Published in EMBO J on October 15, 1998
RhoA inactivation by p190RhoGAP regulates cell spreading and migration by promoting membrane protrusion and polarity. Mol Biol Cell (2001) 3.54
Focal adhesion kinase is involved in mechanosensing during fibroblast migration. Proc Natl Acad Sci U S A (2001) 3.41
FAK deficiency in cells contributing to the basal lamina results in cortical abnormalities resembling congenital muscular dystrophies. Neuron (2003) 2.86
Conditional knockout of focal adhesion kinase in endothelial cells reveals its role in angiogenesis and vascular development in late embryogenesis. J Cell Biol (2005) 2.75
The adaptor protein paxillin is essential for normal development in the mouse and is a critical transducer of fibronectin signaling. Mol Cell Biol (2002) 2.73
Cbl associates with Pyk2 and Src to regulate Src kinase activity, alpha(v)beta(3) integrin-mediated signaling, cell adhesion, and osteoclast motility. J Cell Biol (2001) 2.69
Induced focal adhesion kinase (FAK) expression in FAK-null cells enhances cell spreading and migration requiring both auto- and activation loop phosphorylation sites and inhibits adhesion-dependent tyrosine phosphorylation of Pyk2. Mol Cell Biol (1999) 2.61
Pyk2 regulates multiple signaling events crucial for macrophage morphology and migration. Proc Natl Acad Sci U S A (2003) 2.34
PyK2 and FAK connections to p190Rho guanine nucleotide exchange factor regulate RhoA activity, focal adhesion formation, and cell motility. J Cell Biol (2008) 2.31
Matrix survival signaling: from fibronectin via focal adhesion kinase to c-Jun NH(2)-terminal kinase. J Cell Biol (2000) 2.31
Epidermal growth factor-induced tumor cell invasion and metastasis initiated by dephosphorylation and downregulation of focal adhesion kinase. Mol Cell Biol (2001) 2.24
Shc and FAK differentially regulate cell motility and directionality modulated by PTEN. J Cell Biol (1999) 2.21
Mammary epithelial-specific ablation of the focal adhesion kinase suppresses mammary tumorigenesis by affecting mammary cancer stem/progenitor cells. Cancer Res (2009) 2.04
The role of the dynamics of focal adhesion kinase in the mechanotaxis of endothelial cells. Proc Natl Acad Sci U S A (2002) 2.01
Mechanisms of CAS substrate domain tyrosine phosphorylation by FAK and Src. Mol Cell Biol (2001) 1.91
Mammary epithelial-specific disruption of focal adhesion kinase retards tumor formation and metastasis in a transgenic mouse model of human breast cancer. Am J Pathol (2008) 1.82
Interstitial flow influences direction of tumor cell migration through competing mechanisms. Proc Natl Acad Sci U S A (2011) 1.81
Compensatory role for Pyk2 during angiogenesis in adult mice lacking endothelial cell FAK. J Cell Biol (2008) 1.74
Integrin-mediated activation of focal adhesion kinase is required for signaling to Jun NH2-terminal kinase and progression through the G1 phase of the cell cycle. J Cell Biol (1999) 1.71
SRC-mediated phosphorylation of focal adhesion kinase couples actin and adhesion dynamics to survival signaling. Mol Cell Biol (2004) 1.70
Phosphorylation of focal adhesion kinase at Tyr397 in gastric carcinomas and its clinical significance. Am J Pathol (2010) 1.63
Elucidating Compound Mechanism of Action by Network Perturbation Analysis. Cell (2015) 1.62
SRC catalytic but not scaffolding function is needed for integrin-regulated tyrosine phosphorylation, cell migration, and cell spreading. Mol Cell Biol (2002) 1.61
The tyrosine kinase pyk2 promotes migration and invasion of glioma cells. Neoplasia (2005) 1.60
Roles of focal adhesion kinase (FAK) in megakaryopoiesis and platelet function: studies using a megakaryocyte lineage specific FAK knockout. Blood (2007) 1.54
Focal adhesion kinase mediates the integrin signaling requirement for growth factor activation of MAP kinase. J Cell Biol (1999) 1.52
Suppression of Pyk2 kinase and cellular activities by FIP200. J Cell Biol (2000) 1.47
FERM control of FAK function: implications for cancer therapy. Cell Cycle (2008) 1.43
TGF-β stimulates Pyk2 expression as part of an epithelial-mesenchymal transition program required for metastatic outgrowth of breast cancer. Oncogene (2012) 1.43
Semaphorin 4D/plexin-B1 induces endothelial cell migration through the activation of PYK2, Src, and the phosphatidylinositol 3-kinase-Akt pathway. Mol Cell Biol (2005) 1.42
PTP alpha regulates integrin-stimulated FAK autophosphorylation and cytoskeletal rearrangement in cell spreading and migration. J Cell Biol (2003) 1.37
