Published in EMBO J on July 15, 2003
Capsid is a dominant determinant of retrovirus infectivity in nondividing cells. J Virol (2004) 3.54
tRNAs promote nuclear import of HIV-1 intracellular reverse transcription complexes. PLoS Biol (2006) 2.28
Nuclear import by karyopherin-βs: recognition and inhibition. Biochim Biophys Acta (2010) 2.19
The requirement for cellular transportin 3 (TNPO3 or TRN-SR2) during infection maps to human immunodeficiency virus type 1 capsid and not integrase. J Virol (2009) 1.99
Early steps of retrovirus replicative cycle. Retrovirology (2004) 1.94
Coupling viruses to dynein and kinesin-1. EMBO J (2011) 1.83
The Vpr protein from HIV-1: distinct roles along the viral life cycle. Retrovirology (2005) 1.67
Transportin 3 promotes a nuclear maturation step required for efficient HIV-1 integration. PLoS Pathog (2011) 1.39
HIV infection of non-dividing cells: a divisive problem. Retrovirology (2006) 1.33
Inhibition of HIV-1 infection by TNPO3 depletion is determined by capsid and detectable after viral cDNA enters the nucleus. Retrovirology (2011) 1.32
Integrase interacts with nucleoporin NUP153 to mediate the nuclear import of human immunodeficiency virus type 1. J Virol (2009) 1.26
HIV-1 integrase is capable of targeting DNA to the nucleus via an importin alpha/beta-dependent mechanism. Biochem J (2006) 1.24
Importin 7 and exportin 1 link c-Myc and p53 to regulation of ribosomal biogenesis. Mol Cell (2012) 1.24
Msk is required for nuclear import of TGF-{beta}/BMP-activated Smads. J Cell Biol (2007) 1.23
Novel nuclear import of Vpr promoted by importin alpha is crucial for human immunodeficiency virus type 1 replication in macrophages. J Virol (2007) 1.23
HIV-1 exploits importin 7 to maximize nuclear import of its DNA genome. Retrovirology (2009) 1.20
Evaluation of the functional involvement of human immunodeficiency virus type 1 integrase in nuclear import of viral cDNA during acute infection. J Virol (2004) 1.18
Interplay between HIV entry and transportin-SR2 dependency. Retrovirology (2011) 1.17
Isolation of cell lines that show novel, murine leukemia virus-specific blocks to early steps of retroviral replication. J Virol (2005) 1.16
The cellular protein daxx interacts with avian sarcoma virus integrase and viral DNA to repress viral transcription. J Virol (2005) 1.12
Human nucleoporins promote HIV-1 docking at the nuclear pore, nuclear import and integration. PLoS One (2012) 1.12
Nup153 and Nup98 bind the HIV-1 core and contribute to the early steps of HIV-1 replication. Virology (2013) 1.11
HIV-1 Vpr-a still "enigmatic multitasker". Front Microbiol (2014) 1.07
Importin alpha3 interacts with HIV-1 integrase and contributes to HIV-1 nuclear import and replication. J Virol (2010) 1.07
Importin 7 may be dispensable for human immunodeficiency virus type 1 and simian immunodeficiency virus infection of primary macrophages. J Virol (2005) 1.06
Analysis of the viral elements required in the nuclear import of HIV-1 DNA. J Virol (2009) 1.05
A hard way to the nucleus. Mol Med (2004) 1.05
MAP kinase subcellular localization controls both pattern and proliferation in the developing Drosophila wing. Development (2005) 1.04
Viral and cellular requirements for the nuclear entry of retroviral preintegration nucleoprotein complexes. Viruses (2013) 1.03
Mutations affecting interaction of integrase with TNPO3 do not prevent HIV-1 cDNA nuclear import. Retrovirology (2011) 1.01
Importin-alpha promotes passage through the nuclear pore complex of human immunodeficiency virus type 1 Vpr. J Virol (2005) 1.00
The host cell sulfonation pathway contributes to retroviral infection at a step coincident with provirus establishment. PLoS Pathog (2008) 0.99
Transportin 3 and importin α are required for effective nuclear import of HIV-1 integrase in virus-infected cells. Nucleus (2011) 0.96
Nuclear localization of the ERK MAP kinase mediated by Drosophila alphaPS2betaPS integrin and importin-7. Mol Biol Cell (2007) 0.95
High-throughput, library-based selection of a murine leukemia virus variant to infect nondividing cells. J Virol (2006) 0.94
