Published in EMBO J on July 01, 1997
GLI3 mutations in human disorders mimic Drosophila cubitus interruptus protein functions and localization. Proc Natl Acad Sci U S A (1999) 1.63
Distinct Sonic Hedgehog signaling dynamics specify floor plate and ventral neuronal progenitors in the vertebrate neural tube. Genes Dev (2010) 1.51
Conditional deletion of beta1 integrins in the intestinal epithelium causes a loss of Hedgehog expression, intestinal hyperplasia, and early postnatal lethality. J Cell Biol (2006) 1.44
Monorail/Foxa2 regulates floorplate differentiation and specification of oligodendrocytes, serotonergic raphé neurones and cranial motoneurones. Development (2005) 1.07
Expression profiling and comparative genomics identify a conserved regulatory region controlling midline expression in the zebrafish embryo. Genome Res (2004) 0.98
3D reconstitution of the patterned neural tube from embryonic stem cells. Stem Cell Reports (2014) 0.93
Functional diversification of sonic hedgehog paralog enhancers identified by phylogenomic reconstruction. Genome Biol (2007) 0.82
Dynamic expression of retinoic acid-synthesizing and -metabolizing enzymes in the developing mouse inner ear. J Comp Neurol (2006) 0.81
Conservation of shh cis-regulatory architecture of the coelacanth is consistent with its ancestral phylogenetic position. Evodevo (2010) 0.81
Transcriptional repressor foxl1 regulates central nervous system development by suppressing shh expression in zebra fish. Mol Cell Biol (2006) 0.78
Retinoic acid specifically downregulates Fgf4 and inhibits posterior cell proliferation in the developing mouse autopod. J Anat (2001) 0.78
Biological functional annotation of retinoic acid alpha and beta in mouse liver based on genome-wide binding. Am J Physiol Gastrointest Liver Physiol (2014) 0.75
Evolution of Shh endoderm enhancers during morphological transition from ventral lungs to dorsal gas bladder. Nat Commun (2017) 0.75
The ciliary proteins Meckelin and Jouberin are required for retinoic acid-dependent neural differentiation of mouse embryonic stem cells. Differentiation (2014) 0.75
Methoprene photolytic compounds disrupt zebrafish development, producing phenocopies of mutants in the sonic hedgehog signaling pathway. Mar Biotechnol (NY) (2003) 0.75
Rapid production of full-length cDNAs from rare transcripts: amplification using a single gene-specific oligonucleotide primer. Proc Natl Acad Sci U S A (1988) 35.13
Isolation of monoclonal antibodies specific for human c-myc proto-oncogene product. Mol Cell Biol (1985) 25.52
Cyclopia and defective axial patterning in mice lacking Sonic hedgehog gene function. Nature (1996) 11.46
Sonic hedgehog mediates the polarizing activity of the ZPA. Cell (1993) 8.67
Sonic hedgehog, a member of a family of putative signaling molecules, is implicated in the regulation of CNS polarity. Cell (1993) 7.41
A versatile in vivo and in vitro eukaryotic expression vector for protein engineering. Nucleic Acids Res (1988) 7.28
Expression of achaete-scute homolog 3 in Xenopus embryos converts ectodermal cells to a neural fate. Genes Dev (1994) 6.42
Rapid restriction mapping of DNA cloned in lambda phage vectors. Gene (1984) 6.25
HNF-3 beta is essential for node and notochord formation in mouse development. Cell (1994) 4.08
Hepatocyte nuclear factor 3 alpha belongs to a gene family in mammals that is homologous to the Drosophila homeotic gene fork head. Genes Dev (1991) 4.01
The winged-helix transcription factor HNF-3 beta is required for notochord development in the mouse embryo. Cell (1994) 3.71
Five years on the wings of fork head. Mech Dev (1996) 3.47
Postimplantation expression patterns indicate a role for the mouse forkhead/HNF-3 alpha, beta and gamma genes in determination of the definitive endoderm, chordamesoderm and neuroectoderm. Development (1993) 3.25