Myocyte-restricted focal adhesion kinase deletion attenuates pressure overload-induced hypertrophy. Circ Res (2006) 1.34
Knock-in mutation reveals an essential role for focal adhesion kinase activity in blood vessel morphogenesis and cell motility-polarity but not cell proliferation. J Biol Chem (2010) 1.31
Integrin alpha4beta1 promotes focal adhesion kinase-independent cell motility via alpha4 cytoplasmic domain-specific activation of c-Src. Mol Cell Biol (2005) 1.30
Targeting Pyk2 to beta 1-integrin-containing focal contacts rescues fibronectin-stimulated signaling and haptotactic motility defects of focal adhesion kinase-null cells. J Cell Biol (2001) 1.30
Negative regulation of FAK signaling by SOCS proteins. EMBO J (2003) 1.26
Calcium-sensing soluble adenylyl cyclase mediates TNF signal transduction in human neutrophils. J Exp Med (2005) 1.25
PTP-PEST, a scaffold protein tyrosine phosphatase, negatively regulates lymphocyte activation by targeting a unique set of substrates. EMBO J (2001) 1.25
Regulation of FAK Ser-722 phosphorylation and kinase activity by GSK3 and PP1 during cell spreading and migration. Biochem J (2005) 1.23
Focal adhesion kinase is critical for entry of Kaposi's sarcoma-associated herpesvirus into target cells. J Virol (2006) 1.22
Similarities and differences in RANTES- and (AOP)-RANTES-triggered signals: implications for chemotaxis. J Cell Biol (1999) 1.20
West Nile virus entry requires cholesterol-rich membrane microdomains and is independent of alphavbeta3 integrin. J Virol (2008) 1.19
Pyk2 inhibition of p53 as an adaptive and intrinsic mechanism facilitating cell proliferation and survival. J Biol Chem (2009) 1.18
The interaction between caveolin-1 and Rho-GTPases promotes metastasis by controlling the expression of alpha5-integrin and the activation of Src, Ras and Erk. Oncogene (2011) 1.17
Hic-5-reduced cell spreading on fibronectin: competitive effects between paxillin and Hic-5 through interaction with focal adhesion kinase. Mol Cell Biol (2001) 1.15
The cytoplasmic tyrosines of integrin subunit beta1 are involved in focal adhesion kinase activation. Mol Cell Biol (2000) 1.13
Paxillin binding is not the sole determinant of focal adhesion localization or dominant-negative activity of focal adhesion kinase/focal adhesion kinase-related nonkinase. Mol Biol Cell (2000) 1.13
Conditional deletion of the focal adhesion kinase FAK alters remodeling of the blood-brain barrier in glioma. Cancer Res (2010) 1.13
Reconciling the roles of FAK in osteoblast differentiation, osteoclast remodeling, and bone regeneration. Bone (2007) 1.12
Autophosphorylation-independent and -dependent functions of focal adhesion kinase during development. J Biol Chem (2009) 1.10
The tyrosine kinase PYK-2/RAFTK regulates natural killer (NK) cell cytotoxic response, and is translocated and activated upon specific target cell recognition and killing. J Cell Biol (2000) 1.09
Plasma membrane-associated pY397FAK is a marker of cytotrophoblast invasion in vivo and in vitro. Am J Pathol (2001) 1.08
Usage of heparan sulfate, integrins, and FAK in HPV16 infection. Virology (2010) 1.08
Targeting Pyk2 for therapeutic intervention. Expert Opin Ther Targets (2010) 1.04
Focal adhesion kinase stabilizes the cytoskeleton. Biophys J (2011) 1.04
β2 integrin induces TCRζ-Syk-phospholipase C-γ phosphorylation and paxillin-dependent granule polarization in human NK cells. J Immunol (2011) 1.02
Dynamin reduces Pyk2 Y402 phosphorylation and SRC binding in osteoclasts. Mol Cell Biol (2009) 1.02
Activation of focal adhesion kinase by hepatitis B virus HBx protein: multiple functions in viral replication. J Virol (2006) 1.01
Inhibition of focal adhesion kinase and src increases detachment and apoptosis in human neuroblastoma cell lines. Mol Carcinog (2010) 1.01
Compensatory function of Pyk2 protein in the promotion of focal adhesion kinase (FAK)-null mammary cancer stem cell tumorigenicity and metastatic activity. J Biol Chem (2011) 1.00
Expression of DFak56, a Drosophila homolog of vertebrate focal adhesion kinase, supports a role in cell migration in vivo. Proc Natl Acad Sci U S A (1999) 0.97
CrkII regulates focal adhesion kinase activation by making a complex with Crk-associated substrate, p130Cas. Proc Natl Acad Sci U S A (2004) 0.97
Focal adhesion kinase negatively regulates Lck function downstream of the T cell antigen receptor. J Immunol (2013) 0.95
