PubRank

D W Cleveland

Author PubWeight™ 394.31‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Peptide mapping by limited proteolysis in sodium dodecyl sulfate and analysis by gel electrophoresis. J Biol Chem 1977 72.51
2 Number and evolutionary conservation of alpha- and beta-tubulin and cytoplasmic beta- and gamma-actin genes using specific cloned cDNA probes. Cell 1980 17.55
3 High level transient expression of a chloramphenicol acetyl transferase gene by DEAE-dextran mediated DNA transfection coupled with a dimethyl sulfoxide or glycerol shock treatment. Nucleic Acids Res 1984 10.40
4 CENP-E is a plus end-directed kinetochore motor required for metaphase chromosome alignment. Cell 1997 8.08
5 Wild-type nonneuronal cells extend survival of SOD1 mutant motor neurons in ALS mice. Science 2003 6.35
6 ALS-linked SOD1 mutant G85R mediates damage to astrocytes and promotes rapidly progressive disease with SOD1-containing inclusions. Neuron 1997 6.16
7 An adverse property of a familial ALS-linked SOD1 mutation causes motor neuron disease characterized by vacuolar degeneration of mitochondria. Neuron 1995 6.03
8 Nucleotide and corresponding amino acid sequences encoded by alpha and beta tubulin mRNAs. Nature 1981 5.65
9 CENP-E is a putative kinetochore motor that accumulates just before mitosis. Nature 1992 5.54
10 Aggregation and motor neuron toxicity of an ALS-linked SOD1 mutant independent from wild-type SOD1. Science 1998 5.23
11 A complex of NuMA and cytoplasmic dynein is essential for mitotic spindle assembly. Cell 1996 5.10
12 Dynactin, a conserved, ubiquitously expressed component of an activator of vesicle motility mediated by cytoplasmic dynein. J Cell Biol 1991 5.02
13 A structural scaffolding of intermediate filaments in health and disease. Science 1998 4.70
14 Physical and chemical properties of purified tau factor and the role of tau in microtubule assembly. J Mol Biol 1977 4.60
15 Molecular cloning of cDNA for CENP-B, the major human centromere autoantigen. J Cell Biol 1987 4.50
16 Purification of tau, a microtubule-associated protein that induces assembly of microtubules from purified tubulin. J Mol Biol 1977 4.42
17 CENP-E, a novel human centromere-associated protein required for progression from metaphase to anaphase. EMBO J 1991 4.22
18 CENP-E forms a link between attachment of spindle microtubules to kinetochores and the mitotic checkpoint. Nat Cell Biol 2000 3.96
19 Waiting for anaphase: Mad2 and the spindle assembly checkpoint. Cell 2000 3.88
20 Gamma-tubulin is a centrosomal protein required for cell cycle-dependent microtubule nucleation. Nature 1992 3.87
21 Unpolymerized tubulin modulates the level of tubulin mRNAs. Cell 1981 3.78
22 Autoregulated instability of beta-tubulin mRNAs by recognition of the nascent amino terminus of beta-tubulin. Nature 1988 3.57
23 Superoxide dismutase 1 with mutations linked to familial amyotrophic lateral sclerosis possesses significant activity. Proc Natl Acad Sci U S A 1994 3.36
24 The expression and posttranslational modification of a neuron-specific beta-tubulin isotype during chick embryogenesis. Cell Motil Cytoskeleton 1990 3.25
25 Formation of spindle poles by dynein/dynactin-dependent transport of NuMA. J Cell Biol 2000 3.23
26 Mps1 is a kinetochore-associated kinase essential for the vertebrate mitotic checkpoint. Cell 2001 3.16
27 Evidence for instability of mRNAs containing AUUUA motifs mediated through translation-dependent assembly of a > 20S degradation complex. Genes Dev 1992 3.14
28 Molecular biology and genetics of tubulin. Annu Rev Biochem 1985 3.14
29 Expression of human alpha-tubulin genes: interspecies conservation of 3' untranslated regions. Mol Cell Biol 1983 2.85
30 Two distinct classes of keratin genes and their evolutionary significance. Cell 1981 2.84
31 Peptide mapping in one dimension by limited proteolysis of sodium dodecyl sulfate-solubilized proteins. Methods Enzymol 1983 2.82
32 Slowing of axonal transport is a very early event in the toxicity of ALS-linked SOD1 mutants to motor neurons. Nat Neurosci 1999 2.81
33 The microtubule-dependent motor centromere-associated protein E (CENP-E) is an integral component of kinetochore corona fibers that link centromeres to spindle microtubules. J Cell Biol 1997 2.77