Identification of protein cofactors necessary for sequence-specific plasmid DNA nuclear import. Mol Ther (2009) 0.94
Interaction of the HIV-1 intasome with transportin 3 protein (TNPO3 or TRN-SR2). J Biol Chem (2012) 0.94
Nuclear import of the preintegration complex is blocked upon infection by human immunodeficiency virus type 1 in mouse cells. J Virol (2006) 0.93
Inhibiting the HIV integration process: past, present, and the future. J Med Chem (2013) 0.93
Cysteine (C)-x-C receptor 4 undergoes transportin 1-dependent nuclear localization and remains functional at the nucleus of metastatic prostate cancer cells. PLoS One (2013) 0.93
Characterization of staufen1 ribonucleoproteins by mass spectrometry and biochemical analyses reveal the presence of diverse host proteins associated with human immunodeficiency virus type 1. Front Microbiol (2012) 0.92
A phenotypic recessive, post-entry block in rabbit cells that results in aberrant trafficking of HIV-1. Traffic (2006) 0.89
A cyclophilin homology domain-independent role for Nup358 in HIV-1 infection. PLoS Pathog (2014) 0.88
Involvement of importin-4 in the transport of transition protein 2 into the spermatid nucleus. Mol Cell Biol (2007) 0.88
Proteomic analysis of early HIV-1 nucleoprotein complexes. J Proteome Res (2013) 0.86
RNA interference and antiviral therapy. World J Gastroenterol (2007) 0.86
The inside out of lentiviral vectors. Viruses (2011) 0.85
Stimulated nuclear import by β-like importins. F1000Prime Rep (2013) 0.85
Androgen induces a switch from cytoplasmic retention to nuclear import of the androgen receptor. Mol Cell Biol (2013) 0.84
Misdelivery at the Nuclear Pore Complex-Stopping a Virus Dead in Its Tracks. Cells (2015) 0.84
Retroviral Integrase Structure and DNA Recombination Mechanism. Microbiol Spectr (2015) 0.83
The HIV-1 passage from cytoplasm to nucleus: the process involving a complex exchange between the components of HIV-1 and cellular machinery to access nucleus and successful integration. Int J Biochem Mol Biol (2012) 0.83
The Ty1 integrase protein can exploit the classical nuclear protein import machinery for entry into the nucleus. Nucleic Acids Res (2008) 0.83
Identification of residues in the C-terminal domain of HIV-1 integrase that mediate binding to the transportin-SR2 protein. J Biol Chem (2012) 0.82
Viruses challenge selectivity barrier of nuclear pores. Viruses (2013) 0.82
Cellular cofactors of lentiviral integrase: from target validation to drug discovery. Mol Biol Int (2012) 0.81
Slower uncoating is associated with impaired replicative capability of simian-tropic HIV-1. PLoS One (2013) 0.81
Strategies to inhibit viral protein nuclear import: HIV-1 as a target. Biochim Biophys Acta (2010) 0.81
The Role of TNPO3 in HIV-1 Replication. Mol Biol Int (2012) 0.81
Importin-7 mediates nuclear trafficking of DNA in mammalian cells. Traffic (2012) 0.81
Role of host-encoded proteins in restriction of retroviral integration. Front Microbiol (2012) 0.81
A mechanism of nucleocytoplasmic trafficking for the homeodomain protein PRH. Mol Cell Biochem (2009) 0.79
Interaction of transportin-SR2 with Ras-related nuclear protein (Ran) GTPase. J Biol Chem (2013) 0.78
Nuclear import of Avian Sarcoma Virus integrase is facilitated by host cell factors. Retrovirology (2008) 0.78
ERVK polyprotein processing and reverse transcriptase expression in human cell line models of neurological disease. Viruses (2015) 0.78
Conserved arginines of bovine adenovirus-3 33K protein are important for transportin-3 mediated transport and virus replication. PLoS One (2014) 0.77
The HIV-1 integrase mutant R263A/K264A is 2-fold defective for TRN-SR2 binding and viral nuclear import. J Biol Chem (2014) 0.76
Dynamic Oligomerization of Integrase Orchestrates HIV Nuclear Entry. Sci Rep (2016) 0.76
Delta and Egfr expression are regulated by Importin-7/Moleskin in Drosophila wing development. Dev Biol (2007) 0.75
Adult Muscle Formation Requires Drosophila Moleskin for Proliferation of Wing Disc-Associated Muscle Precursors. Genetics (2017) 0.75
