Published in Proc Natl Acad Sci U S A on August 01, 1984
Diverse effects of beta-tubulin mutations on microtubule formation and function. J Cell Biol (1988) 6.88
Eucaryotic RNA polymerase conditional mutant that rapidly ceases mRNA synthesis. Mol Cell Biol (1987) 5.93
Yeast actin-binding proteins: evidence for a role in morphogenesis. J Cell Biol (1988) 5.46
Deoxyribonucleic acid repair in the yeast Saccharomyces cerevisiae. Microbiol Rev (1988) 4.75
Suppressors of yeast actin mutations. Genetics (1989) 3.87
Isolation and characterization of mutations in the beta-tubulin gene of Saccharomyces cerevisiae. Genetics (1985) 3.77
Unlinked noncomplementation: isolation of new conditional-lethal mutations in each of the tubulin genes of Saccharomyces cerevisiae. Genetics (1988) 3.43
Purification of profilin from Saccharomyces cerevisiae and analysis of profilin-deficient cells. J Cell Biol (1990) 3.42
Actin structure and function: roles in mitochondrial organization and morphogenesis in budding yeast and identification of the phalloidin-binding site. Mol Biol Cell (1993) 3.36
Gene replacement in Dictyostelium: generation of myosin null mutants. EMBO J (1989) 3.04
Two functional alpha-tubulin genes of the yeast Saccharomyces cerevisiae encode divergent proteins. Mol Cell Biol (1986) 3.01
Osmotic stress and the yeast cytoskeleton: phenotype-specific suppression of an actin mutation. J Cell Biol (1992) 2.97
Isolation and characterization of Saccharomyces cerevisiae mRNA transport-defective (mtr) mutants. J Cell Biol (1994) 2.81
Characterization of TPM1 disrupted yeast cells indicates an involvement of tropomyosin in directed vesicular transport. J Cell Biol (1992) 2.76
Transformation in fungi. Microbiol Rev (1989) 2.75
A novel fluorescence-activated cell sorter-based screen for yeast endocytosis mutants identifies a yeast homologue of mammalian eps15. J Cell Biol (1996) 2.62
The ras-like yeast YPT1 gene is itself essential for growth, sporulation, and starvation response. Mol Cell Biol (1987) 2.58
Isolation and characterization of conditional-lethal mutations in the TUB1 alpha-tubulin gene of the yeast Saccharomyces cerevisiae. Genetics (1988) 2.33
Actin-dependent mitochondrial motility in mitotic yeast and cell-free systems: identification of a motor activity on the mitochondrial surface. J Cell Biol (1995) 2.23
Characterization and mutational analysis of a cluster of three genes expressed preferentially during sporulation of Saccharomyces cerevisiae. Mol Cell Biol (1986) 2.11
Temperature-sensitive mutations in the yeast DNA polymerase I gene. Proc Natl Acad Sci U S A (1987) 2.09
Nitrogen-regulated ubiquitination of the Gap1 permease of Saccharomyces cerevisiae. Mol Biol Cell (1998) 2.07
Yeast RPO41 gene product is required for transcription and maintenance of the mitochondrial genome. Proc Natl Acad Sci U S A (1986) 2.00
Dominant suppressors of yeast actin mutations that are reciprocally suppressed. Genetics (1989) 1.91
Mapping actin surfaces required for functional interactions in vivo. J Cell Biol (1994) 1.83
Mlc1p is a light chain for the unconventional myosin Myo2p in Saccharomyces cerevisiae. J Cell Biol (1998) 1.70
Yeast mitochondria contain ATP-sensitive, reversible actin-binding activity. Mol Biol Cell (1994) 1.65
What are the basic functions of microfilaments? Insights from studies in budding yeast. J Cell Biol (1994) 1.64
Structural and functional dissection of a membrane glycoprotein required for vesicle budding from the endoplasmic reticulum. Mol Cell Biol (1991) 1.62
A PEST-like sequence mediates phosphorylation and efficient ubiquitination of yeast uracil permease. Mol Cell Biol (1998) 1.58
Yeast actin filaments display ATP-dependent sliding movement over surfaces coated with rabbit muscle myosin. Proc Natl Acad Sci U S A (1992) 1.56
Histone octamer function in vivo: mutations in the dimer-tetramer interfaces disrupt both gene activation and repression. EMBO J (1997) 1.52
Mapping of residues forming the voltage sensor of the voltage-dependent anion-selective channel. Proc Natl Acad Sci U S A (1993) 1.52