The formation and maintenance of the definitive endoderm lineage in the mouse: involvement of HNF3/forkhead proteins. Development (1993) 3.22
H-2RIIBP (RXR beta) heterodimerization provides a mechanism for combinatorial diversity in the regulation of retinoic acid and thyroid hormone responsive genes. EMBO J (1992) 3.21
RXR alpha, a promiscuous partner of retinoic acid and thyroid hormone receptors. EMBO J (1992) 3.03
Floor plate and motor neuron induction by different concentrations of the amino-terminal cleavage product of sonic hedgehog autoproteolysis. Cell (1995) 2.85
A molecular pathway determining left-right asymmetry in chick embryogenesis. Cell (1995) 2.65
Floor plate and motor neuron induction by vhh-1, a vertebrate homolog of hedgehog expressed by the notochord. Cell (1994) 2.58
Patterning activities of vertebrate hedgehog proteins in the developing eye and brain. Curr Biol (1995) 2.54
Requirement of 19K form of Sonic hedgehog for induction of distinct ventral cell types in CNS explants. Nature (1995) 2.46
A homeobox gene essential for zebrafish notochord development. Nature (1995) 2.25
Patterning of mammalian somites by surface ectoderm and notochord: evidence for sclerotome induction by a hedgehog homolog. Cell (1994) 2.23
Secretion and localized transcription suggest a role in positional signaling for products of the segmentation gene hedgehog. Cell (1992) 2.20
Sonic hedgehog induces the differentiation of ventral forebrain neurons: a common signal for ventral patterning within the neural tube. Cell (1995) 2.05
Hepatocyte nuclear factor 3 beta contains two transcriptional activation domains, one of which is novel and conserved with the Drosophila fork head protein. Mol Cell Biol (1992) 2.01
The transcriptional activation function located in the hormone-binding domain of the human oestrogen receptor is not encoded in a single exon. EMBO J (1989) 1.75
Expression of zebrafish nk2.2 is influenced by sonic hedgehog/vertebrate hedgehog-1 and demarcates a zone of neuronal differentiation in the embryonic forebrain. Development (1995) 1.66
Induction of a specific muscle cell type by a hedgehog-like protein in zebrafish. Nature (1996) 1.65
Axial, a zebrafish gene expressed along the developing body axis, shows altered expression in cyclops mutant embryos. Genes Dev (1993) 1.62
Vitamin A-deficient quail embryos have half a hindbrain and other neural defects. Curr Biol (1996) 1.57
Pintallavis, a gene expressed in the organizer and midline cells of frog embryos: involvement in the development of the neural axis. Development (1992) 1.55
Mice homozygous for a targeted disruption of Hoxd-3 (Hox-4.1) exhibit anterior transformations of the first and second cervical vertebrae, the atlas and the axis. Development (1993) 1.49
Molecular organization and embryonic expression of the hedgehog gene involved in cell-cell communication in segmental patterning of Drosophila. Development (1992) 1.46
Sequential expression of HNF-3 beta and HNF-3 alpha by embryonic organizing centers: the dorsal lip/node, notochord and floor plate. Mech Dev (1993) 1.34
Heterodimerization among thyroid hormone receptor, retinoic acid receptor, retinoid X receptor, chicken ovalbumin upstream promoter transcription factor, and an endogenous liver protein. Mol Endocrinol (1992) 1.32
Hepatocyte nuclear factor 3 determines the amplitude of the glucocorticoid response of the rat tyrosine aminotransferase gene. DNA Cell Biol (1995) 1.31
Expression and regulation of a netrin homologue in the zebrafish embryo. Mech Dev (1997) 1.24
Control of neuronal diversity by the floor plate: contact-mediated induction of midbrain dopaminergic neurons. Cell (1995) 1.17
Pure and functionally homogeneous recombinant retinoid X receptor. J Biol Chem (1994) 1.15
Activin A induced expression of a fork head related gene in posterior chordamesoderm (notochord) of Xenopus laevis embryos. Mech Dev (1992) 1.12
