Published in FEBS Lett on March 24, 1997
B6-responsive disorders: a model of vitamin dependency. J Inherit Metab Dis (2006) 1.55
Proteasome inhibition: a new strategy in cancer treatment. Invest New Drugs (2000) 1.24
Tyrosine aminotransferase: biochemical and structural properties and molecular dynamics simulations. Protein Cell (2010) 0.86
Bioinformatics analysis of transcriptome dynamics during growth in angus cattle longissimus muscle. Bioinform Biol Insights (2013) 0.80
The ubiquitin system. Annu Rev Biochem (1998) 43.36
The ubiquitin system for protein degradation. Annu Rev Biochem (1992) 8.84
pH and the recycling of transferrin during receptor-mediated endocytosis. Proc Natl Acad Sci U S A (1983) 8.41
Components of ubiquitin-protein ligase system. Resolution, affinity purification, and role in protein breakdown. J Biol Chem (1983) 7.03
Ubiquitin dependence of selective protein degradation demonstrated in the mammalian cell cycle mutant ts85. Cell (1984) 6.81
Ubiquitin ligase activity and tyrosine phosphorylation underlie suppression of growth factor signaling by c-Cbl/Sli-1. Mol Cell (1999) 6.79
Thermolability of ubiquitin-activating enzyme from the mammalian cell cycle mutant ts85. Cell (1984) 5.70
Mechanisms of intracellular protein breakdown. Annu Rev Biochem (1982) 4.89
Kinetics of internalization and recycling of transferrin and the transferrin receptor in a human hepatoma cell line. Effect of lysosomotropic agents. J Biol Chem (1983) 4.55
Basic Medical Research Award. The ubiquitin system. Nat Med (2000) 4.03
Regulation of stability and function of the epithelial Na+ channel (ENaC) by ubiquitination. EMBO J (1997) 4.01
Proposed role of ATP in protein breakdown: conjugation of protein with multiple chains of the polypeptide of ATP-dependent proteolysis. Proc Natl Acad Sci U S A (1980) 3.75
Guidelines for the use and interpretation of assays for monitoring cell death in higher eukaryotes. Cell Death Differ (2009) 3.44
Inhibition of ubiquitin/proteasome-dependent protein degradation by the Gly-Ala repeat domain of the Epstein-Barr virus nuclear antigen 1. Proc Natl Acad Sci U S A (1997) 3.31
ATP-dependent conjugation of reticulocyte proteins with the polypeptide required for protein degradation. Proc Natl Acad Sci U S A (1980) 2.96
Functional interaction between SEL-10, an F-box protein, and the nuclear form of activated Notch1 receptor. J Biol Chem (2001) 2.71
The ubiquitin-proteasome pathway and pathogenesis of human diseases. Annu Rev Med (1999) 2.68
Stimulation-dependent I kappa B alpha phosphorylation marks the NF-kappa B inhibitor for degradation via the ubiquitin-proteasome pathway. Proc Natl Acad Sci U S A (1995) 2.61
The ubiquitin conjugation system is required for ligand-induced endocytosis and degradation of the growth hormone receptor. EMBO J (1996) 2.58
Immunochemical analysis of the turnover of ubiquitin-protein conjugates in intact cells. Relationship to the breakdown of abnormal proteins. J Biol Chem (1982) 2.56
Resolution of the ATP-dependent proteolytic system from reticulocytes: a component that interacts with ATP. Proc Natl Acad Sci U S A (1979) 2.37
A Chinese hamster cell cycle mutant arrested at G2 phase has a temperature-sensitive ubiquitin-activating enzyme, E1. J Biol Chem (1988) 2.33
A novel site for ubiquitination: the N-terminal residue, and not internal lysines of MyoD, is essential for conjugation and degradation of the protein. EMBO J (1998) 2.31
Mutation of the E6-AP ubiquitin ligase reduces nuclear inclusion frequency while accelerating polyglutamine-induced pathology in SCA1 mice. Neuron (1999) 2.25
