Nucleotides and two functional states of hsp90.

HSP90 at the hub of protein homeostasis: emerging mechanistic insights. Nat Rev Mol Cell Biol (2010) 7.16

Hsp90: a specialized but essential protein-folding tool. J Cell Biol (2001) 4.51

ATP binding and hydrolysis are essential to the function of the Hsp90 molecular chaperone in vivo. EMBO J (1998) 4.46

In vivo function of Hsp90 is dependent on ATP binding and ATP hydrolysis. J Cell Biol (1998) 3.38

Functional requirement of p23 and Hsp90 in telomerase complexes. Genes Dev (1999) 3.19

The ATPase cycle of Hsp90 drives a molecular 'clamp' via transient dimerization of the N-terminal domains. EMBO J (2000) 3.00

Regulation of Hsp90 ATPase activity by tetratricopeptide repeat (TPR)-domain co-chaperones. EMBO J (1999) 2.71

Polypeptide release by Hsp90 involves ATP hydrolysis and is enhanced by the co-chaperone p23. EMBO J (2000) 1.92

p50(cdc37) acting in concert with Hsp90 is required for Raf-1 function. Mol Cell Biol (1999) 1.83

The Hsp90 chaperone machinery regulates signaling by modulating ligand binding clefts. J Biol Chem (2008) 1.82

SBA1 encodes a yeast hsp90 cochaperone that is homologous to vertebrate p23 proteins. Mol Cell Biol (1998) 1.75

Requirement of heat shock protein 90 for human hepatitis B virus reverse transcriptase function. J Virol (2004) 1.72

Withaferin A targets heat shock protein 90 in pancreatic cancer cells. Biochem Pharmacol (2010) 1.69

Conformational dynamics of the molecular chaperone Hsp90. Q Rev Biophys (2011) 1.61

Dimerization and N-terminal domain proximity underlie the function of the molecular chaperone heat shock protein 90. Proc Natl Acad Sci U S A (2000) 1.53

Heat shock protein 90 as a drug target against protozoan infections: biochemical characterization of HSP90 from Plasmodium falciparum and Trypanosoma evansi and evaluation of its inhibitor as a candidate drug. J Biol Chem (2010) 1.49

In vitro reconstitution of functional hepadnavirus reverse transcriptase with cellular chaperone proteins. J Virol (2002) 1.49

Genetic and biochemical analysis of p23 and ansamycin antibiotics in the function of Hsp90-dependent signaling proteins. Mol Cell Biol (1998) 1.48

Geldanamycin as a potential anti-cancer agent: its molecular target and biochemical activity. Invest New Drugs (1999) 1.46

Characterization of celastrol to inhibit hsp90 and cdc37 interaction. J Biol Chem (2009) 1.45

Heat shock protein 90 positively regulates Chikungunya virus replication by stabilizing viral non-structural protein nsP2 during infection. PLoS One (2014) 1.45

Co-chaperones Bag-1, Hop and Hsp40 regulate Hsc70 and Hsp90 interactions with wild-type or mutant p53. EMBO J (2001) 1.42

The charged region of Hsp90 modulates the function of the N-terminal domain. Proc Natl Acad Sci U S A (1999) 1.38

p23, a simple protein with complex activities. Cell Stress Chaperones (2003) 1.34

Host cell factor requirement for hepatitis C virus enzyme maturation. Proc Natl Acad Sci U S A (2001) 1.27

Structural and functional coupling of Hsp90- and Sgt1-centred multi-protein complexes. EMBO J (2008) 1.24

Role for Hsp90-associated cochaperone p23 in estrogen receptor signal transduction. Mol Cell Biol (1999) 1.22

Aha1 competes with Hop, p50 and p23 for binding to the molecular chaperone Hsp90 and contributes to kinase and hormone receptor activation. Biochem J (2005) 1.19

GCUNC-45 is a novel regulator for the progesterone receptor/hsp90 chaperoning pathway. Mol Cell Biol (2006) 1.17