High level expression of transfected beta- and gamma-actin genes differentially impacts on myoblast cytoarchitecture. J Cell Biol (1992) 1.49
Null alleles of SAC7 suppress temperature-sensitive actin mutations in Saccharomyces cerevisiae. Mol Cell Biol (1990) 1.47
Development of a Comprehensive Genotype-to-Fitness Map of Adaptation-Driving Mutations in Yeast. Cell (2016) 1.47
Actin mutations that show suppression with fimbrin mutations identify a likely fimbrin-binding site on actin. J Cell Biol (1994) 1.46
The essential yeast Tcp1 protein affects actin and microtubules. Mol Biol Cell (1994) 1.43
Organelle-cytoskeletal interactions: actin mutations inhibit meiosis-dependent mitochondrial rearrangement in the budding yeast Saccharomyces cerevisiae. Mol Biol Cell (1995) 1.33
Fission yeast with DNA polymerase delta temperature-sensitive alleles exhibits cell division cycle phenotype. Nucleic Acids Res (1993) 1.32
Molecular genetics of actin function. Biochem J (1993) 1.32
Overexpression of translation elongation factor 1A affects the organization and function of the actin cytoskeleton in yeast. Genetics (2001) 1.28
Uracil-induced down-regulation of the yeast uracil permease. J Bacteriol (1999) 1.26
Isolation and characterization of temperature-sensitive RNA polymerase II mutants of Saccharomyces cerevisiae. Mol Cell Biol (1987) 1.24
Site-directed mutagenesis of the yeast actin gene: a test for actin function in vivo. EMBO J (1991) 1.18
F-actin dynamics in Neurospora crassa. Eukaryot Cell (2010) 1.18
The FKB2 gene of Saccharomyces cerevisiae, encoding the immunosuppressant-binding protein FKBP-13, is regulated in response to accumulation of unfolded proteins in the endoplasmic reticulum. Proc Natl Acad Sci U S A (1993) 1.16
Genetic evidence for functional interactions between actin noncomplementing (Anc) gene products and actin cytoskeletal proteins in Saccharomyces cerevisiae. Genetics (1993) 1.16
Evidence for monomeric actin function in INO80 chromatin remodeling. Nat Struct Mol Biol (2013) 1.12
Generation of an isogenic collection of yeast actin mutants and identification of three interrelated phenotypes. Genetics (2001) 1.03
Nuclear dynamics, mitosis, and the cytoskeleton during the early stages of colony initiation in Neurospora crassa. Eukaryot Cell (2010) 1.03
KEX2 mutations suppress RNA polymerase II mutants and alter the temperature range of yeast cell growth. Mol Cell Biol (1989) 1.02
Adenovirus E1A specifically blocks SWI/SNF-dependent transcriptional activation. Mol Cell Biol (1996) 0.96
Suppressor analysis of fimbrin (Sac6p) overexpression in yeast. Genetics (1999) 0.93
A role for the divergent actin gene, ACT2, in nuclear pore structure and function. EMBO J (1997) 0.89
A high-efficiency method to replace essential genes with mutant alleles in yeast. Yeast (2005) 0.86
Random mutagenesis of an essential Candida albicans gene. Curr Genet (2004) 0.85
Rapid screening for temperature-sensitive alleles in plants. Plant Physiol (2009) 0.84
Genes selectively expressed in proliferating Dictyostelium amoebae. Proc Natl Acad Sci U S A (1985) 0.81
Suppressor mutations define two regions in the Cbp1 protein important for mitochondrial cytochrome b mRNA stability in Saccharomyces cerevisiae. Curr Genet (2003) 0.81
Comprehensive Analysis of the SUL1 Promoter of Saccharomyces cerevisiae. Genetics (2016) 0.79
Analysis of temperature-sensitive mutations in the simian virus 40 gene encoding virion protein 1. Proc Natl Acad Sci U S A (1988) 0.77
An easy and fast alternative to plasmid shuffling for the identification of in vitro mutagenized alleles of essential genes of Saccharomyces cerevisiae. Nucleic Acids Res (1992) 0.75
Sequencing end-labeled DNA with base-specific chemical cleavages. Methods Enzymol (1980) 287.68
Transformation of yeast. Proc Natl Acad Sci U S A (1978) 46.46
Yeast transformation: a model system for the study of recombination. Proc Natl Acad Sci U S A (1981) 26.54
Sterile host yeasts (SHY): a eukaryotic system of biological containment for recombinant DNA experiments. Gene (1979) 19.39
Replacement of chromosome segments with altered DNA sequences constructed in vitro. Proc Natl Acad Sci U S A (1979) 17.55
