Published in J Exp Med on February 02, 1998
Physiological beta cell death triggers priming of self-reactive T cells by dendritic cells in a type-1 diabetes model. J Exp Med (2003) 2.94
Proliferative arrest and rapid turnover of thymic epithelial cells expressing Aire. J Exp Med (2007) 2.84
Regulatory CD4(+) T cells expressing endogenous T cell receptor chains protect myelin basic protein-specific transgenic mice from spontaneous autoimmune encephalomyelitis. J Exp Med (1998) 2.69
Modifier loci condition autoimmunity provoked by Aire deficiency. J Exp Med (2005) 2.08
Natural killer cells distinguish innocuous and destructive forms of pancreatic islet autoimmunity. Proc Natl Acad Sci U S A (2004) 1.96
CD4(+) T cells prevent spontaneous experimental autoimmune encephalomyelitis in anti-myelin basic protein T cell receptor transgenic mice. J Exp Med (1998) 1.63
Crystal structure of HLA-DQ0602 that protects against type 1 diabetes and confers strong susceptibility to narcolepsy. Proc Natl Acad Sci U S A (2004) 1.29
MHC Class II Polymorphisms, Autoreactive T-Cells, and Autoimmunity. Front Immunol (2013) 1.22
The role of MHC class II molecules in susceptibility to type I diabetes: identification of peptide epitopes and characterization of the T cell repertoire. Proc Natl Acad Sci U S A (1999) 1.13
Mouse Models for Type 1 Diabetes. Drug Discov Today Dis Models (2009) 1.09
Molecular aspects of type 1 diabetes. Mol Pathol (2003) 1.05
Functional regulatory T cells produced by inhibiting cyclic nucleotide phosphodiesterase type 3 prevent allograft rejection. Sci Transl Med (2011) 0.99
Detection of glutamic acid decarboxylase-activated T cells with I-Ag7 tetramers. Proc Natl Acad Sci U S A (2000) 0.97
Specificity of peptide selection by antigen-presenting cells homozygous or heterozygous for expression of class II MHC molecules: The lack of competition. Proc Natl Acad Sci U S A (2003) 0.94
Prevention of type 1 diabetes by gene therapy. J Clin Invest (2004) 0.91
Triggering a second T cell receptor on diabetogenic T cells can prevent induction of diabetes. J Exp Med (1999) 0.90
Blockade of the programmed death-1 (PD1) pathway undermines potent genetic protection from type 1 diabetes. PLoS One (2014) 0.84
A selective role of NKG2D in inflammatory and autoimmune diseases. Clin Immunol (2013) 0.82
Induction of mixed chimerism with MHC-mismatched but not matched bone marrow transplants results in thymic deletion of host-type autoreactive T-cells in NOD mice. Diabetes (2011) 0.81
The Protective Role of HLA-DRB1(∗)13 in Autoimmune Diseases. J Immunol Res (2015) 0.80
Antidiabetogenic MHC class II promotes the differentiation of MHC-promiscuous autoreactive T cells into FOXP3+ regulatory T cells. Proc Natl Acad Sci U S A (2013) 0.79
Defective positive selection results in T cell lymphopenia and increased autoimmune diabetes in ADAP-deficient BDC2.5-C57BL/6 mice. Eur J Immunol (2008) 0.78
Breaking T cell tolerance to beta cell antigens by merocytic dendritic cells. Cell Mol Life Sci (2011) 0.77
Collagen Specific T-Cell Repertoire and HLA-DR Alleles: Biomarkers of Active Refractory Rheumatoid Arthritis. EBioMedicine (2015) 0.75
Beta-cell specific autoantibodies: Are they just an indicator of type 1 diabetes? Curr Diabetes Rev (2016) 0.75
HLA-DQ beta gene contributes to susceptibility and resistance to insulin-dependent diabetes mellitus. Nature (1987) 10.70
Hybridoma cell lines secreting monoclonal antibodies to mouse H-2 and Ia antigens. J Immunol (1980) 8.56
A genome-wide search for human type 1 diabetes susceptibility genes. Nature (1994) 7.13
