Direct delivery of exogenous MHC class I molecule-binding oligopeptides to the endoplasmic reticulum of viable cells.

PubWeight™: 1.05‹?› | Rank: Top 15%

🔗 View Article (PMC 21557)

Published in Proc Natl Acad Sci U S A on July 22, 1997

Authors

P M Day1, J W Yewdell, A Porgador, R N Germain, J R Bennink

Author Affiliations

1: Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892-0440, USA.

Articles citing this

Drug hypersensitivity caused by alteration of the MHC-presented self-peptide repertoire. Proc Natl Acad Sci U S A (2012) 1.89

Intrasequence GFP in class I MHC molecules, a rigid probe for fluorescence anisotropy measurements of the membrane environment. Biophys J (2003) 1.31

The majority of H2-M3 is retained intracellularly in a peptide-receptive state and traffics to the cell surface in the presence of N-formylated peptides. J Exp Med (1999) 1.22

Direct visualization of distinct T cell epitopes derived from a melanoma tumor-associated antigen by using human recombinant antibodies with MHC- restricted T cell receptor-like specificity. Proc Natl Acad Sci U S A (2002) 1.03

Direct selection of a human antibody fragment directed against the tumor T-cell epitope HLA-A1-MAGE-A1 from a nonimmunized phage-Fab library. Proc Natl Acad Sci U S A (2000) 1.03

Endogenous viral antigen processing generates peptide-specific MHC class I cell-surface clusters. Proc Natl Acad Sci U S A (2012) 1.01

Burkitt lymphoma: pathogenesis and immune evasion. J Oncol (2010) 0.96

A contiguous compartment functions as endoplasmic reticulum and endosome/lysosome in Giardia lamblia. Eukaryot Cell (2009) 0.94

Processing and presentation of exogenous HLA class I peptides by dendritic cells from human immunodeficiency virus type 1-infected persons. J Virol (2005) 0.94

Trafficking of spontaneously endocytosed MHC proteins. Proc Natl Acad Sci U S A (1999) 0.92

Interaction of Bap31 and MHC class I molecules and their traffic out of the endoplasmic reticulum. J Immunol (2009) 0.88

Promiscuous binding of extracellular peptides to cell surface class I MHC protein. Proc Natl Acad Sci U S A (2012) 0.88

Strategy for identifying dendritic cell-processed CD4+ T cell epitopes from the HIV gag p24 protein. PLoS One (2012) 0.86

Cellular uptake followed by class I MHC presentation of some exogenous peptides contributes to T cell stimulatory capacity. Mol Immunol (2006) 0.85

Premature translational termination products are rapidly degraded substrates for MHC class I presentation. PLoS One (2012) 0.80

Bordetella adenylate cyclase toxin differentially modulates toll-like receptor-stimulated activation, migration and T cell stimulatory capacity of dendritic cells. PLoS One (2014) 0.80

Alpha(1)-Antitrypsin Deficiency. Curr Treat Options Gastroenterol (2000) 0.75

Articles cited by this

Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature (1970) 1528.65

Rapid redistribution of Golgi proteins into the ER in cells treated with brefeldin A: evidence for membrane cycling from Golgi to ER. Cell (1989) 13.41

HLA-A2.1-associated peptides from a mutant cell line: a second pathway of antigen presentation. Science (1992) 8.68

Association of class I major histocompatibility heavy and light chains induced by viral peptides. Nature (1989) 7.11

Herpes simplex virus turns off the TAP to evade host immunity. Nature (1995) 5.93

Localization, quantitation, and in situ detection of specific peptide-MHC class I complexes using a monoclonal antibody. Immunity (1997) 5.44

The rate of bulk flow from the endoplasmic reticulum to the cell surface. Cell (1987) 4.82

Brefeldin A redistributes resident and itinerant Golgi proteins to the endoplasmic reticulum. J Cell Biol (1989) 4.81

