A PEST-like sequence mediates phosphorylation and efficient ubiquitination of yeast uracil permease.

PubWeight™: 1.58‹?› | Rank: Top 4%

🔗 View Article (PMC 121498)

Published in Mol Cell Biol on January 01, 1998

Authors

C Marchal1, R Haguenauer-Tsapis, D Urban-Grimal

Author Affiliations

1: Institut Jacques Monod, CNRS-UMRC9922, Université Paris 7-Denis Diderot, France.

Articles citing this

The TOR nutrient signalling pathway phosphorylates NPR1 and inhibits turnover of the tryptophan permease. EMBO J (1998) 3.54

Monoubiquitin carries a novel internalization signal that is appended to activated receptors. EMBO J (2000) 2.54

Arrestin-like proteins mediate ubiquitination and endocytosis of the yeast metal transporter Smf1. EMBO Rep (2008) 2.03

Direct sorting of the yeast uracil permease to the endosomal system is controlled by uracil binding and Rsp5p-dependent ubiquitylation. Mol Biol Cell (2003) 1.75

Deubiquitination step in the endocytic pathway of yeast plasma membrane proteins: crucial role of Doa4p ubiquitin isopeptidase. Mol Cell Biol (2001) 1.69

Zinc-regulated ubiquitin conjugation signals endocytosis of the yeast ZRT1 zinc transporter. Biochem J (2000) 1.66

Proteasome-mediated degradation of the papillomavirus E2-TA protein is regulated by phosphorylation and can modulate viral genome copy number. J Virol (2000) 1.48

Increased protein kinase or decreased PP2A activity bypasses sphingoid base requirement in endocytosis. EMBO J (2000) 1.41

Akr1p and the type I casein kinases act prior to the ubiquitination step of yeast endocytosis: Akr1p is required for kinase localization to the plasma membrane. Mol Cell Biol (2000) 1.41

Localization of the Rsp5p ubiquitin-protein ligase at multiple sites within the endocytic pathway. Mol Cell Biol (2001) 1.34

A large PEST-like sequence directs the ubiquitination, endocytosis, and vacuolar degradation of the yeast a-factor receptor. J Cell Biol (1998) 1.29

Uracil-induced down-regulation of the yeast uracil permease. J Bacteriol (1999) 1.26

A new family of high-affinity transporters for adenine, cytosine, and purine derivatives in Arabidopsis. Plant Cell (2000) 1.20

Glucose-induced ubiquitylation and endocytosis of the yeast Jen1 transporter: role of lysine 63-linked ubiquitin chains. J Biol Chem (2009) 1.15

WW domains of Rsp5p define different functions: determination of roles in fluid phase and uracil permease endocytosis in Saccharomyces cerevisiae. Genetics (2001) 1.12

Evidence for phosphorylation and ubiquitinylation of the turnip yellow mosaic virus RNA-dependent RNA polymerase domain expressed in a baculovirus-insect cell system. Biochem J (2000) 1.03

Phosphorylation of the yeast nitrate transporter Ynt1 is essential for delivery to the plasma membrane during nitrogen limitation. J Biol Chem (2008) 0.99

Quality control and substrate-dependent downregulation of the nutrient transporter Fur4. Traffic (2013) 0.98

The HPV16 E6 binding protein Tip-1 interacts with ARHGEF16, which activates Cdc42. Br J Cancer (2010) 0.96

Interaction of the deubiquitinating enzyme Ubp2 and the e3 ligase Rsp5 is required for transporter/receptor sorting in the multivesicular body pathway. PLoS One (2009) 0.92

Glc7-Reg1 phosphatase signals to Yck1,2 casein kinase 1 to regulate transport activity and glucose-induced inactivation of Saccharomyces maltose permease. Genetics (2005) 0.91

Role of casein kinase 1 in the glucose sensor-mediated signaling pathway in yeast. BMC Cell Biol (2010) 0.91

Release from myosin V via regulated recruitment of an E3 ubiquitin ligase controls organelle localization. Dev Cell (2014) 0.89

