Published in Mol Cell Biol on November 01, 1997
STAT3 is constitutively phosphorylated on serine 727 residues, binds DNA, and activates transcription in CLL cells. Blood (2010) 2.48
Regulation of c-myc expression by IFN-gamma through Stat1-dependent and -independent pathways. EMBO J (2000) 2.11
Stress-induced phosphorylation of STAT1 at Ser727 requires p38 mitogen-activated protein kinase whereas IFN-gamma uses a different signaling pathway. Proc Natl Acad Sci U S A (1999) 1.72
Stat1 combines signals derived from IFN-gamma and LPS receptors during macrophage activation. EMBO J (1998) 1.71
Ser727-dependent recruitment of MCM5 by Stat1alpha in IFN-gamma-induced transcriptional activation. EMBO J (1998) 1.68
Specificity of signaling by STAT1 depends on SH2 and C-terminal domains that regulate Ser727 phosphorylation, differentially affecting specific target gene expression. EMBO J (2001) 1.59
Collaboration of signal transducer and activator of transcription 1 (STAT1) and BRCA1 in differential regulation of IFN-gamma target genes. Proc Natl Acad Sci U S A (2000) 1.57
Rapid inhibition of interleukin-6 signaling and Stat3 activation mediated by mitogen-activated protein kinases. Proc Natl Acad Sci U S A (1998) 1.56
Recruitment of Stat1 to chromatin is required for interferon-induced serine phosphorylation of Stat1 transactivation domain. Proc Natl Acad Sci U S A (2008) 1.43
Protein tyrosine kinase Pyk2 mediates the Jak-dependent activation of MAPK and Stat1 in IFN-gamma, but not IFN-alpha, signaling. EMBO J (1999) 1.23
The Fanconi anemia protein FANCC binds to and facilitates the activation of STAT1 by gamma interferon and hematopoietic growth factors. Mol Cell Biol (2000) 1.23
Inhibition of protein phosphatase 2A induces serine/threonine phosphorylation, subcellular redistribution, and functional inhibition of STAT3. Proc Natl Acad Sci U S A (1999) 1.22
Identification of two residues in MCM5 critical for the assembly of MCM complexes and Stat1-mediated transcription activation in response to IFN-gamma. Proc Natl Acad Sci U S A (2001) 1.22
Stat1-dependent, p53-independent expression of p21(waf1) modulates oxysterol-induced apoptosis. Mol Cell Biol (2002) 1.03
A Mutation in the SH2 domain of STAT2 prolongs tyrosine phosphorylation of STAT1 and promotes type I IFN-induced apoptosis. Mol Biol Cell (2007) 1.01
The induction of lipocalin-2 protein expression in vivo and in vitro. J Biol Chem (2014) 1.00
The linker domain of Stat1 is required for gamma interferon-driven transcription. Mol Cell Biol (1999) 0.99
Mast cell homeostasis and the JAK-STAT pathway. Genes Immun (2010) 0.94
Respiratory syncytial virus impairs macrophage IFN-alpha/beta- and IFN-gamma-stimulated transcription by distinct mechanisms. Am J Respir Cell Mol Biol (2009) 0.93
Thyroid hormone promotes the phosphorylation of STAT3 and potentiates the action of epidermal growth factor in cultured cells. Biochem J (1999) 0.91
Cross-talk between STAT1 and PI3K/AKT signaling in HIV-1-induced blood-brain barrier dysfunction: role of CCR5 and implications for viral neuropathogenesis. J Neurosci Res (2010) 0.91
Comparative study of the ability of Leishmania mexicana promastigotes and amastigotes to alter macrophage signaling and functions. Infect Immun (2010) 0.90
Toxoplasma gondii triggers phosphorylation and nuclear translocation of dendritic cell STAT1 while simultaneously blocking IFNγ-induced STAT1 transcriptional activity. PLoS One (2013) 0.89
Phosphorylation states of cell cycle and DNA repair proteins can be altered by the nsSNPs. BMC Cancer (2005) 0.88
Signal transducer and activator of transcription 1 negatively regulates constitutive gamma interferon-inducible lysosomal thiol reductase expression. Immunology (2010) 0.84
STAT2 phosphorylation and signaling. JAKSTAT (2013) 0.81
A Cytokine Signalling Network for the Regulation of Inducible Nitric Oxide Synthase Expression in Rheumatoid Arthritis. PLoS One (2016) 0.80
Inhibitory effects of an aqueous extract from Cortex Phellodendri on the growth and replication of broad-spectrum of viruses in vitro and in vivo. BMC Complement Altern Med (2016) 0.78
