Partial hormone resistance in mice with disruption of the steroid receptor coactivator-1 (SRC-1) gene.

PubWeight™: 3.85‹?› | Rank: Top 1%

🔗 View Article (PMID 9506940)

Published in Science on March 20, 1998

Authors

J Xu1, Y Qiu, F J DeMayo, S Y Tsai, M J Tsai, B W O'Malley

Author Affiliations

1: Department of Cell Biology, Baylor College of Medicine, Houston, TX 77030, USA.

Articles citing this

(truncated to the top 100)

The hallmarks of cancer: a long non-coding RNA point of view. RNA Biol (2012) 5.60

The steroid receptor coactivator SRC-3 (p/CIP/RAC3/AIB1/ACTR/TRAM-1) is required for normal growth, puberty, female reproductive function, and mammary gland development. Proc Natl Acad Sci U S A (2000) 3.55

Normal and cancer-related functions of the p160 steroid receptor co-activator (SRC) family. Nat Rev Cancer (2009) 3.33

Transcriptional activation by NF-kappaB requires multiple coactivators. Mol Cell Biol (1999) 3.11

Sharp, an inducible cofactor that integrates nuclear receptor repression and activation. Genes Dev (2001) 2.68

The Angelman syndrome-associated protein, E6-AP, is a coactivator for the nuclear hormone receptor superfamily. Mol Cell Biol (1999) 2.57

ACTR/AIB1 functions as an E2F1 coactivator to promote breast cancer cell proliferation and antiestrogen resistance. Mol Cell Biol (2004) 2.46

Regulation of SRC-3 (pCIP/ACTR/AIB-1/RAC-3/TRAM-1) Coactivator activity by I kappa B kinase. Mol Cell Biol (2002) 2.45

The function of TIF2/GRIP1 in mouse reproduction is distinct from those of SRC-1 and p/CIP. Mol Cell Biol (2002) 2.40

Cyclo-oxygenase-2-derived prostacyclin mediates embryo implantation in the mouse via PPARdelta. Genes Dev (1999) 2.37

Regulation of somatic growth by the p160 coactivator p/CIP. Proc Natl Acad Sci U S A (2000) 2.17

Alternate surfaces of transcriptional coregulator GRIP1 function in different glucocorticoid receptor activation and repression contexts. Proc Natl Acad Sci U S A (2002) 2.12

Signaling within a coactivator complex: methylation of SRC-3/AIB1 is a molecular switch for complex disassembly. Mol Cell Biol (2006) 1.94

Factor recruitment and TIF2/GRIP1 corepressor activity at a collagenase-3 response element that mediates regulation by phorbol esters and hormones. EMBO J (2001) 1.91

COUP-TFII mediates progesterone regulation of uterine implantation by controlling ER activity. PLoS Genet (2007) 1.79

Mice deficient in the steroid receptor co-activator 1 (SRC-1) are resistant to thyroid hormone. EMBO J (1999) 1.78

Progesterone and glucocorticoid receptors recruit distinct coactivator complexes and promote distinct patterns of local chromatin modification. Mol Cell Biol (2003) 1.73

A decline in the levels of progesterone receptor coactivators in the pregnant uterus at term may antagonize progesterone receptor function and contribute to the initiation of parturition. Proc Natl Acad Sci U S A (2003) 1.72

p300 requires its histone acetyltransferase activity and SRC-1 interaction domain to facilitate thyroid hormone receptor activation in chromatin. Mol Cell Biol (2000) 1.66

Disruption of the SRC-1 gene in mice suppresses breast cancer metastasis without affecting primary tumor formation. Proc Natl Acad Sci U S A (2008) 1.62

Tumor necrosis factor and interleukin 1 decrease RXRalpha, PPARalpha, PPARgamma, LXRalpha, and the coactivators SRC-1, PGC-1alpha, and PGC-1beta in liver cells. Metabolism (2007) 1.60

Coactivators and corepressors of NF-kappaB in IkappaB alpha gene promoter. J Biol Chem (2005) 1.57

