Transmission-disequilibrium tests for quantitative traits.

Estimating African American admixture proportions by use of population-specific alleles. Am J Hum Genet (1998) 22.90

A general test of association for quantitative traits in nuclear families. Am J Hum Genet (2000) 22.45

Combined linkage and association sib-pair analysis for quantitative traits. Am J Hum Genet (1999) 11.22

Control of confounding of genetic associations in stratified populations. Am J Hum Genet (2003) 7.99

The power of association studies to detect the contribution of candidate genetic loci to variation in complex traits. Genome Res (1999) 5.03

Transmission/disequilibrium tests for extended marker haplotypes. Am J Hum Genet (1999) 4.07

Joint modeling of linkage and association: identifying SNPs responsible for a linkage signal. Am J Hum Genet (2005) 3.62

A unified association analysis approach for family and unrelated samples correcting for stratification. Am J Hum Genet (2008) 3.00

Power and design considerations for a general class of family-based association tests: quantitative traits. Am J Hum Genet (2002) 2.96

Sibling-based tests of linkage and association for quantitative traits. Am J Hum Genet (1999) 2.64

Removing the sampling restrictions from family-based tests of association for a quantitative-trait locus. Am J Hum Genet (2000) 2.62

Family-based tests of association and linkage that use unaffected sibs, covariates, and interactions. Am J Hum Genet (2000) 2.59

PedGenie: an analysis approach for genetic association testing in extended pedigrees and genealogies of arbitrary size. BMC Bioinformatics (2006) 2.06

Review and evaluation of methods correcting for population stratification with a focus on underlying statistical principles. Hum Hered (2008) 1.92

A genomewide linkage scan for quantitative-trait loci for obesity phenotypes. Am J Hum Genet (2002) 1.91

Transmission/disequilibrium test based on haplotype sharing for tightly linked markers. Am J Hum Genet (2003) 1.84

Fine-mapping of quantitative trait loci by identity by descent in outbred populations: application to milk production in dairy cattle. Proc Natl Acad Sci U S A (1999) 1.67

Linkage disequilibrium analysis of biallelic DNA markers, human quantitative trait loci, and threshold-defined case and control subjects. Am J Hum Genet (2000) 1.65

The power to detect linkage disequilibrium with quantitative traits in selected samples. Am J Hum Genet (2001) 1.64

Why Do We Test Multiple Traits in Genetic Association Studies? J Korean Stat Soc (2009) 1.62

Population admixture may appear to mask, change or reverse genetic effects of genes underlying complex traits. Genetics (2001) 1.57

Experimental designs for reliable detection of linkage disequilibrium in unstructured random population association studies. Genetics (2005) 1.54

Attention deficit/hyperactivity disorder children with a 7-repeat allele of the dopamine receptor D4 gene have extreme behavior but normal performance on critical neuropsychological tests of attention. Proc Natl Acad Sci U S A (2000) 1.53

Refinement of the 6p21.3 quantitative trait locus influencing dyslexia: linkage and association analyses. Hum Genet (2004) 1.51

A test of transmission/disequilibrium for quantitative traits in pedigree data, by multiple regression. Am J Hum Genet (1999) 1.44

Accounting for relatedness in family based genetic association studies. Hum Hered (2007) 1.43

An Association Test for Multiple Traits Based on the Generalized Kendall's Tau. J Am Stat Assoc (2010) 1.41

QTL fine mapping by measuring and testing for Hardy-Weinberg and linkage disequilibrium at a series of linked marker loci in extreme samples of populations. Am J Hum Genet (2000) 1.41

Detection of genes for ordinal traits in nuclear families and a unified approach for association studies. Genetics (2005) 1.38

Joint linkage and linkage disequilibrium mapping in natural populations. Genetics (2001) 1.32

Evidence for linkage and association with reading disability on 6p21.3-22. Am J Hum Genet (2002) 1.31