A novel chaperone-activity-reducing mechanism of the 90-kDa molecular chaperone HSP90. Biochem J (1999) 1.12

Heat shock protein 90-independent activation of truncated hepadnavirus reverse transcriptase. J Virol (2003) 1.07

Structural basis for assembly of Hsp90-Sgt1-CHORD protein complexes: implications for chaperoning of NLR innate immunity receptors. Mol Cell (2010) 1.07

Geldanamycin, a ligand of heat shock protein 90, inhibits the replication of herpes simplex virus type 1 in vitro. Antimicrob Agents Chemother (2004) 1.06

Human butyrate-induced transcript 1 interacts with hepatitis C virus NS5A and regulates viral replication. J Virol (2007) 1.03

BAG3, a host cochaperone, facilitates varicella-zoster virus replication. J Virol (2007) 1.01

Structural and functional analysis of SGT1-HSP90 core complex required for innate immunity in plants. EMBO Rep (2008) 1.01

Hsp90 can accommodate the simultaneous binding of the FKBP52 and HOP proteins. Oncotarget (2011) 1.00

The Chemical Biology of Molecular Chaperones--Implications for Modulation of Proteostasis. J Mol Biol (2015) 0.98

Recruitment of a cytoplasmic chaperone relay by the A2A adenosine receptor. J Biol Chem (2013) 0.96

Heat-shock treatment-mediated increase in transduction by recombinant adeno-associated virus 2 vectors is independent of the cellular heat-shock protein 90. J Biol Chem (2004) 0.95

Heat shock proteins in multiple myeloma. Oncotarget (2014) 0.95

Cooperation of heat shock protein 90 and p23 in aryl hydrocarbon receptor signaling. Cell Stress Chaperones (2004) 0.94

The endoplasmic reticulum chaperone Cosmc directly promotes in vitro folding of T-synthase. J Biol Chem (2009) 0.93

Characterization of a plant homolog of hop, a cochaperone of hsp90. Plant Physiol (2003) 0.89

p50(Cdc37) can buffer the temperature-sensitive properties of a mutant of Hck. Mol Cell Biol (2000) 0.89

Nuclear transport of Epstein-Barr virus DNA polymerase is dependent on the BMRF1 polymerase processivity factor and molecular chaperone Hsp90. J Virol (2013) 0.87

Role of the HSP90-associated cochaperone p23 in enhancing activity of the androgen receptor and significance for prostate cancer. Mol Endocrinol (2012) 0.85

Review: The HSP90 molecular chaperone-an enigmatic ATPase. Biopolymers (2016) 0.84

Differences in conformational dynamics within the Hsp90 chaperone family reveal mechanistic insights. Front Mol Biosci (2014) 0.81

The Aryl-hydrocarbon receptor does not require the p23 co-chaperone for ligand binding and target gene expression in vivo. Toxicol Lett (2009) 0.80

Sulforaphane potentiates the efficacy of 17-allylamino 17-demethoxygeldanamycin against pancreatic cancer through enhanced abrogation of Hsp90 chaperone function. Nutr Cancer (2011) 0.80

Characterization of plant p23-like proteins for their co-chaperone activities. Cell Stress Chaperones (2010) 0.78

Theiler's murine encephalomyelitis virus infection induces a redistribution of heat shock proteins 70 and 90 in BHK-21 cells, and is inhibited by novobiocin and geldanamycin. Cell Stress Chaperones (2011) 0.77

Hsp90 interaction with Cdc2 and Plo1 kinases contributes to actomyosin ring condensation in fission yeast. Curr Genet (2012) 0.77

Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade. Cell (1997) 24.57

Classification of cell death: recommendations of the Nomenclature Committee on Cell Death 2009. Cell Death Differ (2008) 10.45

Molecular definitions of cell death subroutines: recommendations of the Nomenclature Committee on Cell Death 2012. Cell Death Differ (2011) 9.44

The pyroptosome: a supramolecular assembly of ASC dimers mediating inflammatory cell death via caspase-1 activation. Cell Death Differ (2007) 7.74