Steroid receptor coactivator (SRC) family: masters of systems biology. J Biol Chem (2010) 1.57

Nuclear receptor coregulators: modulators of pathology and therapeutic targets. Nat Rev Endocrinol (2012) 1.55

Amplification and overexpression of peroxisome proliferator-activated receptor binding protein (PBP/PPARBP) gene in breast cancer. Proc Natl Acad Sci U S A (1999) 1.54

In vivo activation of PPAR target genes by RXR homodimers. EMBO J (2004) 1.53

Steroid receptor coactivators 1 and 2 mediate fetal-to-maternal signaling that initiates parturition. J Clin Invest (2015) 1.53

Role of the steroid receptor coactivator SRC-3 in cell growth. Mol Cell Biol (2003) 1.53

Lactation defect in mice lacking the helix-loop-helix inhibitor Id2. EMBO J (2000) 1.52

Steroid receptor coactivator 2 is critical for progesterone-dependent uterine function and mammary morphogenesis in the mouse. Mol Cell Biol (2006) 1.52

Developmentally essential protein flightless I is a nuclear receptor coactivator with actin binding activity. Mol Cell Biol (2004) 1.49

The steroid receptor coactivator-1 regulates twist expression and promotes breast cancer metastasis. Cancer Res (2009) 1.48

Differential gene regulation by the SRC family of coactivators. Genes Dev (2004) 1.41

Perturbing the cellular levels of steroid receptor coactivator-2 impairs murine endometrial function. PLoS One (2014) 1.40

A repressive role for prohibitin in estrogen signaling. Mol Endocrinol (2007) 1.40

Mouse steroid receptor coactivator-1 is not essential for peroxisome proliferator-activated receptor alpha-regulated gene expression. Proc Natl Acad Sci U S A (1999) 1.39

The corepressor N-CoR and its variants RIP13a and RIP13Delta1 directly interact with the basal transcription factors TFIIB, TAFII32 and TAFII70. Nucleic Acids Res (1998) 1.39

Oral exposure to bisphenol a increases dimethylbenzanthracene-induced mammary cancer in rats. Environ Health Perspect (2009) 1.38

SRC-1 and GRIP1 coactivate transcription with hepatocyte nuclear factor 4. J Biol Chem (1998) 1.38

Expression of RAC 3, a steroid hormone receptor co-activator in prostate cancer. Br J Cancer (2001) 1.37

Genetic deletion of the repressor of estrogen receptor activity (REA) enhances the response to estrogen in target tissues in vivo. Mol Cell Biol (2005) 1.36

ERAP140, a conserved tissue-specific nuclear receptor coactivator. Mol Cell Biol (2002) 1.34

Estrogen action and cytoplasmic signaling cascades. Part I: membrane-associated signaling complexes. Trends Endocrinol Metab (2002) 1.34

Physiological and molecular determinants of embryo implantation. Mol Aspects Med (2013) 1.33

Mig-6 modulates uterine steroid hormone responsiveness and exhibits altered expression in endometrial disease. Proc Natl Acad Sci U S A (2009) 1.28

Advances in estrogen receptor biology: prospects for improvements in targeted breast cancer therapy. Breast Cancer Res (2003) 1.26

FK506-binding protein 52 is essential to uterine reproductive physiology controlled by the progesterone receptor A isoform. Mol Endocrinol (2006) 1.25

Insecticide resistance resulting from an absence of target-site gene product. Proc Natl Acad Sci U S A (1998) 1.24

Small molecule inhibition of the steroid receptor coactivators, SRC-3 and SRC-1. Mol Endocrinol (2011) 1.23

Absence of the steroid receptor coactivator-3 induces B-cell lymphoma. EMBO J (2006) 1.22

Nuclear receptor coactivators: master regulators of human health and disease. Annu Rev Med (2013) 1.22

Physical and functional interactions between cellular retinoic acid binding protein II and the retinoic acid-dependent nuclear complex. Mol Cell Biol (1999) 1.22