Following a diabetogenic T cell from genesis through pathogenesis. Cell (1993) 6.46
Three recessive loci required for insulin-dependent diabetes in nonobese diabetic mice. Science (1987) 6.36
Mice lacking MHC class II molecules. Cell (1991) 6.25
T cell activation determined by T cell receptor number and tunable thresholds. Science (1996) 5.51
Insulin-dependent diabetes mellitus. Cell (1996) 5.06
Thymic selection of CD8+ single positive cells with a class II major histocompatibility complex-restricted receptor. J Exp Med (1994) 4.91
Different responses are elicited in cytotoxic T lymphocytes by different levels of T cell receptor occupancy. J Exp Med (1996) 3.86
Genetic control of autoimmune diabetes in the NOD mouse. Annu Rev Immunol (1995) 3.71
Acceleration of diabetes in young NOD mice with a CD4+ islet-specific T cell clone. Science (1990) 3.17
The NOD mouse: recessive diabetogenic gene in the major histocompatibility complex. Science (1986) 3.09
Lymphoid development in mice congenitally lacking T cell receptor alpha beta-expressing cells. Science (1992) 2.90
Another view of the selective model of thymocyte selection. Cell (1993) 2.85
Insulin-dependent diabetes mellitus as an autoimmune disease. Endocr Rev (1994) 2.80
The first external domain of the nonobese diabetic mouse class II I-A beta chain is unique. Proc Natl Acad Sci U S A (1987) 2.77
Prevention of insulin-dependent diabetes mellitus in non-obese diabetic mice by transgenes encoding modified I-A beta-chain or normal I-E alpha-chain. Nature (1990) 2.23
Prevention of autoimmune insulitis by expression of I-E molecules in NOD mice. Nature (1987) 2.04
An explanation for the protective effect of the MHC class II I-E molecule in murine diabetes. Nature (1989) 1.97
Genetic control of diabetes progression. Immunity (1997) 1.95
Prevention of diabetes in non-obese diabetic I-Ak transgenic mice. Nature (1990) 1.87
The class II MHC I-Ag7 molecules from non-obese diabetic mice are poor peptide binders. J Immunol (1996) 1.87
The involvement of T cell receptor peptide-specific regulatory CD4+ T cells in recovery from antigen-induced autoimmune disease. J Exp Med (1993) 1.80
Major histocompatibility complex class I molecules are required for the development of insulitis in non-obese diabetic mice. Eur J Immunol (1993) 1.72
Murine CD8+ T cells that specifically delete autologous CD4+ T cells expressing V beta 8 TCR: a role of the Qa-1 molecule. Immunity (1995) 1.72
MHC-linked protection from diabetes dissociated from clonal deletion of T cells. Science (1990) 1.70
Correcting an immune-response deficiency by creating E alpha gene transgenic mice. Nature (1985) 1.67
Genetic control of diabetes and insulitis in the nonobese diabetic (NOD) mouse. J Exp Med (1987) 1.65
Direct evidence for the contribution of the unique I-ANOD to the development of insulitis in non-obese diabetic mice. Nature (1990) 1.61
The expression of I-Ed molecules in F1 hybrid mice detected with antigen-specific, I-Ed-restricted cloned T-cell lines. Immunogenetics (1984) 1.48
Autoimmune syndromes in major histocompatibility complex (MHC) congenic strains of nonobese diabetic (NOD) mice. The NOD MHC is dominant for insulitis and cyclophosphamide-induced diabetes. J Exp Med (1992) 1.46
T cell receptor V gene usage of islet beta cell-reactive T cells is not restricted in non-obese diabetic mice. J Exp Med (1991) 1.40
Tumor necrosis factor alpha in autoimmunity: pretty girl or old witch? Immunol Today (1992) 1.39
Differential expression of Ia glycoprotein complexes in F1 hybrid mice detected with alloreactive cloned T cell lines. J Immunol (1982) 1.32
