Interleukin (IL)-4-independent immunoglobulin class switch to immunoglobulin (Ig)E in the mouse.

PubWeight™: 1.13‹?› | Rank: Top 10%

🔗 View Article (PMC 2192860)

Published in J Exp Med on November 01, 1996

Authors

R A Morawetz1, L Gabriele, L V Rizzo, N Noben-Trauth, R Kühn, K Rajewsky, W Müller, T M Doherty, F Finkelman, R L Coffman, H C Morse

Author Affiliations

1: Laboratory of Immunopathology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA.

Articles citing this

An interleukin 4 (IL-4)-independent pathway for CD4+ T cell IL-4 production is revealed in IL-4 receptor-deficient mice. Proc Natl Acad Sci U S A (1997) 2.67

Interleukin (IL)-4-independent induction of immunoglobulin (Ig)E, and perturbation of T cell development in transgenic mice expressing IL-13. J Exp Med (1998) 1.67

Systemically derived large intestinal CD4(+) Th2 cells play a central role in STAT6-mediated allergic diarrhea. J Clin Invest (2000) 1.66

Hyper immunoglobulin E response in mice with monoclonal populations of B and T lymphocytes. J Exp Med (2001) 1.59

Interleukin-9 enhances resistance to the intestinal nematode Trichuris muris. Infect Immun (1998) 1.42

CD40 ligand/trimer DNA enhances both humoral and cellular immune responses and induces protective immunity to infectious and tumor challenge. J Immunol (1998) 1.32

Distinct roles for signals relayed through the common cytokine receptor gamma chain and interleukin 7 receptor alpha chain in natural T cell development. J Exp Med (1997) 1.24

Th2-mediated host protective immunity to intestinal nematode infections. Philos Trans R Soc Lond B Biol Sci (1997) 1.04

Extract of Nippostrongylus brasiliensis stimulates polyclonal type-2 immunoglobulin response by inducing De novo class switch. Infect Immun (2000) 0.83

STAT6-deficient mice exhibit normal induction of murine AIDS and expression of immunoglobulin E following infection with LP-BM5 murine leukemia viruses. J Virol (1999) 0.81

Interleukin 4 gene-defective mice reconstituted with wild-type bone marrow fail to produce normal immunoglobulin E levels. J Exp Med (1998) 0.81

The immunosuppressive activity of Ascaris suum is due to high molecular weight components. Clin Exp Immunol (1998) 0.80

Glutathione Depletion Is Linked with Th2 Polarization in Mice with a Retrovirus-Induced Immunodeficiency Syndrome, Murine AIDS: Role of Proglutathione Molecules as Immunotherapeutics. J Virol (2016) 0.77

Mimicking the germinal center reaction in hybridoma cells to isolate temperature-selective anti-PEG antibodies. MAbs (2014) 0.75

Articles cited by this

Production of a monoclonal antibody to and molecular characterization of B-cell stimulatory factor-1. Nature (1985) 11.55

Generation and analysis of interleukin-4 deficient mice. Science (1991) 8.80

Disruption of the murine IL-4 gene blocks Th2 cytokine responses. Nature (1993) 6.54

Molecular and biological characterization of a murine ligand for CD40. Nature (1992) 4.83

Suppression of in vivo polyclonal IgE responses by monoclonal antibody to the lymphokine B-cell stimulatory factor 1. Proc Natl Acad Sci U S A (1986) 4.69

Interleukin 13 induces interleukin 4-independent IgG4 and IgE synthesis and CD23 expression by human B cells. Proc Natl Acad Sci U S A (1993) 4.45

IL-4 is required to generate and sustain in vivo IgE responses. J Immunol (1988) 4.04

Resistance of mice deficient in IL-4 to retrovirus-induced immunodeficiency syndrome (MAIDS) Science (1993) 3.51

Humoral immune responses in CD40 ligand-deficient mice. J Exp Med (1994) 3.32

Mechanism and regulation of immunoglobulin isotype switching. Adv Immunol (1993) 3.30

Interleukin 13, an interleukin 4-like cytokine that acts on monocytes and B cells, but not on T cells. Immunol Today (1994) 3.25

Cytokine gene expression after in vivo primary immunization with goat antibody to mouse IgD antibody. J Immunol (1991) 3.04

Defective virus is associated with induction of murine retrovirus-induced immunodeficiency syndrome. Proc Natl Acad Sci U S A (1989) 2.63