A haplotype-based algorithm for multilocus linkage disequilibrium mapping of quantitative trait loci with epistasis. Genetics (2003) 1.31

Population admixture: detection by Hardy-Weinberg test and its quantitative effects on linkage-disequilibrium methods for localizing genes underlying complex traits. Genetics (2001) 1.31

Genetic studies of autism: from the 1970s into the millennium. J Abnorm Child Psychol (2000) 1.27

Admixture-matched case-control study: a practical approach for genetic association studies in admixed populations. Hum Genet (2005) 1.27

Transmission disequilibrium, family controls, and great expectations. Am J Hum Genet (1998) 1.25

Quantitative trait analysis in sequencing studies under trait-dependent sampling. Proc Natl Acad Sci U S A (2013) 1.21

A review of family-based tests for linkage disequilibrium between a quantitative trait and a genetic marker. PLoS Genet (2008) 1.12

Overview of techniques to account for confounding due to population stratification and cryptic relatedness in genomic data association analyses. Heredity (Edinb) (2010) 1.11

Univariate/multivariate genome-wide association scans using data from families and unrelated samples. PLoS One (2009) 1.10

Haplotype-based quantitative trait mapping using a clustering algorithm. BMC Bioinformatics (2006) 1.07

Comparison of linkage-disequilibrium methods for localization of genes influencing quantitative traits in humans. Am J Hum Genet (1999) 1.07

TDT-association analysis of EKN1 and dyslexia in a Colorado twin cohort. Hum Genet (2005) 1.06

Searching for osteoporosis genes in the post-genome era: progress and challenges. Osteoporos Int (2003) 1.05

Inferring linkage disequilibrium between a polymorphic marker locus and a trait locus in natural populations. Genetics (2000) 1.02

Apolipoprotein E is associated with age at onset of amyotrophic lateral sclerosis. Neurogenetics (2004) 1.02

Association of ENPP1 gene polymorphisms with hand osteoarthritis in a Chuvasha population. Arthritis Res Ther (2005) 1.01

Estimating linkage disequilibrium between a polymorphic marker locus and a trait locus in natural populations. Genetics (1999) 1.01

Tests of association for quantitative traits in nuclear families using principal components to correct for population stratification. Ann Hum Genet (2009) 1.01

Statistical distributions of test statistics used for quantitative trait association mapping in structured populations. Genet Sel Evol (2012) 1.01

Estimation and testing of parent-of-origin effects for quantitative traits. Am J Hum Genet (2003) 0.99

Genetic association analysis under complex survey sampling: the Hispanic Community Health Study/Study of Latinos. Am J Hum Genet (2014) 0.98

Application of a rank-based genetic association test to age-at-onset data from the Collaborative Study on the Genetics of Alcoholism study. BMC Genet (2005) 0.94

Convergent evidence from multimodal imaging reveals amygdala abnormalities in schizophrenic patients and their first-degree relatives. PLoS One (2011) 0.93

Unraveling the genetic basis of seed tocopherol content and composition in rapeseed (Brassica napus L.). PLoS One (2012) 0.90

The chemokine (C-C-motif) receptor 3 (CCR3) gene is linked and associated with age at menarche in Caucasian females. Hum Genet (2006) 0.89

Bivariate association analysis in selected samples: application to a GWAS of two bone mineral density phenotypes in males with high or low BMD. Eur J Hum Genet (2011) 0.89

Association test for X-linked QTL in family-based designs. Am J Hum Genet (2009) 0.87

Protein variation in Adh and Adh-related in Drosophila pseudoobscura. Linkage disequilibrium between single nucleotide polymorphisms and protein alleles. Genetics (2001) 0.87

Combined linkage and association mapping of quantitative trait loci by multiple markers. Genetics (2005) 0.86

Nonparametric Covariate-Adjusted Association Tests Based on the Generalized Kendall's Tau(). J Am Stat Assoc (2012) 0.86

