Published in J Rheumatol on October 01, 1995
Monomelic hypertrophic osteoarthropathy secondary to aortic prosthesis infection. J Rheumatol (1995) 1.55
In vitro polyoma DNA synthesis: inhibition by 1-beta-d-arabinofuranosyl CTP. J Virol (1975) 57.17
The protein kinase family: conserved features and deduced phylogeny of the catalytic domains. Science (1988) 35.59
The protein kinase complement of the human genome. Science (2002) 35.36
Transforming gene product of Rous sarcoma virus phosphorylates tyrosine. Proc Natl Acad Sci U S A (1980) 22.30
Oncogenic kinase signalling. Nature (2001) 16.30
Phosphopeptide mapping and phosphoamino acid analysis by two-dimensional separation on thin-layer cellulose plates. Methods Enzymol (1991) 15.04
Protein-tyrosine kinases. Annu Rev Biochem (1985) 14.83
Protein kinases 6. The eukaryotic protein kinase superfamily: kinase (catalytic) domain structure and classification. FASEB J (1995) 14.45
Detection and quantification of phosphotyrosine in proteins. Methods Enzymol (1983) 11.89
p27, a novel inhibitor of G1 cyclin-Cdk protein kinase activity, is related to p21. Cell (1994) 8.90
Platelet-derived growth factor induces rapid but transient expression of the c-fos gene and protein. Nature (1985) 8.36
Integrin-mediated signal transduction linked to Ras pathway by GRB2 binding to focal adhesion kinase. Nature (1995) 8.25
Isolation of a human cyclin cDNA: evidence for cyclin mRNA and protein regulation in the cell cycle and for interaction with p34cdc2. Cell (1989) 8.19
Protein kinase B/Akt-mediated phosphorylation promotes nuclear exclusion of the winged helix transcription factor FKHR1. Proc Natl Acad Sci U S A (1999) 7.70
A thousand and one protein kinases. Cell (1987) 7.61
The tyrosine kinase negative regulator c-Cbl as a RING-type, E2-dependent ubiquitin-protein ligase. Science (1999) 7.60
Oncogene jun encodes a sequence-specific trans-activator similar to AP-1. Nature (1988) 7.45
Human cyclin A is adenovirus E1A-associated protein p60 and behaves differently from cyclin B. Nature (1990) 7.34
Human cyclins A and B1 are differentially located in the cell and undergo cell cycle-dependent nuclear transport. J Cell Biol (1991) 7.18
An activity phosphorylating tyrosine in polyoma T antigen immunoprecipitates. Cell (1979) 7.02
Activation of protein kinase C decreases phosphorylation of c-Jun at sites that negatively regulate its DNA-binding activity. Cell (1991) 6.89
Phospholipase C-gamma is a substrate for the PDGF and EGF receptor protein-tyrosine kinases in vivo and in vitro. Cell (1989) 6.88
Evidence that the phosphorylation of tyrosine is essential for cellular transformation by Rous sarcoma virus. Cell (1980) 6.76
The c-Fos protein interacts with c-Jun/AP-1 to stimulate transcription of AP-1 responsive genes. Cell (1988) 6.75
Characterization of Rous sarcoma virus src gene products synthesized in vitro. J Virol (1978) 6.39
Vinculin: a cytoskeletal target of the transforming protein of Rous sarcoma virus. Cell (1981) 5.74
Changes in protein phosphorylation in Rous sarcoma virus-transformed chicken embryo cells. Mol Cell Biol (1981) 5.67
Comparison of the expression of the src gene of Rous sarcoma virus in vitro and in vivo. J Virol (1978) 5.30
Receptor protein-tyrosine kinases and their signal transduction pathways. Annu Rev Cell Biol (1994) 5.24
Epidermal growth factor induces rapid tyrosine phosphorylation of proteins in A431 human tumor cells. Cell (1981) 5.08
Tyr527 is phosphorylated in pp60c-src: implications for regulation. Science (1986) 4.99
A human peptidyl-prolyl isomerase essential for regulation of mitosis. Nature (1996) 4.65
Human eukaryotic translation initiation factor 4G (eIF4G) recruits mnk1 to phosphorylate eIF4E. EMBO J (1999) 4.65
A structural basis for substrate specificities of protein Ser/Thr kinases: primary sequence preference of casein kinases I and II, NIMA, phosphorylase kinase, calmodulin-dependent kinase II, CDK5, and Erk1. Mol Cell Biol (1996) 4.61
MNK1, a new MAP kinase-activated protein kinase, isolated by a novel expression screening method for identifying protein kinase substrates. EMBO J (1997) 4.39