Cloning and characterization of a binding subunit of the interleukin 13 receptor that is also a component of the interleukin 4 receptor. Proc Natl Acad Sci U S A (1996) 2.57

Towards a comprehensive view of immunoglobulin class switching. Immunol Today (1993) 2.44

Retrovirus-induced murine acquired immunodeficiency syndrome: natural history of infection and differing susceptibility of inbred mouse strains. J Virol (1989) 2.41

Susceptibility to Leishmania major infection in interleukin-4-deficient mice. Science (1996) 2.35

Immunoglobulin heavy-chain switching may be directed by prior induction of transcripts from constant-region genes. Proc Natl Acad Sci U S A (1988) 2.27

Anti-CD40 monoclonal antibodies or CD4+ T cell clones and IL-4 induce IgG4 and IgE switching in purified human B cells via different signaling pathways. J Immunol (1991) 2.07

IgD-secreting murine plasmacytomas: identification and partial characterization of two IgD myeloma proteins. J Immunol (1981) 1.97

Retrovirus-induced immunodeficiency in the mouse: MAIDS as a model for AIDS. AIDS (1992) 1.97

Polyclonal activation of the murine immune system by an antibody to IgD. II. Generation of polyclonal antibody production and cells with surface IgG. J Immunol (1982) 1.96

Quantitation of immunoglobulin mu-gamma 1 heavy chain switch region recombination by a digestion-circularization polymerase chain reaction method. Proc Natl Acad Sci U S A (1992) 1.86

Mitogen plus interleukin 4 induction of C epsilon transcripts in B lymphoid cells. J Exp Med (1988) 1.86

S region transcription per se promotes basal IgE class switch recombination but additional factors regulate the efficiency of the process. EMBO J (1994) 1.84

Polyclonal activation of the murine immune system by a goat antibody to mouse IgD. IX. Induction of a polyclonal IgE response. J Immunol (1987) 1.82

Establishment of a germ-line competent C57BL/6 embryonic stem cell line. Exp Cell Res (1991) 1.70

The immune response to Plasmodium chabaudi malaria in interleukin-4-deficient mice. Eur J Immunol (1994) 1.63

Switch transcripts in immunoglobulin class switching. Science (1995) 1.62

CD4+ subset regulation in viral infection. Preferential activation of Th2 cells during progression of retrovirus-induced immunodeficiency in mice. J Immunol (1992) 1.62

Characteristics of B cell proliferation and activation in murine AIDS. J Immunol (1989) 1.61

Antibodies of the secondary response can be expressed without switch recombination in normal mouse B cells. Proc Natl Acad Sci U S A (1984) 1.57

Clonal and molecular characteristics of the human IgE-committed B cell subset. J Exp Med (1989) 1.50

Infection of IL-4-deficient mice with the parasitic nematode Brugia malayi demonstrates that host resistance is not dependent on a T helper 2-dominated immune response. J Immunol (1995) 1.40

Regulation of murine in vivo IgG and IgE responses by a monoclonal anti-IL-4 receptor antibody. Int Immunol (1991) 1.31

Monoclonal antibodies block murine IL-4 receptor function. J Immunol (1990) 1.29

IL-4 requirements for the generation of secondary in vivo IgE responses. J Immunol (1991) 1.18

Double isotype production by a neoplastic B cell line. II. Allelically excluded production of mu and gamma 1 heavy chains without CH gene rearrangement. J Exp Med (1986) 1.17

Prostaglandin E2 promotes B lymphocyte Ig isotype switching to IgE. J Immunol (1995) 1.14

Resistance to murine acquired immunodeficiency syndrome (MAIDS) Science (1994) 1.07

Induction of germ-line gamma 1 and epsilon Ig gene expression in murine B cells. IL-4 and the CD40 ligand-CD40 interaction provide distinct but synergistic signals. J Immunol (1995) 1.02

Antibody to the ligand for CD40 (gp39) inhibits murine AIDS-associated splenomegaly, hypergammaglobulinemia, and immunodeficiency in disease-susceptible C57BL/6 mice. J Virol (1996) 1.00

Generation of B cell memory and affinity maturation. Induction with Th1 and Th2 T cell clones. J Immunol (1992) 1.00

Prostaglandin E2 promotes IL-4-induced IgE and IgG1 synthesis. J Immunol (1990) 0.97