34 Identification of conserved isotype-defining variable region sequences for four vertebrate beta tubulin polypeptide classes. Proc Natl Acad Sci U S A 1986 2.71
35 Toxicity of ALS-linked SOD1 mutants. Science 2000 2.69
36 Intracellular localization of the high molecular weight microtubule accessory protein by indirect immunofluorescence. J Cell Biol 1978 2.53
37 Immunoflourescent staining of cytoplasmic and spindle microtubules in mouse fibroblasts with antibody to tau protein. Proc Natl Acad Sci U S A 1977 2.41
38 Increased expression of neurofilament subunit NF-L produces morphological alterations that resemble the pathology of human motor neuron disease. Cell 1993 2.40
39 CENP-E as an essential component of the mitotic checkpoint in vitro. Cell 2000 2.40
40 cDNA cloning of human DNA topoisomerase I: catalytic activity of a 67.7-kDa carboxyl-terminal fragment. Proc Natl Acad Sci U S A 1988 2.38
41 Neurofilament gene expression: a major determinant of axonal caliber. Proc Natl Acad Sci U S A 1987 2.36
42 In vivo microtubules are copolymers of available beta-tubulin isotypes: localization of each of six vertebrate beta-tubulin isotypes using polyclonal antibodies elicited by synthetic peptide antigens. J Cell Biol 1987 2.30
43 Primary structure of NuMA, an intranuclear protein that defines a novel pathway for segregation of proteins at mitosis. J Cell Biol 1992 2.21
44 Autoregulation of tubulin expression is achieved through specific degradation of polysomal tubulin mRNAs. Cell 1987 2.13
45 Esperanto for histones: CENP-A, not CenH3, is the centromeric histone H3 variant. Chromosome Res 2013 2.12
46 Superoxide dismutase is an abundant component in cell bodies, dendrites, and axons of motor neurons and in a subset of other neurons. Proc Natl Acad Sci U S A 1995 2.12
47 Identification of novel centromere/kinetochore-associated proteins using monoclonal antibodies generated against human mitotic chromosome scaffolds. J Cell Biol 1991 2.10
48 Pathways of spindle pole formation: different mechanisms; conserved components. J Cell Biol 1997 2.10
49 An essential cytoskeletal linker protein connecting actin microfilaments to intermediate filaments. Cell 1996 2.09
50 Sequences that confer beta-tubulin autoregulation through modulated mRNA stability reside within exon 1 of a beta-tubulin mRNA. Cell 1987 2.09
51 NuMA is required for the proper completion of mitosis. J Cell Biol 1993 2.04
52 Cyclin-like accumulation and loss of the putative kinetochore motor CENP-E results from coupling continuous synthesis with specific degradation at the end of mitosis. J Cell Biol 1994 2.00
53 Tubulin requires tau for growth onto microtubule initiating sites. Proc Natl Acad Sci U S A 1976 1.91
54 Four unique genes required for beta tubulin expression in vertebrates. Cell 1983 1.90
55 Is apparent autoregulatory control of tubulin synthesis nontranscriptionally regulated? J Cell Biol 1983 1.88
56 Autoregulatory control of beta-tubulin mRNA stability is linked to translation elongation. Proc Natl Acad Sci U S A 1989 1.87
57 Specificity of RNA maturation pathways: RNAs transcribed by RNA polymerase III are not substrates for splicing or polyadenylation. Mol Cell Biol 1987 1.83
58 Neurofilaments are obligate heteropolymers in vivo. J Cell Biol 1993 1.82
59 Autoregulated changes in stability of polyribosome-bound beta-tubulin mRNAs are specified by the first 13 translated nucleotides. Mol Cell Biol 1988 1.80
60 Neuronal intermediate filaments. Annu Rev Neurosci 1996 1.78
61 Isolation of separate mRNAs for alpha- and beta-tubulin and characterization of the corresponding in vitro translation products. Cell 1978 1.73
62 Caspase-1 and -3 are sequentially activated in motor neuron death in Cu,Zn superoxide dismutase-mediated familial amyotrophic lateral sclerosis. Proc Natl Acad Sci U S A 2000 1.72
63 A dispersed multigene family encoding tubulin in Drosophila melanogaster. Cell 1980 1.70
64 Elevation of tubulin levels by microinjection suppresses new tubulin synthesis. Nature 1983 1.68
65 Variation in the biochemical/biophysical properties of mutant superoxide dismutase 1 enzymes and the rate of disease progression in familial amyotrophic lateral sclerosis kindreds. Hum Mol Genet 1999 1.62
66 Going new places using an old MAP: tau, microtubules and human neurodegenerative disease. Curr Opin Cell Biol 2001 1.62