Parainfluenza Virus 3 Blocks Antiviral Mediators Downstream of the Interferon Lambda Receptor by Modulating Stat1 Phosphorylation. J Virol (2015) 0.77
Role of STAT1 in the breast. JAKSTAT (2012) 0.76
The role of JAK-STAT signaling pathway and its regulators in the fate of T helper cells. Cell Commun Signal (2017) 0.75
Systems Biological Approaches Reveal Non-additive Responses and Multiple Crosstalk Mechanisms between TLR and GPCR Signaling. Genomics Inform (2012) 0.75
Tannic acid inhibits EGFR/STAT1/3 and enhances p38/STAT1 signalling axis in breast cancer cells. J Cell Mol Med (2016) 0.75
Diptoindonesin G promotes ERK-mediated nuclear translocation of p-STAT1 (Ser727) and cell differentiation in AML cells. Cell Death Dis (2017) 0.75
Crosstalk between STAT5 activation and PI3K/AKT functions in normal and transformed mammary epithelial cells. Mol Cell Endocrinol (2017) 0.75
Stat3: a STAT family member activated by tyrosine phosphorylation in response to epidermal growth factor and interleukin-6. Science (1994) 11.33
Maximal activation of transcription by Stat1 and Stat3 requires both tyrosine and serine phosphorylation. Cell (1995) 10.16
The bisindolylmaleimide GF 109203X is a potent and selective inhibitor of protein kinase C. J Biol Chem (1991) 8.92
Transcriptional responses to polypeptide ligands: the JAK-STAT pathway. Annu Rev Biochem (1995) 8.52
Interferon activation of the transcription factor Stat91 involves dimerization through SH2-phosphotyrosyl peptide interactions. Cell (1994) 5.79
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Wortmannin is a potent phosphatidylinositol 3-kinase inhibitor: the role of phosphatidylinositol 3,4,5-trisphosphate in neutrophil responses. Biochem J (1993) 5.53
The protein tyrosine kinase JAK1 complements defects in interferon-alpha/beta and -gamma signal transduction. Nature (1993) 5.24
Biological and biochemical properties of human rasH genes mutated at codon 61. Cell (1986) 5.05
Complementation of a mutant cell line: central role of the 91 kDa polypeptide of ISGF3 in the interferon-alpha and -gamma signal transduction pathways. EMBO J (1993) 4.35
Complementation by the protein tyrosine kinase JAK2 of a mutant cell line defective in the interferon-gamma signal transduction pathway. Nature (1993) 4.20
Definition of a consensus sequence for peptide substrate recognition by p44mpk, the meiosis-activated myelin basic protein kinase. J Biol Chem (1991) 3.70
Use of a selectable marker regulated by alpha interferon to obtain mutations in the signaling pathway. Mol Cell Biol (1989) 3.49
Identification of substrate recognition determinants for human ERK1 and ERK2 protein kinases. J Biol Chem (1991) 3.37
Requirement of serine phosphorylation for formation of STAT-promoter complexes. Science (1995) 3.07
Ligand-induced IFN gamma receptor tyrosine phosphorylation couples the receptor to its signal transduction system (p91). EMBO J (1994) 2.82
Mapping of Stat3 serine phosphorylation to a single residue (727) and evidence that serine phosphorylation has no influence on DNA binding of Stat1 and Stat3. Nucleic Acids Res (1997) 2.24
Phosphorylation and activation of the DNA binding activity of purified Stat1 by the Janus protein-tyrosine kinases and the epidermal growth factor receptor. J Biol Chem (1995) 1.72
Activation of STAT4 by IL-12 and IFN-alpha: evidence for the involvement of ligand-induced tyrosine and serine phosphorylation. J Immunol (1996) 1.68
Formation of STAT1-STAT2 heterodimers and their role in the activation of IRF-1 gene transcription by interferon-alpha. J Biol Chem (1996) 1.65
STAT3 activation by cytokines utilizing gp130 and related transducers involves a secondary modification requiring an H7-sensitive kinase. Proc Natl Acad Sci U S A (1995) 1.65
Early events in signalling by interferons. Trends Biochem Sci (1993) 1.50
Interleukin-2 activation of STAT5 requires the convergent action of tyrosine kinases and a serine/threonine kinase pathway distinct from the Raf1/ERK2 MAP kinase pathway. EMBO J (1996) 1.40