Rho5p is involved in mediating the osmotic stress response in Saccharomyces cerevisiae, and its activity is regulated via Msi1p and Npr1p by phosphorylation and ubiquitination. Eukaryot Cell (2008) 0.86

Alteration of plasma membrane organization by an anticancer lysophosphatidylcholine analogue induces intracellular acidification and internalization of plasma membrane transporters in yeast. J Biol Chem (2013) 0.83

A role for p53 in the regulation of extracellular matrix metalloproteinase inducer in human cancer cells. Cancer Biol Ther (2009) 0.82

Sequences in the N-terminal cytoplasmic domain of Saccharomyces cerevisiae maltose permease are required for vacuolar degradation but not glucose-induced internalization. Curr Genet (2006) 0.81

Ssh4, Rcr2 and Rcr1 affect plasma membrane transporter activity in Saccharomyces cerevisiae. Genetics (2007) 0.81

Functional characterization of G-protein-coupled receptors: a bioinformatics approach. Neuroscience (2014) 0.80

Reduction of glucose uptake through inhibition of hexose transporters and enhancement of their endocytosis by methylglyoxal in Saccharomyces cerevisiae. J Biol Chem (2011) 0.80

Only one of the charged amino acids located in membrane-spanning regions is important for the function of the Saccharomyces cerevisiae uracil permease. Biochem J (1999) 0.80

The casein kinase I protein Cck1 regulates multiple signaling pathways and is essential for cell integrity and fungal virulence in Cryptococcus neoformans. Eukaryot Cell (2011) 0.79

Hax-1 is rapidly degraded by the proteasome dependent on its PEST sequence. BMC Cell Biol (2012) 0.79

Pkh1/2-dependent phosphorylation of Vps27 regulates ESCRT-I recruitment to endosomes. Mol Biol Cell (2012) 0.79

Large putative PEST-like sequence motif at the carboxyl tail of human calcium receptor directs lysosomal degradation and regulates cell surface receptor level. J Biol Chem (2011) 0.78

Gly-46 and His-50 of yeast maltose transporter Mal21p are essential for its resistance against glucose-induced degradation. J Biol Chem (2009) 0.76

Luciferase NanoLuc as a reporter for gene expression and protein levels in Saccharomyces cerevisiae. Yeast (2016) 0.76

Protein interactions of the vesicular glutamate transporter VGLUT1. PLoS One (2014) 0.76

Articles cited by this

DNA sequencing with chain-terminating inhibitors. Proc Natl Acad Sci U S A (1977) 790.54

Improved method for high efficiency transformation of intact yeast cells. Nucleic Acids Res (1992) 34.33

Cyclin is degraded by the ubiquitin pathway. Nature (1991) 17.93

Elevated recombination rates in transcriptionally active DNA. Cell (1989) 17.42

Amino acid sequences common to rapidly degraded proteins: the PEST hypothesis. Science (1986) 15.84

Ubiquitin-dependent protein degradation. Annu Rev Genet (1996) 10.97

The ubiquitin-proteasome proteolytic pathway. Cell (1994) 9.75

PEST sequences and regulation by proteolysis. Trends Biochem Sci (1996) 8.90

Ubiquitination of a yeast plasma membrane receptor signals its ligand-stimulated endocytosis. Cell (1996) 6.51

Mapping of the inducible IkappaB phosphorylation sites that signal its ubiquitination and degradation. Mol Cell Biol (1996) 4.56

Cdc53 targets phosphorylated G1 cyclins for degradation by the ubiquitin proteolytic pathway. Cell (1996) 4.06

Regulated degradation of the transcription factor Gcn4. EMBO J (1994) 3.64

Construction and genetic characterization of temperature-sensitive mutant alleles of the yeast actin gene. Proc Natl Acad Sci U S A (1984) 3.47

Rapid degradation of the G1 cyclin Cln2 induced by CDK-dependent phosphorylation. Science (1996) 3.30