Human ICE/CED-3 protease nomenclature. Cell (1996) 7.11

A conserved XIAP-interaction motif in caspase-9 and Smac/DIABLO regulates caspase activity and apoptosis. Nature (2001) 6.62

Ordering the cytochrome c-initiated caspase cascade: hierarchical activation of caspases-2, -3, -6, -7, -8, and -10 in a caspase-9-dependent manner. J Cell Biol (1999) 6.24

CPP32, a novel human apoptotic protein with homology to Caenorhabditis elegans cell death protein Ced-3 and mammalian interleukin-1 beta-converting enzyme. J Biol Chem (1994) 5.51

IAPs block apoptotic events induced by caspase-8 and cytochrome c by direct inhibition of distinct caspases. EMBO J (1998) 5.28

Autoactivation of procaspase-9 by Apaf-1-mediated oligomerization. Mol Cell (1998) 5.06

A receptor molecule for estrogens: isolation from the rat uterus and preliminary characterization. Proc Natl Acad Sci U S A (1966) 4.73

Ligandin: a hepatic protein which binds steroids, bilirubin, carcinogens and a number of exogenous organic anions. Nature (1971) 3.93

Cryopyrin and pyrin activate caspase-1, but not NF-kappaB, via ASC oligomerization. Cell Death Differ (2006) 3.77

Structure-based discovery of an organic compound that binds Bcl-2 protein and induces apoptosis of tumor cells. Proc Natl Acad Sci U S A (2000) 3.69

In vitro activation of CPP32 and Mch3 by Mch4, a novel human apoptotic cysteine protease containing two FADD-like domains. Proc Natl Acad Sci U S A (1996) 3.53

Guidelines for the use and interpretation of assays for monitoring cell death in higher eukaryotes. Cell Death Differ (2009) 3.44

Identification of Ipaf, a human caspase-1-activating protein related to Apaf-1. J Biol Chem (2001) 3.37

Negative regulation of the Apaf-1 apoptosome by Hsp70. Nat Cell Biol (2000) 3.05

Structural basis of caspase-7 inhibition by XIAP. Cell (2001) 2.99

Structural basis of procaspase-9 recruitment by the apoptotic protease-activating factor 1. Nature (1999) 2.95

Negative regulation of erythropoiesis by caspase-mediated cleavage of GATA-1. Nature (1999) 2.88

A receptor molecule for estrogens: studies using a cell-free system. Proc Natl Acad Sci U S A (1967) 2.70

Molecular ordering of the Fas-apoptotic pathway: the Fas/APO-1 protease Mch5 is a CrmA-inhibitable protease that activates multiple Ced-3/ICE-like cysteine proteases. Proc Natl Acad Sci U S A (1996) 2.65

Mch2, a new member of the apoptotic Ced-3/Ice cysteine protease gene family. Cancer Res (1995) 2.56

Death effector domain-containing herpesvirus and poxvirus proteins inhibit both Fas- and TNFR1-induced apoptosis. Proc Natl Acad Sci U S A (1997) 2.50

Crystal structure of a procaspase-7 zymogen: mechanisms of activation and substrate binding. Cell (2001) 2.39

Cleavage of lamin A by Mch2 alpha but not CPP32: multiple interleukin 1 beta-converting enzyme-related proteases with distinct substrate recognition properties are active in apoptosis. Proc Natl Acad Sci U S A (1996) 2.31

Overexpressed full-length human BCL2 extends the survival of baculovirus-infected Sf9 insect cells. Proc Natl Acad Sci U S A (1992) 2.28

Hormone receptors: studies on the interaction of estrogen with the uterus. Recent Prog Horm Res (1968) 2.28

Identification and molecular cloning of two novel receptors for the cytotoxic ligand TRAIL. J Biol Chem (1997) 2.26

CARD11 and CARD14 are novel caspase recruitment domain (CARD)/membrane-associated guanylate kinase (MAGUK) family members that interact with BCL10 and activate NF-kappa B. J Biol Chem (2001) 2.25