A new isoform of steroid receptor coactivator-1 is crucial for pathogenic progression of endometriosis. Nat Med (2012) 1.20

Partially redundant functions of SRC-1 and TIF2 in postnatal survival and male reproduction. Proc Natl Acad Sci U S A (2004) 1.19

Uterine disorders and pregnancy complications: insights from mouse models. J Clin Invest (2010) 1.17

A histone methyltransferase is required for maximal response to female sex hormones. Mol Cell Biol (2004) 1.17

Haploinsufficiency of the corepressor of estrogen receptor activity (REA) enhances estrogen receptor function in the mammary gland. Proc Natl Acad Sci U S A (2006) 1.17

Steroid receptor coactivator 3 maintains circulating insulin-like growth factor I (IGF-I) by controlling IGF-binding protein 3 expression. Mol Cell Biol (2008) 1.17

Steroid receptor coactivator-1 (SRC-1) mediates the development of sex-specific brain morphology and behavior. Proc Natl Acad Sci U S A (2000) 1.16

The nuclear hormone receptor coactivator NRC is a pleiotropic modulator affecting growth, development, apoptosis, reproduction, and wound repair. Mol Cell Biol (2004) 1.16

Inactivation of the nuclear receptor coactivator RAP250 in mice results in placental vascular dysfunction. Mol Cell Biol (2003) 1.12

Differential expression of the peroxisome proliferator-activated receptor gamma (PPARgamma) and its coactivators steroid receptor coactivator-1 and PPAR-binding protein PBP in the brown fat, urinary bladder, colon, and breast of the mouse. Am J Pathol (1998) 1.10

Steroid receptor coactivator-1 upregulates integrin α₅ expression to promote breast cancer cell adhesion and migration. Cancer Res (2011) 1.08

Selective estrogen receptor modulators 4-hydroxytamoxifen and raloxifene impact the stability and function of SRC-1 and SRC-3 coactivator proteins. Mol Cell Biol (2004) 1.08

Progesterone action in human tissues: regulation by progesterone receptor (PR) isoform expression, nuclear positioning and coregulator expression. Nucl Recept Signal (2009) 1.08

The regulation of embryo implantation and endometrial decidualization by progesterone receptor signaling. Mol Cell Endocrinol (2011) 1.07

Steroid receptor coactivator 2 is required for female fertility and mammary morphogenesis: insights from the mouse, relevance to the human. Nucl Recept Signal (2007) 1.06

Role of estrogen receptor signaling in breast cancer metastasis. Int J Breast Cancer (2011) 1.06

Negative regulation by thyroid hormone receptor requires an intact coactivator-binding surface. J Clin Invest (2005) 1.05

Expression and transcriptional activity of progesterone receptor A and progesterone receptor B in mammalian cells. Breast Cancer Res (2002) 1.05

Coactivators in PPAR-Regulated Gene Expression. PPAR Res (2010) 1.04

Segregation of steroid receptor coactivator-1 from steroid receptors in mammary epithelium. Proc Natl Acad Sci U S A (1999) 1.04

Act locally and think globally: intracerebral testosterone implants induce seasonal-like growth of adult avian song control circuits. Proc Natl Acad Sci U S A (2002) 1.04

Ligand-dependent contribution of RXRbeta to cholesterol homeostasis in Sertoli cells. EMBO Rep (2004) 1.01

SIP, a novel ankyrin repeat containing protein, sequesters steroid receptor coactivators in the cytoplasm. EMBO J (2007) 1.00

The function of steroid receptor coactivator-1 in normal tissues and cancer. Int J Biol Sci (2012) 1.00

Minireview: the SRC family of coactivators: an entrée to understanding a subset of polygenic diseases? Mol Endocrinol (2009) 0.99

Selective interaction of vitamin D receptor with transcriptional coactivators by a vitamin D analog. Mol Cell Biol (1999) 0.99

