A novel alpha integrin subunit associates with betaPS and functions in tissue morphogenesis and movement during Drosophila development.

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Published in Development on November 01, 1997

Authors

K A Stark1, G H Yee, C E Roote, E L Williams, S Zusman, R O Hynes

Author Affiliations

1: Howard Hughes Medical Institute and the Center for Cancer Research, Department of Biology, Massachusetts Institute of Technology, Cambridge 02139, USA.

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Fibronectins: multifunctional modular glycoproteins. J Cell Biol (1982) 8.05

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Defects in mesoderm, neural tube and vascular development in mouse embryos lacking fibronectin. Development (1993) 6.56

Id1 and Id3 are required for neurogenesis, angiogenesis and vascularization of tumour xenografts. Nature (1999) 6.50

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10 nm filaments in normal and transformed cells. Cell (1978) 4.77

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The structure of human thrombospondin, an adhesive glycoprotein with multiple calcium-binding sites and homologies with several different proteins. J Cell Biol (1986) 4.16

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Plakoglobin: a protein common to different kinds of intercellular adhering junctions. Cell (1986) 4.01

Thrombospondin-1 is required for normal murine pulmonary homeostasis and its absence causes pneumonia. J Clin Invest (1998) 4.00

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Control of alternative pre-mRNA splicing by distributed pentameric repeats. Proc Natl Acad Sci U S A (1997) 1.82

Hypoxia-induced exocytosis of endothelial cell Weibel-Palade bodies. A mechanism for rapid neutrophil recruitment after cardiac preservation. J Clin Invest (1996) 1.81

Fibronectin localization in the rat glomerulus. J Cell Biol (1980) 1.80

Mesodermal defects and cranial neural crest apoptosis in alpha5 integrin-null embryos. Development (1997) 1.75

Effects of LETS glycoprotein on cell motility. Cell (1978) 1.69

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Defects in hemostasis in P-selectin-deficient mice. Blood (1996) 1.64

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Ras activation is necessary for integrin-mediated activation of extracellular signal-regulated kinase 2 and cytosolic phospholipase A2 but not for cytoskeletal organization. J Biol Chem (1996) 1.62

A difference between plasma and cellular fibronectins located with monoclonal antibodies. Cell (1981) 1.62

Transformed mammalian cells secrete specific proteins and phosphoproteins. Cell (1979) 1.62

Effects of cytochalasin B and colchicine on attachment of a major surface protein of fibroblasts. Biochim Biophys Acta (1977) 1.61

Fibronectins. Sci Am (1986) 1.61

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Xenopus laevis integrins. Structural conservation and evolutionary divergence of integrin beta subunits. J Biol Chem (1988) 1.57

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Multiple, targeted deficiencies in selectins reveal a predominant role for P-selectin in leukocyte recruitment. Proc Natl Acad Sci U S A (1999) 1.55

Mesodermal development in mouse embryos mutant for fibronectin. Dev Dyn (1996) 1.55

Elements regulating an alternatively spliced exon of the rat fibronectin gene. Mol Cell Biol (1993) 1.54

Alpha4 integrins regulate the proliferation/differentiation balance of multilineage hematopoietic progenitors in vivo. Immunity (1999) 1.51

Overlapping and independent functions of fibronectin receptor integrins in early mesodermal development. Dev Biol (1999) 1.51

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On the origin of species of fibronectin. Proc Natl Acad Sci U S A (1985) 1.51

Alternative splicing of chicken fibronectin in embryos and in normal and transformed cells. Mol Cell Biol (1987) 1.51

Role of endothelial selectins in wound repair. Am J Pathol (1997) 1.50

Immunocytochemical localization of fibronectin in embryonic chick trunk and area vasculosa. Dev Biol (1981) 1.48