"Covalent affinity" purification of ubiquitin-activating enzyme. J Biol Chem (1982) 2.15
Ubiquitin-dependent degradation of certain protein substrates in vitro requires the molecular chaperone Hsc70. J Biol Chem (1997) 2.14
The ubiquitin-mediated proteolytic pathway and mechanisms of energy-dependent intracellular protein degradation. J Cell Biochem (1984) 2.10
The asialoglycoprotein receptor internalizes and recycles independently of the transferrin and insulin receptors. Cell (1983) 2.10
The ubiquitin pathway for the degradation of intracellular proteins. Prog Nucleic Acid Res Mol Biol (1986) 1.98
Basal and human papillomavirus E6 oncoprotein-induced degradation of Myc proteins by the ubiquitin pathway. Proc Natl Acad Sci U S A (1998) 1.88
Modes of regulation of ubiquitin-mediated protein degradation. J Cell Physiol (2000) 1.82
Inhibition of NF-kappa-B cellular function via specific targeting of the I-kappa-B-ubiquitin ligase. EMBO J (1997) 1.78
Itch: a HECT-type E3 ligase regulating immunity, skin and cancer. Cell Death Differ (2008) 1.77
Protein synthesis elongation factor EF-1 alpha is essential for ubiquitin-dependent degradation of certain N alpha-acetylated proteins and may be substituted for by the bacterial elongation factor EF-Tu. Proc Natl Acad Sci U S A (1994) 1.72
Role of arginine-tRNA in protein degradation by the ubiquitin pathway. Nature (1987) 1.71
Degradation of the E7 human papillomavirus oncoprotein by the ubiquitin-proteasome system: targeting via ubiquitination of the N-terminal residue. Oncogene (2000) 1.67
How are substrates recognized by the ubiquitin-mediated proteolytic system? Trends Biochem Sci (1989) 1.66
SCF(beta)(-TrCP) ubiquitin ligase-mediated processing of NF-kappaB p105 requires phosphorylation of its C-terminus by IkappaB kinase. EMBO J (2000) 1.55
Characterization of the heat-stable polypeptide of the ATP-dependent proteolytic system from reticulocytes. J Biol Chem (1980) 1.51
Degradation of ornithine decarboxylase in reticulocyte lysate is ATP-dependent but ubiquitin-independent. J Biol Chem (1989) 1.50
Degradation of the proto-oncogene product c-Fos by the ubiquitin proteolytic system in vivo and in vitro: identification and characterization of the conjugating enzymes. Mol Cell Biol (1995) 1.48
Activation of the heat-stable polypeptide of the ATP-dependent proteolytic system. Proc Natl Acad Sci U S A (1981) 1.48
Complete switch from Mdm2 to human papillomavirus E6-mediated degradation of p53 in cervical cancer cells. Proc Natl Acad Sci U S A (2001) 1.47
Degradation of ornithine decarboxylase in mammalian cells is ATP dependent but ubiquitin independent. Eur J Biochem (1989) 1.45
Degradation of myogenic transcription factor MyoD by the ubiquitin pathway in vivo and in vitro: regulation by specific DNA binding. Mol Cell Biol (1998) 1.41
Degradation of the epstein-barr virus latent membrane protein 1 (LMP1) by the ubiquitin-proteasome pathway. Targeting via ubiquitination of the N-terminal residue. J Biol Chem (2000) 1.40
Identification of the ubiquitin carrier proteins, E2s, involved in signal-induced conjugation and subsequent degradation of IkappaBalpha. J Biol Chem (1999) 1.39
Ubiquitination of E3 ligases: self-regulation of the ubiquitin system via proteolytic and non-proteolytic mechanisms. Cell Death Differ (2011) 1.39
Molecular cloning, sequence, and tissue distribution of the human ubiquitin-activating enzyme E1. Proc Natl Acad Sci U S A (1991) 1.38
Degradation of proteins with acetylated amino termini by the ubiquitin system. Science (1989) 1.37