Isolation and sequence of the gene for actin in Saccharomyces cerevisiae. Proc Natl Acad Sci U S A (1980) 11.24
Structure of a split yeast gene: complete nucleotide sequence of the actin gene in Saccharomyces cerevisiae. Proc Natl Acad Sci U S A (1980) 8.88
DNA rearrangements associated with a transposable element in yeast. Cell (1980) 7.03
Lethal disruption of the yeast actin gene by integrative DNA transformation. Science (1982) 6.88
A method for the recovery of DNA from agarose gels. Nucleic Acids Res (1978) 6.24
Isolation of the beta-tubulin gene from yeast and demonstration of its essential function in vivo. Cell (1983) 6.22
Biochemistry of actomyosin-dependent cell motility (a review). Proc Natl Acad Sci U S A (1978) 5.35
Cold-sensitive cell-division-cycle mutants of yeast: isolation, properties, and pseudoreversion studies. Genetics (1982) 4.66
Nonmuscle contractile proteins: the role of actin and myosin in cell motility and shape determination. Annu Rev Biochem (1977) 4.25
A DNA fragment with an alpha-phosphorothioate nucleotide at one end is asymmetrically blocked from digestion by exonuclease III and can be replicated in vivo. Proc Natl Acad Sci U S A (1981) 3.14
Molecular cloning of the actin gene from yeast Saccharomyces cerevisiae. Nucleic Acids Res (1980) 2.81
Actin from Saccharomyces cerevisiae. Mol Cell Biol (1982) 2.26
Directed mutagenesis with sodium bisulfite. Methods Enzymol (1983) 2.07
Multigene families encoding actin and tubulin. Cell (1981) 1.96
Identification of an actin-like protein and of its messenger ribonucleic acid in Saccharomyces cerevisiae. J Bacteriol (1980) 1.51
Dissociation of the DNAse-I . actin complex by formamide. Eur J Biochem (1980) 1.14
Gene ontology: tool for the unification of biology. The Gene Ontology Consortium. Nat Genet (2000) 336.52
Cluster analysis and display of genome-wide expression patterns. Proc Natl Acad Sci U S A (1998) 192.97
Molecular portraits of human breast tumours. Nature (2000) 94.14
Mapping mendelian factors underlying quantitative traits using RFLP linkage maps. Genetics (1989) 79.44
Construction of a genetic linkage map in man using restriction fragment length polymorphisms. Am J Hum Genet (1980) 75.25
Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implications. Proc Natl Acad Sci U S A (2001) 71.82
Distinct types of diffuse large B-cell lymphoma identified by gene expression profiling. Nature (2000) 64.32
Comprehensive identification of cell cycle-regulated genes of the yeast Saccharomyces cerevisiae by microarray hybridization. Mol Biol Cell (1998) 62.20
The Gene Ontology (GO) database and informatics resource. Nucleic Acids Res (2004) 54.37
The transcriptional program of sporulation in budding yeast. Science (1998) 37.23
Genomic expression programs in the response of yeast cells to environmental changes. Mol Biol Cell (2000) 36.09
Two differentially regulated mRNAs with different 5' ends encode secreted with intracellular forms of yeast invertase. Cell (1982) 25.10
Systematic variation in gene expression patterns in human cancer cell lines. Nat Genet (2000) 24.22
Identification of 23 complementation groups required for post-translational events in the yeast secretory pathway. Cell (1980) 23.17
Genomic binding sites of the yeast cell-cycle transcription factors SBF and MBF. Nature (2001) 21.55
Genetic and physical maps of Saccharomyces cerevisiae. Nature (1997) 21.48
Missing value estimation methods for DNA microarrays. Bioinformatics (2001) 20.84
Genetic engineering in vivo using translocatable drug-resistance elements. New methods in bacterial genetics. J Mol Biol (1977) 20.29
SGD: Saccharomyces Genome Database. Nucleic Acids Res (1998) 20.26
A Saccharomyces cerevisiae genomic plasmid bank based on a centromere-containing shuttle vector. Gene (1987) 19.68
Sterile host yeasts (SHY): a eukaryotic system of biological containment for recombinant DNA experiments. Gene (1979) 19.39
The transcriptional program in the response of human fibroblasts to serum. Science (1999) 19.19
Exploring the new world of the genome with DNA microarrays. Nat Genet (1999) 19.05