Steroid receptor coactivator-1 is necessary for regulation of corticotropin-releasing hormone by chronic stress and glucocorticoids. Proc Natl Acad Sci U S A (2009) 0.99

Differential ligand-dependent protein-protein interactions between nuclear receptors and a neuronal-specific cofactor. Proc Natl Acad Sci U S A (2000) 0.98

PELP1: A novel therapeutic target for hormonal cancers. IUBMB Life (2010) 0.98

Roles of steroid receptor coactivator (SRC)-1 and transcriptional intermediary factor (TIF) 2 in androgen receptor activity in mice. Proc Natl Acad Sci U S A (2005) 0.98

Steroid receptor coactivator-1 mediates estrogenic actions to prevent body weight gain in female mice. Endocrinology (2012) 0.98

Nuclear receptor coactivators function in estrogen receptor- and progestin receptor-dependent aspects of sexual behavior in female rats. Horm Behav (2006) 0.96

Nuclear receptor coactivator/coregulator NCoA6(NRC) is a pleiotropic coregulator involved in transcription, cell survival, growth and development. Nucl Recept Signal (2008) 0.95

Genetic ablation of the steroid receptor coactivator-ubiquitin ligase, E6-AP, results in tissue-selective steroid hormone resistance and defects in reproduction. Mol Cell Biol (2002) 0.95

Who's in charge? Nuclear receptor coactivator and corepressor function in brain and behavior. Front Neuroendocrinol (2009) 0.94

Subfertility linked to combined luteal insufficiency and uterine progesterone resistance. Endocrinology (2010) 0.94

Identification of a novel LXXLL motif in α-actinin 4-spliced isoform that is critical for its interaction with estrogen receptor α and co-activators. J Biol Chem (2012) 0.93

Dynamic cell type specificity of SRC-1 coactivator in modulating uterine progesterone receptor function in mice. Mol Cell Biol (2005) 0.93

SRC-1 and Twist1 expression positively correlates with a poor prognosis in human breast cancer. Int J Biol Sci (2014) 0.93

Role of nuclear receptor coactivator 3 (Ncoa3) in pluripotency maintenance. J Biol Chem (2012) 0.92

Progesterone receptors - animal models and cell signaling in breast cancer: Role of steroid receptor coactivators and corepressors of progesterone receptors in breast cancer. Breast Cancer Res (2002) 0.92

Minireview: nuclear receptor and coregulator proteomics--2012 and beyond. Mol Endocrinol (2012) 0.91

Peroxisome proliferators and peroxisome proliferator-activated receptor alpha: biotic and xenobiotic sensing. Am J Pathol (2004) 0.91

Dual functions of the steroid hormone receptor coactivator 3 in modulating resistance to thyroid hormone. Mol Cell Biol (2005) 0.91

GAS, a new glutamate-rich protein, interacts differentially with SRCs and is involved in oestrogen receptor function. EMBO Rep (2008) 0.90

The role of SRC-1 in murine prostate cancinogenesis is nonessential due to a possible compensation of SRC-3/AIB1 overexpression. Int J Biol Sci (2009) 0.90

In vivo interaction of steroid receptor coactivator (SRC)-1 and the activation function-2 domain of the thyroid hormone receptor (TR) beta in TRbeta E457A knock-in and SRC-1 knockout mice. Endocrinology (2009) 0.90

Roles of coactivators in hypoxic induction of the erythropoietin gene. PLoS One (2010) 0.90

Articles by these authors

Molecular mechanisms of action of steroid/thyroid receptor superfamily members. Annu Rev Biochem (1994) 10.75

Sequence and characterization of a coactivator for the steroid hormone receptor superfamily. Science (1995) 10.42

Nuclear receptor coregulators: cellular and molecular biology. Endocr Rev (1999) 7.42

Specific 5' flanking sequences are required for faithful initiation of in vitro transcription of the ovalbumin gene. Proc Natl Acad Sci U S A (1981) 7.40