Protein kinase C phosphorylation of the EGF receptor at a threonine residue close to the cytoplasmic face of the plasma membrane. Nature (1984) 4.27
Structural basis for phosphoserine-proline recognition by group IV WW domains. Nat Struct Biol (2000) 4.25
Structural and functional analysis of the mitotic rotamase Pin1 suggests substrate recognition is phosphorylation dependent. Cell (1997) 4.24
Phosphorylation sites in enolase and lactate dehydrogenase utilized by tyrosine protein kinases in vivo and in vitro. J Biol Chem (1984) 4.20
Intermittent etidronate therapy to prevent corticosteroid-induced osteoporosis. N Engl J Med (1997) 4.18
Cell cycle regulation of the E2F transcription factor involves an interaction with cyclin A. Cell (1991) 3.98
C-kinase phosphorylates the epidermal growth factor receptor and reduces its epidermal growth factor-stimulated tyrosine protein kinase activity. J Biol Chem (1984) 3.88
Characterization of T antigens in polyoma-infected and transformed cells. Cell (1978) 3.76
Brassinosteroid-insensitive-1 is a ubiquitously expressed leucine-rich repeat receptor serine/threonine kinase. Plant Physiol (2000) 3.73
A cyclin A-protein kinase complex possesses sequence-specific DNA binding activity: p33cdk2 is a component of the E2F-cyclin A complex. Cell (1992) 3.64
Transcriptional control by protein phosphorylation: signal transmission from the cell surface to the nucleus. Curr Biol (1995) 3.61
Substrate specificity of protein kinase C. Use of synthetic peptides corresponding to physiological sites as probes for substrate recognition requirements. Eur J Biochem (1986) 3.37
Analysis of the sequence of amino acids surrounding sites of tyrosine phosphorylation. Proc Natl Acad Sci U S A (1982) 3.28
A tail of two src's: mutatis mutandis. Cell (1987) 3.28
p34cdc2: the S and M kinase? New Biol (1990) 3.26
Temperature-sensitive transformation by Rous sarcoma virus and temperature-sensitive protein kinase activity. J Virol (1980) 3.25
Cancer-predisposing mutations within the RING domain of BRCA1: loss of ubiquitin protein ligase activity and protection from radiation hypersensitivity. Proc Natl Acad Sci U S A (2001) 3.24
Evidence for in vivo phosphorylation of the Grb2 SH2-domain binding site on focal adhesion kinase by Src-family protein-tyrosine kinases. Mol Cell Biol (1996) 3.21
cDNA cloning and sequencing of the protein-tyrosine kinase substrate, ezrin, reveals homology to band 4.1. EMBO J (1989) 3.10
Role of methionine in the initiation of haemoglobin synthesis. Nature (1970) 3.02
Regulation of the human WEE1Hu CDK tyrosine 15-kinase during the cell cycle. EMBO J (1995) 2.96
Similar effects of platelet-derived growth factor and epidermal growth factor on the phosphorylation of tyrosine in cellular proteins. Cell (1982) 2.92
Four different classes of retroviruses induce phosphorylation of tyrosines present in similar cellular proteins. Mol Cell Biol (1981) 2.88
Loss of RCC1, a nuclear DNA-binding protein, uncouples the completion of DNA replication from the activation of cdc2 protein kinase and mitosis. EMBO J (1991) 2.86
Phosphatidylinositol 3-kinase signaling controls levels of hypoxia-inducible factor 1. Cell Growth Differ (2001) 2.85
Structure of the human anti-apoptotic protein survivin reveals a dimeric arrangement. Nat Struct Biol (2000) 2.85
The characteristics of inhibition of protein synthesis by double-stranded ribonucleic acid in reticulocyte lysates. J Biol Chem (1975) 2.84
Integrin signalling and tyrosine phosphorylation: just the FAKs? Trends Cell Biol (1998) 2.83
Fibronectin-stimulated signaling from a focal adhesion kinase-c-Src complex: involvement of the Grb2, p130cas, and Nck adaptor proteins. Mol Cell Biol (1997) 2.83
PRC1: a human mitotic spindle-associated CDK substrate protein required for cytokinesis. Mol Cell (1998) 2.83
NeW wrinkles for an old domain. Cell (2000) 2.72
Product of in vitro translation of the Rous sarcoma virus src gene has protein kinase activity. J Virol (1979) 2.72
