal CA1 neurons. Science (1993) 4.31

Calcium gradients in single smooth muscle cells revealed by the digital imaging microscope using Fura-2. Nature (1986) 4.21

Quantitation of transcription and clonal selection of single living cells with beta-lactamase as reporter. Science (1998) 4.15

Is cytosolic ionized calcium regulating neutrophil activation? Science (1983) 3.97

Synapse-specific, long-term facilitation of aplysia sensory to motor synapses: a function for local protein synthesis in memory storage. Cell (1997) 3.93

Identification of a gene encoding a hyperpolarization-activated pacemaker channel of brain. Cell (1998) 3.90

Requirement of a critical period of transcription for induction of a late phase of LTP. Science (1994) 3.85

Genetically encoded reporters of protein kinase A activity reveal impact of substrate tethering. Proc Natl Acad Sci U S A (2001) 3.77

Requirement for intrinsic protein tyrosine kinase in the immediate and late actions of the EGF receptor. Nature (1987) 3.75

The long and the short of long-term memory--a molecular framework. Nature (1986) 3.68

Serotonin and cyclic AMP close single K+ channels in Aplysia sensory neurones. Nature (1982) 3.61

Changes of free calcium levels with stages of the cell division cycle. Nature (1985) 3.48

Na+/H+ exchange and cytoplasmic pH in the action of growth factors in human fibroblasts. Nature (1983) 3.47

Optical imaging of calcium transients in neurons and pharyngeal muscle of C. elegans. Neuron (2000) 3.44

Photochemically generated cytosolic calcium pulses and their detection by fluo-3. J Biol Chem (1989) 3.44

Lymphocyte membrane potential assessed with fluorescent probes. Biochim Biophys Acta (1980) 3.33

Cytosolic Ca2+ homeostasis in Ehrlich and Yoshida carcinomas. A new, membrane-permeant chelator of heavy metals reveals that these ascites tumor cell lines have normal cytosolic free Ca2+. J Biol Chem (1985) 3.31

A critical period for macromolecular synthesis in long-term heterosynaptic facilitation in Aplysia. Science (1986) 3.30

Measurement of cytosolic free Ca2+ in individual small cells using fluorescence microscopy with dual excitation wavelengths. Cell Calcium (1985) 3.23

Tissue-plasminogen activator is induced as an immediate-early gene during seizure, kindling and long-term potentiation. Nature (1993) 3.23

Changes in intramitochondrial and cytosolic pH: early events that modulate caspase activation during apoptosis. Nat Cell Biol (2000) 3.20

Anomalous rectification in the metacerebral giant cells and its consequences for synaptic transmission. J Physiol (1966) 3.18

Structural changes accompanying memory storage. Annu Rev Physiol (1993) 3.11

Molecular spectroscopy and dynamics of intrinsically fluorescent proteins: coral red (dsRed) and yellow (Citrine). Proc Natl Acad Sci U S A (2000) 3.07

Controlling cell chemistry with caged compounds. Annu Rev Physiol (1993) 2.99

Fluorescent indicators for cytosolic sodium. J Biol Chem (1989) 2.89

Injection of the cAMP-responsive element into the nucleus of Aplysia sensory neurons blocks long-term facilitation. Nature (1990) 2.85

Genome-wide analysis of single-nucleotide polymorphisms in human expressed sequences. Nat Genet (2000) 2.82

Toward a molecular definition of long-term memory storage. Proc Natl Acad Sci U S A (1996) 2.81

Alteration of stimulus-specific guard cell calcium oscillations and stomatal closing in Arabidopsis det3 mutant. Science (2000) 2.80

Genetically encoded fluorescent reporters of protein tyrosine kinase activities in living cells. Proc Natl Acad Sci U S A (2001) 2.77

A transient, neuron-wide form of CREB-mediated long-term facilitation can be stabilized at specific synapses by local protein synthesis. Cell (1999) 2.77

Aplysia CREB2 represses long-term facilitation: relief of repression converts transient facilitation into long-term functional and structural change. Cell (1995) 2.75

Free calcium ions in neurones of Helix aspersa measured with ion-selective micro-electrodes. J Physiol (1981) 2.75

Different training procedures recruit either one or two critical periods for contextual memory consolidation, each of which requires protein synthesis and PKA. Learn Mem (1999) 2.72

Synaptic facilitation and behavioral sensitization in Aplysia: possible role of serotonin and cyclic AMP. Science (1976) 2.72

The 3'-untranslated region of CaMKII alpha is a cis-acting signal for the localization and translation of mRNA in dendrites. Proc Natl Acad Sci U S A (1996) 2.70

Presynaptic modulation of voltage-dependent Ca2+ current: mechanism for behavioral sensitization in Aplysia californica. Proc Natl Acad Sci U S A (1978) 2.68

Inositol 1,4,5-trisphosphate: a possible chemical link in excitation-contraction coupling in muscle. Proc Natl Acad Sci U S A (1985) 2.68

Anti-immunoglobulin, cytoplasmic free calcium, and capping in B lymphocytes. J Cell Biol (1982) 2.67

Tests of the roles of two diffusible substances in long-term potentiation: evidence for nitric oxide as a possible early retrograde messenger. Proc Natl Acad Sci U S A (1991) 2.64

Inducible and reversible enhancement of learning, memory, and long-term potentiation by genetic inhibition of calcineurin. Cell (2001) 2.62

Cytoplasmic free Ca2+ in human platelets: Ca2+ thresholds and Ca-independent activation for shape-change and secretion. FEBS Lett (1982) 2.60

cAMP contributes to mossy fiber LTP by initiating both a covalently mediated early phase and macromolecular synthesis-dependent late phase. Cell (1994) 2.59

Some forms of cAMP-mediated long-lasting potentiation are associated with release of BDNF and nuclear translocation of phospho-MAP kinase. Neuron (2001) 2.59

Imaging of cytosolic Ca2+ transients arising from Ca2+ stores and Ca2+ channels in sympathetic neurons. Neuron (1988) 2.56

Free calcium in heart muscle at rest and during contraction measured with Ca2+ -sensitive microelectrodes. Nature (1980) 2.55

Spatially resolved dynamics of cAMP and protein kinase A subunits in Aplysia sensory neurons. Science (1993) 2.51

MAP kinase translocates into the nucleus of the presynaptic cell and is required for long-term facilitation in Aplysia. Neuron (1997) 2.50

Ubiquitin C-terminal hydrolase is an immediate-early gene essential for long-term facilitation in Aplysia. Cell (1997) 2.50

Interactive cloning with the SH3 domain of N-src identifies a new brain specific ion channel protein, with homology to eag and cyclic nucleotide-gated channels. Proc Natl Acad Sci U S A (1997) 2.48

Fluorescence photooxidation with eosin: a method for high resolution immunolocalization and in situ hybridization detection for light and electron microscopy. J Cell Biol (1994) 2.48

The mouse intestinal microflora with emphasis on the strict anaerobes. J Exp Med (1971) 2.46

Generation of calcium oscillations in fibroblasts by positive feedback between calcium and IP3. Science (1991) 2.45

Neuronal mechanisms of habituation and dishabituation of the gill-withdrawal reflex in Aplysia. Science (1970) 2.43

C/EBP is an immediate-early gene required for the consolidation of long-term facilitation in Aplysia. Cell (1994) 2.42

D1/D5 receptor agonists induce a protein synthesis-dependent late potentiation in the CA1 region of the hippocampus. Proc Natl Acad Sci U S A (1995) 2.42