Inactivation of T cell receptor peptide-specific CD4 regulatory T cells induces chronic experimental autoimmune encephalomyelitis (EAE). J Exp Med (1996) 1.28
Islet-specific T-cell clones from nonobese diabetic mice express heterogeneous T-cell receptors. Proc Natl Acad Sci U S A (1991) 1.27
A unified hypothesis for the complex genetics of HLA associations with IDDM. Diabetes (1990) 1.24
Determinant capture as a possible mechanism of protection afforded by major histocompatibility complex class II molecules in autoimmune disease. J Exp Med (1993) 1.19
Development of autoimmune insulitis is prevented in E alpha d but not in A beta k NOD transgenic mice. Int Immunol (1989) 1.19
An Abd transgene prevents diabetes in nonobese diabetic mice by inducing regulatory T cells. Proc Natl Acad Sci U S A (1993) 1.14
Human CD8+ T lymphocyte clones specific for T cell receptor V beta families expressed on autologous CD4+ T cells. Immunity (1995) 1.06
Functional sites on Ia molecules: a molecular dissection of A alpha immunogenicity. Cell (1986) 1.01
Failure of a protective major histocompatibility complex class II molecule to delete autoreactive T cells in autoimmune diabetes. Proc Natl Acad Sci U S A (1993) 1.00
The effect of excess beta-chain synthesis on cell-surface expression of allele-mismatched class II heterodimers in vivo. Proc Natl Acad Sci U S A (1990) 1.00
Complete characterization of the expressed immune response genes in Biozzi AB/H mice: structural and functional identity between AB/H and NOD A region molecules. Immunogenetics (1993) 0.93
Dual T cell receptor T cells have a decreased sensitivity to physiological ligands due to reduced density of each T cell receptor. Eur J Immunol (1996) 0.92
Immune deficiency due to high copy numbers of an Ak beta transgene. Proc Natl Acad Sci U S A (1990) 0.91
The effect of bone marrow and thymus chimerism between non-obese diabetic (NOD) and NOD-E transgenic mice, on the expression and prevention of diabetes. Eur J Immunol (1993) 0.89
Aspartate at position 57 of nonobese diabetic I-Ag7 beta-chain diminishes the spontaneous incidence of insulin-dependent diabetes mellitus. J Immunol (1995) 0.87
Complete prevention of diabetes in transgenic NOD mice expressing I-E molecules. Immunol Lett (1992) 0.86
Prevention of autoimmune insulitis in nonobese diabetic mice by expression of major histocompatibility complex class I Ld molecules. Proc Natl Acad Sci U S A (1992) 0.83
Exacerbated autoimmunity associated with a T helper-1 cytokine profile shift in H-2E-transgenic mice. Eur J Immunol (1995) 0.80
High copy number I-Ab transgenes induce production of IgE through an interluekin 4-dependent mechanism. Proc Natl Acad Sci U S A (1996) 0.79
Genetics of insulin-dependent diabetes mellitus. Curr Opin Genet Dev (1996) 0.79
MHC control of the naive TCR alpha-chain repertoire. J Immunol (1994) 0.77
In vivo sequence requirements of the SV40 early promotor region. Nature (1981) 25.00
Characterization of an avian influenza A (H5N1) virus isolated from a child with a fatal respiratory illness. Science (1998) 19.40
The ovalbumin gene-sequence of putative control regions. Nucleic Acids Res (1980) 18.04
Ovalbumin gene: evidence for a leader sequence in mRNA and DNA sequences at the exon-intron boundaries. Proc Natl Acad Sci U S A (1978) 14.82
Racial variations in the prevalence of primary open-angle glaucoma. The Baltimore Eye Survey. JAMA (1991) 9.42
Organisation and sequences at the 5' end of a cloned complete ovalbumin gene. Nature (1979) 9.30
Deletions covering the putative promoter region of early mRNAs of simian virus 40 do not abolish T-antigen expression. Proc Natl Acad Sci U S A (1980) 7.77
