Published in J Biol Chem on January 25, 1975
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A general method for gene knockdown in mice by using lentiviral vectors expressing small interfering RNA. Proc Natl Acad Sci U S A (2003) 4.17
Interactions between double-stranded RNA regulators and the protein kinase DAI. Mol Cell Biol (1992) 4.16
Adenovirus virus-associated RNA and translation control. J Virol (1991) 3.77
Adenovirus VAI RNA prevents phosphorylation of the eukaryotic initiation factor 2 alpha subunit subsequent to infection. Proc Natl Acad Sci U S A (1985) 3.09
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Human cytotoxic T lymphocytes with reduced sensitivity to Fas-induced apoptosis. Blood (2005) 1.36
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Functional dissection of adenovirus VAI RNA. J Virol (1989) 1.26
Double-stranded RNA-activated protein kinase (PKR) is negatively regulated by 60S ribosomal subunit protein L18. Mol Cell Biol (1999) 1.20
Evidence for involvement of trans-acting factors in selection of the AUG start codon during eukaryotic translational initiation. Mol Cell Biol (1996) 1.15
Binding of the adenovirus VAI RNA to the interferon-induced 68-kDa protein kinase correlates with function. Proc Natl Acad Sci U S A (1991) 1.13
In situ phosphorylation of the alpha subunit of eukaryotic initiation factor 2 in reticulocyte lysates inhibited by heme deficiency, double-stranded RNA, oxidized glutathione, or the heme-regulated protein kinase. Proc Natl Acad Sci U S A (1979) 1.13
Paradoxical interactions between human delta hepatitis agent RNA and the cellular protein kinase PKR. J Virol (1996) 1.08
Structural features of adenovirus 2 virus-associated RNA required for binding to the protein kinase DAI. Nucleic Acids Res (1994) 1.06
Partial characterization of a cellular factor that regulates the double-stranded RNA-dependent eIF-2 alpha kinase in 3T3-F442A fibroblasts. Mol Cell Biol (1991) 0.99
Translational regulation of human beta interferon mRNA: association of the 3' AU-rich sequence with the poly(A) tail reduces translation efficiency in vitro. Mol Cell Biol (1993) 0.99
dsRNA expression in the mouse elicits RNAi in oocytes and low adenosine deamination in somatic cells. Nucleic Acids Res (2011) 0.97
Possible involvement of the double-stranded RNA-binding core protein sigmaA in the resistance of avian reovirus to interferon. J Virol (2000) 0.97
Domain stabilities in protein kinase R (PKR): evidence for weak interdomain interactions. Biochemistry (2008) 0.97
RNA silencing in plants by the expression of siRNA duplexes. Nucleic Acids Res (2004) 0.94
Structural requirements of polynucleotides for the activation of (2' - 5')An polymerase and protein kinase. Nucleic Acids Res (1981) 0.94
Poly(riboadenylic acid) preferentially inhibits in vitro translation of cellular mRNAs compared with vaccinia virus mRNAs: possible role in vaccinia virus cytopathology. Proc Natl Acad Sci U S A (1986) 0.93
Regulation of in vitro translation by double-stranded RNA in mammalian cell mRNA preparations. Nucleic Acids Res (1988) 0.92
Suppression of the translation defect phenotype specific for a virus-associated RNA-deficient adenovirus mutant in monkey cells by simian virus 40. J Virol (1986) 0.92
Analysis of high-affinity binding of protein kinase R to double-stranded RNA. Biochemistry (2012) 0.90
The interferon renaissance: molecular aspects of induction and action. Microbiol Rev (1981) 0.89
Regulation of double-stranded RNA-activated eukaryotic initiation factor 2 alpha kinase by type 2 protein phosphatase in reticulocyte lysates. Proc Natl Acad Sci U S A (1982) 0.89
Magnesium-dependent interaction of PKR with adenovirus VAI. J Mol Biol (2010) 0.89
Action of spontaneously produced beta interferon in differentiation of embryonal carcinoma cells through an autoinduction mechanism. Mol Cell Biol (1993) 0.88
Structural features of double-stranded polyribonucleotides required for immunological specificity and interferon induction. Proc Natl Acad Sci U S A (1975) 0.88
Heparin activates PKR by inducing dimerization. J Mol Biol (2011) 0.87
A kinase able to phosphorylate exogenous protein synthesis initiation factor eIF-2 alpha is present in lysates of mengovirus-infected L cells. J Virol (1986) 0.87
Characterization and mapping of the double-stranded regions involved in activation of PKR within a cellular RNA from 3T3-F442A cells. Nucleic Acids Res (1997) 0.87