Antibiotic radicicol binds to the N-terminal domain of Hsp90 and shares important biologic activities with geldanamycin. Cell Stress Chaperones (1998) 2.25

Negative regulation of cytochrome c-mediated oligomerization of Apaf-1 and activation of procaspase-9 by heat shock protein 90. EMBO J (2000) 2.13

Regulation of IL-1beta generation by Pseudo-ICE and ICEBERG, two dominant negative caspase recruitment domain proteins. Cell Death Differ (2001) 2.09

The Ced-3/interleukin 1beta converting enzyme-like homolog Mch6 and the lamin-cleaving enzyme Mch2alpha are substrates for the apoptotic mediator CPP32. J Biol Chem (1996) 2.07

Mutations in NALP12 cause hereditary periodic fever syndromes. Proc Natl Acad Sci U S A (2008) 2.06

Recruitment, activation and retention of caspases-9 and -3 by Apaf-1 apoptosome and associated XIAP complexes. EMBO J (2001) 2.06

Natural killer (NK) cell-mediated cytotoxicity: differential use of TRAIL and Fas ligand by immature and mature primary human NK cells. J Exp Med (1998) 2.03

DNA-dependent protein kinase catalytic subunit: a target for an ICE-like protease in apoptosis. EMBO J (1996) 1.97

Cytochrome c and dATP-mediated oligomerization of Apaf-1 is a prerequisite for procaspase-9 activation. J Biol Chem (1999) 1.96

The assembly of progesterone receptor-hsp90 complexes using purified proteins. J Biol Chem (1998) 1.90

CARD9 is a novel caspase recruitment domain-containing protein that interacts with BCL10/CLAP and activates NF-kappa B. J Biol Chem (2000) 1.89

FLAME-1, a novel FADD-like anti-apoptotic molecule that regulates Fas/TNFR1-induced apoptosis. J Biol Chem (1997) 1.86

Human regulatory gene for inducible tyrosine aminotransferase in rat-human hybrids. Proc Natl Acad Sci U S A (1973) 1.84

Molecular cloning and functional analysis of the mouse homologue of the KILLER/DR5 tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) death receptor. Cancer Res (1999) 1.80

Temperature-sensitive differential affinity of TRAIL for its receptors. DR5 is the highest affinity receptor. J Biol Chem (2000) 1.68

Functional characterization of mitochondria in neutrophils: a role restricted to apoptosis. Cell Death Differ (2004) 1.65

Induction of cytolysis of cultured lymphoma cells by adenosine 3':5'-cyclic monophosphate and the isolation of resistant variants. Proc Natl Acad Sci U S A (1973) 1.61

Molecular determinants of the caspase-promoting activity of Smac/DIABLO and its role in the death receptor pathway. J Biol Chem (2000) 1.58

CRADD, a novel human apoptotic adaptor molecule for caspase-2, and FasL/tumor necrosis factor receptor-interacting protein RIP. Cancer Res (1997) 1.57

Involvement of BCL-2 in glucocorticoid-induced apoptosis of human pre-B-leukemias. Cancer Res (1992) 1.54

Dimerization and N-terminal domain proximity underlie the function of the molecular chaperone heat shock protein 90. Proc Natl Acad Sci U S A (2000) 1.53

Generation of constitutively active recombinant caspases-3 and -6 by rearrangement of their subunits. J Biol Chem (1998) 1.52

The serine protease Omi/HtrA2 is released from mitochondria during apoptosis. Omi interacts with caspase-inhibitor XIAP and induces enhanced caspase activity. Cell Death Differ (2002) 1.52

Cooperative action of Hsp70, Hsp90, and DnaJ proteins in protein renaturation. Biochemistry (1996) 1.50

Interaction of the baculovirus anti-apoptotic protein p35 with caspases. Specificity, kinetics, and characterization of the caspase/p35 complex. Biochemistry (1998) 1.48