Cellular minichromosome maintenance complex component 5 (MCM5) is incorporated into HIV-1 virions and modulates viral replication in the newly infected cells. Virology (2016) 0.75
RNA Viruses: RNA Roles in Pathogenesis, Coreplication and Viral Load. Curr Genomics (2015) 0.75
Cytoplasmic transport and nuclear import of plasmid DNA. Biosci Rep (2017) 0.75
N-terminally truncated POM121C inhibits HIV-1 replication. PLoS One (2017) 0.75
Selective extraction of polyoma DNA from infected mouse cell cultures. J Mol Biol (1967) 106.91
Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells. Nature (2001) 57.23
In vivo gene delivery and stable transduction of nondividing cells by a lentiviral vector. Science (1996) 28.95
Identification of a major co-receptor for primary isolates of HIV-1. Nature (1996) 23.81
A short amino acid sequence able to specify nuclear location. Cell (1984) 21.17
Pneumocystis carinii pneumonia and mucosal candidiasis in previously healthy homosexual men: evidence of a new acquired cellular immunodeficiency. N Engl J Med (1981) 14.62
Transport between the cell nucleus and the cytoplasm. Annu Rev Cell Dev Biol (1999) 13.27
Multiply attenuated lentiviral vector achieves efficient gene delivery in vivo. Nat Biotechnol (1997) 12.11
The yeast nuclear pore complex: composition, architecture, and transport mechanism. J Cell Biol (2000) 10.20
Nuclear protein import in permeabilized mammalian cells requires soluble cytoplasmic factors. J Cell Biol (1990) 8.75
Integration of murine leukemia virus DNA depends on mitosis. EMBO J (1993) 7.62
Protein import into nuclei: association and dissociation reactions involving transport substrate, transport factors, and nucleoporins. Cell (1995) 6.97
Active nuclear import of human immunodeficiency virus type 1 preintegration complexes. Proc Natl Acad Sci U S A (1992) 6.85
Isolation of a protein that is essential for the first step of nuclear protein import. Cell (1994) 6.63
Tables for estimating sedimentation through linear concentration gradients of sucrose solution. Anal Biochem (1967) 6.48
Association of integrase, matrix, and reverse transcriptase antigens of human immunodeficiency virus type 1 with viral nucleic acids following acute infection. Proc Natl Acad Sci U S A (1993) 6.44
Identification of conserved amino acid residues critical for human immunodeficiency virus type 1 integrase function in vitro. J Virol (1992) 6.07
HIV-1 genome nuclear import is mediated by a central DNA flap. Cell (2000) 5.87
Human immunodeficiency virus type 1 preintegration complexes: studies of organization and composition. J Virol (1997) 5.73
Determination of viral proteins present in the human immunodeficiency virus type 1 preintegration complex. J Virol (1991) 5.49
Cytosolic proteins that specifically bind nuclear location signals are receptors for nuclear import. Cell (1991) 5.17
The asymmetric distribution of the constituents of the Ran system is essential for transport into and out of the nucleus. EMBO J (1997) 5.08
HIV-1 structural gene expression requires the binding of multiple Rev monomers to the viral RRE: implications for HIV-1 latency. Cell (1991) 4.61
HIV-1 infection of nondividing cells through the recognition of integrase by the importin/karyopherin pathway. Proc Natl Acad Sci U S A (1997) 4.59
A novel class of RanGTP binding proteins. J Cell Biol (1997) 4.36
Dominant-negative mutants of importin-beta block multiple pathways of import and export through the nuclear pore complex. EMBO J (1997) 4.06
Importin beta, transportin, RanBP5 and RanBP7 mediate nuclear import of ribosomal proteins in mammalian cells. EMBO J (1998) 3.86
Characterization of intracellular reverse transcription complexes of human immunodeficiency virus type 1. J Virol (2001) 3.66
A 41 amino acid motif in importin-alpha confers binding to importin-beta and hence transit into the nucleus. EMBO J (1996) 3.65
Dynamic disruptions in nuclear envelope architecture and integrity induced by HIV-1 Vpr. Science (2001) 3.37
Transportin-mediated nuclear import of heterogeneous nuclear RNP proteins. J Cell Biol (1997) 3.36