Expression of IgE from a nonrearranged epsilon locus in cloned B-lymphoblastoid cells that also express IgM. J Immunol (1990) 0.96

Coexpression of mu and gamma 1 heavy chains can occur by a discontinuous transcription mechanism from the same unrearranged chromosome. Proc Natl Acad Sci U S A (1992) 0.96

Retrovirus-elicited interleukin-12 and tumour necrosis factor-alpha as inducers of interferon-gamma-mediated pathology in mouse AIDS. Immunology (1996) 0.93

Prostaglandin E2 and cAMP inhibit B lymphocyte activation and simultaneously promote IgE and IgG1 synthesis. J Immunol (1992) 0.91

Regulation of germ-line epsilon transcription and induction of epsilon switching in cloned EBV-transformed and malignant human B cell lines by cytokines and CD4+ T cells. J Immunol (1992) 0.90

Regulation of the expression of human C epsilon germline transcript. Identification of a novel IL-4 responsive element. J Immunol (1993) 0.90

Cells and cytokines in the pathogenesis of MAIDS, a retrovirus-induced immunodeficiency syndrome of mice. Springer Semin Immunopathol (1995) 0.90

Germline and productive C epsilon gene expression during in vivo IgE responses. J Immunol (1993) 0.89

IFN-gamma represses epsilon germline transcription and subsequently down-regulates switch recombination to epsilon. Int Immunol (1994) 0.89

IL-4 induces germ-line IgE heavy chain gene transcription in human fetal pre-B cells. Evidence for differential expression of functional IL-4 and IL-13 receptors during B cell ontogeny. J Immunol (1995) 0.86

T helper cell membranes promote IL-4-independent expression of germ-line C gamma 1 transcripts in B cells. J Immunol (1992) 0.85

Prostaglandin E2 as a selective stimulator of antigen-specific IgE response in murine lymphocytes. Eur J Immunol (1990) 0.80

Pentoxifylline and meclofenamic acid treatment reduces clinical manifestations in a murine model of AIDS. J Pharmacol Exp Ther (1994) 0.79

Kinetics of interleukin-4 induction and interferon-gamma inhibition of IgE secretion by Epstein-Barr virus-infected human peripheral blood B cells. Cell Immunol (1991) 0.77

Articles by these authors

Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins. J Immunol (1986) 35.41

TH1 and TH2 cells: different patterns of lymphokine secretion lead to different functional properties. Annu Rev Immunol (1989) 31.72

Interleukin-10 and the interleukin-10 receptor. Annu Rev Immunol (2001) 25.63

Interleukin-10-deficient mice develop chronic enterocolitis. Cell (1993) 22.57

Inducible gene targeting in mice. Science (1995) 21.22

A new mouse myeloma cell line that has lost immunoglobulin expression but permits the construction of antibody-secreting hybrid cell lines. J Immunol (1979) 16.56

Deletion of a DNA polymerase beta gene segment in T cells using cell type-specific gene targeting. Science (1994) 13.47

A B cell-deficient mouse by targeted disruption of the membrane exon of the immunoglobulin mu chain gene. Nature (1991) 13.19

A cre-transgenic mouse strain for the ubiquitous deletion of loxP-flanked gene segments including deletion in germ cells. Nucleic Acids Res (1995) 12.21

Independent control of immunoglobulin switch recombination at individual switch regions evidenced through Cre-loxP-mediated gene targeting. Cell (1993) 11.76

Reciprocal expression of interferon gamma or interleukin 4 during the resolution or progression of murine leishmaniasis. Evidence for expansion of distinct helper T cell subsets. J Exp Med (1989) 11.36

An essential role for interleukin 10 in the function of regulatory T cells that inhibit intestinal inflammation. J Exp Med (1999) 10.67

Phenotypically distinct subsets of CD4+ T cells induce or protect from chronic intestinal inflammation in C. B-17 scid mice. Int Immunol (1993) 9.97

Inhibition of Th1 responses prevents inflammatory bowel disease in scid mice reconstituted with CD45RBhi CD4+ T cells. Immunity (1994) 9.63

Heavy chain variable region contribution to the NPb family of antibodies: somatic mutation evident in a gamma 2a variable region. Cell (1981) 9.54

Generation and analysis of interleukin-4 deficient mice. Science (1991) 8.80

Enterocolitis and colon cancer in interleukin-10-deficient mice are associated with aberrant cytokine production and CD4(+) TH1-like responses. J Clin Invest (1996) 7.97