Hydrolysis of phosphatidylcholine is stimulated by Ras proteins during mitogenic signal transduction. Mol Cell Biol (1992) 1.11
Multisite phosphorylation of microtubule-associated protein 2 (MAP-2) in rat brain: peptide mapping distinguishes between cyclic AMP-, calcium/calmodulin-, and calcium/phospholipid-regulated phosphorylation mechanisms. J Mol Neurosci (1989) 0.87
Stat3 as an oncogene. Cell (1999) 17.39
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Evidence for virus-specific noncapsid proteins in poliovirus-infected HeLa cells. Proc Natl Acad Sci U S A (1965) 11.84
Stat3: a STAT family member activated by tyrosine phosphorylation in response to epidermal growth factor and interleukin-6. Science (1994) 11.33
An adenylic acid-rich sequence in messenger RNA of HeLa cells and its possible relationship to reiterated sites in DNA. Proc Natl Acad Sci U S A (1971) 11.01
Polyadenylic acid sequences: role in conversion of nuclear RNA into messenger RNA. Science (1971) 10.54
Maximal activation of transcription by Stat1 and Stat3 requires both tyrosine and serine phosphorylation. Cell (1995) 10.16
Variety in the level of gene control in eukaryotic cells. Nature (1982) 9.61
Transcriptional control in the production of liver-specific mRNAs. Cell (1981) 9.35
Transcriptional responses to polypeptide ligands: the JAK-STAT pathway. Annu Rev Biochem (1995) 8.52
A single phosphotyrosine residue of Stat91 required for gene activation by interferon-gamma. Science (1993) 6.44
The role of STATs in transcriptional control and their impact on cellular function. Oncogene (2000) 6.42
Steps in the processing of Ad2 mRNA: poly(A)+ nuclear sequences are conserved and poly(A) addition precedes splicing. Cell (1978) 6.36
Liver-enriched transcription factor HNF-4 is a novel member of the steroid hormone receptor superfamily. Genes Dev (1990) 6.33
Ribonucleic acids from animal cells. Bacteriol Rev (1968) 6.13
Interferon-dependent tyrosine phosphorylation of a latent cytoplasmic transcription factor. Science (1992) 6.09
Interferon-induced nuclear factors that bind a shared promoter element correlate with positive and negative transcriptional control. Genes Dev (1988) 6.08
Aspects of the synthesis of poliovirus RNA and the formation of virus particles. Virology (1966) 5.85
Interferon activation of the transcription factor Stat91 involves dimerization through SH2-phosphotyrosyl peptide interactions. Cell (1994) 5.79
The primary transcription unit of the mouse beta-major globin gene. Cell (1981) 5.75
Activation of transcription by IFN-gamma: tyrosine phosphorylation of a 91-kD DNA binding protein. Science (1992) 5.71
Proteins of transcription factor ISGF-3: one gene encodes the 91-and 84-kDa ISGF-3 proteins that are activated by interferon alpha. Proc Natl Acad Sci U S A (1992) 5.50
Cytoplasmic activation of ISGF3, the positive regulator of interferon-alpha-stimulated transcription, reconstituted in vitro. Genes Dev (1989) 5.09
Choice of STATs and other substrates specified by modular tyrosine-based motifs in cytokine receptors. Science (1995) 4.90
Leptin activation of Stat3 in the hypothalamus of wild-type and ob/ob mice but not db/db mice. Nat Genet (1996) 4.84
Transcriptional induction of two genes in human cells by beta interferon. Proc Natl Acad Sci U S A (1984) 4.84
Rapidly labeled HeLa cell nuclear RNA. I. Identification by zone sedimentation of a heterogeneous fraction separate from ribosomal precursor RNA. J Mol Biol (1966) 4.83
The initiation sites for RNA transcription in Ad2 DNA. Cell (1977) 4.76
A common nuclear signal transduction pathway activated by growth factor and cytokine receptors. Science (1993) 4.65
Interferon-induced transcription of a gene encoding a 15-kDa protein depends on an upstream enhancer element. Proc Natl Acad Sci U S A (1987) 4.61
Identification of the membrane protein and "core" protein of Sindbis virus. Proc Natl Acad Sci U S A (1968) 4.52
Addition of polyadenylate sequences to virus-specific RNA during adenovirus replication. Proc Natl Acad Sci U S A (1971) 4.48
Multiple hepatocyte-enriched nuclear factors function in the regulation of transthyretin and alpha 1-antitrypsin genes. Mol Cell Biol (1989) 4.47