Integrating functional genomic information into the Saccharomyces genome database. Nucleic Acids Res (2000) 18.52
Singular value decomposition for genome-wide expression data processing and modeling. Proc Natl Acad Sci U S A (2000) 18.42
Diversity of gene expression in adenocarcinoma of the lung. Proc Natl Acad Sci U S A (2001) 17.36
A common language for physical mapping of the human genome. Science (1989) 17.36
Genome-wide analysis of DNA copy-number changes using cDNA microarrays. Nat Genet (1999) 14.96
Distinctive gene expression patterns in human mammary epithelial cells and breast cancers. Proc Natl Acad Sci U S A (1999) 14.16
Using the Saccharomyces Genome Database (SGD) for analysis of protein similarities and structure. Nucleic Acids Res (1999) 13.65
A gene expression database for the molecular pharmacology of cancer. Nat Genet (2000) 13.31
Promoter-specific binding of Rap1 revealed by genome-wide maps of protein-DNA association. Nat Genet (2001) 13.05
Homozygosity mapping: a way to map human recessive traits with the DNA of inbred children. Science (1987) 12.20
Mutagenesis by insertion of a drug-resistance element carrying an inverted repetition. J Mol Biol (1975) 11.14
Order of events in the yeast secretory pathway. Cell (1981) 10.13
Structure and function of the yeast URA3 gene: expression in Escherichia coli. Gene (1984) 10.07
Strategies for studying heterogeneous genetic traits in humans by using a linkage map of restriction fragment length polymorphisms. Proc Natl Acad Sci U S A (1986) 9.51
Phenotypic analysis of temperature-sensitive yeast actin mutants. Cell (1985) 8.53
Local mutagenesis: a method for generating viral mutants with base substitutions in preselected regions of the viral genome. Proc Natl Acad Sci U S A (1978) 8.36
Mapping complex genetic traits in humans: new methods using a complete RFLP linkage map. Cold Spring Harb Symp Quant Biol (1986) 8.22
Secretion and cell-surface growth are blocked in a temperature-sensitive mutant of Saccharomyces cerevisiae. Proc Natl Acad Sci U S A (1979) 8.03
The Stanford Microarray Database. Nucleic Acids Res (2001) 7.77
The yeast GTP-binding YPT1 protein and a mammalian counterpart are associated with the secretion machinery. Cell (1988) 7.39
Plasmid construction by homologous recombination in yeast. Gene (1987) 7.26
Diverse effects of beta-tubulin mutations on microtubule formation and function. J Cell Biol (1988) 6.88
Lethal disruption of the yeast actin gene by integrative DNA transformation. Science (1982) 6.88
Evidence for transcriptional regulation of orotidine-5'-phosphate decarboxylase in yeast by hybridization of mRNA to the yeast structural gene cloned in Escherichia coli. Proc Natl Acad Sci U S A (1979) 6.81
Properties of the translocatable tetracycline-resistance element Tn10 in Escherichia coli and bacteriophage lambda. Genetics (1978) 6.73
Genomic expression responses to DNA-damaging agents and the regulatory role of the yeast ATR homolog Mec1p. Mol Biol Cell (2001) 6.39
Comparison of the complete protein sets of worm and yeast: orthology and divergence. Science (1998) 6.28
The Exocyst is a multiprotein complex required for exocytosis in Saccharomyces cerevisiae. EMBO J (1996) 6.26
Isolation of the beta-tubulin gene from yeast and demonstration of its essential function in vivo. Cell (1983) 6.22
Specialized transduction of tetracycline resistance by phage P22 in Salmonella typhimurium. II. Properties of a high-frequency-transducing lysate. Virology (1972) 6.21
Mutants of yeast defective in sucrose utilization. Genetics (1981) 6.20
DNA topoisomerase II is required at the time of mitosis in yeast. Cell (1985) 6.08
Compartmentalized assembly of oligosaccharides on exported glycoproteins in yeast. Cell (1981) 5.51
Yeast actin-binding proteins: evidence for a role in morphogenesis. J Cell Biol (1988) 5.46
Systematic changes in gene expression patterns following adaptive evolution in yeast. Proc Natl Acad Sci U S A (1999) 5.45
The exocyst is an effector for Sec4p, targeting secretory vesicles to sites of exocytosis. EMBO J (1999) 5.35