Regulation of the double-stranded RNA-dependent protein kinase PKR by RNAs encoded by a repeated sequence in the Epstein-Barr virus genome. Nucleic Acids Res (1996) 0.84
Reversal of the phenotype by K-rasval12 silencing mediated by adenovirus-delivered siRNA in human pancreatic cancer cell line Panc-1. World J Gastroenterol (2005) 0.84
Bacterial Riboswitches and Ribozymes Potently Activate the Human Innate Immune Sensor PKR. ACS Chem Biol (2016) 0.81
Multistep regulatory system for activation of a cyclic AMP-independent eukaryotic initiation factor 2 kinase. Proc Natl Acad Sci U S A (1979) 0.81
Efficient expression of small RNA polymerase III genes from a novel simian virus 40 vector and their effect on viral gene expression. Nucleic Acids Res (1989) 0.81
PAd-shRNA-PTN reduces pleiotrophin of pancreatic cancer cells and inhibits neurite outgrowth of DRG. World J Gastroenterol (2011) 0.80
Sensitivity of an epstein-barr virus-positive tumor line, Daudi, to alpha interferon correlates with expression of a GC-rich viral transcript. Mol Cell Biol (1999) 0.80
Analysis of PKR activation using analytical ultracentrifugation. Macromol Biosci (2010) 0.79
The Regulatory and Kinase Domains but Not the Interdomain Linker Determine Human Double-stranded RNA-activated Kinase (PKR) Sensitivity to Inhibition by Viral Non-coding RNAs. J Biol Chem (2015) 0.77
Activation of PKR by short stem-loop RNAs containing single-stranded arms. RNA (2016) 0.76
Rhinovirus multistranded RNA: dependence of the replicative form on the presence of actinomycin D. J Virol (1976) 0.75
Evidence that vesicular stomatitis virus produces double-stranded RNA that inhibits protein synthesis in a reticulocyte lysate. J Virol (1982) 0.75
In vitro polyoma DNA synthesis: inhibition by 1-beta-d-arabinofuranosyl CTP. J Virol (1975) 57.17
An efficient mRNA-dependent translation system from reticulocyte lysates. Eur J Biochem (1976) 46.42
The protein kinase family: conserved features and deduced phylogeny of the catalytic domains. Science (1988) 35.59
The protein kinase complement of the human genome. Science (2002) 35.36
Transforming gene product of Rous sarcoma virus phosphorylates tyrosine. Proc Natl Acad Sci U S A (1980) 22.30
Oncogenic kinase signalling. Nature (2001) 16.30
Phosphopeptide mapping and phosphoamino acid analysis by two-dimensional separation on thin-layer cellulose plates. Methods Enzymol (1991) 15.04
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Protein kinases 6. The eukaryotic protein kinase superfamily: kinase (catalytic) domain structure and classification. FASEB J (1995) 14.45
Detection and quantification of phosphotyrosine in proteins. Methods Enzymol (1983) 11.89
Cyclin: a protein specified by maternal mRNA in sea urchin eggs that is destroyed at each cleavage division. Cell (1983) 9.90
p27, a novel inhibitor of G1 cyclin-Cdk protein kinase activity, is related to p21. Cell (1994) 8.90
A novel kinase cascade triggered by stress and heat shock that stimulates MAPKAP kinase-2 and phosphorylation of the small heat shock proteins. Cell (1994) 8.52
Platelet-derived growth factor induces rapid but transient expression of the c-fos gene and protein. Nature (1985) 8.36
Integrin-mediated signal transduction linked to Ras pathway by GRB2 binding to focal adhesion kinase. Nature (1995) 8.25
Isolation of a human cyclin cDNA: evidence for cyclin mRNA and protein regulation in the cell cycle and for interaction with p34cdc2. Cell (1989) 8.19
A prokaryotic-like mode of cytoplasmic eukaryotic ribosome binding to the initiation codon during internal translation initiation of hepatitis C and classical swine fever virus RNAs. Genes Dev (1998) 7.72
Protein kinase B/Akt-mediated phosphorylation promotes nuclear exclusion of the winged helix transcription factor FKHR1. Proc Natl Acad Sci U S A (1999) 7.70
A thousand and one protein kinases. Cell (1987) 7.61
The tyrosine kinase negative regulator c-Cbl as a RING-type, E2-dependent ubiquitin-protein ligase. Science (1999) 7.60
Oncogene jun encodes a sequence-specific trans-activator similar to AP-1. Nature (1988) 7.45
Preparation and use of nuclease-treated rabbit reticulocyte lysates for the translation of eukaryotic messenger RNA. Methods Enzymol (1983) 7.38
Prevention of prolonged labour. Br Med J (1969) 7.37
Human cyclin A is adenovirus E1A-associated protein p60 and behaves differently from cyclin B. Nature (1990) 7.34
Human cyclins A and B1 are differentially located in the cell and undergo cell cycle-dependent nuclear transport. J Cell Biol (1991) 7.18
An activity phosphorylating tyrosine in polyoma T antigen immunoprecipitates. Cell (1979) 7.02
