AP-1 transcriptional activity is regulated by a direct association between thioredoxin and Ref-1.

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Published in Proc Natl Acad Sci U S A on April 15, 1997

Authors

K Hirota1, M Matsui, S Iwata, A Nishiyama, K Mori, J Yodoi

Author Affiliations

1: Department of Anesthesia, Kyoto University Hospital, Japan.

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Failure of regulation of Tac antigen/TCGF receptor on adult T-cell leukemia cells by anti-Tac monoclonal antibody. Blood (1983) 1.65

G-language Genome Analysis Environment: a workbench for nucleotide sequence data mining. Bioinformatics (2003) 1.64

Structure and function of Cas-L, a 105-kD Crk-associated substrate-related protein that is involved in beta 1 integrin-mediated signaling in lymphocytes. J Exp Med (1996) 1.64

A method that preserves circulation during preparation of the pectoralis major myocutaneous flap in head and neck reconstruction. Plast Reconstr Surg (1998) 1.63

Synchronized oscillatory discharges of mitral/tufted cells with different molecular receptive ranges in the rabbit olfactory bulb. J Neurophysiol (1999) 1.63

Heparin modulates integrin function in human platelets. J Vasc Surg (2001) 1.62

Amyloid beta induces neuronal cell death through ROS-mediated ASK1 activation. Cell Death Differ (2005) 1.62

Development of a digital image database for chest radiographs with and without a lung nodule: receiver operating characteristic analysis of radiologists' detection of pulmonary nodules. AJR Am J Roentgenol (2000) 1.61

Adult-onset Krabbe disease with homozygous T1853C mutation in the galactocerebrosidase gene. Unusual MRI findings of corticospinal tract demyelination. Neurology (1997) 1.61

ER stress activates the NLRP3 inflammasome via an UPR-independent pathway. Cell Death Dis (2012) 1.60

Detection of circulating intercellular adhesion molecule-1 antigen in malignant diseases. Clin Exp Immunol (1991) 1.59

Relation between nocturnal decline in blood pressure and mortality. The Ohasama Study. Am J Hypertens (1997) 1.59

Respiratory mechanics and peripheral airway inflammation and dysfunction in asthma. Clin Exp Allergy (2013) 1.59