'Gene shaving' as a method for identifying distinct sets of genes with similar expression patterns. Genome Biol (2000) 5.29
Directed mutagenesis. Annu Rev Genet (1981) 5.27
A rapid, efficient method for isolating DNA from yeast. Gene (1986) 5.20
Ultrastructure of the yeast actin cytoskeleton and its association with the plasma membrane. J Cell Biol (1994) 5.14
Secretion of beta-lactamase requires the carboxy end of the protein. Cell (1980) 5.03
Systematic mutational analysis of the yeast ACT1 gene. Genetics (1992) 5.02
Denatured states of proteins. Annu Rev Biochem (1991) 4.86
Simple Mendelian inheritance of the reiterated ribosomal DNA of yeast. Proc Natl Acad Sci U S A (1977) 4.86
Relation of gene expression phenotype to immunoglobulin mutation genotype in B cell chronic lymphocytic leukemia. J Exp Med (2001) 4.83
Yeast genes fused to beta-galactosidase in Escherichia coli can be expressed normally in yeast. Proc Natl Acad Sci U S A (1981) 4.79
Cold-sensitive cell-division-cycle mutants of yeast: isolation, properties, and pseudoreversion studies. Genetics (1982) 4.66
Construction and use of gene fusions to lacZ (beta-galactosidase) that are expressed in yeast. Methods Enzymol (1983) 4.63
Two yeast forkhead genes regulate the cell cycle and pseudohyphal growth. Nature (2000) 4.52
Conditional-lethal mutations that suppress genetic defects in morphogenesis by altering structural proteins. Proc Natl Acad Sci U S A (1975) 4.52
Molecular genetics of bacteriophage P22. Microbiol Rev (1978) 4.51
Sec9 is a SNAP-25-like component of a yeast SNARE complex that may be the effector of Sec4 function in exocytosis. Cell (1994) 4.46
A group of interacting yeast DNA replication genes. Genes Dev (1991) 4.45
Genetically essential and nonessential alpha-tubulin genes specify functionally interchangeable proteins. Mol Cell Biol (1986) 4.33
Many random sequences functionally replace the secretion signal sequence of yeast invertase. Science (1987) 4.33
Genome-wide characterization of the Zap1p zinc-responsive regulon in yeast. Proc Natl Acad Sci U S A (2000) 4.30
Nomenclature of transposable elements in prokaryotes. Gene (1979) 4.13
Phosphoinositides as regulators in membrane traffic. Science (1996) 4.13
ADP-ribosylation factor is functionally and physically associated with the Golgi complex. Proc Natl Acad Sci U S A (1990) 4.12
The role of Myo2, a yeast class V myosin, in vesicular transport. J Cell Biol (1995) 4.11
The secreted form of invertase in Saccharomyces cerevisiae is synthesized from mRNA encoding a signal sequence. Mol Cell Biol (1983) 3.96
Homology of a yeast actin-binding protein to signal transduction proteins and myosin-I. Nature (1990) 3.90
Suppressors of yeast actin mutations. Genetics (1989) 3.87
Sec6, Sec8, and Sec15 are components of a multisubunit complex which localizes to small bud tips in Saccharomyces cerevisiae. J Cell Biol (1995) 3.85
Propagation of some human DNA sequences in bacteriophage lambda vectors requires mutant Escherichia coli hosts. Proc Natl Acad Sci U S A (1985) 3.82
A suppressor of SNF1 mutations causes constitutive high-level invertase synthesis in yeast. Genetics (1984) 3.81
Isolation and characterization of mutations in the beta-tubulin gene of Saccharomyces cerevisiae. Genetics (1985) 3.77
Regulatory mutants of simian virus 40: constructed mutants with base substitutions at the origin of DNA replication. J Mol Biol (1979) 3.75
Host/vector interactions which affect the viability of recombinant phage lambda clones. Gene (1986) 3.75
WISP genes are members of the connective tissue growth factor family that are up-regulated in wnt-1-transformed cells and aberrantly expressed in human colon tumors. Proc Natl Acad Sci U S A (1998) 3.73
Requirement of yeast fimbrin for actin organization and morphogenesis in vivo. Nature (1991) 3.70
Subcellular localization of Cdc42p, a Saccharomyces cerevisiae GTP-binding protein involved in the control of cell polarity. Mol Biol Cell (1993) 3.70
Genetic analysis of the yeast cytoskeleton. Annu Rev Genet (1987) 3.67
Homologs of the synaptobrevin/VAMP family of synaptic vesicle proteins function on the late secretory pathway in S. cerevisiae. Cell (1993) 3.67