Ubiquitin lys63 is involved in ubiquitination of a yeast plasma membrane protein. EMBO J (1997) 3.24

p34Cdc28-mediated control of Cln3 cyclin degradation. Mol Cell Biol (1995) 3.23

NPl1, an essential yeast gene involved in induced degradation of Gap1 and Fur4 permeases, encodes the Rsp5 ubiquitin-protein ligase. Mol Microbiol (1995) 3.19

Mutations affecting the repressibility of arginine biosynthetic enzymes in Saccharomyces cerevisiae. Eur J Biochem (1970) 3.17

Ubiquitination mediated by the Npi1p/Rsp5p ubiquitin-protein ligase is required for endocytosis of the yeast uracil permease. J Biol Chem (1996) 3.13

The ABC-transporter Ste6 accumulates in the plasma membrane in a ubiquitinated form in endocytosis mutants. EMBO J (1994) 3.10

Endocytosis and degradation of the yeast uracil permease under adverse conditions. J Biol Chem (1994) 3.09

Activation of cyclin E/CDK2 is coupled to site-specific autophosphorylation and ubiquitin-dependent degradation of cyclin E. EMBO J (1996) 2.61

The ubiquitin conjugation system is required for ligand-induced endocytosis and degradation of the growth hormone receptor. EMBO J (1996) 2.58

Yeast sugar transporters. Crit Rev Biochem Mol Biol (1993) 2.43

Targeting of membrane proteins to endosomes and lysosomes. Trends Cell Biol (1994) 2.38

An overview of membrane transport proteins in Saccharomyces cerevisiae. Yeast (1995) 2.34

Transcriptional and posttranslational regulation of the general amino acid permease of Saccharomyces cerevisiae. J Bacteriol (1995) 2.21

Degradation of G alpha by the N-end rule pathway. Science (1994) 2.15

Suppressors of YCK-encoded yeast casein kinase 1 deficiency define the four subunits of a novel clathrin AP-like complex. EMBO J (1997) 2.10

Ubiquitination of the yeast a-factor receptor. J Cell Biol (1996) 2.06

The yeast multidrug transporter Pdr5 of the plasma membrane is ubiquitinated prior to endocytosis and degradation in the vacuole. FEBS Lett (1996) 1.93

The yeast actin-related protein Arp2p is required for the internalization step of endocytosis. Mol Biol Cell (1997) 1.83

Casein kinase II phosphorylates I kappa B alpha at S-283, S-289, S-293, and T-291 and is required for its degradation. Mol Cell Biol (1996) 1.72

Constitutive phosphorylation of IkappaBalpha by casein kinase II occurs preferentially at serine 293: requirement for degradation of free IkappaBalpha. Mol Cell Biol (1996) 1.67

Membrane insertion of uracil permease, a polytopic yeast plasma membrane protein. Mol Cell Biol (1991) 1.65

The linker region of the ABC-transporter Ste6 mediates ubiquitination and fast turnover of the protein. EMBO J (1997) 1.45

Catabolite inactivation of the galactose transporter in the yeast Saccharomyces cerevisiae: ubiquitination, endocytosis, and degradation in the vacuole. J Bacteriol (1997) 1.33

Primary structure of the uracil transport protein of Saccharomyces cerevisiae. Eur J Biochem (1988) 1.31

Cloning and transcriptional control of a eucaryotic permease gene. Mol Cell Biol (1982) 1.27

Catabolite inactivation of the yeast maltose transporter requires ubiquitin-ligase npi1/rsp5 and ubiquitin-hydrolase npi2/doa4. FEMS Microbiol Lett (1997) 1.18

A C-terminal di-leucine motif and nearby sequences are required for NH4(+)-induced inactivation and degradation of the general amino acid permease, Gap1p, of Saccharomyces cerevisiae. Mol Microbiol (1997) 1.17

Phylogenetic classification of the major superfamily of membrane transport facilitators, as deduced from yeast genome sequencing. FEBS Lett (1995) 1.17

In vivo phosphorylation of the yeast uracil permease. J Biol Chem (1992) 1.15

Yeast nutrient transporters. Biochim Biophys Acta (1997) 1.10

Phosphorylation of yeast plasma membrane H+-ATPase by casein kinase I. J Biol Chem (1996) 1.06