Expression of axial and sonic hedgehog in wildtype and midline defective zebrafish embryos. Int J Dev Biol (1996) 1.06
Mice lacking all isoforms of retinoic acid receptor beta develop normally and are susceptible to the teratogenic effects of retinoic acid. Mech Dev (1995) 1.05
Anterior duplication of the Sonic hedgehog expression pattern in the pectoral fin buds of zebrafish treated with retinoic acid. Dev Biol (1995) 1.05
Retinoic acid is required for the initiation of outgrowth in the chick limb bud. Curr Biol (1996) 1.04
Developmental abnormalities in cultured mouse embryos deprived of retinoic by inhibition of yolk-sac retinol binding protein synthesis. Proc Natl Acad Sci U S A (1996) 0.99
Restrictions to floor plate induction by hedgehog and winged-helix genes in the neural tube of frog embryos. Mol Cell Neurosci (1995) 0.93
Relationship between retinoic acid and sonic hedgehog, two polarizing signals in the chick wing bud. Development (1994) 0.92
Mesoderm-inducing factors: a small class of molecules. Development (1988) 0.87
Early stages of notochord and floor plate development in the chick embryo defined by normal and induced expression of HNF-3 beta. Dev Biol (1995) 0.84
Mouse embryos lacking RXR alpha are resistant to retinoic-acid-induced limb defects. Development (1995) 0.84
Early neurogenesis in the zebrafish embryo. FASEB J (1994) 0.77
Cooperativity of glucocorticoid response elements located far upstream of the tyrosine aminotransferase gene. Cell (1987) 6.12
Groucho is required for Drosophila neurogenesis, segmentation, and sex determination and interacts directly with hairy-related bHLH proteins. Cell (1994) 4.95
Oestrogen and glucocorticoid responsive elements are closely related but distinct. Nature (1987) 3.95
A functionally conserved homolog of the Drosophila segment polarity gene hh is expressed in tissues with polarizing activity in zebrafish embryos. Cell (1993) 3.90
In vivo protein-DNA interactions in a glucocorticoid response element require the presence of the hormone. Nature (1987) 3.39
Abnormal ion permeation through cystic fibrosis respiratory epithelium. Science (1983) 3.31
smoothened encodes a receptor-like serpentine protein required for hedgehog signalling. Nature (1996) 2.37
hedgehog is required for the proliferation and specification of ovarian somatic cells prior to egg chamber formation in Drosophila. Development (1996) 2.35
Transcriptional activation of hedgehog target genes in Drosophila is mediated directly by the cubitus interruptus protein, a member of the GLI family of zinc finger DNA-binding proteins. Genes Dev (1996) 2.23
Spatial regulation of a zebrafish patched homologue reflects the roles of sonic hedgehog and protein kinase A in neural tube and somite patterning. Development (1996) 2.18
Insights into early vasculogenesis revealed by expression of the ETS-domain transcription factor Fli-1 in wild-type and mutant zebrafish embryos. Mech Dev (2000) 2.13
A gene that regulates the bithorax complex differentially in larval and adult cells of Drosophila. Cell (1984) 2.12
Sonic hedgehog is not required for the induction of medial floor plate cells in the zebrafish. Development (1998) 2.08
The correct activation of Antennapedia and bithorax complex genes requires the fushi tarazu gene. Nature (1987) 2.04
The zebrafish neckless mutation reveals a requirement for raldh2 in mesodermal signals that pattern the hindbrain. Development (2001) 1.99
Role of segment polarity genes in the definition and maintenance of cell states in the Drosophila embryo. Development (1988) 1.95
Wnt5 is required for tail formation in the zebrafish embryo. Cold Spring Harb Symp Quant Biol (1997) 1.91
Zebrafish Clock rhythmic expression reveals independent peripheral circadian oscillators. Nat Neurosci (1998) 1.90
Anisometropia and binocularity. Ophthalmology (1996) 1.87
By-passing in vitro screening--next generation sequencing technologies applied to antibody display and in silico candidate selection. Nucleic Acids Res (2010) 1.87