Quantitative trait association in parent offspring trios: Extension of case/pseudocontrol method and comparison of prospective and retrospective approaches. Genet Epidemiol (2007) 0.85

Association of the calcium-sensing receptor gene with blood pressure and urinary calcium in African-Americans. J Clin Endocrinol Metab (2008) 0.84

A quantile-based method for association mapping of quantitative phenotypes: an application to rheumatoid arthritis phenotypes. BMC Proc (2009) 0.84

Gene-environment interaction tests for family studies with quantitative phenotypes: A review and extension to longitudinal measures. Hum Genomics (2010) 0.83

Common polymorphic variation in the genetically diverse African insulin gene and its association with size at birth. Hum Genet (2009) 0.83

Modeling linkage disequilibrium between a polymorphic marker locus and a locus affecting complex dichotomous traits in natural populations. Genetics (2001) 0.82

AKAP10 (I646V) functional polymorphism predicts heart rate and heart rate variability in apparently healthy, middle-aged European-Americans. Psychophysiology (2009) 0.81

A polymorphic variant inside the osteopontin gene shows association with disease course in oligoarticular juvenile idiopathic arthritis. Ann Rheum Dis (2005) 0.81

Polymorphic variation in choline transporter gene (CHT1) is associated with early, subclinical measures of carotid atherosclerosis in humans. Int J Cardiovasc Imaging (2011) 0.80

Increase in power of transmission-disequilibrium tests for quantitative traits. Genet Epidemiol (2002) 0.79

Statistical Analysis in Genetic Studies of Mental Illnesses. Stat Sci (2011) 0.79

Searching for genes underlying susceptibility to osteoporotic fracture: current progress and future prospect. Osteoporos Int (2007) 0.78

Human complex trait genetics: lifting the lid of the genomics toolbox - from pathways to prediction. Curr Genomics (2012) 0.78

Association and linkage analyses of interleukin-6 gene 634C/G polymorphism and bone phenotypes in Chinese. J Bone Miner Metab (2005) 0.78

Analysis of Case-Parent Trios Using a Loglinear Model with Adjustment for Transmission Ratio Distortion. Front Genet (2016) 0.77

Association of insulin sensitivity and glucose tolerance with the c.825C>T variant of the G protein beta-3 subunit gene. J Diabetes Complications (2008) 0.77

AHSG gene polymorphisms are associated with bone mineral density in Caucasian nuclear families. Eur J Epidemiol (2007) 0.77

Analysis of Sequence Data Under Multivariate Trait-Dependent Sampling. J Am Stat Assoc (2015) 0.77

Genetic Variants of Microtubule Actin Cross-linking Factor 1 (MACF1) Confer Risk for Parkinson's Disease. Mol Neurobiol (2016) 0.77

Gene expression studies of osteoporosis: implications for microarray research. Osteoporos Int (2003) 0.77

Power, validity, bias and robustness of family-based association analysis methods in the presence of linkage for late onset diseases. Ann Hum Genet (2008) 0.77

Complex pedigrees in the sequencing era: to track transmissions or decorrelate? Genet Epidemiol (2014) 0.76

A statistical framework for testing the causal effects of fetal drive. Front Genet (2015) 0.76

No association between LRP5 gene polymorphisms and bone and obesity phenotypes in Chinese male-offspring nuclear families. Acta Pharmacol Sin (2010) 0.76

Risk Alleles in/near ADCY5, ADRA2A, CDKAL1, CDKN2A/B, GRB10, and TCF7L2 Elevate Plasma Glucose Levels at Birth and in Early Childhood: Results from the FAMILY Study. PLoS One (2016) 0.76

Software for quantitative trait analysis. Hum Genomics (2005) 0.75

A novel transmission-based test of association for multivariate phenotypes: an application to systolic and diastolic blood pressure levels. BMC Proc (2014) 0.75