Activation of protein kinase C decreases phosphorylation of c-Jun at sites that negatively regulate its DNA-binding activity. Cell (1991) 6.89
Phospholipase C-gamma is a substrate for the PDGF and EGF receptor protein-tyrosine kinases in vivo and in vitro. Cell (1989) 6.88
Evidence that the phosphorylation of tyrosine is essential for cellular transformation by Rous sarcoma virus. Cell (1980) 6.76
The c-Fos protein interacts with c-Jun/AP-1 to stimulate transcription of AP-1 responsive genes. Cell (1988) 6.75
Characterization of Rous sarcoma virus src gene products synthesized in vitro. J Virol (1978) 6.39
Phosphorylation of initiation factor elF-2 and the control of reticulocyte protein synthesis. Cell (1977) 6.22
Vinculin: a cytoskeletal target of the transforming protein of Rous sarcoma virus. Cell (1981) 5.74
Changes in protein phosphorylation in Rous sarcoma virus-transformed chicken embryo cells. Mol Cell Biol (1981) 5.67
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Purification and properties of ribonuclease III from Escherichia coli. J Biol Chem (1968) 5.48
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A replication cycle for viroids and other small infectious RNA's. Science (1984) 5.18
Epidermal growth factor induces rapid tyrosine phosphorylation of proteins in A431 human tumor cells. Cell (1981) 5.08
Tyr527 is phosphorylated in pp60c-src: implications for regulation. Science (1986) 4.99
Cut2 proteolysis required for sister-chromatid seperation in fission yeast. Nature (1996) 4.86
Recombinant leptin for weight loss in obese and lean adults: a randomized, controlled, dose-escalation trial. JAMA (1999) 4.71
Cyclin is a component of maturation-promoting factor from Xenopus. Cell (1990) 4.70
A human peptidyl-prolyl isomerase essential for regulation of mitosis. Nature (1996) 4.65
Human eukaryotic translation initiation factor 4G (eIF4G) recruits mnk1 to phosphorylate eIF4E. EMBO J (1999) 4.65
A structural basis for substrate specificities of protein Ser/Thr kinases: primary sequence preference of casein kinases I and II, NIMA, phosphorylase kinase, calmodulin-dependent kinase II, CDK5, and Erk1. Mol Cell Biol (1996) 4.61
Translation of cyclin mRNA is necessary for extracts of activated xenopus eggs to enter mitosis. Cell (1989) 4.56
In vitro translation of poliovirus RNA: utilization of internal initiation sites in reticulocyte lysate. J Virol (1984) 4.54
Unique features of internal initiation of hepatitis C virus RNA translation. EMBO J (1995) 4.44
MNK1, a new MAP kinase-activated protein kinase, isolated by a novel expression screening method for identifying protein kinase substrates. EMBO J (1997) 4.39
Protein kinase C phosphorylation of the EGF receptor at a threonine residue close to the cytoplasmic face of the plasma membrane. Nature (1984) 4.27
The A- and B-type cyclin associated cdc2 kinases in Xenopus turn on and off at different times in the cell cycle. EMBO J (1990) 4.25
Structural basis for phosphoserine-proline recognition by group IV WW domains. Nat Struct Biol (2000) 4.25
Structural and functional analysis of the mitotic rotamase Pin1 suggests substrate recognition is phosphorylation dependent. Cell (1997) 4.24
Phosphorylation sites in enolase and lactate dehydrogenase utilized by tyrosine protein kinases in vivo and in vitro. J Biol Chem (1984) 4.20
Studies on the nature of polysomes. Biochem J (1964) 4.18
Accumulation of Krebs cycle intermediates and over-expression of HIF1alpha in tumours which result from germline FH and SDH mutations. Hum Mol Genet (2005) 4.12
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Initiation of encephalomyocarditis virus RNA translation: the authentic initiation site is not selected by a scanning mechanism. EMBO J (1990) 3.92
C-kinase phosphorylates the epidermal growth factor receptor and reduces its epidermal growth factor-stimulated tyrosine protein kinase activity. J Biol Chem (1984) 3.88
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Messenger RNA for the coat protein of tobacco mosaic virus. Nature (1976) 3.85
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Transcriptional control by protein phosphorylation: signal transmission from the cell surface to the nucleus. Curr Biol (1995) 3.61
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Temperature-sensitive transformation by Rous sarcoma virus and temperature-sensitive protein kinase activity. J Virol (1980) 3.25
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