67 Autoregulated instability of tubulin mRNAs: a novel eukaryotic regulatory mechanism. Trends Biochem Sci 1988 1.61
68 The kinesin-like protein CENP-E is kinetochore-associated throughout poleward chromosome segregation during anaphase-A. J Cell Sci 1996 1.59
69 A monoclonal antibody against the type II isotype of beta-tubulin. Preparation of isotypically altered tubulin. J Biol Chem 1988 1.55
70 Caspase-1 is activated in neural cells and tissue with amyotrophic lateral sclerosis-associated mutations in copper-zinc superoxide dismutase. Proc Natl Acad Sci U S A 1998 1.55
71 Differential utilization of beta-tubulin isotypes in differentiating neurites. J Cell Biol 1989 1.54
72 The multitubulin hypothesis revisited: what have we learned? J Cell Biol 1987 1.50
73 Physical evidence for cotranslational regulation of beta-tubulin mRNA degradation. Mol Cell Biol 1992 1.49
74 Regional modulation of neurofilament organization by myelination in normal axons. J Neurosci 1994 1.49
75 Programmed expression of beta-tubulin genes during development and differentiation of the chicken. J Cell Biol 1984 1.48
76 A mutant neurofilament subunit causes massive, selective motor neuron death: implications for the pathogenesis of human motor neuron disease. Neuron 1994 1.46
77 Characterization of dominant and recessive assembly-defective mutations in mouse neurofilament NF-M. J Cell Biol 1990 1.45
78 Superoxide dismutase 1 subunits with mutations linked to familial amyotrophic lateral sclerosis do not affect wild-type subunit function. J Biol Chem 1995 1.45
79 A rapidly rearranging retrotransposon within the miniexon gene locus of Crithidia fasciculata. Mol Cell Biol 1990 1.41
80 Subunit composition of neurofilaments specifies axonal diameter. J Cell Biol 1996 1.39
81 Elevated free nitrotyrosine levels, but not protein-bound nitrotyrosine or hydroxyl radicals, throughout amyotrophic lateral sclerosis (ALS)-like disease implicate tyrosine nitration as an aberrant in vivo property of one familial ALS-linked superoxide dismutase 1 mutant. Proc Natl Acad Sci U S A 1997 1.39
82 Multiple alpha and beta tubulin genes represent unlinked and dispersed gene families. J Biol Chem 1981 1.38
83 CENP-meta, an essential kinetochore kinesin required for the maintenance of metaphase chromosome alignment in Drosophila. J Cell Biol 2000 1.38
84 AU-A, an RNA-binding activity distinct from hnRNP A1, is selective for AUUUA repeats and shuttles between the nucleus and the cytoplasm. Nucleic Acids Res 1994 1.37
85 Sequence of a highly divergent beta tubulin gene reveals regional heterogeneity in the beta tubulin polypeptide. J Cell Biol 1984 1.37
86 Assembly properties of dominant and recessive mutations in the small mouse neurofilament (NF-L) subunit. J Cell Biol 1990 1.34
87 Characterization of DLC-A and DLC-B, two families of cytoplasmic dynein light chain subunits. Mol Biol Cell 1994 1.33
88 The tubulins: from DNA to RNA to protein and back again. Cell 1983 1.33
89 RNA polymerase specificity of mRNA production and enhancer action. Proc Natl Acad Sci U S A 1986 1.33
90 Conservation of microtubule associated proteins. Isolation and characterization of tau and the high molecular weight microtubule associated protein from chicken brain and from mouse fibroblasts and comparison to the corresponding mammalian brain proteins. J Biol Chem 1979 1.32
91 Beyond nuclear transport. Ran-GTP as a determinant of spindle assembly. J Cell Biol 1999 1.31
92 New consensus research on neuropathological aspects of familial amyotrophic lateral sclerosis with superoxide dismutase 1 (SOD1) gene mutations: inclusions containing SOD1 in neurons and astrocytes. Amyotroph Lateral Scler Other Motor Neuron Disord 2000 1.29
93 Increasing neurofilament subunit NF-M expression reduces axonal NF-H, inhibits radial growth, and results in neurofilamentous accumulation in motor neurons. J Cell Biol 1995 1.25
94 Expression of NF-L in both neuronal and nonneuronal cells of transgenic mice: increased neurofilament density in axons without affecting caliber. J Cell Biol 1990 1.24
95 Retention of autoregulatory control of tubulin synthesis in cytoplasts: demonstration of a cytoplasmic mechanism that regulates the level of tubulin expression. J Cell Biol 1985 1.23