Lymphokine control of in vivo immunoglobulin isotype selection. Annu Rev Immunol (1990) 7.93

Intraclonal generation of antibody mutants in germinal centres. Nature (1991) 7.39

In vivo ablation of surface immunoglobulin on mature B cells by inducible gene targeting results in rapid cell death. Cell (1997) 7.18

Immunoregulation of cutaneous leishmaniasis. T cell lines that transfer protective immunity or exacerbation belong to different T helper subsets and respond to distinct parasite antigens. J Exp Med (1988) 7.02

Specific immune-based diagnosis of tuberculosis. Lancet (2000) 6.81

A critical role for transforming growth factor-beta but not interleukin 4 in the suppression of T helper type 1-mediated colitis by CD45RB(low) CD4+ T cells. J Exp Med (1996) 6.73

High gradient magnetic cell separation with MACS. Cytometry (1990) 6.69

Surface antigen expression and immunoglobulin gene rearrangement during mouse pre-B cell development. Immunol Rev (1982) 6.43

Human immunoglobulin (Ig)M+IgD+ peripheral blood B cells expressing the CD27 cell surface antigen carry somatically mutated variable region genes: CD27 as a general marker for somatically mutated (memory) B cells. J Exp Med (1998) 6.32

B cell stimulatory factor-1 enhances the IgE response of lipopolysaccharide-activated B cells. J Immunol (1986) 6.16

A T cell activity that enhances polyclonal IgE production and its inhibition by interferon-gamma. J Immunol (1986) 6.03

Heterogeneity of cytokine secretion patterns and functions of helper T cells. Adv Immunol (1989) 5.92

In the absence of endogenous IL-10, mice acutely infected with Toxoplasma gondii succumb to a lethal immune response dependent on CD4+ T cells and accompanied by overproduction of IL-12, IFN-gamma and TNF-alpha. J Immunol (1996) 5.79

The requirement of more than one antigenic determinant for immunogenicity. J Exp Med (1969) 5.61

Regulation of antibody isotype secretion by subsets of antigen-specific helper T cells. Nature (1988) 5.56

B lymphocyte-specific, Cre-mediated mutagenesis in mice. Nucleic Acids Res (1997) 5.43

From systemic T cell self-reactivity to organ-specific autoimmune disease via immunoglobulins. Immunity (1999) 5.38

IFN-gamma regulates the isotypes of Ig secreted during in vivo humoral immune responses. J Immunol (1988) 5.12

Lymphoid development in mice with a targeted deletion of the interleukin 2 receptor gamma chain. Proc Natl Acad Sci U S A (1995) 5.06

Requirement of mammalian DNA polymerase-beta in base-excision repair. Nature (1996) 4.95

Regulation of immunity to parasites by T cells and T cell-derived cytokines. Annu Rev Immunol (1992) 4.92

Induction of T and B cell immunity by anti-idiotypic antibody. Eur J Immunol (1975) 4.79

NKT cell-mediated repression of tumor immunosurveillance by IL-13 and the IL-4R-STAT6 pathway. Nat Immunol (2000) 4.75

Immunodeficiency and chronic myelogenous leukemia-like syndrome in mice with a targeted mutation of the ICSBP gene. Cell (1996) 4.74

B220: a B cell-specific member of th T200 glycoprotein family. Nature (1981) 4.65

IL-13, IL-4Ralpha, and Stat6 are required for the expulsion of the gastrointestinal nematode parasite Nippostrongylus brasiliensis. Immunity (1998) 4.65

Conditional gene targeting. J Clin Invest (1996) 4.60

IL-4 induces a Th2 response in Leishmania major-infected mice. J Immunol (1992) 4.43

The characterization of four monoclonal antibodies specific for mouse IL-5 and development of mouse and human IL-5 enzyme-linked immunosorbent. J Immunol (1988) 4.38

Essential role for TrkB receptors in hippocampus-mediated learning. Neuron (1999) 4.20

Regulatory interactions between CD45RBhigh and CD45RBlow CD4+ T cells are important for the balance between protective and pathogenic cell-mediated immunity. J Exp Med (1994) 4.10

Impairment of T-cell-dependent B-cell responses and B-1 cell development in CD19-deficient mice. Nature (1995) 4.10