HLA-A2 molecules in an antigen-processing mutant cell contain signal sequence-derived peptides. Nature (1992) 4.53

Affinity panning of a library of peptides displayed on bacteriophages reveals the binding specificity of BiP. Cell (1993) 3.93

Host resistance directed selectively against H-2-deficient lymphoma variants. Analysis of the mechanism. J Exp Med (1985) 3.86

Impaired assembly and transport of HLA-A and -B antigens in a mutant TxB cell hybrid. EMBO J (1986) 3.78

Assembly of MHC class I molecules analyzed in vitro. Cell (1990) 3.77

De novo formation of caveolae in lymphocytes by expression of VIP21-caveolin. Proc Natl Acad Sci U S A (1995) 3.73

Roles for calreticulin and a novel glycoprotein, tapasin, in the interaction of MHC class I molecules with TAP. Immunity (1996) 3.18

Endocytosis of simian virus 40 into the endoplasmic reticulum. J Cell Biol (1989) 3.06

Brefeldin A implicates egress from endoplasmic reticulum in class I restricted antigen presentation. Nature (1989) 3.02

Brefeldin A specifically inhibits presentation of protein antigens to cytotoxic T lymphocytes. Science (1989) 2.81

Generation, translocation, and presentation of MHC class I-restricted peptides. Annu Rev Biochem (1995) 2.76

Antigen processing and presentation by the class I major histocompatibility complex. Annu Rev Immunol (1996) 2.69

ATP is required for receptor-mediated endocytosis in intact cells. J Cell Biol (1990) 1.97

The role of beta 2-microglobulin in peptide binding by class I molecules. Science (1990) 1.80

Endogenously synthesized peptide with an endoplasmic reticulum signal sequence sensitizes antigen processing mutant cells to class I-restricted cell-mediated lysis. J Exp Med (1991) 1.77

Caveolin cycles between plasma membrane caveolae and the Golgi complex by microtubule-dependent and microtubule-independent steps. J Cell Biol (1995) 1.67

Recognition of cloned influenza virus hemagglutinin gene products by cytotoxic T lymphocytes. J Virol (1986) 1.62

Increased cytotoxic activity of Pseudomonas exotoxin and two chimeric toxins ending in KDEL. J Biol Chem (1991) 1.61

Efficient dissociation of the p88 chaperone from major histocompatibility complex class I molecules requires both beta 2-microglobulin and peptide. J Exp Med (1992) 1.61

Disruption of the Golgi apparatus by brefeldin A inhibits the cytotoxicity of ricin, modeccin, and Pseudomonas toxin. Exp Cell Res (1991) 1.60

Trimming of antigenic peptides in an early secretory compartment. J Exp Med (1994) 1.47

The capacity to retrieve escaped ER proteins extends to the trans-most cisterna of the Golgi stack. J Cell Biol (1995) 1.45

Dissociation of beta 2-microglobulin leads to the accumulation of a substantial pool of inactive class I MHC heavy chains on the cell surface. Cell (1991) 1.37

Trimming of TAP-translocated peptides in the endoplasmic reticulum and in the cytosol during recycling. J Exp Med (1994) 1.36

Reassociation with beta 2-microglobulin is necessary for Kb class I major histocompatibility complex binding of exogenous peptides. Proc Natl Acad Sci U S A (1990) 1.24

Processing of major histocompatibility class I-restricted antigens in the endoplasmic reticulum. J Exp Med (1995) 1.23

Effect of TAP on the generation and intracellular trafficking of peptide-receptive major histocompatibility complex class I molecules. Immunity (1995) 1.20

Addition of an endoplasmic reticulum retrieval sequence to ricin A chain significantly increases its cytotoxicity to mammalian cells. J Biol Chem (1993) 1.19

Capping and receptor-mediated endocytosis of cell-bound verotoxin (Shiga-like toxin). 1: Chemical identification of an amino acid in the B subunit necessary for efficient receptor glycolipid binding and cellular internalization. J Cell Physiol (1994) 1.02