Clinically detectable nerve fiber atrophy precedes the onset of glaucomatous field loss. Arch Ophthalmol (1991) 7.61
Blindness and visual impairment in an American urban population. The Baltimore Eye Survey. Arch Ophthalmol (1990) 6.66
Following a diabetogenic T cell from genesis through pathogenesis. Cell (1993) 6.46
Organ-specific disease provoked by systemic autoimmunity. Cell (1996) 6.44
A multiplicity of CCAAT box-binding proteins. Cell (1987) 6.37
Mice lacking MHC class II molecules. Cell (1991) 6.25
Efficacy of vitamin A in reducing preschool child mortality in Nepal. Lancet (1991) 6.25
Blindness and visual impairment in southern Malawi. Bull World Health Organ (1986) 6.07
Relationship between intraocular pressure and primary open angle glaucoma among white and black Americans. The Baltimore Eye Survey. Arch Ophthalmol (1991) 5.82
Transformation of mouse fibroblasts to methotrexate resistance by a recombinant plasmid expressing a prokaryotic dihydrofolate reductase. Proc Natl Acad Sci U S A (1981) 5.38
From systemic T cell self-reactivity to organ-specific autoimmune disease via immunoglobulins. Immunity (1999) 5.38
Effect of neonatal circumcision on pain response during subsequent routine vaccination. Lancet (1997) 5.35
Arthritis provoked by linked T and B cell recognition of a glycolytic enzyme. Science (1999) 4.97
Racial differences in the cause-specific prevalence of blindness in east Baltimore. N Engl J Med (1991) 4.73
beta-Cell death during progression to diabetes. Nature (2001) 4.61
Contribution of central neuroplasticity to pathological pain: review of clinical and experimental evidence. Pain (1993) 4.09
The prevalence of blindness and visual impairment among nursing home residents in Baltimore. N Engl J Med (1995) 4.03
T helper cell subsets in insulin-dependent diabetes. Science (1995) 3.92
Initiation of autoimmune diabetes by developmentally regulated presentation of islet cell antigens in the pancreatic lymph nodes. J Exp Med (1999) 3.85
Cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) regulates the unfolding of autoimmune diabetes. J Exp Med (1998) 3.70
An evaluation of optic disc and nerve fiber layer examinations in monitoring progression of early glaucoma damage. Ophthalmology (1992) 3.70
Regulation of major histocompatibility complex class-II genes: X, Y and other letters of the alphabet. Annu Rev Immunol (1990) 3.68
Induction of altered chromatin structures by simian virus 40 enhancer and promoter elements. Nature (1984) 3.68
The dendritic cell populations of mouse lymph nodes. J Immunol (2001) 3.57
TRANCE/RANKL knockout mice are protected from bone erosion in a serum transfer model of arthritis. Am J Pathol (2001) 3.53
The value of routine preoperative medical testing before cataract surgery. Study of Medical Testing for Cataract Surgery. N Engl J Med (2000) 3.45
Evolution of the H3 influenza virus hemagglutinin from human and nonhuman hosts. J Virol (1992) 3.37
Antigen/MHC-specific T cells are preferentially exported from the thymus in the presence of their MHC ligand. Cell (1989) 3.29
Surgical management of renal tumors 4 cm. or less in a contemporary cohort. J Urol (2000) 3.26
A population-based evaluation of glaucoma screening: the Baltimore Eye Survey. Am J Epidemiol (1991) 3.23
Superantigens interact with MHC class II molecules outside of the antigen groove. Cell (1990) 3.20
Structure of transcribing chromatin. Prog Nucleic Acid Res Mol Biol (1980) 3.09
A postoperative prognostic nomogram for renal cell carcinoma. J Urol (2001) 3.01