96 Absence of neurofilaments reduces the selective vulnerability of motor neurons and slows disease caused by a familial amyotrophic lateral sclerosis-linked superoxide dismutase 1 mutant. Proc Natl Acad Sci U S A 1998 1.23
97 Local control of neurofilament accumulation during radial growth of myelinating axons in vivo. Selective role of site-specific phosphorylation. J Cell Biol 2000 1.22
98 Glycosylation of mammalian neurofilaments. Localization of multiple O-linked N-acetylglucosamine moieties on neurofilament polypeptides L and M. J Biol Chem 1993 1.21
99 The role of NuMA in the interphase nucleus. J Cell Sci 1998 1.21
100 Chaperone-facilitated copper binding is a property common to several classes of familial amyotrophic lateral sclerosis-linked superoxide dismutase mutants. Proc Natl Acad Sci U S A 1998 1.21
101 Analysis of anticentromere autoantibodies using cloned autoantigen CENP-B. Proc Natl Acad Sci U S A 1987 1.20
102 Apparent gene conversion between beta-tubulin genes yields multiple regulatory pathways for a single beta-tubulin polypeptide isotype. Mol Cell Biol 1985 1.20
103 Neurofilament subunit NF-H modulates axonal diameter by selectively slowing neurofilament transport. J Cell Biol 1996 1.20
104 NuMA, a nuclear protein involved in mitosis and nuclear reformation. Curr Opin Cell Biol 1994 1.20
105 Sequence and expression of the chicken beta 3 tubulin gene. A vertebrate testis beta-tubulin isotype. J Biol Chem 1986 1.19
106 Surprising S1-resistant trimolecular hybrids: potential complication in interpretation of S1 mapping analyses. Mol Cell Biol 1985 1.19
107 The rod domain of NF-L determines neurofilament architecture, whereas the end domains specify filament assembly and network formation. J Cell Biol 1993 1.16
108 Neurofilament-dependent radial growth of motor axons and axonal organization of neurofilaments does not require the neurofilament heavy subunit (NF-H) or its phosphorylation. J Cell Biol 1998 1.16
109 Axonal transport of mutant superoxide dismutase 1 and focal axonal abnormalities in the proximal axons of transgenic mice. Neurobiol Dis 1998 1.16
110 The copper chaperone CCS is abundant in neurons and astrocytes in human and rodent brain. J Neurochem 1999 1.13
111 Cytoplasmic O-GlcNAc modification of the head domain and the KSP repeat motif of the neurofilament protein neurofilament-H. J Biol Chem 1996 1.12
112 Sequence and expression of the chicken beta 5- and beta 4-tubulin genes define a pair of divergent beta-tubulins with complementary patterns of expression. Mol Cell Biol 1986 1.11
113 In vivo coassembly of a divergent beta-tubulin subunit (c beta 6) into microtubules of different function. J Cell Biol 1987 1.11
114 Protective effect of neurofilament heavy gene overexpression in motor neuron disease induced by mutant superoxide dismutase. Proc Natl Acad Sci U S A 1998 1.11
115 Glyceraldehyde 3-phosphate dehydrogenase protein and mRNA are both differentially expressed in adult chickens but not chick embryos. Nucleic Acids Res 1983 1.10
116 Expression of NF-L and NF-M in fibroblasts reveals coassembly of neurofilament and vimentin subunits. J Cell Biol 1989 1.10
117 An amino-terminal tetrapeptide specifies cotranslational degradation of beta-tubulin but not alpha-tubulin mRNAs. Mol Cell Biol 1994 1.07
118 Sequence of chicken c beta 7 tubulin. Analysis of a complete set of vertebrate beta-tubulin isotypes. J Mol Biol 1988 1.06
119 Neurofilament and tubulin expression recapitulates the developmental program during axonal regeneration: induction of a specific beta-tubulin isotype. Proc Natl Acad Sci U S A 1988 1.03
120 Intermediate filaments and their associated proteins: multiple dynamic personalities. Curr Opin Cell Biol 1998 1.03
121 Diversity among tubulin subunits: toward what functional end? Cell Motil Cytoskeleton 1990 1.03
122 Cell cycle. Some importin news about spindle assembly. Science 2001 1.02
123 The value of transgenic models for the study of neurodegenerative diseases. Ann N Y Acad Sci 2000 1.02
124 Oxidation versus aggregation - how do SOD1 mutants cause ALS? Nat Med 2000 1.01
125 The sequence and expression of the divergent beta-tubulin in chicken erythrocytes. J Biol Chem 1987 1.00