MHC class I molecules form ternary complexes with calnexin and TAP and undergo peptide-regulated interaction with TAP via their extracellular domains. J Exp Med (1996) 1.01

Class I molecules retained in the endoplasmic reticulum bind antigenic peptides. J Exp Med (1993) 1.01

Flow cytometry as an analytical and preparative tool in immunology. J Immunol Methods (1982) 0.99

Characterization of an incompletely assembled major histocompatibility class I molecule (H-2Kb) associated with unusually long peptides: implications for antigen processing and presentation. Proc Natl Acad Sci U S A (1994) 0.95

Inhibition of the proteolytic activity of the multicatalytic proteinase complex (proteasome) by substrate-related peptidyl aldehydes. J Biol Chem (1994) 0.90

Analysis of the association of peptides of optimal length to class I molecules on the surface of cells. Proc Natl Acad Sci U S A (1992) 0.90

Articles by these authors

The antigenic structure of the influenza virus A/PR/8/34 hemagglutinin (H1 subtype). Cell (1982) 12.44

A novel influenza A virus mitochondrial protein that induces cell death. Nat Med (2001) 9.90

Immunodominance in major histocompatibility complex class I-restricted T lymphocyte responses. Annu Rev Immunol (1999) 7.18

Rapid degradation of a large fraction of newly synthesized proteins by proteasomes. Nature (2000) 7.10

In vivo microbial stimulation induces rapid CD40 ligand-independent production of interleukin 12 by dendritic cells and their redistribution to T cell areas. J Exp Med (1997) 6.53

Localization, quantitation, and in situ detection of specific peptide-MHC class I complexes using a monoclonal antibody. Immunity (1997) 5.44

Influenza A virus nucleoprotein is a major target antigen for cross-reactive anti-influenza A virus cytotoxic T lymphocytes. Proc Natl Acad Sci U S A (1985) 5.42

CD1 recognition by mouse NK1+ T lymphocytes. Science (1995) 5.33

Brefeldin A redistributes resident and itinerant Golgi proteins to the endoplasmic reticulum. J Cell Biol (1989) 4.81

Recognition of haemagglutinins on virus-infected cells by NKp46 activates lysis by human NK cells. Nature (2001) 4.76

An immunodominant epitope of the human immunodeficiency virus envelope glycoprotein gp160 recognized by class I major histocompatibility complex molecule-restricted murine cytotoxic T lymphocytes. Proc Natl Acad Sci U S A (1988) 4.72

IL-10 inhibits macrophage costimulatory activity by selectively inhibiting the up-regulation of B7 expression. J Immunol (1993) 4.65

Proteasome inhibition interferes with gag polyprotein processing, release, and maturation of HIV-1 and HIV-2. Proc Natl Acad Sci U S A (2000) 4.31

Immunology. The ins and outs of antigen processing and presentation. Nature (1986) 4.08

Antigenic variation in three distinct determinants of an influenza type A haemagglutinin molecule. Nature (1979) 3.91

A single major pathway of T-lymphocyte interactions in antigen-specific immune suppression. Scand J Immunol (1981) 3.85

Monoclonal antibody analysis of p53 expression in normal and transformed cells. J Virol (1986) 3.72

Monoclonal antibodies against the antigen receptor on a cloned T-cell hybrid. Proc Natl Acad Sci U S A (1983) 3.66

The immune response genes of the major histocompatibility complex. Immunol Rev (1978) 3.61

Zeta phosphorylation without ZAP-70 activation induced by TCR antagonists or partial agonists. Science (1995) 3.40

Recombinant vaccinia virus primes and stimulates influenza haemagglutinin-specific cytotoxic T cells. Nature (1984) 3.21

Antigen- and receptor-driven regulatory mechanisms. IV. Idiotype-bearing I-J+ suppressor T cell factors induce second-order suppressor T cells which express anti-idiotypic receptors. J Exp Med (1980) 3.21