The permeability barrier of nuclear pore complexes appears to operate via hydrophobic exclusion. EMBO J (2002) 3.34
NTF2 mediates nuclear import of Ran. EMBO J (1998) 2.79
Import of adenovirus DNA involves the nuclear pore complex receptor CAN/Nup214 and histone H1. Nat Cell Biol (2001) 2.72
Characterization of intracellular reverse transcription complexes of Moloney murine leukemia virus. J Virol (1999) 2.61
Human immunodeficiency virus type 2 infection and fusion of CD4-negative human cell lines: induction and enhancement by soluble CD4. J Virol (1992) 2.59
The importin beta/importin 7 heterodimer is a functional nuclear import receptor for histone H1. EMBO J (1999) 2.31
Importins fulfil a dual function as nuclear import receptors and cytoplasmic chaperones for exposed basic domains. EMBO J (2002) 2.17
Interactions between HIV Rev and nuclear import and export factors: the Rev nuclear localisation signal mediates specific binding to human importin-beta. J Mol Biol (1997) 2.00
Nuclear import of influenza virus RNA can be mediated by viral nucleoprotein and transport factors required for protein import. J Biol Chem (1995) 2.00
Importin 13: a novel mediator of nuclear import and export. EMBO J (2001) 1.98
Phosphorylation-dependent binding of hepatitis B virus core particles to the nuclear pore complex. J Cell Biol (1999) 1.92
Reassessment of the roles of integrase and the central DNA flap in human immunodeficiency virus type 1 nuclear import. J Virol (2002) 1.91
Establishment of a new system for determination of coreceptor usages of HIV based on the human glioma NP-2 cell line. Biochem Biophys Res Commun (1999) 1.75
Wild-type levels of nuclear localization and human immunodeficiency virus type 1 replication in the absence of the central DNA flap. J Virol (2002) 1.62
Postentry restriction to human immunodeficiency virus-based vector transduction in human monocytes. J Virol (2001) 1.60
Intracellular trafficking of retroviral genomes during the early phase of infection: viral exploitation of cellular pathways. J Gene Med (2002) 1.58
Nuclear import of adenovirus DNA in vitro involves the nuclear protein import pathway and hsc70. J Biol Chem (2000) 1.36
FG-rich repeats of nuclear pore proteins form a three-dimensional meshwork with hydrogel-like properties. Science (2006) 4.34
A saturated FG-repeat hydrogel can reproduce the permeability properties of nuclear pore complexes. Cell (2007) 3.90
The permeability barrier of nuclear pore complexes appears to operate via hydrophobic exclusion. EMBO J (2002) 3.34
A selective block of nuclear actin export stabilizes the giant nuclei of Xenopus oocytes. Nat Cell Biol (2006) 3.09
Exp5 exports eEF1A via tRNA from nuclei and synergizes with other transport pathways to confine translation to the cytoplasm. EMBO J (2002) 3.03
Characterisation of the passive permeability barrier of nuclear pore complexes. EMBO J (2009) 2.21
Importins fulfil a dual function as nuclear import receptors and cytoplasmic chaperones for exposed basic domains. EMBO J (2002) 2.17
NES consensus redefined by structures of PKI-type and Rev-type nuclear export signals bound to CRM1. Nat Struct Mol Biol (2010) 2.12
Crystal structure of the nuclear export receptor CRM1 in complex with Snurportin1 and RanGTP. Science (2009) 2.08
Exportin 6: a novel nuclear export receptor that is specific for profilin.actin complexes. EMBO J (2003) 1.89
NDC1: a crucial membrane-integral nucleoporin of metazoan nuclear pore complexes. J Cell Biol (2006) 1.67
The nuclear F-actin interactome of Xenopus oocytes reveals an actin-bundling kinesin that is essential for meiotic cytokinesis. EMBO J (2013) 1.58
The permeability of reconstituted nuclear pores provides direct evidence for the selective phase model. Cell (2012) 1.50
Ran-dependent nuclear export mediators: a structural perspective. EMBO J (2011) 1.42
NuSAP, a mitotic RanGTP target that stabilizes and cross-links microtubules. Mol Biol Cell (2006) 1.37
Systematic analysis of barrier-forming FG hydrogels from Xenopus nuclear pore complexes. EMBO J (2012) 1.27