A protein with several possible membrane-spanning domains encoded by the Drosophila segment polarity gene patched. Nature (1989) 1.77
Notochord induction of zebrafish slow muscle mediated by Sonic hedgehog. Genes Dev (1997) 1.73
The role of segment polarity genes during early oogenesis in Drosophila. Development (1996) 1.68
Induction of a specific muscle cell type by a hedgehog-like protein in zebrafish. Nature (1996) 1.65
Axial, a zebrafish gene expressed along the developing body axis, shows altered expression in cyclops mutant embryos. Genes Dev (1993) 1.62
Glucocorticoid receptor binds cooperatively to adjacent recognition sites. EMBO J (1989) 1.61
Comparative analysis of structurally defined heparin binding sequences reveals a distinct spatial distribution of basic residues. J Biol Chem (1993) 1.57
Carboxy-terminal cleavage of the human foamy virus Gag precursor molecule is an essential step in the viral life cycle. J Virol (1997) 1.57
The u-boot mutation identifies a Hedgehog-regulated myogenic switch for fiber-type diversification in the zebrafish embryo. Genes Dev (2001) 1.54
Ribavirin inhibits West Nile virus replication and cytopathic effect in neural cells. J Infect Dis (2000) 1.52
Characterization of a cis-acting sequence in the Pol region required to transfer human foamy virus vectors. J Virol (1998) 1.46
Genetic analysis of hedgehog signalling in the Drosophila embryo. Dev Suppl (1993) 1.42
The activity of neurogenin1 is controlled by local cues in the zebrafish embryo. Development (1997) 1.41
Mutations in the sterol-sensing domain of Patched suggest a role for vesicular trafficking in Smoothened regulation. Curr Biol (2001) 1.41
Intronic enhancers control expression of zebrafish sonic hedgehog in floor plate and notochord. Development (1999) 1.39
Ethanol impairs migration of the prechordal plate in the zebrafish embryo. Dev Biol (1998) 1.38
A clonal analysis of the requirement for the trithorax gene in the diversification of segments in Drosophila. J Embryol Exp Morphol (1985) 1.38
Control of muscle cell-type specification in the zebrafish embryo by Hedgehog signalling. Dev Biol (1999) 1.37
The spatial and temporal deployment of Dfd and Scr transcripts throughout development of Drosophila. Development (1987) 1.37
TBP is not universally required for zygotic RNA polymerase II transcription in zebrafish. Curr Biol (2001) 1.32
Expression and regulation of a netrin homologue in the zebrafish embryo. Mech Dev (1997) 1.24
Hedgehog signaling pathway is essential for pancreas specification in the zebrafish embryo. Curr Biol (2001) 1.24
The Pax protein Noi is required for commissural axon pathway formation in the rostral forebrain. Development (1997) 1.23
Functional domains and sub-cellular distribution of the Hedgehog transducing protein Smoothened in Drosophila. Mech Dev (2004) 1.22
A crucial component of the endoderm formation pathway, CASANOVA, is encoded by a novel sox-related gene. Genes Dev (2001) 1.22
Natural history and treatment of low and high risk superficial bladder tumors. J Urol (1988) 1.22
Establishment and characterization of molecular clones of porcine endogenous retroviruses replicating on human cells. J Virol (2000) 1.19
Cleavage of the BMP-4 antagonist chordin by zebrafish tolloid. Science (1997) 1.17
Characterisation of a second patched gene in the zebrafish Danio rerio and the differential response of patched genes to Hedgehog signalling. Dev Biol (1999) 1.17
Regulation of left-right asymmetries in the zebrafish by Shh and BMP4. Dev Biol (1999) 1.16
Contrasting distributions of patched and hedgehog proteins in the Drosophila embryo. Mech Dev (1993) 1.15
Genetic control of the spatial pattern of selector gene expression in Drosophila. Cold Spring Harb Symp Quant Biol (1985) 1.12