Sorting and recycling of cell surface receptors and endocytosed ligands: the asialoglycoprotein and transferrin receptors. J Cell Biochem (1983) 1.37
Regulation of the synthesis of tyrosine aminotransferase: the relationship to mRNATAT. Mol Cell Biochem (1983) 1.34
Mammalian reticulocytes lose adhesion to fibronectin during maturation to erythrocytes. Proc Natl Acad Sci U S A (1985) 1.32
Role of UEV-1, an inactive variant of the E2 ubiquitin-conjugating enzymes, in in vitro differentiation and cell cycle behavior of HT-29-M6 intestinal mucosecretory cells. Mol Cell Biol (1998) 1.30
Intracellular transport of transferrin- and asialoorosomucoid-colloidal gold conjugates to lysosomes after receptor-mediated endocytosis. J Histochem Cytochem (1985) 1.27
Differential interaction of plakoglobin and beta-catenin with the ubiquitin-proteasome system. Oncogene (2000) 1.25
Regulation of the Drosophila ubiquitin ligase DIAP1 is mediated via several distinct ubiquitin system pathways. Cell Death Differ (2007) 1.23
Transfer RNA is an essential component of the ubiquitin- and ATP-dependent proteolytic system. Proc Natl Acad Sci U S A (1985) 1.23
Structural motifs involved in ubiquitin-mediated processing of the NF-kappaB precursor p105: roles of the glycine-rich region and a downstream ubiquitination domain. Mol Cell Biol (1999) 1.22
Purification and characterization of a novel species of ubiquitin-carrier protein, E2, that is involved in degradation of non-"N-end rule" protein substrates. J Biol Chem (1994) 1.21
c-Abl regulates p53 levels under normal and stress conditions by preventing its nuclear export and ubiquitination. Mol Cell Biol (2001) 1.19
Post-translational addition of an arginine moiety to acidic NH2 termini of proteins is required for their recognition by ubiquitin-protein ligase. J Biol Chem (1990) 1.15
Identification of the active amino acid residue of the polypeptide of ATP-dependent protein breakdown. J Biol Chem (1981) 1.14
The nuclear ubiquitin-proteasome system degrades MyoD. J Biol Chem (2001) 1.13
Transfer RNA is required for conjugation of ubiquitin to selective substrates of the ubiquitin- and ATP-dependent proteolytic system. J Biol Chem (1986) 1.13
Degradation of ornithine decarboxylase by the mammalian and yeast 26S proteasome complexes requires all the components of the protease. Eur J Biochem (1995) 1.09
Immunoelectron microscopic localization of ubiquitin in hepatoma cells. EMBO J (1988) 1.09
The ubiquitin-activating enzyme, E1, is required for stress-induced lysosomal degradation of cellular proteins. J Biol Chem (1991) 1.07
Antibody-induced receptor loss. Different fates for asialoglycoproteins and the asialoglycoprotein receptor in HepG2 cells. J Biol Chem (1986) 1.06
Ubiquitin-activating enzyme, E1, is associated with maturation of autophagic vacuoles. J Cell Biol (1992) 1.04
On the involvement of calpains in the degradation of the tumor suppressor protein p53. FEBS Lett (1997) 1.03
The eye lens has an active ubiquitin-protein conjugation system. J Biol Chem (1986) 1.02
Purification, characterization, and rapid inactivation of thermolabile ubiquitin-activating enzyme from the mammalian cell cycle mutant ts85. J Biol Chem (1989) 1.02
Inhibition by sodium butyrate of enzyme induction by glucocorticoids and dibutyryl cyclic AMP. A role for the rapid form of histone acetylation. J Biol Chem (1983) 1.01
NOXA, a sensor of proteasome integrity, is degraded by 26S proteasomes by an ubiquitin-independent pathway that is blocked by MCL-1. Cell Death Differ (2012) 1.00