Identification of human cancers deficient in antigen processing. J Exp Med (1993) 3.21

Induction of CD8+ cytotoxic T cells by immunization with purified HIV-1 envelope protein in ISCOMs. Nature (1990) 3.15

Dissecting the multifactorial causes of immunodominance in class I-restricted T cell responses to viruses. Immunity (2000) 2.94

Defective ribosomal products (DRiPs): a major source of antigenic peptides for MHC class I molecules? J Immunol (1996) 2.88

Predominant role for directly transfected dendritic cells in antigen presentation to CD8+ T cells after gene gun immunization. J Exp Med (1998) 2.84

Brefeldin A specifically inhibits presentation of protein antigens to cytotoxic T lymphocytes. Science (1989) 2.81

The formation of immunogenic major histocompatibility complex class II-peptide ligands in lysosomal compartments of dendritic cells is regulated by inflammatory stimuli. J Exp Med (2000) 2.80

Cell biology of antigen processing and presentation to major histocompatibility complex class I molecule-restricted T lymphocytes. Adv Immunol (1992) 2.77

Cross-reactivity between hepatitis C virus and Influenza A virus determinant-specific cytotoxic T cells. J Virol (2001) 2.77

Natural ligand of mouse CD1d1: cellular glycosylphosphatidylinositol. Science (1998) 2.76

Antigenic characterization of viruses by monoclonal antibodies. Annu Rev Microbiol (1981) 2.63

Cells process exogenous proteins for recognition by cytotoxic T lymphocytes. Science (1988) 2.59

Efficient cell surface expression of class II MHC molecules in the absence of associated invariant chain. J Exp Med (1986) 2.55

Cytotoxic T-cell responses in mice infected with influenza and vaccinia viruses vary in magnitude with H-2 genotype. J Exp Med (1978) 2.54

Selection of influenza A virus adsorptive mutants by growth in the presence of a mixture of monoclonal antihemagglutinin antibodies. J Virol (1986) 2.52

A novel lymphocyte function-associated antigen (LFA-1): cellular distribution, quantitative expression, and structure. J Immunol (1981) 2.52

Shared idiotypic determinants on antibodies and T-cell-derived suppressor factor specific for the random terpolymer L-glutamic acid60-L-alanine30-L-tyrosine10. J Exp Med (1979) 2.51

Nuclear localization of a double-stranded RNA-binding protein encoded by the vaccinia virus E3L gene. Virology (1993) 2.40

Hapten-specific T-cell responses to 4-hydroxy-3-nitrophenyl acetyl. II. Demonstration of idiotypic determinants on suppressor T cells. J Exp Med (1979) 2.40

Characterization of T cell receptor gamma chain expression in a subset of murine thymocytes. Science (1986) 2.40

CD4 glycoprotein degradation induced by human immunodeficiency virus type 1 Vpu protein requires the function of proteasomes and the ubiquitin-conjugating pathway. J Virol (1998) 2.38

Expression of influenza A virus internal antigens on the surface of infected P815 cells. J Immunol (1981) 2.36

A role for peptide in determining MHC class II structure. Nature (1991) 2.32

A single amino acid interchange yields reciprocal CTL specificities for HIV-1 gp160. Science (1989) 2.32

Flanking sequences influence the presentation of an endogenously synthesized peptide to cytotoxic T lymphocytes. J Exp Med (1992) 2.29

Immunoproteasomes shape immunodominance hierarchies of antiviral CD8(+) T cells at the levels of T cell repertoire and presentation of viral antigens. J Exp Med (2001) 2.28

Defective major histocompatibility complex class II assembly, transport, peptide acquisition, and CD4+ T cell selection in mice lacking invariant chain expression. J Exp Med (1993) 2.27

Receptor-mediated uptake of antigen/heat shock protein complexes results in major histocompatibility complex class I antigen presentation via two distinct processing pathways. J Exp Med (2000) 2.25