Mice lacking progesterone receptor exhibit pleiotropic reproductive abnormalities. Genes Dev (1995) 7.16

Sequence of chicken ovalbumin mRNA. Nature (1978) 6.73

The MAD-related protein Smad7 associates with the TGFbeta receptor and functions as an antagonist of TGFbeta signaling. Cell (1997) 6.34

Steroid receptor coactivator-1 is a histone acetyltransferase. Nature (1997) 6.15

Diabetes, defective pancreatic morphogenesis, and abnormal enteroendocrine differentiation in BETA2/neuroD-deficient mice. Genes Dev (1997) 5.66

A steroid receptor coactivator, SRA, functions as an RNA and is present in an SRC-1 complex. Cell (1999) 4.65

Tissue-specific regulation of the insulin gene by a novel basic helix-loop-helix transcription factor. Genes Dev (1995) 4.07

Metastatic prostate cancer in a transgenic mouse. Cancer Res (1996) 4.02

The steroid receptor coactivator SRC-3 (p/CIP/RAC3/AIB1/ACTR/TRAM-1) is required for normal growth, puberty, female reproductive function, and mammary gland development. Proc Natl Acad Sci U S A (2000) 3.55

Cloning and expression of full-length cDNA encoding human vitamin D receptor. Proc Natl Acad Sci U S A (1988) 3.53

Molecular interactions of steroid hormone receptor with its enhancer element: evidence for receptor dimer formation. Cell (1988) 3.46

The late phase of ischemic preconditioning is abrogated by targeted disruption of the inducible NO synthase gene. Proc Natl Acad Sci U S A (1999) 3.32

Nucleotide sequence homology at 12 intron--exon junctions in the chick ovalbumin gene. Nature (1978) 3.30

The 26S proteasome is required for estrogen receptor-alpha and coactivator turnover and for efficient estrogen receptor-alpha transactivation. Mol Cell (2000) 3.23

A paracrine role for the epithelial progesterone receptor in mammary gland development. Proc Natl Acad Sci U S A (1998) 3.23

COUP transcription factor is a member of the steroid receptor superfamily. Nature (1989) 3.21

Temperature extremes and mortality from coronary heart disease and cerebral infarction in elderly Chinese. Lancet (1995) 3.18

The orphan nuclear receptor COUP-TFII is required for angiogenesis and heart development. Genes Dev (1999) 3.14

Demonstration of an early and a late phase of ischemic preconditioning in mice. Am J Physiol (1998) 3.11

Interaction of human thyroid hormone receptor beta with transcription factor TFIIB may mediate target gene derepression and activation by thyroid hormone. Proc Natl Acad Sci U S A (1993) 3.09

Members of the steroid hormone receptor superfamily interact with TFIIB (S300-II). J Biol Chem (1992) 3.09

Synergistic roles of bone morphogenetic protein 15 and growth differentiation factor 9 in ovarian function. Mol Endocrinol (2001) 2.91

Human progesterone receptor A form is a cell- and promoter-specific repressor of human progesterone receptor B function. Mol Endocrinol (1993) 2.89

Female steroid hormones and target cell nuclei. Science (1974) 2.87

Transcription of structural and intervening sequences in the ovalbumin gene and identification of potential ovalbumin mRNA precursors. Cell (1978) 2.87

Tissue-specific expression of a chicken calmodulin pseudogene lacking intervening sequences. Proc Natl Acad Sci U S A (1983) 2.86

Proteasome-dependent degradation of the human estrogen receptor. Proc Natl Acad Sci U S A (1999) 2.81

FRAP reveals that mobility of oestrogen receptor-alpha is ligand- and proteasome-dependent. Nat Cell Biol (2001) 2.76

Ischemic preconditioning induces selective translocation of protein kinase C isoforms epsilon and eta in the heart of conscious rabbits without subcellular redistribution of total protein kinase C activity. Circ Res (1997) 2.76

Molecular cloning of complementary DNA encoding the avian receptor for vitamin D. Science (1987) 2.71