126 Neurofilament function and dysfunction: involvement in axonal growth and neuronal disease. Curr Opin Cell Biol 1994 0.98
127 CENP-E is an essential kinetochore motor in maturing oocytes and is masked during mos-dependent, cell cycle arrest at metaphase II. Proc Natl Acad Sci U S A 1997 0.97
128 A combination of RNase H and S1 nuclease circumvents an artefact inherent to conventional S1 analysis of RNA splicing. Nucleic Acids Res 1987 0.96
129 Pathogenesis of two axonopathies does not require axonal neurofilaments. Nature 1998 0.94
130 Attitudes and life commitments of older siblings of mentally retarded adults: an exploratory study. Ment Retard 1977 0.93
131 A divergent testis-specific alpha-tubulin isotype that does not contain a coded C-terminal tyrosine. Mol Cell Biol 1987 0.92
132 Reconstruction of appropriate tubulin and actin gene regulation after transient transfection of cloned beta-tubulin and beta-actin genes. Mol Cell Biol 1985 0.92
133 Mechanisms of selective motor neuron death in ALS: insights from transgenic mouse models of motor neuron disease. Neuropathol Appl Neurobiol 1996 0.92
134 Evidence of discontinuous transcription in the trypanosomatid Crithidia fasciculata. J Biol Chem 1987 0.90
135 Ferritin synthesis is controlled by iron-dependent translational derepression and by changes in synthesis/transport of nuclear ferritin RNAs. Proc Natl Acad Sci U S A 1993 0.90
136 Oxidative stress and iron are implicated in fragmenting vacuoles of Saccharomyces cerevisiae lacking Cu,Zn-superoxide dismutase. J Biol Chem 1999 0.89
137 Motor neurone disease and animal models. Neurobiol Dis 1994 0.89
138 Advanced glycation endproduct-modified superoxide dismutase-1 (SOD1)-positive inclusions are common to familial amyotrophic lateral sclerosis patients with SOD1 gene mutations and transgenic mice expressing human SOD1 with a G85R mutation. Acta Neuropathol 2000 0.89
139 Centromere identity, function, and epigenetic propagation across cell divisions. Cold Spring Harb Symp Quant Biol 2011 0.89
140 Autoregulatory control of expression of alpha and beta tubulin. J Submicrosc Cytol 1983 0.88
141 Toxic mutants in Charcot's sclerosis. Nature 1995 0.87
142 Cytoskeletal linkers: new MAPs for old destinations. Curr Biol 1999 0.87
143 Neurofilaments, radial growth of axons, and mechanisms of motor neuron disease. Cold Spring Harb Symp Quant Biol 1996 0.87
144 Formation of advanced glycation end-product-modified superoxide dismutase-1 (SOD1) is one of the mechanisms responsible for inclusions common to familial amyotrophic lateral sclerosis patients with SOD1 gene mutation, and transgenic mice expressing human SOD1 gene mutation. Neuropathology 2001 0.86
145 Involvement of neurofilaments in motor neuron disease. J Cell Sci Suppl 1993 0.86
146 In vivo discrimination among beta-tubulin isotypes: selective degradation of a type IV beta-tubulin isotype following overexpression in cultured animal cells. New Biol 1990 0.85
147 Use of molecular cloning methods to map the distribution of epitopes on topoisomerase I (Scl-70) recognized by sera of scleroderma patients. Arthritis Rheum 1990 0.84
148 Sequence variants in human neurofilament proteins: absence of linkage to familial amyotrophic lateral sclerosis. Ann Neurol 1996 0.84
149 A survey of the alpha-tubulin gene family in chicken: unexpected sequence heterogeneity in the polypeptides encoded by five expressed genes. EMBO J 1988 0.83
150 Tubulin site interpretation. Nature 1990 0.80
151 Neuronal intermediate filaments: new progress on an old subject. Curr Opin Neurobiol 1994 0.79
152 Reconstruction of tubulin gene regulation in cultured mammalian cells. Ann N Y Acad Sci 1986 0.78
153 Neurodegenerative diseases and model systems. Cold Spring Harb Symp Quant Biol 1996 0.77
154 Bcl-2 overexpression does not protect neurons from mutant neurofilament-mediated motor neuron degeneration. J Neurosci 1999 0.76
155 Hypoxia and Lou Gehrig. Nat Genet 2001 0.76
156 Treadmilling of tubulin and actin. Cell 1982 0.76
157 Forensic DNA typing. Science 1992 0.75
158 Motor neuron disease and model systems: aetiologies, mechanisms and therapies. Ciba Found Symp 1996 0.75
159 Going public. New Biol 1991 0.75
160 Post-transcriptional processes. Curr Opin Cell Biol 1992 0.75
161 A cellular structure: the cytoskeleton. Science 1986 0.75