Characterization of a new low molecular weight RNA in HeLa cell ribosomes. J Mol Biol (1968) 4.44
Sindbis virus infection of chick and hamster cells: synthesis of virus-specific proteins. Virology (1969) 4.38
Complementation of a mutant cell line: central role of the 91 kDa polypeptide of ISGF3 in the interferon-alpha and -gamma signal transduction pathways. EMBO J (1993) 4.35
The definition of a large viral transcription unit late in Ad2 infection of HeLa cells: mapping by effects of ultraviolet irradiation. Cell (1977) 4.13
ISGF3, the transcriptional activator induced by interferon alpha, consists of multiple interacting polypeptide chains. Proc Natl Acad Sci U S A (1990) 4.11
A STAT protein domain that determines DNA sequence recognition suggests a novel DNA-binding domain. Genes Dev (1995) 4.11
Stat3 activation is required for cellular transformation by v-src. Mol Cell Biol (1998) 4.09
A transcriptional hierarchy involved in mammalian cell-type specification. Nature (1992) 4.08
Biogenesis of mRNA: genetic regulation in mammalian cells. Science (1973) 4.01
Hepatocyte nuclear factor 3 alpha belongs to a gene family in mammals that is homologous to the Drosophila homeotic gene fork head. Genes Dev (1991) 4.01
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Subunit of an alpha-interferon-responsive transcription factor is related to interferon regulatory factor and Myb families of DNA-binding proteins. Mol Cell Biol (1992) 3.90
Crystal structure of a tyrosine phosphorylated STAT-1 dimer bound to DNA. Cell (1998) 3.79
Disruption of the HNF-4 gene, expressed in visceral endoderm, leads to cell death in embryonic ectoderm and impaired gastrulation of mouse embryos. Genes Dev (1994) 3.76
The proteins of ISGF-3, the interferon alpha-induced transcriptional activator, define a gene family involved in signal transduction. Proc Natl Acad Sci U S A (1992) 3.74
Polypeptide signalling to the nucleus through tyrosine phosphorylation of Jak and Stat proteins. Nature (1993) 3.73
The winged-helix transcription factor HNF-3 beta is required for notochord development in the mouse embryo. Cell (1994) 3.71
Production of mRNA in Chinese hamster cells: relationship of the rate of synthesis to the cytoplasmic concentration of nine specific mRNA sequences. Cell (1979) 3.67
Transcriptional induction by interferon. New protein(s) determine the extent and length of the induction. J Biol Chem (1986) 3.63
Transcriptionally active Stat1 is required for the antiproliferative effects of both interferon alpha and interferon gamma. Proc Natl Acad Sci U S A (1996) 3.62
HNF-3A, a hepatocyte-enriched transcription factor of novel structure is regulated transcriptionally. Genes Dev (1990) 3.50
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The decrease in size and synthetic activity of poliovirus polysomes late in the infectious cycle. Virology (1967) 3.41
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Implications of RNA-RNA splicing in evolution of eukaryotic cells. Science (1978) 3.39
The turnover of nuclear DNA-like RNA in HeLa cells. J Cell Biol (1968) 3.39
A poly(A) addition site and a downstream termination region are required for efficient cessation of transcription by RNA polymerase II in the mouse beta maj-globin gene. Proc Natl Acad Sci U S A (1987) 3.38
Interleukin 12 signaling in T helper type 1 (Th1) cells involves tyrosine phosphorylation of signal transducer and activator of transcription (Stat)3 and Stat4. J Exp Med (1995) 3.37
The definition of a large viral transcription unit late in Ad2 infection of HeLa cells: mapping of nascent RNA molecules labeled in isolated nuclei. Cell (1977) 3.32
Purification and cloning of interferon-stimulated gene factor 2 (ISGF2): ISGF2 (IRF-1) can bind to the promoters of both beta interferon- and interferon-stimulated genes but is not a primary transcriptional activator of either. Mol Cell Biol (1990) 3.31
Cytoplasmic activation of GAF, an IFN-gamma-regulated DNA-binding factor. EMBO J (1991) 3.28