Computational and experimental models of cancer cell response to fluid shear stress. Front Oncol (2013) 0.95
Predicting functional gene interactions with the hierarchical interaction score. Nat Methods (2013) 0.94
Pyk2 is required for neutrophil degranulation and host defense responses to bacterial infection. J Immunol (2010) 0.94
Differential FAK phosphorylation at Ser-910, Ser-843 and Tyr-397 induced by angiotensin II, LPA and EGF in intestinal epithelial cells. Cell Signal (2006) 0.94
Differential ligand binding to a human cytomegalovirus chemokine receptor determines cell type-specific motility. PLoS Pathog (2009) 0.94
B cell receptor-induced phosphorylation of Pyk2 and focal adhesion kinase involves integrins and the Rap GTPases and is required for B cell spreading. J Biol Chem (2009) 0.93
FAK/src-family dependent activation of the Ste20-like kinase SLK is required for microtubule-dependent focal adhesion turnover and cell migration. PLoS One (2008) 0.93
Pyk2 promotes tumor progression in multiple myeloma. Blood (2014) 0.92
Calcium- and integrin-binding protein 1 regulates megakaryocyte ploidy, adhesion, and migration. Blood (2011) 0.92
Pyk2 activation triggers epidermal growth factor receptor signaling and cell motility after wounding sheets of epithelial cells. J Biol Chem (2010) 0.91
FAK is required for c-Met/β-catenin-driven hepatocarcinogenesis. Hepatology (2014) 0.90
Extended survival of Pyk2 or FAK deficient orthotopic glioma xenografts. J Neurooncol (2008) 0.90
Dissecting GRB7-mediated signals for proliferation and migration in HER2 overexpressing breast tumor cells: GTP-ase rules. Am J Cancer Res (2013) 0.89
Interferon-gamma-dependent tyrosine phosphorylation of MEKK4 via Pyk2 is regulated by annexin II and SHP2 in keratinocytes. Biochem J (2005) 0.87
Metformin inhibits androgen-induced IGF-IR up-regulation in prostate cancer cells by disrupting membrane-initiated androgen signaling. Endocrinology (2014) 0.87
Focal adhesion kinase can play unique and opposing roles in regulating the morphology of differentiating oligodendrocytes. J Neurochem (2010) 0.87
Characterization of heparanase-induced phosphatidylinositol 3-kinase-AKT activation and its integrin dependence. J Biol Chem (2013) 0.86
Regulation of osteoclast structure and function by FAK family kinases. J Leukoc Biol (2012) 0.85
HCMV pUS28 initiates pro-migratory signaling via activation of Pyk2 kinase. Herpesviridae (2010) 0.85
Fibronectin stimulates endothelin-1 synthesis in rat hepatic myofibroblasts via a Src/ERK-regulated signaling pathway. Gastroenterology (2009) 0.85
Cardiac fibroblasts require focal adhesion kinase for normal proliferation and migration. Am J Physiol Heart Circ Physiol (2009) 0.84
Polymeric immunoglobulin receptor-mediated invasion of Streptococcus pneumoniae into host cells requires a coordinate signaling of SRC family of protein-tyrosine kinases, ERK, and c-Jun N-terminal kinase. J Biol Chem (2010) 0.84
Functions of the FAK family kinases in T cells: beyond actin cytoskeletal rearrangement. Immunol Res (2014) 0.82
Focal adhesion kinase plays a role in osteoblast mechanotransduction in vitro but does not affect load-induced bone formation in vivo. PLoS One (2012) 0.82
Extracellular ATP stimulates epithelial cell motility through Pyk2-mediated activation of the EGF receptor. Cell Signal (2011) 0.81
Modulation of FAK and Src adhesion signaling occurs independently of adhesion complex composition. J Cell Biol (2016) 0.81
Differential expression of FAK and Pyk2 in metastatic and non-metastatic EL4 lymphoma cell lines. Clin Exp Metastasis (2011) 0.81
Focal adhesion kinase is involved in rabies virus infection through its interaction with viral phosphoprotein P. J Virol (2014) 0.81
Dynamin and PTP-PEST cooperatively regulate Pyk2 dephosphorylation in osteoclasts. Int J Biochem Cell Biol (2012) 0.81
Homozygous mutation of focal adhesion kinase in embryonic stem cell derived neurons: normal electrophysiological and morphological properties in vitro. BMC Neurosci (2006) 0.81
Off-targets effects underlie the inhibitory effect of FAK inhibitors on platelet activation: studies using Fak-deficient mice. J Thromb Haemost (2013) 0.80
The Pyk2 FERM regulates Pyk2 complex formation and phosphorylation. Cell Signal (2010) 0.80
Understanding the roles of FAK in cancer: inhibitors, genetic models, and new insights. J Histochem Cytochem (2014) 0.79
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