Race-, age-, gender-, and refractive error-related differences in the normal optic disc. Arch Ophthalmol (1994) 2.86
Another view of the selective model of thymocyte selection. Cell (1993) 2.85
Several mechanisms can account for defective E alpha gene expression in different mouse haplotypes. Proc Natl Acad Sci U S A (1983) 2.84
Mice lacking all conventional MHC class II genes. Proc Natl Acad Sci U S A (1999) 2.83
Increased risk of respiratory disease and diarrhea in children with preexisting mild vitamin A deficiency. Am J Clin Nutr (1984) 2.82
Racial differences in the prevalence of age-related macular degeneration: the Baltimore Eye Survey. Ophthalmology (1999) 2.80
The impact of overnight wear on the risk of contact lens-associated ulcerative keratitis. Arch Ophthalmol (1994) 2.75
The pentose cycle, triose phosphate isomerization, and lipogenesis in rat adipose tissue. J Biol Chem (1966) 2.72
CD1-restricted CD4+ T cells in major histocompatibility complex class II-deficient mice. J Exp Med (1995) 2.70
Hypertension, perfusion pressure, and primary open-angle glaucoma. A population-based assessment. Arch Ophthalmol (1995) 2.67
Epidemiology of myopia. Epidemiol Rev (1996) 2.64
Futile cycles in the metabolism of glucose. Curr Top Cell Regul (1976) 2.63
Why cheat? Nature (1992) 2.56
Conserved major histocompatibility complex class II boxes--X and Y--are transcriptional control elements and specifically bind nuclear proteins. Proc Natl Acad Sci U S A (1987) 2.55
Intraobserver and interobserver agreement in measurement of optic disc characteristics. Ophthalmology (1988) 2.54
Checkpoints in the progression of autoimmune disease: lessons from diabetes models. Proc Natl Acad Sci U S A (1996) 2.53
Rate of progression in open-angle glaucoma estimated from cross-sectional prevalence of visual field damage. Am J Ophthalmol (1996) 2.51
Co-evolution from yeast to mouse: cDNA cloning of the two NF-Y (CP-1/CBF) subunits. EMBO J (1990) 2.49
The incidence of class "zero" airway and the impact of Mallampati score, age, sex, and body mass index on prediction of laryngoscopy grade. Anesth Analg (2001) 2.47
Mice lacking TdT: mature animals with an immature lymphocyte repertoire. Science (1993) 2.42
Incidence of acute angle-closure glaucoma after pharmacologic mydriasis. Am J Ophthalmol (1995) 2.42
Targeted complementation of MHC class II deficiency by intrathymic delivery of recombinant adenoviruses. Immunity (1997) 2.38
Cassette vectors directing expression of T cell receptor genes in transgenic mice. J Immunol Methods (1995) 2.37
Mice lacking H2-M complexes, enigmatic elements of the MHC class II peptide-loading pathway. Cell (1996) 2.32
Mice lacking the MHC class II-associated invariant chain. Cell (1993) 2.30
The cause-specific prevalence of visual impairment in an urban population. The Baltimore Eye Survey. Ophthalmology (1996) 2.29
Impaired cellular immunity in kwashiorkor with improvement after therapy. Br Med J (1971) 2.29
How much TCR does a T cell need? Immunity (2001) 2.18
Subcutaneous IGF-1 is not beneficial in 2-year ALS trial. Neurology (2008) 2.17
Diabetes, intraocular pressure, and primary open-angle glaucoma in the Baltimore Eye Survey. Ophthalmology (1995) 2.14
Use and efficacy of low-dose ketamine in the management of acute postoperative pain: a review of current techniques and outcomes. Pain (1999) 2.14
Multimodal analgesia before thoracic surgery does not reduce postoperative pain. Br J Anaesth (1994) 2.11
The metabolism of tritiated glucose by rat adipose tissue. J Biol Chem (1966) 2.11
Compartmentalization of MHC class II gene expression in transgenic mice. Cell (1988) 2.08