11Beta-hydroxysteroid dehydrogenase, mineralocorticoid receptor, and thiazide-sensitive Na-Cl cotransporter expression by distal tubules. J Am Soc Nephrol (1998) 1.46

Card10 is a novel caspase recruitment domain/membrane-associated guanylate kinase family member that interacts with BCL10 and activates NF-kappa B. J Biol Chem (2001) 1.45

Isolation and properties of cortisol metabolite binding proteins of rat liver cytosol. Biochemistry (1969) 1.42

Processing/activation of at least four interleukin-1beta converting enzyme-like proteases occurs during the execution phase of apoptosis in human monocytic tumor cells. J Cell Biol (1997) 1.40

Activation of the Ikappa B kinases by RIP via IKKgamma /NEMO-mediated oligomerization. J Biol Chem (2000) 1.39

Identification of an endogenous dominant-negative short isoform of caspase-9 that can regulate apoptosis. Cancer Res (1999) 1.36

Ligandin, the glutathione S-transferases, and chemically induced hepatocarcinogenesis: a review. Cancer Res (1977) 1.33

Calpain activation is upstream of caspases in radiation-induced apoptosis. Cell Death Differ (1998) 1.31

Cell permeable Bcl-2 binding peptides: a chemical approach to apoptosis induction in tumor cells. Cancer Res (2000) 1.30

Cleavage and activation of p21-activated protein kinase gamma-PAK by CPP32 (caspase 3). Effects of autophosphorylation on activity. J Biol Chem (1998) 1.30

Activation of the CPP32 protease in apoptosis induced by 1-beta-D-arabinofuranosylcytosine and other DNA-damaging agents. Blood (1996) 1.24

Abrogation of mitochondrial cytochrome c release and caspase-3 activation in acquired multidrug resistance. J Biol Chem (1998) 1.24

Cloning and expression of four novel isoforms of human interleukin-1 beta converting enzyme with different apoptotic activities. J Biol Chem (1995) 1.23

Processing of the Nedd2 precursor by ICE-like proteases and granzyme B. Genes Cells (1996) 1.23

Caspase cleavage enhances the apoptosis-inducing effects of BAD. Mol Cell Biol (2001) 1.21

Activation of the CED3/ICE-related protease CPP32 in cerebellar granule neurons undergoing apoptosis but not necrosis. J Neurosci (1997) 1.19

How can we improve our understanding of cardiovascular safety liabilities to develop safer medicines? Br J Pharmacol (2011) 1.19

Target tissue receptors for progesterone: the influence of estrogen treatment. Endocrinology (1972) 1.18

Glucocorticoid-induced apoptosis in lymphocytes. Biochem Biophys Res Commun (2000) 1.18

Spodoptera frugiperda caspase-1, a novel insect death protease that cleaves the nuclear immunophilin FKBP46, is the target of the baculovirus antiapoptotic protein p35. J Biol Chem (1997) 1.17

In situ localization of progesterone receptors in normal mouse mammary glands: absence of receptors in the connective and adipose stroma and a heterogeneous distribution in the epithelium. J Steroid Biochem Mol Biol (1998) 1.16

Activation of a CrmA-insensitive, p35-sensitive pathway in ionizing radiation-induced apoptosis. J Biol Chem (1997) 1.15

Activity of lapatinib a novel HER2 and EGFR dual kinase inhibitor in human endometrial cancer cells. Br J Cancer (2008) 1.15

Apaf-1 protein deficiency confers resistance to cytochrome c-dependent apoptosis in human leukemic cells. Blood (2001) 1.13

CLAP, a novel caspase recruitment domain-containing protein in the tumor necrosis factor receptor pathway, regulates NF-kappaB activation and apoptosis. J Biol Chem (1999) 1.11

Activation of internucleosomal DNA cleavage in human CEM lymphocytes by glucocorticoid and novobiocin. Evidence for a non-Ca2(+)-requiring mechanism(s). J Biol Chem (1990) 1.11