Analysis of C-MYC function in normal cells via conditional gene-targeted mutation. Immunity (2001) 4.09

Tracing B cell development in human germinal centres by molecular analysis of single cells picked from histological sections. EMBO J (1993) 3.85

Clonal expansions of CD8(+) T cells dominate the T cell infiltrate in active multiple sclerosis lesions as shown by micromanipulation and single cell polymerase chain reaction. J Exp Med (2000) 3.84

Targeted disruption of mu chain membrane exon causes loss of heavy-chain allelic exclusion. Nature (1992) 3.82

An eosinophil-dependent mechanism for the antitumor effect of interleukin-4. Science (1992) 3.78

IMGT, the international ImMunoGeneTics database. Nucleic Acids Res (1999) 3.77

Loss of a gp130 cardiac muscle cell survival pathway is a critical event in the onset of heart failure during biomechanical stress. Cell (1999) 3.76

Development of a natural model of cutaneous leishmaniasis: powerful effects of vector saliva and saliva preexposure on the long-term outcome of Leishmania major infection in the mouse ear dermis. J Exp Med (1998) 3.68

Ku80 is required for immunoglobulin isotype switching. EMBO J (1998) 3.67

NEMO/IKK gamma-deficient mice model incontinentia pigmenti. Mol Cell (2000) 3.60

T-cell and mast cell lines respond to B-cell stimulatory factor 1. Proc Natl Acad Sci U S A (1986) 3.56

Most peripheral B cells in mice are ligand selected. J Exp Med (1991) 3.50

Evaluation of knee ligament injuries with the IKDC form. Knee Surg Sports Traumatol Arthrosc (1993) 3.48

Analysis of the repertoire of anti-NP antibodies in C57BL/6 mice by cell fusion. I. Characterization of antibody families in the primary and hyperimmune response. Eur J Immunol (1978) 3.48

Hybrid cell lines secreting monoclonal antibody specific for major histocompatibility antigens of the mouse. Nature (1978) 3.45

Contribution of receptor editing to the antibody repertoire. Science (2001) 3.45

Interleukin-10 is a central regulator of the response to LPS in murine models of endotoxic shock and the Shwartzman reaction but not endotoxin tolerance. J Clin Invest (1995) 3.43

Identification of common germinal-center B-cell precursors in two patients with both Hodgkin's disease and non-Hodgkin's lymphoma. N Engl J Med (1999) 3.37

Ku70 is required for late B cell development and immunoglobulin heavy chain class switching. J Exp Med (1998) 3.37

Studies of the binding of actinomycin and related compounds to DNA. J Mol Biol (1968) 3.35

Depletion of murine CD4+ T lymphocytes prevents antigen-induced airway hyperreactivity and pulmonary eosinophilia. Am J Respir Cell Mol Biol (1994) 3.32

Role of T-cell derived cytokines in the downregulation of immune responses in parasitic and retroviral infection. Immunol Rev (1992) 3.30

Sequence homologies, N sequence insertion and JH gene utilization in VHDJH joining: implications for the joining mechanism and the ontogenetic timing of Ly1 B cell and B-CLL progenitor generation. EMBO J (1990) 3.25

Role of cytokines and CD4+ T-cell subsets in the regulation of parasite immunity and disease. Immunol Rev (1989) 3.21

A multifunctional gene (tetR) controls Tn10-encoded tetracycline resistance. J Bacteriol (1982) 3.19

MHC class I expression in mice lacking the proteasome subunit LMP-7. Science (1994) 3.17

Maintenance of B-cell memory by long-lived cells generated from proliferating precursors. Nature (1990) 3.14

A monoclonal antibody that recognizes B cells and B cell precursors in mice. J Exp Med (1981) 3.13

Role of interleukin-10 in T helper cell dysfunction in asymptomatic individuals infected with the human immunodeficiency virus. J Clin Invest (1994) 3.12

Critical role for beta7 integrins in formation of the gut-associated lymphoid tissue. Nature (1996) 3.11

A critical role of lambda 5 protein in B cell development. Cell (1992) 3.09

Aberrant B cell development and immune response in mice with a compromised BCR complex. Science (1996) 3.01

Shutdown of class switch recombination by deletion of a switch region control element. Science (1993) 2.99

Heterogeneous Hadean hafnium: evidence of continental crust at 4.4 to 4.5 ga. Science (2005) 2.92