Two contact regions between Stat1 and CBP/p300 in interferon gamma signaling. Proc Natl Acad Sci U S A (1996) 3.26
Effect of adenovirus on metabolism of specific host mRNAs: transport control and specific translational discrimination. Mol Cell Biol (1983) 3.25
Rapidly labeled HeLa cell nuclear RNA. II. Base composition and cellular localization of a heterogeneous RNA fraction. J Mol Biol (1966) 3.22
Double-stranded regions in heterogeneous nuclear RNA from Hela cells. Proc Natl Acad Sci U S A (1972) 3.21
Biogenesis and characterization of histone messenger RNA in HeLa cells. J Mol Biol (1972) 3.14
Polyadenylic acid segment in mRNA becomes shorter with age. Nat New Biol (1973) 3.09
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SV40-specific RNA in the nucleus and polyribosomes of transformed cells. Proc Natl Acad Sci U S A (1970) 3.05
Adenovirus E1B proteins are required for accumulation of late viral mRNA and for effects on cellular mRNA translation and transport. Mol Cell Biol (1985) 3.04
Methylated, blocked 5 termini in HeLa cell mRNA. Proc Natl Acad Sci U S A (1975) 3.02
Changes in liver-specific compared to common gene transcription during primary culture of mouse hepatocytes. Mol Cell Biol (1983) 3.01
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Regulation of the primary expression of the early adenovirus transcription units. J Virol (1979) 2.92
Spacing of palindromic half sites as a determinant of selective STAT (signal transducers and activators of transcription) DNA binding and transcriptional activity. Proc Natl Acad Sci U S A (1995) 2.92
Identification of a Stat gene that functions in Drosophila development. Cell (1996) 2.90
Expression of transcription factor HNF-4 in the extraembryonic endoderm, gut, and nephrogenic tissue of the developing mouse embryo: HNF-4 is a marker for primary endoderm in the implanting blastocyst. Proc Natl Acad Sci U S A (1994) 2.85
Stat3 and Stat4: members of the family of signal transducers and activators of transcription. Proc Natl Acad Sci U S A (1994) 2.81
Synergistic interaction between interferon-alpha and interferon-gamma through induced synthesis of one subunit of the transcription factor ISGF3. EMBO J (1990) 2.75
Globin RNA transcription: a possible termination site and demonstration of transcriptional control correlated with altered chromatin structure. Cell (1982) 2.72
Antagonism between apolipoprotein AI regulatory protein 1, Ear3/COUP-TF, and hepatocyte nuclear factor 4 modulates apolipoprotein CIII gene expression in liver and intestinal cells. Mol Cell Biol (1992) 2.72
Overlapping elements in the guanylate-binding protein gene promoter mediate transcriptional induction by alpha and gamma interferons. Mol Cell Biol (1991) 2.71
Processing of adenovirus specific nuclear RNA during virus replication. Virology (1972) 2.71
A liver-specific DNA-binding protein recognizes multiple nucleotide sites in regulatory regions of transthyretin, alpha 1-antitrypsin, albumin, and simian virus 40 genes. Proc Natl Acad Sci U S A (1988) 2.71
The effects of methionine deprivation on ribosome synthesis in HeLa cells. Proc Natl Acad Sci U S A (1967) 2.66
Further evidence on the nuclear origin and transfer to the cytoplasm of polyadenylic acid sequences in mammalian cell RNA. J Mol Biol (1973) 2.61
The inhibition by DRB (5,6-dichloro-1-beta-D-ribofuranosylbenzimidazole) of hnRNA and mRNA production in HeLa cells. Cell (1976) 2.60
Two interferon-induced nuclear factors bind a single promoter element in interferon-stimulated genes. Proc Natl Acad Sci U S A (1988) 2.58
The rapid inactivation of nuclear tyrosine phosphorylated Stat1 depends upon a protein tyrosine phosphatase. EMBO J (1996) 2.50
Hepatocyte nuclear factor 3/fork head or "winged helix" proteins: a family of transcription factors of diverse biologic function. Proc Natl Acad Sci U S A (1993) 2.47
Carbohydrate content of the membrane protein of Sindbis virus. J Mol Biol (1970) 2.45
Transcriptional control of the mouse prealbumin (transthyretin) gene: both promoter sequences and a distinct enhancer are cell specific. Mol Cell Biol (1986) 2.43