The yeast plasma membrane uracil permease is stabilized against stress induced degradation by a point mutation in a cyclin-like "destruction box". Biochem Biophys Res Commun (1994) 1.04

The allantoin and uracil permease gene sequences of Saccharomyces cerevisiae are nearly identical. Yeast (1992) 1.03

Isolation and characterization of a thiamin transport gene, THI10, from Saccharomyces cerevisiae. J Biol Chem (1997) 0.94

Replacement of Lys by Glu in a transmembrane segment strongly impairs the function of the uracil permease from Saccharomyces cerevisiae. Biochem J (1995) 0.93

Membrane topology of the yeast uracil permease. Mol Microbiol (1996) 0.92

Articles by these authors

Ubiquitin lys63 is involved in ubiquitination of a yeast plasma membrane protein. EMBO J (1997) 3.24

NPl1, an essential yeast gene involved in induced degradation of Gap1 and Fur4 permeases, encodes the Rsp5 ubiquitin-protein ligase. Mol Microbiol (1995) 3.19

Ubiquitination mediated by the Npi1p/Rsp5p ubiquitin-protein ligase is required for endocytosis of the yeast uracil permease. J Biol Chem (1996) 3.13

Endocytosis and degradation of the yeast uracil permease under adverse conditions. J Biol Chem (1994) 3.09

Ubiquitination and endocytosis of plasma membrane proteins: role of Nedd4/Rsp5p family of ubiquitin-protein ligases. J Membr Biol (2000) 2.59

Membrane transport: ubiquitylation in endosomal sorting. Curr Biol (2001) 2.07

Skp1p and the F-box protein Rcy1p form a non-SCF complex involved in recycling of the SNARE Snc1p in yeast. Mol Cell Biol (2001) 1.87

The yeast actin-related protein Arp2p is required for the internalization step of endocytosis. Mol Biol Cell (1997) 1.83

A yeast t-SNARE involved in endocytosis. Mol Biol Cell (1998) 1.82

Ubiquitin and endocytic internalization in yeast and animal cells. Biochim Biophys Acta (2004) 1.78

The F-box protein Rcy1p is involved in endocytic membrane traffic and recycling out of an early endosome in Saccharomyces cerevisiae. J Cell Biol (2000) 1.70

Genetic and biochemical characterization of mutants of Saccharomyces cerevisiae blocked in six different steps of heme biosynthesis. Mol Gen Genet (1981) 1.69

Deubiquitination step in the endocytic pathway of yeast plasma membrane proteins: crucial role of Doa4p ubiquitin isopeptidase. Mol Cell Biol (2001) 1.69

Membrane insertion of uracil permease, a polytopic yeast plasma membrane protein. Mol Cell Biol (1991) 1.65

A deletion that includes the signal peptidase cleavage site impairs processing, glycosylation, and secretion of cell surface yeast acid phosphatase. Mol Cell Biol (1984) 1.61

NH4+-induced down-regulation of the Saccharomyces cerevisiae Gap1p permease involves its ubiquitination with lysine-63-linked chains. J Cell Sci (1999) 1.53

BCMAp: an integral membrane protein in the Golgi apparatus of human mature B lymphocytes. Int Immunol (1995) 1.42

Casein kinase I-dependent phosphorylation within a PEST sequence and ubiquitination at nearby lysines signal endocytosis of yeast uracil permease. J Biol Chem (2000) 1.35

Localization of the Rsp5p ubiquitin-protein ligase at multiple sites within the endocytic pathway. Mol Cell Biol (2001) 1.34

A novel EH domain protein of Saccharomyces cerevisiae, Ede1p, involved in endocytosis. J Cell Sci (2000) 1.32

The nucleotide sequence of the HEM1 gene and evidence for a precursor form of the mitochondrial 5-aminolevulinate synthase in Saccharomyces cerevisiae. Eur J Biochem (1986) 1.32

Uracil-induced down-regulation of the yeast uracil permease. J Bacteriol (1999) 1.26