Recognition of viral hemagglutinins by NKp44 but not by NKp30. Eur J Immunol (2001) 2.25

Major histocompatibility complex class I presentation of peptides derived from soluble exogenous antigen by a subset of cells engaged in phagocytosis. J Exp Med (1995) 2.24

A recombinant vector derived from the host range-restricted and highly attenuated MVA strain of vaccinia virus stimulates protective immunity in mice to influenza virus. Vaccine (1994) 2.22

Inhibition of cell-mediated cytolysis of trinitrophenyl-derivatized target cells by alloantisera directed to the products of the K and D loci of the H-2 complex. Proc Natl Acad Sci U S A (1976) 2.20

Exclusion of CD43 from the immunological synapse is mediated by phosphorylation-regulated relocation of the cytoskeletal adaptor moesin. Immunity (2001) 2.17

Dislocation of type I membrane proteins from the ER to the cytosol is sensitive to changes in redox potential. J Cell Biol (1998) 2.16

Production, specificity, and functionality of monoclonal antibodies to specific peptide-major histocompatibility complex class II complexes formed by processing of exogenous protein. Proc Natl Acad Sci U S A (1997) 2.13

PB1-F2, an influenza A virus-encoded proapoptotic mitochondrial protein, creates variably sized pores in planar lipid membranes. J Virol (2004) 2.12

Antigen processing in vivo and the elicitation of primary CTL responses. J Immunol (1995) 2.12

MHC affinity, peptide liberation, T cell repertoire, and immunodominance all contribute to the paucity of MHC class I-restricted peptides recognized by antiviral CTL. J Immunol (1997) 2.12

Specific antigen-Ia activation of transfected human T cells expressing murine Ti alpha beta-human T3 receptor complexes. Nature (1987) 2.11

Hapten-specific T cell responses to 4-hydroxy-3-nitrophenyl acetyl. V. Role of idiotypes in the suppressor pathway. J Exp Med (1980) 2.11

Peptide-major histocompatibility complex class II complexes with mixed agonist/antagonist properties provide evidence for ligand-related differences in T cell receptor-dependent intracellular signaling. J Exp Med (1993) 2.09

Murine I-A beta chain polymorphism: nucleotide sequences of three allelic I-A beta genes. Science (1983) 2.04

Intracellular localization of proteasomal degradation of a viral antigen. J Cell Biol (1999) 2.04

Mechanism of protective immunity against influenza virus infection in mice without antibodies. J Immunol (1998) 2.03

The binary logic of antigen processing and presentation to T cells. Cell (1990) 2.03

Nucleotide sequence and expression of a mouse interleukin 2 receptor cDNA. J Immunol (1985) 2.00

TAP-independent, beta 2-microglobulin-dependent surface expression of functional mouse CD1.1. J Exp Med (1995) 1.96

MHC class II interaction with CD4 mediated by a region analogous to the MHC class I binding site for CD8. Nature (1992) 1.95

Information transfer at the immunological synapse. Curr Biol (2001) 1.95

Expression of a membrane protease enhances presentation of endogenous antigens to MHC class I-restricted T lymphocytes. Cell (1992) 1.93

"Exon-shuffling" maps control of antibody- and T-cell-recognition sites to the NH2-terminal domain of the class II major histocompatibility polypeptide A beta. Proc Natl Acad Sci U S A (1985) 1.93

Influenza and vaccinia viruses expressing malaria CD8+ T and B cell epitopes. Comparison of their immunogenicity and capacity to induce protective immunity. J Immunol (1994) 1.90

Induction of broadly cross-reactive cytotoxic T cells recognizing an HIV-1 envelope determinant. Science (1992) 1.89

Anti-influenza virus cytotoxic T lymphocytes recognize the three viral polymerases and a nonstructural protein: responsiveness to individual viral antigens is major histocompatibility complex controlled. J Virol (1987) 1.88