Two distinct cell populations in the floor plate of the zebrafish are induced by different pathways. Dev Biol (2000) 1.12
Autocatalytic ftz activation and metameric instability induced by ectopic ftz expression. Cell (1989) 1.11
Developmental regulation of Tbx5 in zebrafish embryogenesis. Mech Dev (2000) 1.10
The major histocompatibility complex and human evolution. Trends Genet (1990) 1.10
Direct action of the nodal-related signal cyclops in induction of sonic hedgehog in the ventral midline of the CNS. Development (2000) 1.10
The human hnRNP-M proteins: structure and relation with early heat shock-induced splicing arrest and chromosome mapping. Nucleic Acids Res (1996) 1.09
Conversion of zebrafish blastomeres to an endodermal fate by TGF-beta-related signaling. Curr Biol (1998) 1.09
Expression of ptc and gli genes in talpid3 suggests bifurcation in Shh pathway. Development (1999) 1.09
Inactivation of dispatched 1 by the chameleon mutation disrupts Hedgehog signalling in the zebrafish embryo. Dev Biol (2004) 1.08
The Drosophila segment polarity gene patched is involved in a position-signalling mechanism in imaginal discs. Development (1990) 1.08
Differential expression of bithorax complex genes in the absence of the extra sex combs and trithorax genes. Nature (2014) 1.08
Comparison of replication-competent molecular clones of porcine endogenous retrovirus class A and class B derived from pig and human cells. J Virol (2001) 1.07
Expression of axial and sonic hedgehog in wildtype and midline defective zebrafish embryos. Int J Dev Biol (1996) 1.06
Secretion of the amino-terminal fragment of the hedgehog protein is necessary and sufficient for hedgehog signalling in Drosophila. Curr Biol (1995) 1.05
A simple and efficient procedure for non-isotopic in situ hybridization to sectioned material. Trends Genet (1994) 1.04
Cloning of human 2H9 heterogeneous nuclear ribonucleoproteins. Relation with splicing and early heat shock-induced splicing arrest. J Biol Chem (1997) 1.01
Is perceived social support a predictor of survival for patients undergoing autologous peripheral blood stem cell transplantation? Psychooncology (2005) 0.98
Zebrafish developmental genetics and central nervous system development. Hum Mol Genet (2000) 0.98
Expression and characterization of the Borna disease virus polymerase. J Virol (2000) 0.96
The hedgehog gene family in Drosophila and vertebrate development. Dev Suppl (1994) 0.95
one-eyed pinhead is required for development of the ventral midline of the zebrafish (Danio rerio) neural tube. Genes Funct (1997) 0.95
The smoothened gene and hedgehog signal transduction in Drosophila and vertebrate development. Cold Spring Harb Symp Quant Biol (1997) 0.94
Plasticity in zebrafish hox expression in the hindbrain and cranial neural crest. Dev Biol (2001) 0.94
Characterization of zebrafish smad1, smad2 and smad5: the amino-terminus of smad1 and smad5 is required for specific function in the embryo. Mech Dev (1999) 0.93
The generation and interpretation of positional information within the vertebrate myotome. Mech Dev (1998) 0.93
Identification of sites that act together to direct dimerization of human foamy virus RNA in vitro. Virology (1997) 0.92
Molecular and genetic analysis of the hairy locus in Drosophila. Cold Spring Harb Symp Quant Biol (1985) 0.92
Molecularly cloned porcine endogenous retroviruses replicate on human cells. Transplant Proc (2000) 0.91
Molecular cloning and characterization of dystrophin and Dp71, two products of the Duchenne Muscular Dystrophy gene, in zebrafish. Gene (2001) 0.90
Prevention of aspirin-induced drop in gastric potential difference with 16, 16-dimethyl-prostaglandin E2. Lancet (1981) 0.90
Blood pressure telemonitoring is useful to achieve blood pressure control in inadequately treated patients with arterial hypertension. J Hum Hypertens (2011) 0.89
Distribution of cannabinoid receptor 1 in the CNS of zebrafish. Neuroscience (2005) 0.89