Stress-induced alterations in autophagic pathway: relationship to ubiquitin system. Am J Physiol (1992) 0.97
The ubiquitin proteasome system and its involvement in cell death pathways. Cell Death Differ (2010) 0.94
Decreased level of the cell cycle regulator p27 and increased level of its ubiquitin ligase Skp2 in endometrial carcinoma but not in normal secretory or in hyperstimulated endometrium. Mol Hum Reprod (2004) 0.93
Isolation, characterization, and partial purification of a novel ubiquitin-protein ligase, E3. Targeting of protein substrates via multiple and distinct recognition signals and conjugating enzymes. J Biol Chem (1996) 0.93
The ubiquitin-activating enzyme E1 is phosphorylated and localized to the nucleus in a cell cycle-dependent manner. J Biol Chem (1996) 0.92
Immunoelectron microscopic localization of the ubiquitin-activating enzyme E1 in HepG2 cells. Proc Natl Acad Sci U S A (1992) 0.91
Identification of native tyrosine aminotransferase and an explanation for the multiple forms. J Biol Chem (1980) 0.91
Organ specificity of glucocorticoid-sensitive tyrosine aminotransferase. Separation from aspartate aminotransferase isoenzymes. J Biol Chem (1984) 0.90
Purification and characterization of a novel protein that is required for degradation of N-alpha-acetylated proteins by the ubiquitin system. J Biol Chem (1991) 0.90
E2A protein degradation by the ubiquitin-proteasome system is stage-dependent during muscle differentiation. Oncogene (2006) 0.90
Processing of p105 is inhibited by docking of p50 active subunits to the ankyrin repeat domain, and inhibition is alleviated by signaling via the carboxyl-terminal phosphorylation/ ubiquitin-ligase binding domain. J Biol Chem (2001) 0.88
Rescue of the complex temperature-sensitive phenotype of Chinese hamster ovary E36ts20 cells by expression of the human ubiquitin-activating enzyme cDNA. Biochem J (1994) 0.88
Human ubiquitin-activating enzyme, E1. Indication of potential nuclear and cytoplasmic subpopulations using epitope-tagged cDNA constructs. J Biol Chem (1994) 0.87
Protein synthesis elongation factor EF-1 alpha is an isopeptidase essential for ubiquitin-dependent degradation of certain proteolytic substrates. Adv Exp Med Biol (1996) 0.87
Identification of a region within the ubiquitin-activating enzyme required for nuclear targeting and phosphorylation. J Biol Chem (1997) 0.86
Testicular contractile cells and sperm transport. Fertil Steril (1977) 0.86
Complete reconstitution of conjugation and subsequent degradation of the tumor suppressor protein p53 by purified components of the ubiquitin proteolytic system. FEBS Lett (1994) 0.86
The 26S proteasome of the yeast Saccharomyces cerevisiae. FEBS Lett (1994) 0.86
Growth hormone inhibition of tyrosine aminotransferase in primary cultures of rat liver cells. Biochim Biophys Acta (1982) 0.84
Physical properties, limited proteolysis, and acetylation of tyrosine aminotransferase from rat liver. J Biol Chem (1981) 0.84
Mammalian cell cycle mutant defective in intracellular protein degradation and ubiquitin-protein conjugation. Prog Clin Biol Res (1985) 0.82
ATP-stimulated degradation of endogenous proteins in cell-free extracts of BHK 21/C13 fibroblasts. A key role for the proteinase, macropain, in the ubiquitin-dependent degradation of short-lived proteins. Biochim Biophys Acta (1991) 0.81
Nuclear localization of the ubiquitin-activating enzyme, E1, is cell-cycle-dependent. Biochem J (1994) 0.81
Differences in glycogen, lipids, and enzymes in livers from rats flown on COSMOS 2044. J Appl Physiol (1985) (1992) 0.81