Amyloid-like interactions within nucleoporin FG hydrogels. Proc Natl Acad Sci U S A (2010) 1.26
FG/FxFG as well as GLFG repeats form a selective permeability barrier with self-healing properties. EMBO J (2009) 1.22
Exportin 4 mediates a novel nuclear import pathway for Sox family transcription factors. J Cell Biol (2009) 1.22
Structural basis for the cytoskeletal association of Bcr-Abl/c-Abl. Mol Cell (2005) 1.21
Nuclear pore complex assembly and maintenance in POM121- and gp210-deficient cells. J Cell Biol (2006) 1.20
Inducible expression of coding and inhibitory RNAs from retargetable genomic loci. Nucleic Acids Res (2009) 1.17
Exportin 7 defines a novel general nuclear export pathway. EMBO J (2004) 1.17
Myelin membrane assembly is driven by a phase transition of myelin basic proteins into a cohesive protein meshwork. PLoS Biol (2013) 1.14
Ultrathin nucleoporin phenylalanine-glycine repeat films and their interaction with nuclear transport receptors. EMBO Rep (2010) 1.10
NADPH oxidases as regulators of tumor angiogenesis: current and emerging concepts. Antioxid Redox Signal (2012) 1.02
Structural analysis of large protein complexes using solvent paramagnetic relaxation enhancements. Angew Chem Int Ed Engl (2011) 0.97
Predictors of indoor air concentrations in smoking and non-smoking residences. Int J Environ Res Public Health (2010) 0.91
Transport of hypoxia-inducible factor HIF-1alpha into the nucleus involves importins 4 and 7. Biochem Biophys Res Commun (2009) 0.90
A field study to assess the degradation and transport of diuron and its metabolites in a calcareous soil. Sci Total Environ (2002) 0.89
Structural characterization of nanoscale meshworks within a nucleoporin FG hydrogel. Biomacromolecules (2012) 0.87
Cohesiveness tunes assembly and morphology of FG nucleoporin domain meshworks - Implications for nuclear pore permeability. Biophys J (2013) 0.86
Feasibility and acceptability of point of care HIV testing in community outreach and GUM drop-in services in the North West of England: a programmatic evaluation. BMC Public Health (2011) 0.85
Histones to the cytosol: exportin 7 is essential for normal terminal erythroid nuclear maturation. Blood (2014) 0.83
Facile hydrothermal preparation of titanium dioxide decorated reduced graphene oxide nanocomposite. Int J Nanomedicine (2012) 0.82
Prazosin, an α(1)-adrenoceptor antagonist, prevents memory deterioration in the APP23 transgenic mouse model of Alzheimer's disease. Neurobiol Aging (2012) 0.80
Anti-infective activity of apolipoprotein domain derived peptides in vitro: identification of novel antimicrobial peptides related to apolipoprotein B with anti-HIV activity. BMC Immunol (2010) 0.79
c-Jun localizes to the nucleus independent of its phosphorylation by and interaction with JNK and vice versa promotes nuclear accumulation of JNK. Biochem Biophys Res Commun (2011) 0.79
Comparison of batch mode and dynamic physiologically based bioaccessibility tests for PAHs in soil samples. Environ Sci Technol (2010) 0.78
Dynamically biased RRKM model of activated gas-surface reactivity: vibrational efficacy and rotation as a spectator in the dissociative chemisorption of CH4 on Pt(111). Phys Chem Chem Phys (2011) 0.75
Effusive molecular beam study of C2H6 dissociation on Pt(111). J Phys Chem B (2006) 0.75
Using effusive molecular beams and microcanonical unimolecular rate theory to characterize CH4 dissociation on Pt(111). J Phys Chem B (2006) 0.75
Microencapsulated fragrances in melamine formaldehyde resins. Chimia (Aarau) (2011) 0.75
Microcanonical transition state theory for activated gas-surface reaction dynamics: application to H2/CU(111) with rotation as a spectator. J Phys Chem A (2007) 0.75
Dissociative chemisorption and energy transfer for methane on Ir(111). J Phys Chem B (2005) 0.75
Nonequilibrium activated dissociative chemisorption: SiH4 on Si(100). J Phys Chem B (2005) 0.75
Correction: Nanobodies: site-specific labeling for super-resolution imaging, rapid epitope-mapping and native protein complex isolation. Elife (2016) 0.75