Cooperative binding of steroid hormone receptors contributes to transcriptional synergism at target enhancer elements. Cell (1989) 2.69

Complete nucleotide sequence of the chicken chromosomal ovalbumin gene and its biological significance. Biochemistry (1981) 2.67

Chicken ovalbumin upstream promoter transcription factor (COUP-TF) dimers bind to different GGTCA response elements, allowing COUP-TF to repress hormonal induction of the vitamin D3, thyroid hormone, and retinoic acid receptors. Mol Cell Biol (1992) 2.59

Ovomucoid intervening sequences specify functional domains and generate protein polymorphism. Cell (1980) 2.57

The Angelman syndrome-associated protein, E6-AP, is a coactivator for the nuclear hormone receptor superfamily. Mol Cell Biol (1999) 2.57

Subgroup of reproductive functions of progesterone mediated by progesterone receptor-B isoform. Science (2000) 2.57

The ovalbumin gene: alleles created by mutations in the intervening sequences of the natural gene. Cell (1979) 2.56

Structure and expression of a chicken gene coding for U1 RNA. Cell (1981) 2.51

Steroid receptor family: structure and functions. Endocr Rev (1990) 2.49

Chick ovalbumin upstream promoter-transcription factors (COUP-TFs): coming of age. Endocr Rev (1997) 2.43

Preparation and preliminary characterization of purified ovalbumin messenger RNA from the hen oviduct. Biochemistry (1975) 2.42

Coactivator and corepressor regulation of the agonist/antagonist activity of the mixed antiestrogen, 4-hydroxytamoxifen. Mol Endocrinol (1997) 2.42

Role of co-activators and co-repressors in the mechanism of steroid/thyroid receptor action. Recent Prog Horm Res (1997) 2.41

CREB binding protein acts synergistically with steroid receptor coactivator-1 to enhance steroid receptor-dependent transcription. Proc Natl Acad Sci U S A (1996) 2.41

The tau 4 activation domain of the thyroid hormone receptor is required for release of a putative corepressor(s) necessary for transcriptional silencing. Mol Cell Biol (1995) 2.39

The mechanism of RU486 antagonism is dependent on the conformation of the carboxy-terminal tail of the human progesterone receptor. Cell (1992) 2.37

Actively transcribed genes are associated with the nuclear matrix. Nature (1984) 2.36

Regulation of the pancreatic islet-specific gene BETA2 (neuroD) by neurogenin 3. Mol Cell Biol (2000) 2.34

Dopaminergic and ligand-independent activation of steroid hormone receptors. Science (1991) 2.33

Loss of BETA2/NeuroD leads to malformation of the dentate gyrus and epilepsy. Proc Natl Acad Sci U S A (2000) 2.32

Studies on the mechanism of steroid hormone regulation of synthesis of specific proteins. Recent Prog Horm Res (1969) 2.31

A regulatory system for use in gene transfer. Proc Natl Acad Sci U S A (1994) 2.22

Definition of 5' and 3' structural boundaries of the chromatin domain containing the ovalbumin multigene family. J Biol Chem (1982) 2.22

Estrogen binding, receptor mRNA, and biologic response in osteoblast-like osteosarcoma cells. Science (1988) 2.22

The rat probasin gene promoter directs hormonally and developmentally regulated expression of a heterologous gene specifically to the prostate in transgenic mice. Mol Endocrinol (1994) 2.22

The protective effect of late preconditioning against myocardial stunning in conscious rabbits is mediated by nitric oxide synthase. Evidence that nitric oxide acts both as a trigger and as a mediator of the late phase of ischemic preconditioning. Circ Res (1997) 2.19

The nitric oxide hypothesis of late preconditioning. Basic Res Cardiol (1998) 2.19

Point mutations in the human vitamin D receptor gene associated with hypocalcemic rickets. Science (1988) 2.15

Vascular MADs: two novel MAD-related genes selectively inducible by flow in human vascular endothelium. Proc Natl Acad Sci U S A (1997) 2.15