Dosage transmission disequilibrium test (dTDT) for linkage and association detection. PLoS One (2013) 0.75

A new transmission test for affected sib-pair families. BMC Proc (2007) 0.75

Including non-informative parents in transmission-based association tests. J Hum Genet (2017) 0.75

Polymorphisms in Wnt signaling pathway genes are associated with peak bone mineral density, lean mass, and fat mass in Chinese male nuclear families. Osteoporos Int (2016) 0.75

The future of genetic studies of complex human diseases. Science (1996) 64.76

Transmission test for linkage disequilibrium: the insulin gene region and insulin-dependent diabetes mellitus (IDDM). Am J Hum Genet (1993) 51.42

Genetic dissection of complex traits: guidelines for interpreting and reporting linkage results. Nat Genet (1995) 49.77

The investigation of linkage between a quantitative trait and a marker locus. Behav Genet (1972) 24.92

The transmission/disequilibrium test: history, subdivision, and admixture. Am J Hum Genet (1995) 24.52

Multiple trait analysis of genetic mapping for quantitative trait loci. Genetics (1995) 8.84

A haplotype-based 'haplotype relative risk' approach to detecting allelic associations. Hum Hered (1992) 8.71

Mapping by admixture linkage disequilibrium in human populations: limits and guidelines. Am J Hum Genet (1994) 7.16

Extreme discordant sib pairs for mapping quantitative trait loci in humans. Science (1995) 7.00

Mapping disease genes: family-based association studies. Am J Hum Genet (1995) 5.82

An extended transmission/disequilibrium test (TDT) for multi-allele marker loci. Ann Hum Genet (1995) 5.47

Linkage analysis of quantitative traits: increased power by using selected samples. Am J Hum Genet (1991) 4.23

Extended multipoint identity-by-descent analysis of human quantitative traits: efficiency, power, and modeling considerations. Am J Hum Genet (1993) 4.13

Alcoholism and alleles of the human D2 dopamine receptor locus. Studies of association and linkage. Arch Gen Psychiatry (1991) 4.12

Nontraditional epidemiologic approaches in the analysis of gene-environment interaction: case-control studies with no controls! Am J Epidemiol (1996) 3.98

The haplotype-relative-risk (HRR) method for analysis of association in nuclear families. Am J Hum Genet (1993) 2.96

Multivariate multipoint linkage analysis of quantitative trait loci. Behav Genet (1996) 2.24

Practical implications of modes of statistical inference for causal effects and the critical role of the assignment mechanism. Biometrics (1991) 2.03

Statistical properties of the allelic and genotypic transmission/disequilibrium test for multiallelic markers. Genet Epidemiol (1995) 1.92

Novel approaches to linkage mapping. Curr Opin Genet Dev (1995) 1.87

A comparison of univariate and multivariate tests for genetic linkage. Genet Epidemiol (1993) 1.68

Identification of clusters of biallelic polymorphic sequence-tagged sites (pSTSs) that generate highly informative and automatable markers for genetic linkage mapping. Genomics (1992) 1.55

Chromosomal localization of the callipyge gene in sheep (Ovis aries) using bovine DNA markers. Proc Natl Acad Sci U S A (1994) 1.38

Using multivariate genetic modeling to detect pleiotropic quantitative trait loci. Behav Genet (1996) 1.30

Linkage disequilibrium between an allele at the dopamine D4 receptor locus and Tourette syndrome, by the transmission-disequilibrium test. Am J Hum Genet (1996) 1.29

When is it worth measuring a covariate in a randomized clinical trial? J Consult Clin Psychol (1995) 1.25

Effective testing of gene-disease associations. Am J Hum Genet (1990) 1.05

Multivariate genetic analysis of an oligogenic disease. Genet Epidemiol (1995) 0.97

Statistical validity for testing associations between genetic markers and quantitative traits in family data. Genet Epidemiol (1995) 0.96