A new assay for protoporphyrinogen oxidase - evidence for a total deficiency in that activity in a heme-less mutant of Saccharomyces cerevisiae. Biochem Biophys Res Commun (1982) 1.15

In vivo phosphorylation of the yeast uracil permease. J Biol Chem (1992) 1.15

The yeast plasma membrane uracil permease is stabilized against stress induced degradation by a point mutation in a cyclin-like "destruction box". Biochem Biophys Res Commun (1994) 1.04

In vitro biosynthesis and membrane insertion of gamma-glutamyl transpeptidase. J Biol Chem (1984) 1.02

The HECT ubiquitin ligase Rsp5p is required for proper nuclear export of mRNA in Saccharomyces cerevisiae. Traffic (2003) 1.01

Replacement of Lys by Glu in a transmembrane segment strongly impairs the function of the uracil permease from Saccharomyces cerevisiae. Biochem J (1995) 0.93

Membrane topology of the yeast uracil permease. Mol Microbiol (1996) 0.92

The effects in vivo of mutationally modified uroporphyrinogen decarboxylase in different hem12 mutants of baker's yeast (Saccharomyces cerevisiae). Biochem J (1988) 0.90

The novel protein Ccz1p required for vacuolar assembly in Saccharomyces cerevisiae functions in the same transport pathway as Ypt7p. J Cell Sci (2000) 0.89

'ER degradation' of a mutant yeast plasma membrane protein by the ubiquitin-proteasome pathway. FASEB J (1998) 0.89

The yeast acid phosphatase can enter the secretory pathway without its N-terminal signal sequence. Mol Cell Biol (1987) 0.89

Unmasking of an essential thiol during function of the membrane bound enzyme II of the phosphoenolpyruvate glucose phosphotransferase system of Escherichia coli. Biochim Biophys Acta (1977) 0.87

A deletion that includes the segment coding for the signal peptidase cleavage site delays release of Saccharomyces cerevisiae acid phosphatase from the endoplasmic reticulum. Mol Cell Biol (1986) 0.86

Changes in accessibility of the membrane bound transport enzyme glucose phosphotransferase of E. coli to protein group reagents in presence of substrate or absence of energy source. Biochem Biophys Res Commun (1973) 0.84

Different sidedness of functionally homologous essential thiols in two membrane-bound phosphotransferase enzymes of Escherichia coli detected by permeant and nonpermeant thiol reagents. J Biol Chem (1980) 0.82

Endocytose and degradation of the uracil permease of S. cerevisiae under stress conditions: possible role of ubiquitin. Folia Microbiol (Praha) (1994) 0.82

Solubilization by proteolysis of an activated form of rat liver membrane guanylate cyclase. FEBS Lett (1980) 0.81

Only one of the charged amino acids located in membrane-spanning regions is important for the function of the Saccharomyces cerevisiae uracil permease. Biochem J (1999) 0.80

Trypsin solubilization of rat liver membrane-bound guanylate cyclase results in a form kinetically distinct from the cytosolic enzyme. J Biol Chem (1981) 0.78

Functional analysis of the signal-sequence processing site of yeast acid phosphatase. Eur J Biochem (1989) 0.77

The presequence of yeast 5-aminolevulinate synthase is not required for targeting to mitochondria. J Biol Chem (1988) 0.76

In vivo translocation of the cell wall acid phosphatase across the yeast endoplasmic reticulum membrane: are there multiple signals for the targeting process? Biochimie (1990) 0.76

Disruption of six novel genes from the left arm of chromosome XV of Saccharomyces cerevisiae and basic phenotypic analysis of the generated mutants. Yeast (1999) 0.75

The role of enzyme I in the unmasking of an essential thiol of the membrane-bound enzyme II of the phosphoenolpyruvate-glucose phosphotransferase system of Escherichia coli. Biochim Biophys Acta (1977) 0.75

Unmasking of an essential thiol during function of the membrane-bound enzyme II of the phosphenolpyruvate beta-glucoside phosphotransferase system of Escherichia coli. Biochim Biophys Acta (1979) 0.75