Transcription. A growing coactivator network. Nature (1996) 2.71
c-rel activates but v-rel suppresses transcription from kappa B sites. Proc Natl Acad Sci U S A (1991) 2.65
Protein kinase C phosphorylates pp60src at a novel site. Cell (1985) 2.63
The protein-tyrosine kinase substrate, p81, is homologous to a chicken microvillar core protein. J Cell Biol (1986) 2.63
Casein kinase II is a negative regulator of c-Jun DNA binding and AP-1 activity. Cell (1992) 2.62
In vitro polyoma DNA synthesis: characterization of a system from infected 3T3 cells. J Virol (1974) 2.52
Multiple Grb2-mediated integrin-stimulated signaling pathways to ERK2/mitogen-activated protein kinase: summation of both c-Src- and focal adhesion kinase-initiated tyrosine phosphorylation events. Mol Cell Biol (1998) 2.52
The protein kinases of Caenorhabditis elegans: a model for signal transduction in multicellular organisms. Proc Natl Acad Sci U S A (1999) 2.51
trkB, a neural receptor protein-tyrosine kinase: evidence for a full-length and two truncated receptors. Mol Cell Biol (1991) 2.48
Three glycolytic enzymes are phosphorylated at tyrosine in cells transformed by Rous sarcoma virus. Nature (1983) 2.47
The mouse c-rel protein has an N-terminal regulatory domain and a C-terminal transcriptional transactivation domain. Mol Cell Biol (1990) 2.47
The neurotrophic factors brain-derived neurotrophic factor and neurotrophin-3 are ligands for the trkB tyrosine kinase receptor. Cell (1991) 2.46
Characterization of the mRNAs for alpha-, beta- and gamma-actin. Cell (1977) 2.44
TGF-beta-stimulated cooperation of smad proteins with the coactivators CBP/p300. Genes Dev (1998) 2.40
In vitro polyoma DNA synthesis: discontinuous chain growth. J Mol Biol (1974) 2.40
Dependence of cyclin E-CDK2 kinase activity on cell anchorage. Science (1996) 2.38
Dual-specificity protein kinases: will any hydroxyl do? Trends Biochem Sci (1992) 2.38
Transactivation by NF-IL6/LAP is enhanced by phosphorylation of its activation domain. Nature (1993) 2.37
The cDNA sequence for the protein-tyrosine kinase substrate p36 (calpactin I heavy chain) reveals a multidomain protein with internal repeats. Cell (1986) 2.36
Multistep regulation of DNA replication by Cdk phosphorylation of HsCdc6. Proc Natl Acad Sci U S A (1999) 2.35
Focal adhesion kinase overexpression enhances ras-dependent integrin signaling to ERK2/mitogen-activated protein kinase through interactions with and activation of c-Src. J Biol Chem (1997) 2.34
Fluid shear stress activation of focal adhesion kinase. Linking to mitogen-activated protein kinases. J Biol Chem (1997) 2.34
Regulation of cell growth and transformation by tyrosine-specific protein kinases: the search for important cellular substrate proteins. Curr Top Microbiol Immunol (1983) 2.32
The differential localization of human cyclins A and B is due to a cytoplasmic retention signal in cyclin B. EMBO J (1994) 2.32
Altered sites of tyrosine phosphorylation in pp60c-src associated with polyomavirus middle tumor antigen. Mol Cell Biol (1986) 2.32
Letter: In vitro polyoma DNA synthesis: involvement of RNA in discontinuous chain growth. J Mol Biol (1974) 2.30
Tyr721 regulates specific binding of the CSF-1 receptor kinase insert to PI 3'-kinase SH2 domains: a model for SH2-mediated receptor-target interactions. EMBO J (1992) 2.29
Diverse mitogenic agents induce the phosphorylation of two related 42,000-dalton proteins on tyrosine in quiescent chick cells. Mol Cell Biol (1984) 2.28
Detection of a transforming gene product in cells transformed by Moloney murine sarcoma virus. Cell (1982) 2.27
Restriction of the in vitro and in vivo tyrosine protein kinase activities of pp60c-src relative to pp60v-src. Mol Cell Biol (1985) 2.25
Epidermal growth factor-induced tumor cell invasion and metastasis initiated by dephosphorylation and downregulation of focal adhesion kinase. Mol Cell Biol (2001) 2.24
Platelet-derived growth factor induces multisite phosphorylation of pp60c-src and increases its protein-tyrosine kinase activity. Mol Cell Biol (1988) 2.22